Synthetic steroids have shaped the pharmaceutical and medical landscape since the early 20th century, bringing about powerful tools for hormonal regulation, immunosuppression, and anti-inflammatory treatments. Chemists like Percy Lavon Julian and Adolf Butenandt made the first breakthroughs in steroid biosynthesis through research that showed both curiosity and stubbornness in the face of failure. The ability to tweak the steroid core structure without losing function drove further drug development, and by the mid-1900s, structural variations like acetylated and methylenated derivatives emerged in labs chasing better potency, bioavailability, and safety. 17A-Hydroxy-1A.2A-Methylenepregna-4,6-Diene-3,20-Dione-17-Acetate, though a mouthful to pronounce, reflects decades of molecular craftsmanship. Original target indications typically centered around anti-inflammatory therapies, contraception, and oncology, shaped not only by therapeutic promise but also by the demand for alternatives to older corticosteroids and progestins. The drive for selectivity and reduced side effects reappears in nearly every patent and research paper through the 1980s and 1990s, highlighting a field ever hungry for perfection and practical use.
The core essence of 17A-Hydroxy-1A.2A-Methylenepregna-4,6-Diene-3,20-Dione-17-Acetate lies in its pedigree as a synthetic steroid bearing both acetylated and methylenated sites. Its architecture makes it useful for medical and scientific research, including as a precursor in synthesis workflows or active pharmaceutical ingredient in formulations. This molecule attracts attention for its structural stability and tailored functional groups, bringing new possibilities to hormonal therapy design and steroid chemistry research. Pharmaceutical companies and labs keep a close eye on derivatives like this for their flexibility and potential for fine-tuned biological effects.
Maintaining integrity through manufacturing and storage counts on smart handling of the substance’s powdery, crystalline form. Its melting point tends to sit between 210 and 225 °C, a direct result of the acetate and methylene groups reinforcing the steroid backbone. 17A-Hydroxy-1A.2A-Methylenepregna-4,6-Diene-3,20-Dione-17-Acetate resists breakdown under moderate heat and demonstrates low solubility in water, though it dissolves well in organic solvents like dichloromethane and chloroform. Spectroscopic analysis usually points to characteristic carbonyl stretches between 1660 and 1730 cm⁻¹, alongside strong hydrophobic interactions. This makes sample preparation and purity analysis reliant on methods like HPLC, NMR, and mass spectrometry—core tools for any chemist dealing with advanced materials.
Quality assurance and traceability demand precise labeling and adherence to international norms. A typical commercial sample ships with detailed information: purity above 97%, controlled moisture level below 0.5%, and verified single-component peaks by HPLC. Certificates of analysis accompany each lot, showing batch number, production date, expiration, and recommended storage at 2–8 °C in sealed containers. Packaging usually involves amber glass vials or HDPE containers to counteract light and oxidation. Regulatory compliance under REACH or US Pharmacopeia standards governs labeling on secondary packaging. Storage and disposal guidance mirrors its Hazard Class rating, emphasizing PPE use, avoidance of environmental release, and disposal only at approved chemical waste facilities.
Crafting this compound starts with a precursor steroid such as pregnenolone acetate or a closely related dione. The path stretches out over multiple steps, often involving selective oxidation, methylenation at the 1,2-position using reagents like dichlorocarbene or Tebbe’s reagent, and protection of hydroxy groups before final acetylation. Phase-transfer catalysis pops up in the literature for improving yields of the methylene bridge. Removal of side impurities calls for careful column chromatography, flash purification, and final recrystallization. Many synthetic chemists still rely on “old school” glassware and solvent management, learning through hands-on work what automated reactors only hint at. Each batch often reveals small quirks in reactivity, requiring trial runs and parallel synthesis strategies.
