Product Name: 11Α,17Α Dihydroxy-Progesterone
Chemical Name: (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
CAS Number: 567-63-1
Identified uses: Pharmaceutical intermediate, research chemical
Supplier Information: Manufacturer or distributor details according to packaging
Emergency Contact: Emergency phone number printed on container label
Classification: Not classified as hazardous according to GHS criteria, yet exposure requires prudent handling
Potential Hazards: Dust may irritate eyes, skin, respiratory system; chronic exposure may cause endocrine disruption
GHS Label Elements: Signal word: Warning, Pictograms: Exclamation mark for skin/eye/respiratory irritation
Hazard Statements: May cause minor respiratory and skin irritation; may alter hormonal balance upon significant or repeated exposure
Precautionary Statements: Avoid breathing dust; prevent contact with eyes and skin; use in well-ventilated areas
Other Hazards: Not flammable or reactive under normal use but can produce harmful dust if mishandled
Chemical Identity: 11Α,17Α Dihydroxy-Progesterone
CAS Number: 567-63-1
Formula: C21H30O3
Synonyms: 11,17-Dihydroxyprogesterone
Impurities: Typically less than 1% related steroidal impurities, further details depend on batch
Purity: >98% (pharmaceutical grade)
Inhalation: Move person to fresh air and keep comfortable; seek medical attention for persistent symptoms
Skin Contact: Wash area thoroughly with soap and water; remove contaminated clothing; get medical help if irritation develops
Eye Contact: Flush eyes with plenty of water for at least 15 minutes; remove contact lenses if present; seek medical attention if irritation persists
Ingestion: Rinse mouth with water; do not induce vomiting; seek immediate medical attention if large amounts swallowed or symptoms develop
Medical Attention: Treat symptomatically and provide supportive care based on individual response
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, or foam. Use water spray for larger fires, but prevent contamination of drains
Unsuitable Extinguishing Media: Avoid direct water jet which could spread powder
Specific Hazards: Combustion may produce oxides of carbon, irritant fumes
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Special Procedures: Cool exposed containers with water spray to prevent explosion; contain runoff
Personal Precautions: Avoid generating dust; wear appropriate PPE including gloves, lab coat, eye protection, and dust mask or respirator
Environmental Precautions: Prevent entry into sewers, surface and ground waters
Cleanup Methods: Sweep up material carefully; avoid dust formation; place in a suitable, closed container for disposal; ventilate area after clean-up
Decontamination: Wash area with soapy water to remove residue
Spill Reporting: Report large releases to relevant authorities as required by law
Handling: Minimize dust generation and accumulation; avoid breathing dust; keep container tightly closed; use in well-ventilated area; wear suitable PPE
Storage: Store in original container in a cool, dry, well-ventilated area; keep away from incompatible substances such as strong oxidizers; avoid exposure to direct sunlight and moisture
Storage Conditions: Store below 25°C; keep container tightly sealed; segregate from food and animal feed
Specific Uses: For laboratory or manufacturing use only; not for human or veterinary medicinal purposes unless specifically authorized
Occupational Exposure Limits: No specific exposure limits established; maintain workplace concentrations as low as possible
Engineering Controls: Work with local exhaust ventilation and dust extraction; maintain negative pressure in handling areas
Personal Protective Equipment (PPE):
Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 235-245°C
Boiling Point: Decomposes before boiling
Solubility: Poorly soluble in water; soluble in organic solvents like ethanol and dimethyl sulfoxide (DMSO)
pH: Not applicable (insoluble in water)
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Kow): Expected to be high (lipid soluble)
Flash Point: Not flammable under normal conditions
Density: Approx. 1.18 g/cm³
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not reactive with typical laboratory or storage materials
Conditions to Avoid: Heat, moisture, direct sunlight
Incompatible Materials: Strong oxidizing agents, acids, bases
Hazardous Decomposition Products: May yield carbon oxides and steroidal fumes upon thermal decomposition
Acute Toxicity: No direct data for LD50; categorically low acute toxicity for related steroids
Routes of Exposure: Inhalation, skin contact, eye contact, accidental ingestion
Skin/Eye Irritation: Mild irritant; may cause redness or discomfort
Respiratory Irritation: Inhalation of dust can irritate nose, throat, lungs
Chronic Effects: May act as hormone disruptor with prolonged exposure; possible impact on adrenal/gonadal axis in laboratory animals
Reproductive Toxicity: Steroids may impact reproductive function at high doses; occupationally relevant levels unlikely to cause systemic effects with proper controls
Carcinogenicity: Not listed as carcinogenic by IARC, ACGIH, NTP, or OSHA
Sensitization: No data, yet potential for skin sensitization in predisposed individuals
Ecotoxicity: No specific data for species; similar compounds may impact aquatic organisms at high concentrations
Persistence and Degradability: Expected to be persistent in soil and water, biodegradable under aerobic conditions; breaks down slowly
Bioaccumulation: Steroid structure suggests potential for biomagnification in aquatic environments
Mobility in Soil: Low mobility due to low water solubility and strong sorption
Other Adverse Effects: At sufficient release quantities, can disrupt hormone balance in aquatic wildlife
Waste Disposal Methods: Dispose of via licensed chemical disposal contractor; do not discard into drains or watercourses
Contaminated Packaging: Dispose containers as hazardous waste; ensure residues are managed appropriately
Special Precautions: Incinerate at authorized facilities following local, national regulations; avoid discharge to environment
UN Number: Not classified as dangerous goods for transport
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not applicable
Packing Group: Not regulated under ADR, IMDG, IATA
Special Precautions: Ensure container integrity during transport to prevent spills; avoid exposure to heat and moisture
Environmental Hazards: Not a marine pollutant but prevent large releases to environment
Safety, Health, and Environmental Regulations: No specific regulatory listing for this compound; subject to general chemical safety and hygiene laws
Labelling Requirements: Employers must display laboratory safety data, maintain inventory of hazardous chemicals
Other Regulations: Compliance with OSHA or equivalent country regulations for chemical handling in the workplace; assess product under TSCA or REACH frameworks for industrial use
Worker Protection: Adhere to all applicable workplace standards for exposure controls, PPE, and emergency planning
Inventory Listings: May not appear on all national chemical inventories; use in accordance with license or exemption where required
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