11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione: A Commentary

Historical Development

Science never moves in a straight line, and the discovery of 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione, often referenced in labs by its shorthand methylprednisolone, shows just how winding the road can get. Decades ago, chemists saw the possibilities in modifying steroid structures to create medications with dramatic physiological effects and manageable side effects. Beginning in the late 1950s, the need for anti-inflammatory options gave researchers a push. The methyl group at the 6-alpha position brought new strength to the corticosteroid market, appealing to teams hungry for compounds less harsh on the body than predecessors like cortisone. Labs put in the hours analyzing how small changes to the steroid backbone altered potency and side effect profiles, which ultimately helped nudge 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione toward mainstream clinical use.

Product Overview

From the dusty warehouse shelves to the polished surfaces of modern hospital pharmacies, this molecule comes around in many forms—raw powders, tablets, injectables. Most people meet it under trade names like Depo-Medrol or Medrol. Production usually involves fermentation followed by a cascade of precise chemical modifications, so sourcing plays a role in price and purity. It stays in demand because doctors often reach for it to calm powerful inflammation when the stakes get high. Unlike older steroids, this one packs its punch with a bit more finesse, helping patients avoid the nastier side effects tied to sodium retention or bone loss.

Physical and Chemical Properties

The molecule stands out under a microscope and behind the chemical hood alike. Chemically, it’s a synthetic glucocorticoid, made up of twenty-two carbon atoms, thirty hydrogen atoms, and three oxygen atoms, all locked in a pattern that chemists spent years fine-tuning. It forms white or off-white crystalline powders, melting well above typical room temperatures, which means shipping and storing it doesn’t require much drama. Solubility in water sits low, but the compound dissolves well in organic solvents, so making injections and tablets depends on the right carrier and preservation method. Stability works in its favor, letting it stay potent on shelves for years if packaging standards stay tight.

Technical Specifications and Labeling

Pharmaceutical companies stick to a list of technical expectations with this molecule. Purity checks use HPLC and melting-point tests, often reporting a result above 98% for medical-grade batches. Standard vials or tablets contain precise weights, set by pharmacopeia or regulatory bodies. Labels always state the exact compound name, manufacturer, expiration date, and batch number. Drug facts show recommended doses and note both strengths and limits: not for patients with untreated infections or systemic fungal disease. Manufacturers must print warnings about potential side effects, interactions, and storage requirements, set in plain language. As a patient, reading the fine print reveals just how much oversight and effort trails behind each pill or injection.

Preparation Method

Chemists start with raw corticoid skeletons, often sourced from plant sterols like diosgenin or from bacterially derived fermentation products. Skilled work in the lab follows: methylation, oxidation, and selective reduction. Each step brings the molecule closer to its final shape, requiring careful temperature control and fine-tuned reagents. After synthesis, purification steps weed out contaminants—solvent washes, crystallization runs, and filter steps all guard purity. Equipment must stay clean, records airtight, and all processes traceable. The experience feels like balancing on a tightrope since one slip can change the activity or toxicity of the compound.

Chemical Reactions and Modifications

Given its versatile backbone, 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione becomes a playground for chemical ingenuity. Chemists have tried attaching various esters to improve absorption or to lengthen the action in the body. Acylation, halogenation, and even selective hydrogenation adjust pharmacokinetics or open up new application routes. These modifications matter since they let one base molecule fill a broader range of therapeutic roles. Sometimes, minor tweaks shift a molecule’s lipid solubility or its binding affinity to steroid receptors—one reason this compound led to a host of “cousins” used across global clinics.

Synonyms and Product Names

Few patients recognize the full IUPAC name, but plenty know products like Solu-Medrol, Medrol, and Methylprednisolone acetate. Synonyms include 6-alpha-Methylprednisolone, 6-alpha-Methyl-17-alpha,21-dihydroxy-pregna-1,4-diene-3,20-dione, and dozens more found on the regulatory filings or technical papers. In hospital settings, the shorthand ‘MP’ rolls off doctors’ tongues, especially in trauma or severe allergy situations. Each synonym signals context—injectable products for quick relief, oral formulations for long-term plans, and depot injections for chronic conditions.