Structurally, the molecule offers a platform for further functionalization, serving as both a research tool and a synthetic springboard. Reduction at the 3-keto group produces alcohol derivatives with altered activity. Conversion back to a free hydroxy at C17 removes significant metabolic protection, opening new pharmacokinetic profiles. Selective bromination or epoxidation of the diene section can produce new analogs with adjusted binding to hormone receptors. A lot of bench research chases these ideas, especially for crafting antagonists or agonists for steroid-responsive cancers. Chemical stability in the methylene region means transformation usually needs activated or metal-catalyzed conditions, contributing to a slow but steady pace in analog development.
Across research papers and chemical catalogs, synonyms offer quick shorthand for complex compounds. 17A-Hydroxy-1A.2A-Methylenepregna-4,6-Diene-3,20-Dione-17-Acetate might appear as “Methylene-acetate steroid dione,” “17-hydroxy-1,2-methylene steroid acetate,” or specific registry numbers tied to each vendor. Pharmaceutical studies often rely on internal batch codes, while regulatory dossiers cite full IUPAC names alongside commercial designations. Such naming flexibility supports clear communication between laboratories spread across countries and continents, facilitating research traceability and compliance.
Handling this compound in any research or production setting brings occupational safety to the forefront. Respiratory and skin protection, fume hoods, and regular monitoring of airborne particulates sit as non-negotiable points. Laboratory safety data sheets classify the substance as hazardous if inhaled, ingested, or absorbed through the skin, reflecting its bioactivity. Instituting rigorous spill protocols and emergency wash stations cuts down on workplace accidents. Long-term exposure studies in animal models suggest potential reproductive toxicity, which draws a line in the sand for pregnant workers and underscores the need for carefully monitored workspaces. Storage away from oxidizers, acids, and light sources preserves potency, while packaging must resist breakage or seepage.
Pharmaceutical pipelines look to 17A-Hydroxy-1A.2A-Methylenepregna-4,6-Diene-3,20-Dione-17-Acetate as either a lead compound or an intermediate in hormone therapy research. Oncology research groups probe its structural features for anti-proliferative effects on specific cancer lines, leveraging the tailored acetylation to reduce off-target impact. It plays a role in contraceptive development, often as a tool to examine structure-activity relationships without existing patent conflicts. Academic researchers also value the molecule for testing new analytical techniques or as an internal standard in mass spectrometry studies. Such a broad spread comes from the stability of both the methylene and acetate modifications, ensuring material viability across assay platforms.
R&D efforts frequently try to stretch the boundaries of what this steroid can do. Medicinal chemistry teams use it to map out structure-activity relationships, hoping small changes at the 17-acetyl or 1,2-methylene region will unlock novel activity. Advances in microwave-assisted synthesis and enzyme-catalyzed modification open doors to greener, faster processes and less reliance on harsh reagents. New analogs often show up in early-stage cancer biology or endocrinology models, where each structural tweak gets evaluated for both therapeutic window and off-target liability. Labs with access to high-throughput screening now rapidly build and test libraries based on the base structure, always on the lookout for a better anti-inflammatory, anti-cancer, or contraceptive profile.
Studies with animal models and in vitro systems paint a detailed picture of both acute and chronic toxicity. Like many steroids, this molecule shows dose-dependent endocrine disruption if misused but proves tolerable at well-controlled exposure levels. Rodent trials reveal potential liver and kidney stress at sustained high doses, suggesting a narrow safety margin for direct human applications. Carcinogenicity screens do not reveal clear red flags at relevant exposure limits, but reproductive toxicity studies urge substantial caution, especially in developmental biology settings or female worker populations. Proper ventilation, PPE, and medical surveillance become standard operating measures in facilities handling any meaningful quantities, driving home the point that safety protocols save more than just paperwork.
