Product Name: 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione
Synonyms: Methylprednisolone
CAS Number: 83-43-2
Recommended Uses: Pharmaceutical ingredient, corticosteroid research, chemical synthesis
Supplier Information: Manufacturer or laboratory supply company details should appear here along with address and phone number
Emergency Contact: Specify a 24-hour emergency contact provided by manufacturer or company, including phone and response instructions
Classification: Eye irritation, skin irritation, may cause respiratory irritation, may affect reproductive health, suspected mutagen
GHS Label Elements: Warning symbol for health hazard and exclamation mark
Signal Word: Warning
Hazard Statements: Possible harm if swallowed, irritation to eyes and skin on contact, risk of dizziness or drowsiness after inhalation, possible risk to fertility or unborn child, repeated exposure may cause organ damage
Precautionary Statements: Avoid breathing dust, do not get in eyes or skin, wear protective gloves and face shield, use only with proper ventilation, wash hands thoroughly after handling, store locked away from children and untrained users
Chemical Name: 11Beta,17Alpha-Dihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione
Formula: C22H30O5
Weight %: 98-100% (purity depends on grade and supplier)
Impurities: Trace solvent residues, possible lower molecular weight steroids
Additives: None unless formulated or processed into another product
Other Identification: No common additives, ingredients, or hazardous impurities in pharmaceutical grade
Inhalation: Remove person to fresh air immediately, keep comfortable for breathing, contact physician if symptoms develop
Skin Contact: Remove contaminated clothing, wash exposed skin area with plenty of water and soap, seek medical advice if redness or irritation persists
Eye Contact: Rinse eyes gently with water for at least 15 minutes, remove contact lenses if present and easy to do, call healthcare professional right away
Ingestion: Rinse mouth, do not induce vomiting, seek medical advice and present label whenever possible
Suitable Extinguishing Media: Use water spray, dry chemical powder, foam, or carbon dioxide to extinguish any fire involving this substance
Hazardous Combustion Products: Forms carbon monoxide, carbon dioxide, possibly irritating or toxic fumes under fire conditions
Firefighter Protection: Use full protective gear and self-contained breathing apparatus, keep containers cool with water spray from a safe distance, avoid direct contact with hazardous dust and smoke
Special Procedures: Evacuate area, avoid walking through spilled powder, ventilate area after fire
Personal Precautions: Wear gloves, safety goggles, lab coat or suit, provide adequate ventilation, avoid breathing dust or contact with skin
Environmental Precautions: Avoid disposal into drains, soil, or surface water, prevent run-off and contamination of public water sources
Clean-Up Methods: Use non-reactive absorbent (sand, vermiculite), collect spilled powder carefully and place into secure, labeled disposal container, wash spill site after material pickup is complete
Handling: Use inside chemical fume hood or ventilated environment, keep containers sealed when not in use, avoid direct contact and liquid splash, do not eat, drink, or smoke in work area, wash hands thoroughly after handling
Storage: Store in original, tightly closed container at room temperature or as advised by supplier, isolate from incompatible substances (oxidizing agents, acids), avoid extreme heat and light, keep out of reach of unauthorized personnel
Exposure Limits: No established occupational exposure limits for this compound; use general control limits of dusts where applicable
Engineering Controls: Ensure local exhaust or adequate general ventilation, work in laboratory hood for all weighing, mixing, or transfer steps
Personal Protection: Wear approved chemical-resistant gloves and lab gown, use safety goggles or face shield, select respiratory protection if dust formation may occur or levels approach workplace limits, always remove and wash contaminated clothing immediately
Appearance: White or off-white crystalline powder
Odor: Odorless or slight chemical odor
Molecular Weight: 374.5 g/mol
Melting Point: 231-235°C
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Sparingly soluble in water, freely soluble in methanol, ethanol, chloroform
pH: Not available
Flash Point: Not flammable under normal laboratory conditions
Partition Coefficient (log Pow): 1.79 (estimated)
Vapor Pressure: Not significant at room temperature
Other Data: Stable solid under ordinary conditions of use and storage
Chemical Stability: Stable under recommended storage and use conditions
Reactivity: No specific reactivity issues with ordinary materials
Conditions to Avoid: Prolonged exposure to light, excessive heat, contact with strong acids or alkalis
Incompatible Materials: Strong oxidizing and reducing agents, strong acids
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, various organic compounds under fire or decomposition
Polymerization: Does not undergo hazardous polymerization under normal processing
Acute Toxicity: No formal human lethal dose data available, animal models report toxicity at moderate to high levels
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Symptoms: Respiratory tract and mucous membrane irritation, gastrointestinal discomfort if ingested, eye and skin redness or pain
Chronic Effects: Animal studies link long-term exposure to immune suppression, hormonal imbalance, reproductive effects
Sensitization: May cause allergic reactions in sensitive individuals
Mutagenic/Carcinogenic Potential: Some evidence suggests possible genotoxicity in structure-activity studies; no full animal carcinogenicity data
Other Information: Excessive exposure may pose long-term risks—handle with special care in reproductive-age women and sensitive populations
Ecotoxicity: Data for freshwater organisms limited; corticosteroids can disrupt aquatic invertebrate life cycles at high levels
Mobility: Moderate; will bind to sediment and organic matter in soil or water, with potential for bioaccumulation
Persistence and Degradability: Compound degrades slowly in environment, especially under low light or oxygen conditions
Bioaccumulation Potential: May accumulate in aquatic organisms in exposed environments over time
Aquatic Toxicity: Possible risk to fish, amphibians, or water insects with extended environmental release
Other Adverse Effects: Environmental concentrations should be minimized through containment and correct disposal
Waste Treatment Methods: Treat as non-hazardous chemical waste if uncontaminated, otherwise as hazardous pharmaceutical waste
Disposal Containers: Use screw-top, leak-proof containers clearly labeled for hazardous chemicals
Methods for Disposal: Dispose of through licensed hazardous waste contractor approved by local authorities, incineration preferred according to best practice
Regulations: Do not discharge to rivers, lakes, or general communal wastewater
Other Information: Containers and spill clean-up materials must be disposed of using same procedures as main product
UN Number: Not classified as dangerous for transport according to major road, rail, air, or sea transport guidelines (e.g., DOT, ADR, IATA, IMDG)
Proper Shipping Name: Chemical substance, not otherwise specified
Transport Hazard Class: Non-hazardous—take reasonable measures to prevent dust release
Packing Group: Not assigned
Environmental Hazards: Not classified as environmentally hazardous for transport; avoid entry into water or sewage
Special Precautions: Secure packaging recommended to prevent accidental release, use strong cartons or plastic drums
Labeling Requirements: Compliant with OSHA Hazard Communication Standard; use standard warning statements and hazard pictograms
US Federal Regulations: Not specifically listed under SARA, CERCLA, or TSCA, subject to OSHA General Duty Clause
EU Regulatory Status: Not listed in major EU restrictions, should follow local workplace hygiene and chemical safety directives
Other Country Regulations: May be regulated under pharmaceuticals or controlled chemicals in some jurisdictions
Additional Notes: Ensure users are appropriately trained in chemical handling, have access to this MSDS, and are familiar with emergency procedures relevant to this compound
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