Safety and Operational Standards

Handling methylprednisolone calls for discipline. Workers wear gloves and goggles in the lab, and engineering controls cut down accidental exposure. Pharma-grade plants lock down environmental controls, venting fine particles safely and washing residues off working surfaces at the end of every shift. Regulations in the U.S., EU, and elsewhere dictate strict batch sampling for contaminants, with results logged and audited by inspectors. All finished lots face microbiological testing and residual solvent analysis. Practically, following guidelines protects not just workers but also hospitals and patients—no one wants to trace an adverse event to a slip in QA at a distant supplier.

Application Area

Doctors reach for this compound to slam the brakes on runaway immune responses. Severe allergic reactions, asthma attacks, multiple sclerosis flares, and even spinal cord trauma find some relief thanks to its anti-inflammatory power. It’s standard in post-transplant protocols to fend off rejection, and in some cancer regimens to ease pain and swelling. Not every patient needs this heavyweight; long-term use can bring muscle wasting, bruising, or mood swings. Skilled practitioners weigh the benefits against the risks, often relying on a deep understanding developed through decades of use and plenty of personal experience treating troubled patients.

Research and Development

Research keeps unlocking new angles with this molecule, from better delivery systems to fresh insight into the underlying biology of corticosteroids. New formulations—for example, liposomal carriers—try to target inflamed tissue more directly, reducing collateral impacts on healthy organs. Biologists dig into receptor subtypes to tease out why some patients resist its effects or suffer rare reactions. AI and machine learning now comb through clinical records to spot patterns in side effects. Animal studies and clinical trials press onward, steering clear of overpromising but slowly chipping away at unanswered questions. As new needs arise—drug-resistant autoimmune disorders, for instance—scientists return to this compound, hoping for a tweak or a new application.

Toxicity Research

Every medication with the power to help brings risks, and 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione makes no exception. Lab tests show high-dose or long-term exposure can disrupt calcium balance, suppress adrenal functions, and thin the skin. Early studies flagged immune suppression as a risk, which led to careful timing of vaccinations and infection monitoring for patients. Dog and rodent models highlight specific organ risks at toxic doses, while real-world reports add nuance that controlled trials sometimes miss. Regulatory agencies and internal review boards pore over toxicity data, ready to revise label warnings as new data comes in. Most clinicians have seen at least one case of steroid-induced complications, making it a shared challenge in practice.

Future Prospects

Innovation refuses to stand still. Researchers are hunting for ways to harness the anti-inflammatory muscle of this compound without the toll on bones or immune defenses. Nanotechnology holds promise for smart, site-specific drug delivery. Gene editing and mRNA-based therapies may alter how these molecules interact with cells, possibly sidestepping side effects altogether. Meanwhile, regulators keep raising the bar for factory safety, traceability, and patient monitoring. The real hope sits in learning from experience, using big data to shape more personalized treatment plans and catch rare dangers sooner. With chronic diseases and immune conditions surging, smart development—rooted in solid science and open debate—remains both necessary and possible. Individual stories drive the next set of ideas, from new synthetic routes in the lab to the lived reality of patients searching for relief.



What is 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione used for?

The Science Behind the Name

11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione isn’t a compound you hear about at family gatherings. For most, it sounds intimidating and about as accessible as rocket science. Scientists and healthcare professionals, though, tend to know it better as the mouthful behind certain corticosteroids, primarily used in the management of inflammation and immune responses.

From Lab Bench to Hospital Pharmacy

In real-world medicine, this compound plays a crucial role in synthetic glucocorticoids. Pharmacists often see this name buried in ingredient lists, but doctors, nurses, and patients feel its impact. Its relatives show up in dosed tablets or topical creams for asthma, arthritis, skin rashes, and autoimmune diseases. When I spent time shadowing in a hospital pharmacy, I saw how patients with severe asthma relied on glucocorticoids when other medicines didn’t cut it. A person gasping for breath, suddenly stabilized—these are moments where science meets human need.

Why Does This Compound Matter?

More than a chemical curiosity, 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione directly impacts millions who live with chronic inflammation. Take someone struggling with rheumatoid arthritis. When pain flares up, daily routines fall apart—holding a coffee cup or getting dressed feels impossible. This class of medication brings the body’s over-active immune response under control, easing pain and letting people hold onto their daily routines.

Beneath the Surface: Side Effects and Controversies

These medicines do heavy lifting in acute crises, but they come with a price. As a pharmacy tech, I watched patients dread another round of steroids because of the bloating, insomnia, or the risk of long-term side effects like osteoporosis. For kids, long-term steroid use can stall growth. Adults on regular doses worry about blood sugar, blood pressure, and mood swings. It’s no secret that these risks lead doctors to prescribe the lowest effective dose.