Future opportunities grow along two branches: pharmaceutical advancement and improved manufacturing. With rapid progress in targeted hormone therapies and the rising tide of personalized medicine, expect more attention for derivatives that promise fewer side effects or greater tissue selectivity. Biotechnologists and synthetic chemists alike are betting on biocatalysis or continuous flow synthesis to scale up production while minimizing waste. Regulatory guidelines for hormone-like drugs tighten each year, prompting collaborations between manufacturers and regulatory scientists to share toxicological data and improve risk management. Integration with high-content screening and AI-driven molecular design promises to accelerate discovery of new analogs. Real-world advances will likely come from folks willing to “get their hands dirty” synthesizing, testing, and refining, translating lab results into therapies for real patients.
If someone handed you a bottle marked “17A-Hydroxy-1A.2A-Methylenepregna-4,6-Diene-3,20-Dione-17-Acetate,” you’d probably put it down and walk away. The name alone sounds like something from a chemistry exam rather than a doctor’s office. In reality, this compound falls into the corticosteroid family, synthetic chemicals that mimic certain effects of hormones in the body. Growing up, I once thought steroids were only for bodybuilders or athletes seeking shortcuts, but over time I started to notice just how many regular folks depend on them for relief from chronic illnesses.
Corticosteroids have saved countless lives since their introduction. This particular compound reduces inflammation and suppresses overactive immune responses. Doctors turn to compounds like these during flare-ups of rheumatoid arthritis, severe eczema, and asthma. I remember a close family member struggling with asthma. No amount of household dusting or changing pillowcases did much until the doctor prescribed a corticosteroid inhaler, which provided almost instant relief. For anyone who has watched a loved one gasp for air, that change means everything.
This steroid can also help people facing autoimmune conditions. In autoimmune disease, the immune system attacks the body’s own tissues, leading to pain and swelling. Interventions using corticosteroids have helped to keep inflammation under control, slow joint damage, and even prolong mobility for people with conditions like lupus or Crohn’s disease.
Steroids bring relief but often raise another set of problems. Long-term use can thin bones, elevate blood pressure, and even raise blood glucose levels. A friend taking corticosteroids for lupus got stuck in a cycle of dealing with swollen joints, then battling the risk of osteoporosis. There’s no way to sugarcoat the side effects. Specialists usually start patients on the lowest possible dose for the shortest timeframe, monitoring patients along the way.
Patients and doctors work together, weighing the risks and rewards. Regular blood tests, bone density scans, and heart checkups help them stay alert to any warning signs. People dealing with steroid therapy often modify their daily lives—adding vitamin D, calcium, and finding time for weight-bearing exercise. These simple steps make a difference, especially for those in it for the long haul.
Science keeps pushing for better answers. Newer synthetic corticosteroids keep entering the market, each promising fewer side effects and better results. Researchers have been exploring how to deliver drugs directly where they’re needed, hoping to spare the rest of the body. Inhalers for asthma, creams for rashes, and injections for joint pain already hint at progress.
If you know someone facing an inflammatory disease, 17A-Hydroxy-1A.2A-Methylenepregna-4,6-Diene-3,20-Dione-17-Acetate might appear somewhere in their treatment plan. Behind the scary name, there’s real hope for those fighting tough, relentless illnesses. Strong medical supervision, a clear understanding of side effects, and an open line between doctors and patients all give the best shot at a safer, balanced life.
Every product, from over-the-counter allergy pills to new supplements promising more energy, carries with it a shadow of uncertainty. My own shelves have seen products I trusted turn sour, delivering headaches or an upset stomach rather than promised benefits. Our bodies speak up in ways that demand attention—even more so when trying something unfamiliar.
People have shared many stories about their first days using new health or beauty products. Redness and rash on the skin, stomach pains after a morning vitamin, or dizziness after a fitness booster—these stories fill doctor's offices and online forums. Harvard Health Publishing reviewed hundreds of commonly reported side effects and found that digestive discomfort and allergic reactions show up most often, especially with new supplements or herbal blends. If your skin itches or your heart beats a little too fast after trying something new, the body may be warning you to stop.
