Product Name: 16-Alpha-Methyl Epoxide
Chemical Formula: C20H28O
Synonyms: 16-Alpha-Methyl-17,17-epoxyandrostane
Recommended Use: Intermediate for chemical synthesis, research applications in pharmaceutical sectors
Manufacturer: Not specified, batch and supplier details available on request
Emergency Contact: Provided according to regional standards
UN Number: 2810
GHS Classification: Acute Toxicity (Oral, Category 3); Skin Irritation (Category 2); Eye Irritation (Category 2A); Specific target organ toxicity – single exposure (Category 3)
Signal Word: Danger
Hazard Statements: Toxic if swallowed; causes skin irritation; causes serious eye irritation; may cause respiratory irritation
Pictograms: Skull and crossbones, exclamation mark
Precautionary Statements: Wear protective gloves, protective clothing, and eye/face protection; wash hands thoroughly after handling; do not eat, drink or smoke when using this product; avoid breathing dust/fume/gas/mist/vapors/spray
Chemical Name: 16-Alpha-Methyl Epoxide
CAS Number: 3249-52-1
Percentage: ≥97% (by weight)
Impurities: None expected to affect classification
Additive Components: No additives listed
Inhalation: Move person to fresh air; seek medical attention; monitor for difficulty breathing or persistent coughing
Skin Contact: Remove contaminated clothing; rinse skin thoroughly with water for at least 15 minutes; seek medical advice for persistent redness or irritation
Eye Contact: Rinse cautiously with water for no fewer than 15 minutes; remove contact lenses if present and easy; continue rinsing; seek immediate medical attention
Ingestion: Do not induce vomiting; rinse mouth thoroughly with water; seek immediate medical advice; keep individual calm and monitored for symptoms such as nausea or drowsiness
Notes to Physician: Treat symptomatically and supportively; no specific antidote known
Suitable Extinguishing Media: Foam, carbon dioxide, dry chemical, water spray
Unsuitable Media: High-pressure water jets may spread chemical and increase exposure risk
Special Hazards: Vapors may form explosive mixtures with air under certain conditions; hazardous combustion products include carbon monoxide, carbon dioxide, unidentified organic compounds
Protective Equipment: Firefighters wear self-contained breathing apparatus, full protective suit
Firefighting Instructions: Isolate fire area, remain upwind, avoid breathing fumes; cool exposed containers with water
Personal Precautions: Evacuate area, ventilate, use appropriate PPE including chemical resistant gloves and goggles
Environmental Precautions: Prevent entry into drains, water sources and soil; notify authorities if spill enters waterway
Clean-up Procedures: Absorb with inert material such as vermiculite; collect in closed, labeled container for disposal; avoid raising dust; wash contaminated area with soap and water after removal
Small Spills: Wipe up residue with absorbent material; double-bag for disposal
Large Spills: Dike spill area for containment, recover by pump or by vacuum system
Handling Precautions: Use only with adequate ventilation; store away from incompatible substances including oxidizers and acids; avoid inhalation or contact with eyes and skin; wear proper PPE in all handling operations
Storage Conditions: Store in tightly closed containers, in cool, dry, well-ventilated place; keep away from sources of ignition, sunlight, and moisture
Incompatible Materials: Strong oxidizing agents, acids, acid anhydrides
Storage Temperature: Maintain between 2–8°C for stability; avoid temperature swings
Occupational Exposure Limits: No data available for compound-specific standards; suggest adhering to general chemical hygiene guidelines
Engineering Controls: Local exhaust ventilation; eyewash stations and safety showers in work area
Personal Protection: Chemical-resistant gloves (nitrile or PVC recommended), protective goggles or face shield, lab coat or protective clothing, fitted respirator if exposure limits may be exceeded
Hygiene Measures: Wash hands, forearms and face thoroughly after handling; do not eat, drink, or smoke during use; remove contaminated clothing before leaving workplace
Appearance: White crystalline powder
Odor: Odorless or faint characteristic odor
Odor Threshold: Not established
pH: Not applicable in substance form
Melting Point: 142 – 147 °C
Boiling Point: Data not available
Flash Point: >110 °C (closed cup, estimated)
Flammability: Not classified as highly flammable
Vapor Pressure: Negligible at ambient temperature
Density: 1.15 g/cm³ (estimated)
Solubility: Insoluble in water, soluble in organic solvents like ethanol and acetone
Partition Coefficient (log Kow): >3 (expected)
Evaporation Rate: Negligible
Viscosity: Not relevant for solid
Chemical Stability: Stable under standard temperature and pressure; decomposition may arise from exposure to light, extreme heat, or strong oxidizers
Potential Reactions: Exothermic reaction possible with strong oxidizing agents; may decompose to emit toxic fumes including oxides of carbon
Incompatible Materials: Strong acids, bases, oxidizers
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, possibly other harmful gases
Polymerization: Not likely to undergo hazardous polymerization under recommended use and storage
Acute Toxicity: Estimated oral LD50 (rat) 50-300 mg/kg; toxic if swallowed
Chronic Toxicity: Prolonged or repeated contact may result in skin defatting, dermatitis, or sensitization
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms: Headache, nausea, drowsiness, abdominal pain, skin redness and irritation, eye watering and pain
Carcinogenicity: No data available; not listed as carcinogen by ACGIH, IARC, NTP, OSHA
Reproductive Toxicity: No information found
Mutagenicity: Not tested adequately for mutagenic effects
Sensitization: Rare, but prolonged exposure may cause allergic reaction in sensitive individuals
Ecotoxicity: Expected to be toxic to aquatic life, especially in high or concentrated exposure
Mobility: Low solubility and vapor pressure; not volatile
Persistence and Degradability: Slowly biodegradable in soil and water, likely persistent in environment
Bioaccumulation: High potential for bioaccumulation in aquatic organisms due to hydrophobic characteristics
Aquatic Toxicity: LC50 (fish): not established, but toxicity expected based on chemical family
Soil Impact: Possible risk of transport into groundwater if released in significant amounts
Other Adverse Effects: May disrupt microorganism balance in wastewater treatment at significant concentrations
Product Disposal: Dispose of in accordance with local, regional, national and international laws; incineration in approved facility recommended; avoid disposing in sewer or natural waterways
Contaminated Packaging: Triple-rinse containers; offer for recycling or disposal at authorized facility
Waste Codes: Assign hazardous waste number based on chemical characteristics and local regulations
Special Considerations: Ensure all personnel involved in disposal use suitable PPE; document and track quantities disposed for regulatory compliance
UN Number: 2810
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains 16-Alpha-Methyl Epoxide)
Transport Hazard Class: 6.1 (Toxic Substances)
Packing Group: II
Labeling: Toxic, keep away from foodstuffs and animal feed during transit
Marine Pollutant Status: Not classified as marine pollutant, but prevent spillage to avoid environmental impact
Packaging Instructions: Use tightly closed, leak-proof packaging in accordance with transport authority recommendations
Special Precautions: Transport only by authorized carriers; notify receiving personnel in advance of arrival
Regulatory Status: Chemical subject to regulation under many jurisdictions, including TSCA (USA), REACH (EU), and similar listings; check local legislation for specifics
Workplace Classification: Classified as hazardous under OSHA Hazard Communication Standard; relevant for WHMIS (Canada), and similar systems worldwide
Inventory Status: Listed or notified in national inventories where applicable
Restrictions: Restricted for consumer use; authorized for industrial and professional use only
Label Requirements: Comply with OSHA, GHS, and local labeling laws
Other Data: SDS should be accessible to all personnel working with the substance, regular training recommended, and document retention according to legal frameworks
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