Balancing Risks and Benefits

Doctors must walk a fine line, trying to tame inflammation without triggering a new set of problems. In my experience, informed patients cope better—they ask more questions, track their symptoms, and engage with all their care options. Integrating physical therapy and lifestyle tweaks often keeps doses lower. Medical guidelines emphasize short courses and regular reviews to limit harm.

Pushing Science Forward

The demand for safer treatments drives ongoing research. Clinical trials dig into newer drugs that weaken the immune system less bluntly. Biologics and targeted therapies often step in when steroids lose their usefulness or pile up too many side effects. Community-based education, patient advocacy, and shared decision-making can help narrow the risks that come with medications like these.

Looking Ahead

Living with chronic conditions gets tough when treatments fix one thing but upset another. While 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione still has a place in treatment plans, healthcare teams now fight for better options. Listening to patients, ramping up research, and practicing responsible prescribing bring real improvements into daily life. There’s no one-size-fits-all cure, but there’s always progress to be made.

Is 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione safe to use?

The Story Behind This Synthetic Steroid

11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione doesn’t roll off the tongue. Popular in bodybuilding circles under names like methylprednisolone acetate or "Designer Prohormones," this synthetic steroid shows up where people want fast muscle gains, weight loss, or performance edge.

Why So Many Seek It

I remember friends at my gym talking about these hormone derivatives as shortcuts. People worried about side effects of old-school anabolic steroids hoped that tweaking the molecule would dodge liver damage, estrogen spikes, or mood swings—especially since sellers market these compounds as “legal” alternatives with fewer risks. Stories spread about stacked transformations in weeks, leading more people to take a leap.

The Real Risks Lurking

Let’s get straight to it. Chemically, this steroid tweaks standard corticosteroid and androgen pathways. The main problem? It’s mostly untested on humans outside narrow medical research. Claims pile up about fewer side effects, but hard numbers are lacking. Reports in the medical literature connect drugs like this to high blood pressure, troubled blood sugar, messed-up cholesterol, liver stress, plus mood changes ranging from agitation to major lows. The odds of these problems go up with dosage, stacking, or if users already have health issues like heart disease or kidney trouble.

I watched a friend rely on a similar compound to speed up fat loss before a competition. The initial energy boost wore off, and what followed was a storm of joint pain, wild swings in appetite, sleepless nights, and skin breakouts. Only later did blood tests spotlight rising liver enzymes—a big red flag. A lesson learned too late for many users who assume “research chemical” equals “laboratory safety.”

Where Science and Hype Part Ways

Published safety data on 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione alone is thin. Medical journals flag case studies of users landing in emergency rooms with organ stress. The FDA sent strong warnings about many over-the-counter steroids dressed up as supplements containing this compound without clear labeling. That should make anyone stop and think, even before looking for any legal supplier.

Doctors caution that synthetic steroids—no matter the molecular tweak—don’t wear a “risk-free” badge. They carry similar dangers as older prescription drugs, but without regular lab work or informed dosing. In the gym world, rumors travel faster than science. Just because some athletes escape bad outcomes doesn’t mean most people will.

Better Paths Than Blind Experimentation

Instead of trying to outwit biology one molecule at a time, safer strategies still turn up better long-term results. Balanced nutrition, rest, and realistic training goals keep far more people healthy. Nutrition studies support steady gains with protein-rich diets, regular resistance exercise, and mindful recovery. Tools like blood work, honest conversation with doctors, and skepticism toward miracle solutions help people avoid the ER.

The next time a new performance booster pops up on a supplement label or gym forum, take a step back. Ask where the data comes from, who stands behind safety claims, and what happens if things go wrong. Informed choices start with asking better questions—and not trusting a chemical name just because it sounds new.

What are the possible side effects of 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione?

What Is This Compound, and Why the Caution?

11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione. The name almost feels like a dare, but it refers to a synthetic steroid compound. Some people know it as Methyldienolone or by other handles in bodybuilding circles. Compared to familiar steroids, this one doesn’t make the rounds for medical therapy—it slid onto the scene as a performance enhancer. Stuff like this can pull ahead in muscle growth but seldom stays on the safe side for health.