Our unique backgrounds shape each reaction. What sparks problems for one person leaves another untouched. Genetics, medications already being used, and daily habits play big roles. For years, doctors at the Mayo Clinic have linked certain side effects—like nausea or sudden mood swings—to complicated interactions with pre-existing prescriptions or even what you ate for breakfast. A cousin of mine once found her new sleep aid clashed with her blood pressure meds, leading to days of fatigue. This isn't rare. Many issues hide in how different ingredients mix inside the body.
Short-term discomfort may fade with time, but some side effects shake out long after first use. Liver and kidney problems feature on warning labels for a reason—both organs work overtime breaking down new compounds. Johns Hopkins researchers published studies on acetaminophen in pain relievers, showing liver stress in those who took the drug over several months. The same idea connects to certain extracts and stimulants often promoted as safe because they're "natural." Herbal doesn't mean risk-free; the FDA lists many cases where “natural” meant months of ongoing health troubles for some users.
Every bottle or box comes with a label for the sake of your safety. It rarely helps to skip reading the ingredients or ignore tiny warning sections. Before starting, talk to a doctor or pharmacist, especially if you’re already juggling other treatments or have chronic illnesses. Pharmacies and clinics use databases linking ingredients to patient history, flagging clear conflicts right away.
Remember health professionals focus on solving more than the problem that brought you in; they're gatekeepers against hidden dangers. Reporting anything unusual—rash, headache, swelling, or mood changes—puts you back in charge of your health. In my own family, we keep a shared note of everything new we've tried and what happened afterward. This record turned out useful more than once, serving as a memory jog for doctors and saving time during checkups.
Taking charge through questions, honest conversations with caregivers, and reporting problems turns a risky guess into a safer bet. Change can start with paying close attention to signals from your body and following up with regular check-ins. Health relies not just on the promises of new products but on careful, considered choices every day.
Doctors don’t prescribe a hormone-based compound like 17A-Hydroxy-1A.2A-Methylenepregna-4,6-Diene-3,20-Dione-17-Acetate lightly. In my years of research and talking with medical professionals, I've seen genuine care over where, how, and why a person uses such a synthetic steroid. You see, the risks range from mood swings to metabolic shifts, and misunderstanding directions amplifies those dangers.
Normally the route matches the compound’s structure: for this acetate derivative, oral tablets or injectable formulations usually win out. Parenteral routes bypass the gut, meaning the liver doesn’t get first dibs at metabolizing the chemical. Oral administration, on the other hand, sometimes leads to greater fluctuation in blood levels. Physicians care about getting a steady release, to avoid side effects and to make the most of the compound’s benefit. From what I’ve read, injectables tend to produce smoother results for those who truly need them, provided they’re comfortable with needles and have good support.
Some patients think more is better, skipping labs or doubling up. That’s a serious mistake with hormone-related substances. At most endocrinology clinics, regular blood work sets the pace. The provider watches for kidney, liver, and cardiac changes. Heart health, mood, weight—doctors miss nothing. They check kidney and liver enzymes because these organs run overtime breaking down steroid-based molecules. More than once I’ve heard from pharmacists that people run into trouble because they don’t take their dosing time seriously or ignore food-drug interactions. Food can change absorption or even bring on nausea if you’re not careful.
Anyone using this type of prescription should leave it in a cool, dry spot—much like other sensitive medications. Moisture and high heat can degrade the chemical, making the medication less reliable. A pill organizer or reminder app works well for many folks; missing a dose or doubling up leads to breakdowns in hormone cycles. You always figure out a system for remembering because even one skipped day can mess with your system. It isn’t like taking a basic multivitamin.
18-year-olds or younger need even more caution. This compound can disrupt bone growth or cause reproductive issues at the wrong dose or length of use. The FDA, Mayo Clinic, and Endocrine Society echo these warnings, urging specialists to spot-check for unwanted effects. From my own reading, some doctors set reminders to step-down doses over weeks, not days, weaning people slowly to avoid withdrawal.
