Product Name: 16A-Hydroxy Prednisolone
Chemical Name: 11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione
Synonyms: Hydrocortisol, 16α-Hydroxyprednisolone
Molecular Formula: C21H28O6
Molecular Weight: 376.44 g/mol
Recommended Use: Pharmaceutical synthesis, corticosteroid research
Supplier: Contact responsible distributor or manufacturer for full company information
Emergency Contact: Refer to national Poison Control Center or local emergency number
GHS Classification: Not classified as hazardous under GHS criteria in most jurisdictions
Physical Hazards: Not flammable or explosive under normal conditions
Health Hazards: May cause irritation to eyes, skin, and respiratory tract if there is direct exposure; long-term contact brings risk of hormonal side effects
Environmental Hazards: Low risk to aquatic life in standard concentrations; persistence and degradation data remains limited
Label Elements: Not required by GHS in most countries; handle with professional practices and care for hormone activity
Other Hazards: Not intended for direct human or veterinary therapeutic use except under supervision
Chemical Identity: 16A-Hydroxy Prednisolone
Purity: Typically exceeds 95% (exact value documented per lot)
Impurities: Trace byproducts from synthesis (typically less than 2%)
Additives: None
CAS Number: 80-85-7
Inhalation: Move affected person to fresh air, allow quiet rest, consult physician for symptoms
Skin Contact: Remove contaminated clothing, wash exposed skin with plenty of water and soap
Eye Contact: Rinse immediately with plenty of water for several minutes, seek medical help if irritation persists
Ingestion: Rinse mouth, seek prompt medical advice or attention, don't induce vomiting unless instructed by medical personnel
Most Important Symptoms: Irritation to eyes, skin, and mucous membranes; at higher exposures, symptoms related to glucocorticoid activity such as metabolic or immune response disruption
Notes for Physicians: Symptomatic and supportive treatment recommended, monitor for potential hormone effects
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Extinguishing Media: None documented
Hazardous Combustion Products: Releases carbon oxides (CO, CO2) and potentially irritating fumes
Special Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Fire and Explosion Risk: Not reactive or volatile under normal conditions; avoid inhaling smoke or fumes
Additional Measures: Prevent run-off water from entering sewers or watercourses whenever possible
Personal Precautions: Use personal protective equipment including gloves, goggles, and a lab coat
Environmental Precautions: Contain spill to prevent leak into drains or waterways
Clean-Up Methods: Scoop up spilled powder with non-sparking tools, collect in properly labeled container for proper disposal
Decontamination: Wash area with soap and water, ventilate affected space
Secondary Risks: Clean thoroughly to prevent accidental hormone exposure for others
Safe Handling Practices: Avoid breathing dust, minimize dust generation, avoid contact with skin and eyes, practice good hygiene
Technical Measures: Use only in well-ventilated areas, employ local exhaust ventilation whenever available
Storage Conditions: Store in tightly closed containers at 2-8°C, protected from light, moisture, and incompatible materials
Incompatible Materials: Strong oxidizing agents, acids, alkalis
Storage Class: Pharmaceuticals or hazardous organics as per facility guidelines
Specific End Use: For laboratory use, reagent, or pharmaceutical synthesis under professional direction
Exposure Limits: No occupational exposure limits set for this compound
Engineering Controls: Use laboratory fume hood or local exhaust ventilation
Personal Protection: Wear chemical-resistant gloves (nitrile recommended), safety goggles, lab coat
Respiratory Protection: Dust mask or respirator certified for chemical particulates in case of insufficient ventilation
Hygiene Measures: Wash hands after handling, avoid eating or drinking in lab areas
Environmental Exposure Controls: Ensure waste is collected and handled in line with facility environmental and safety standards
Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 230-235°C
Solubility: Slightly soluble in water, freely soluble in methanol, ethanol, acetone
pH: Not measured in aqueous solution
Boiling Point: Decomposes before boiling
Vapor Pressure: Negligible at room temperature
Density: Approximately 1.4 g/cm3
Partition Coefficient: log P (octanol/water) around 1.6-2.0
Other Properties: Stable under recommended storage; no dangerous reactions under normal use
Chemical Stability: Stable in solid state and recommended liquid solvents if stored properly
Reactivity: Not reactive with common laboratory substances; avoid strong agents
Possibility of Hazardous Reactions: Unlikely under routine use
Conditions to Avoid: Excessive heat, light, moisture
Incompatible Materials: Strong bases, powerful oxidizers, strong acids
Hazardous Decomposition Products: Emits carbon oxides and unidentified toxic fumes if burned or decomposed thermally
Acute Toxicity: Data limited, low acute risk under standard laboratory handling; ingestion or chronic exposure may alter liver and hormonal function
Skin Corrosion/Irritation: Prolonged contact may cause irritation or sensitization
Eye Damage/Irritation: Direct contact may cause redness, irritation
Respiratory Effects: Dust inhalation can irritate respiratory mucous membranes
Long-term Effects: Risk of hormone imbalance, immune suppression, metabolic changes over chronic exposure
Mutagenicity/Carcinogenicity: No direct evidence, but corticosteroids broadly linked to tumor promotion with long-term misuse
Reproductive Toxicity: Expected risk due to hormonal activity
Additional Data: Handle with care due to possible risk for those pregnant, planning pregnancy, or immunocompromised
Ecotoxicity: Little toxicity at laboratory release concentrations but hormone activity may disturb aquatic organisms
Persistence and Degradability: Biodegradability not fully documented, likely partial degradation in environment
Bioaccumulative Potential: Not expected to significantly bioaccumulate in higher organisms
Soil Mobility: Low to moderate mobility due to lipophilicity, tendency to adsorb to soil matter
Other Adverse Effects: Persistent hormone influence may disrupt small waterway microbial and animal systems if released in quantity
Waste Disposal: Collect as hazardous pharmaceutical waste in sealed, labeled containers
Contaminated Packaging: Triple rinse, puncture, and manage as hazardous laboratory waste
Recycling/Reuse: Not recommended
Disposal Regulation: Follow national or regional legal requirements for hormone or pharmaceutical waste disposal to safeguard ecosystem and water sources
UN Number: Not regulated for transport in most jurisdictions
Proper Shipping Name: Not classified as a dangerous good for transport
Transport Hazard Class: Not applicable
Packing Group: Not assigned
Environmental Hazards During Transport: None documented; contain to avoid accidental release
Special Precautions: Ship in tightly sealed containers, avoid extreme temperatures and light exposure during transit
Safety, Health, Environmental Regulations: Not classified as controlled substance but falls under pharmaceutical regulatory oversight in most regions
EU Regulation: Not subject to REACH registration
US Regulation: Not listed as hazardous under OSHA Hazard Communication Standard
International Inventory Status: Not universally listed; for research and industrial use only
Labeling Requirements: Standard laboratory precautionary labeling; additional requirements may apply per local workplace regulations
Additional Guidance: Users must follow institutional and governmental policies for handling, storage, and waste
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