Real Risks: The Liver Takes a Hit

Liver strain rises to the top of the risk ladder with this kind of compound. My background in pharmacy makes it clear: methylated oral steroids tend to punch the liver harder than most. Elevated liver enzymes show up in blood work. Jaundice happens too often for comfort. The liver, which helps process so much of what we take in, bears the brunt of artificial hormones. Studies line up with this concern, linking the use of methylated steroids like this one with hepatitis, liver tumors, and cholestasis. These are not rare flukes either—they’ve all sent people I’ve met in clinic to the emergency room.

Hormones: A Natural Balance Disrupted

This steroid can shake up the body’s hormone patterns. Men report testicular shrinkage and reduced natural testosterone. Mood swings land as heavy as the gains promised—depression, irritability, and even rage become real side effects in lived experiences. Serious risks include gynecomastia, which means breast tissue swelling from hormonal confusion. Women don’t have it easier. Virilization can occur: deeper voice, facial hair, changes in menstruation. Once these things start, they sometimes stick around longer than anyone expects.

Heart Health: Not Built for the Long Haul

Steroids with structures like this often climb into cholesterol and blood pressure territory. I’ve seen cholesterol labs swing in the wrong direction—HDL drops, LDL climbs, triglycerides follow. Over time, arteries stiffen up and blood doesn’t flow with the same freedom it used to. The risk for heart attack shoots up. High blood pressure sneaks in. Anyone with a family history of heart disease should think twice, and then a third time.

Kidneys, Skin, and More

Behind every slick ad about quick muscle, stories pile up about acne breakouts, hair loss, and male-pattern baldness. Sometimes users notice their urine turning dark or cloudy, foreshadowing kidney trouble. I sat in on more than one appointment with young men learning about high creatinine and protein in their urine, not from football hits, but from supplement experiments gone wrong. Sleep problems and appetite changes often follow, rounding out the package of side effects.

Safe Choices and Real Solutions

None of this means people chase these results out of ignorance. Pressure to perform or look a certain way runs deep. Real alternatives involve evidence-based fitness, honest conversations with healthcare providers, and using only substances that have been thoroughly vetted for safety. The temptation for shortcuts feels personal for many, but shortcuts hide longer detours in health down the line.

Changing the trend means reliable information gets out—no mystery behind the label, no hush in the gym changing room. Doctors, trainers, and experienced athletes who’ve left steroids behind hold the stories that matter. Policies that regulate supplement shelves and educational campaigns in schools put power back in the hands of people making choices about their health.

How should I dose or take 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione?

Understanding What You’re Dealing With

The name itself points toward a synthetic steroid, most known on the street as “Methyldienolone” or “Dienedione,” often sold in bodybuilding circles. This isn’t a casual supplement—this is a potent, non-medical anabolic steroid. People reach for it trying to pack on muscle or boost strength beyond their natural ceiling. Looking up dosing advice online brings up a mess of speculation, plenty of bold claims, and a lot of risk.

Medical Guidance? Not Likely Here

Doctors aren’t handing out prescriptions for it—and don’t hand out detailed instructions on how to use it safely, either. What you get is message board advice, anecdotal cycles, and “bro science.” The FDA never approved this compound, and reliable clinical studies in humans are missing entirely. Anyone who’s planning to use it flies blind into unknown territory.

The Risks Most Folks Ignore

I’ve seen friends chase big bench numbers with oral steroids and end up with nosebleeds, wild mood swings, yellowed eyes, and what they thought was “just a headache.” Liver enzymes go through the roof. Blood pressure sneaks up. Lipid profiles tank. There’s no quick fix—once your health feels off, it takes months or years to recover, if you’re lucky.

Online, people toss out dosing like “5-20 mg per day for 4-6 weeks.” Side effects don’t always punch in at the same dose or on the same timeline for every person. One guy might handle it for a month and walk away feeling fine. Someone else could notice hair loss, back acne, low libido after ten days.

What Makes Dosing So Tricky

Potency matters. Accuracy of the label matters. Batches bought online or from gym locker rooms get produced with less oversight than homebrew moonshine. The dose that ends up in one capsule could be double or half the next. Some don’t even contain what’s on the label. It isn’t paranoia—test labs have caught counterfeit or underdosed products year after year.

Liver toxicity stands out as the big risk. Oral steroids that survive digestion often stress your liver hard. Add alcohol, acetaminophen, low water intake, and the odds of injury climb fast. Most users try to “run” support supplements, but milk thistle doesn’t patch a blown gasket.