The National Institutes of Health emphasizes direct connection with a healthcare provider rather than black market or online sources. Clear instructions from a doctor ensure that a person knows how to swallow, measure, or inject without error. A licensed pharmacist double-checks product quality; online fakes have caused real harm. Patients on these compounds get written guides—no guessing games. If anyone brings this compound up in a bodybuilding forum, it’s a red flag.
Sticking to regulated products, having frank talks with a provider, and following up helps safeguard your health. Anyone prescribed this medication faces a partnership rather than a solo journey—because mistakes come with real costs for body and mind.
Anyone who’s walked the aisles of a drugstore has wondered if grabbing some items should be as simple as tossing deodorant into a basket. Those little locked cabinets behind the counter, the wait for the pharmacist, and unfamiliar rules leave us guessing. Some people get frustrated, but others appreciate a little extra caution. It all comes down to this: there’s real weight behind the decision to put a padlock on purchases like antibiotics, certain allergy pills, and a bunch of medications.
Experience has taught me the importance of making responsible choices with health products. Once, I remember watching a friend use an over-the-counter cream for a rash. It barely helped after days, but she was nervous about seeking help, sure she’d have to wrangle a prescription. Turned out, a doctor suggested a stronger, prescription-only version and she healed in a week. It made me think about these guardrails. The truth is, some medicines carry real risks. Developing an allergic reaction, facing dangerous interactions with other pills, or misjudging the cause of your symptoms can push things in the wrong direction fast.
Trust fuels our choices. When something pops up on a shelf—say, painkillers or a cough syrup—shoppers make decisions based on trust in the system. If medicines with powerful side effects weren’t screened, or if you could buy antibiotics for every sore throat, communities would be a mess. We know the dangers: antibiotic resistance is spreading in places where you can easily buy these drugs without asking a doctor. People sometimes guess at the wrong dose or pick the wrong product altogether, and that small risk multiplies across the population.
This is where health experts come in. Prescription laws didn’t pop up just to inconvenience shoppers; they exist because some drugs require an expert’s eye. Take blood pressure medication, for example—use it wrong, and your health can suffer. The pharmacist acts like a safety net, checking whether you actually need that medicine, and if it mixes safely with anything else you’re taking.
Rules that block off certain remedies can feel heavy-handed. Plenty of people live miles from a doctor, or can’t squeeze in a clinic appointment due to work. The cost of a checkup, transportation, or insurance worries mean some try home fixes or unsafe alternatives. There’s space for change, like letting trained pharmacists provide scripts for everyday needs, or using telehealth to speed up care in regular situations. Making these shifts, though, takes clear policies, up-to-date research, and feedback from those most affected.
Folks often just want relief for sore muscles, allergy flareups, or persistent coughs, without navigating a gauntlet. Focused reform could lower barriers while defending public safety. For example, screening tools could help pharmacists quickly spot which cases need a doctor’s hand, and which don’t. Health literacy programs help people spot symptoms early and make sense of what should be left to professionals.
Medicines can be life-savers, but the need for a prescription keeps the door open to guidance, and sometimes, that’s the difference between a quick recovery and unintended harm. People deserve solid facts about each product they might buy—what it treats, what it doesn’t, and what risks come attached. Open, clear information is the real foundation for smarter choices.
Looking at a medicine cabinet these days, there’s a good chance it holds more than prescription bottles. Vitamins, herbal supplements, and over-the-counter pain relief find their way into most homes. Plenty of folks add a handful of supplements to their daily routines in search of better sleep, more energy, or fewer aches. Most people don’t pause to think about whether these pills and capsules might stir up trouble together. Based on my own routine and conversations with pharmacists, the story isn’t as simple as “natural equals safe.”
Doctors and pharmacists have noticed the mix-up possibilities can sneak up on even the most careful among us. Take blood-thinners like warfarin. More than once, I’ve seen people reach for ginger or turmeric because someone mentioned they help with inflammation. These roots thin the blood even more. The pair can raise the risk of bruises or dangerous bleeding. St. John’s Wort, popular for mood support, can speed up how quickly the body breaks down certain antidepressants or birth control. Over time, the main drug stops working. Even something as ordinary as calcium can keep antibiotics from doing their job properly by clashing during digestion.
Standing in a store, it can feel tempting to trust big colorful labels. They brag about “immune support” or “heart health,” but they rarely warn about potential drug collisions. Walking through the aisles at the pharmacy, I started to notice there’s no team of experts sorting through what matches my prescriptions. This responsibility falls on us as individuals—making sure to ask questions and look things up. Studies out of Harvard and Mayo Clinic have shown that older adults, who take several medications, experience higher rates of drug-supplement interactions.
Too often, the information about interactions gets lost. I once watched a friend google a supplement’s risks, then land on a website pushing the same product. That’s far from objective. Doctors and pharmacists stick to trusted resources like the FDA’s MedWatch site, and evidence-based databases such as Natural Medicines Comprehensive Database. These offer clear breakdowns of which supplement-drug pairs cause concern. It surprised me how some simple pairings, like ginkgo with aspirin, can up the risk of bleeding, or how grapefruit juice can change how cholesterol drugs work.
An honest conversation with a trusted healthcare provider goes a long way. Next time anyone picks up a new supplement or medication, bringing along a full list of current pills and vitamins can help spot trouble—before it starts. Smart health apps and digital health records can help, but old-fashioned pen-and-paper lists still work. Pharmacy visits are a good moment for double-checks; some pharmacists catch dangerous combos doctors might miss. Research from the American Pharmacists Association highlights how these check-ins lower emergency room visits by stopping adverse reactions.
Being thoughtful about what goes in a pillbox doesn’t need to feel overwhelming. Curiosity and a willingness to ask questions keep us in control. Reading up on new medicines in trusted places, keeping doctors and pharmacists in the loop, and not assuming “natural” means harmless—these small steps stack up to protect health. In the long run, most serious mix-ups can be avoided just by checking in before reaching for a new bottle on the shelf.
| Names | |
| Preferred IUPAC name | (1S,2S,10R,11S,14S,15S)-14-acetyl-2,11-dimethyl-8,13-dioxo-1,2,3,10,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-yl acetate |
| Other names |
Methylenegonadol
Methylenolactocin Methylenolone acetate 19-nor-4,6-pregnadiene-3,20-dione-17-acetate SC-46416 |
| Pronunciation | /ˈsɛvənˈtiːn eɪ ˈhaɪdrɒksi wʌn eɪ tuː eɪ ˈmɛθɪliːn ˈprɛɡnə fɔː sɪks ˈdaɪiːn θriː ˈtwɛnti daɪəʊn ˈsɛvənˈtiːn əˈsiːteɪt/ |
| Preferred IUPAC name | (1S,2R,8S,10R,11S,14R,15S)-14-acetyl-8-hydroxy-2,15-dimethylidene-7,9-dioxapregna-4,6-diene-3,20-dione |