Better Paths for Muscle and Strength

Building real, lasting strength still comes back to eating enough, training consistently, and sleeping plenty. The old-school lifts, incremental progress, tracking food and weight—boring to some, but these never left anyone with jaundice or kidney pain. If a doctor prescribes hormone therapy, it comes with checkups and lab monitoring. That kind of safety net isn’t part of the picture with gray-market compounds.

If you’re after muscle, look for methods that earn trust, not shortcuts. The stories about lifelong regrets from hormone use rarely make front-page news, but lurk on forums and in gym locker rooms. I’ve sat with guys regretting the quick shot at size, wishing for a chance to restart.

Your Health, Your Call

Decisions around off-label steroids like 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione go beyond simple dosing questions. Taking big risks for small rewards feels thrilling in the short run. Years later, those consequences become clear. Always seek medical advice from a real professional. Health is tough to fix once the damage gets done.

Is a prescription required to purchase 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione?

Stumbling through the long name of 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione may leave the tongue tired, but it’s really just the proper name for methylprednisolone, a common corticosteroid. Doctors reach for it to cool inflammation in conditions like arthritis, asthma, and certain allergic reactions. As an asthma patient myself, I know the sigh of relief these medications bring during a bad flare-up. Still, the ease of picking it up shouldn’t lull anyone into thinking it’s just another vitamin on the pharmacy shelf.

The Legal Barriers

No U.S. pharmacy will hand over methylprednisolone or similar steroids without a doctor’s prescription. Not a policy wrapped in bureaucratic tape—it’s a public safety move. Imagine someone self-medicating for joint pain, not realizing long-term steroid abuse can raise blood pressure, weaken bones, and harm blood sugar levels. I’ve watched friends tempted by quick fixes, only to land in worse shape than when they began.

Misuse: More Common Than You Think

It’s easy to get swept into online health forums, where some claim these medications speed muscle gains or help control every ache. A few websites sneak around regulations, selling overseas or hawking “research chemicals” with little oversight. These sites rarely warn about dramatic mood swings, immune suppression, or the body’s dependence after long use. In 2022, the FDA issued warnings against unregulated online pharmacies precisely because too many folks wound up with knockoff drugs—or lost money altogether. These risks go way beyond a wasted paycheck.

Doctors Matter—And So Does Ongoing Supervision

Prescription-only isn’t just a hurdle; it’s an agreement. You and your doctor track results, side effects, infections, and labs like blood sugar or liver enzymes. I remember getting my dose adjusted multiple times after routine blood tests flagged trouble. The safest way forward is real medical oversight—not lone-wolf guesswork based on vague online advice.

Stopping Abuse, Protecting Health

Folks rarely talk about the slow, silent damage that misuse inflicts. Chronic steroid use can thin bones, stunt kids’ growth, or trigger diabetes in adults. Doctors also see rebound effects when people quit abruptly. More than one clinic patient has landed in the ER after trying to “tough it out” and stop without guidance.

What Needs Fixing

Smarter access starts with better education. Pharmacies and doctors should be crystal-clear: methylprednisolone isn’t a shortcut to better health. Tightening import laws helps, but nothing replaces honest conversations between patient and provider. Insurance can still be a stumbling block. Affordable options, especially for chronic conditions, make following medical advice realistic for more Americans. Pushing policymakers to support affordable and safe access—especially for folks with routine or severe inflammation—matters much more than slapping on more red tape.

Getting a prescription requirement for 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione isn’t a nuisance. It’s a line of defense, one I appreciate every time my symptoms settle down under the watchful eye of a professional. Tempting as shortcuts may look, experience and research show that a bit of extra caution saves far more than just a trip to the doctor’s office.

11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione
Names
Preferred IUPAC name (6α)-6-Methyl-11β,17-dihydroxypregna-1,4-diene-3,20-dione
Other names Methyldienolone
Methyldienolone acetate
6-Methyl-19-norprogesterone
6α-Methyl-19-norpregna-4,9-diene-3,20-dione
Pronunciation /ˌɛlɛvənˈbeɪtə ˌsɛvənˈtiːˈæl.fə daɪˈhaɪdrɒksi ˈsɪksˈæl.fə ˈmɛθ.əlˈprɛg.nə ˈwʌn faɪv ˈdaɪ.ɛn ˈθriːˈtwɛnti daɪˈoʊn/
Preferred IUPAC name (6S,8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-6,10,13-trimethyl-1,4,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,20-dione
Other names Methyldienolone
11β,17α-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione
Methyldienolone acetate
Pronunciation /ˌɪlˈbɛtə ˌsɛvənˈtiːˌælfə daɪˈhaɪdrɒksi ˌsɪksˈælfə ˈmiːθəlˌprɛɡnə ˌwʌn fɔːr daɪˈiːn θriː twɛnti daɪˈoʊn/
Identifiers
CAS Number 2626-04-2
Beilstein Reference 1535044
ChEBI CHEBI:76267
ChEMBL CHEMBL1496
ChemSpider 69097
DrugBank DB00635
ECHA InfoCard 03ee369a-6542-4b0a-8ea6-1627bc9c0b67
EC Number 244-825-8
Gmelin Reference 1447171
KEGG C16155
MeSH Dexamethasone
PubChem CID 10167
RTECS number YF7510000
UNII 92R8I8E77D
UN number UN2811
CAS Number 2207-75-2
Beilstein Reference 3951877
ChEBI CHEBI:7622
ChEMBL CHEMBL1389
ChemSpider 21567742
DrugBank DB00635
ECHA InfoCard ECHA-InfoCard-100.040.207
EC Number 260-967-7
Gmelin Reference 1155115
KEGG C16535
MeSH Dexamethasone
PubChem CID 3033860
RTECS number RY0900000
UNII 0X6WQ6UH9O
UN number UN2811
Properties
Chemical formula C22H28O4
Molar mass 394.477 g/mol
Appearance White to Off-White Solid
Odor Odorless
Density 1.2 g/cm³
Solubility in water Practically insoluble in water
log P 1.9
Vapor pressure 2.97 x 10^-8 mm Hg at 25°C
Acidity (pKa) 12.65
Basicity (pKb) 2.80
Magnetic susceptibility (χ) -85.0e-6 cm³/mol
Refractive index (nD) 1.618
Viscosity Free flowing powder
Dipole moment 3.49 D
Chemical formula C22H28O4
Molar mass 394.495 g/mol
Appearance White Solid
Odor Odorless
Density 1.21 g/cm³
Solubility in water Slightly soluble in water
log P 1.95
Vapor pressure 8.29E-11 mm Hg at 25°C
Acidity (pKa) 12.59
Basicity (pKb) 2.55
Magnetic susceptibility (χ) -72.6e-6 cm³/mol
Refractive index (nD) 1.613
Viscosity Viscous liquid
Dipole moment 3.25 D
Thermochemistry
Std molar entropy (S⦵298) 587.6 J K⁻¹ mol⁻¹
Std enthalpy of combustion (ΔcH⦵298) -7147 kJ/mol
Std molar entropy (S⦵298) 570.6 J·mol⁻¹·K⁻¹
Std enthalpy of combustion (ΔcH⦵298) -7391.2 kJ/mol
Pharmacology
ATC code H02AB04
ATC code H02AB04
Hazards
Main hazards Causes damage to organs through prolonged or repeated exposure.
GHS labelling GHS02, GHS07
Pictograms `COC1=CC2=C(C=C1)C(=O)C(=C(O2)C3CC(C4C3CCC5=CC(=O)CCC45)O)C`
Signal word Warning
Hazard statements H302, H315, H319, H335
Precautionary statements P210, P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P362+P364, P403+P233, P405, P501
LD50 (median dose) > 3160 mg/kg (rat, oral)
NIOSH GZ8963000
PEL (Permissible) Not established
REL (Recommended) 0.01 mg/m³
Main hazards Harmful if swallowed. Causes serious eye irritation. Causes skin irritation. May cause respiratory irritation.
GHS labelling GHS02,GHS07,GHS08
Pictograms GHS06,GHS08
Signal word Danger
Hazard statements H315, H319, H335
Precautionary statements P210, P261, P264, P280, P301+P312, P305+P351+P338, P337+P313
NFPA 704 (fire diamond) 0-0-0
LD50 (median dose) LD50 (median dose): >3000 mg/kg (rat, oral)
NIOSH GY0175000
PEL (Permissible) Not established
REL (Recommended) 0.05 mg/m3
IDLH (Immediate danger) Not listed
Related compounds
Related compounds Cortisol
Prednisolone
Hydrocortisone
Dexamethasone
Betamethasone
Methylprednisolone
Triamcinolone
Fludrocortisone
Related compounds Prednisolone
Methylprednisolone
Hydrocortisone
Prednisone
Cortisol