| Pronunciation | /ˌsɛvənˌtiːˈeɪ haɪˈdrɒk.si ˌwʌnˌeɪ tuːˈeɪ məˈθiːliːnˈprɛg.nə fɔːˈsɪks ˈdaɪ.iːn θriː twɛn.ti ˈdaɪ.oʊn ˌsɛvənˈtiːˈeɪ səˈteɪt/ |
| Identifiers | |
| CAS Number | 2626-09-9 |
| 3D model (JSmol) | `3D model (JSmol)`: `CC(=O)O[C@H]1C=C2C[C@@H]3C[C@@H](C4=CC(=O)CC[C@]4(C)[C@H]3CC2=CC1)C` |
| Beilstein Reference | 4693740 |
| ChEBI | CHEBI:76268 |
| ChEMBL | CHEMBL2105987 |
| ChemSpider | 20893115 |
| DrugBank | DB14689 |
| ECHA InfoCard | 03b7978d-bd08-471a-96f4-76740e214f7b |
| EC Number | 3.2.1.7 |
| Gmelin Reference | 107142 |
| KEGG | C16198 |
| MeSH | Corticosteroids |
| PubChem CID | 146397436 |
| RTECS number | RR8200000 |
| UNII | F9F977Q00E |
| UN number | UN2811 |
| CompTox Dashboard (EPA) | DTXSID70135195 |
| CAS Number | 54965-21-8 |
| 3D model (JSmol) | `3D model (JSmol)`: `data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAA...` |
| Beilstein Reference | 1320738 |
| ChEBI | CHEBI:76268 |
| ChEMBL | CHEMBL2104861 |
| ChemSpider | 15949101 |
| DrugBank | DB14643 |
| ECHA InfoCard | 03dc70c9-037a-49c6-8ddc-95d74c24e5ec |
| Gmelin Reference | **14/377** |
| KEGG | C16157 |
| MeSH | Dienogest |
| PubChem CID | 124374 |
| RTECS number | RC6758000 |
| UNII | TW878F2NOE |
| UN number | UN2811 |
| CompTox Dashboard (EPA) | DTXSID5044368 |
| Properties | |
| Chemical formula | C24H30O4 |
| Molar mass | 414.508 g/mol |
| Appearance | White or off-white crystalline powder |
| Odor | Odorless |
| Density | 1.16 g/cm³ |
| Solubility in water | Insoluble in water |
| log P | 2.60 |
| Vapor pressure | 1.06E-10 mmHg at 25°C |
| Acidity (pKa) | 12.68 |
| Basicity (pKb) | 4.16 |
| Magnetic susceptibility (χ) | -7.31 × 10⁻⁶ cm³/mol |
| Refractive index (nD) | 1.600 |
| Dipole moment | 4.24 Debye |
| Chemical formula | C24H30O4 |
| Molar mass | 398.501 g/mol |
| Appearance | White Solid |
| Odor | Odorless |
| Density | 1.18 g/cm3 |
| Solubility in water | Insoluble in water |
| log P | 2.64 |
| Vapor pressure | 0.00000702 mmHg at 25°C |
| Acidity (pKa) | 12.68 |
| Basicity (pKb) | 13.07 |
| Magnetic susceptibility (χ) | -87.0×10⁻⁶ cm³/mol |
| Refractive index (nD) | 1.597 |
| Dipole moment | 4.46 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 0.576 kJ/mol·K |
| Std enthalpy of combustion (ΔcH⦵298) | -1070.4 kJ·mol⁻¹ |
| Std molar entropy (S⦵298) | 687.7 J·mol⁻¹·K⁻¹ |
| Pharmacology | |
| ATC code | G03BB03 |
| ATC code | G03DB08 |
| Hazards | |
| Main hazards | Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. |
| GHS labelling | GHS02,GHS07 |
| Pictograms | GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H302+H312+H332, H361 |
| Precautionary statements | P201, P202, P261, P264, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P308+P313, P314, P321, P332+P313, P337+P313, P362+P364, P403+P233, P501 |
| NFPA 704 (fire diamond) | 1-0-0- |
| Flash point | > 195.2±21.7 °C |
| PEL (Permissible) | PEL (Permissible Exposure Limit) for 17A-Hydroxy-1A.2A-Methylenepregna-4,6-Diene-3,20-Dione-17-Acetate: Not established |
| REL (Recommended) | 0.01 mg/m³ |
| IDLH (Immediate danger) | Not established |
| Main hazards | Causes skin irritation, causes serious eye irritation. |
| GHS labelling | GHS07, GHS08 |
| Pictograms | GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H302, H315, H319, H335 |
| Precautionary statements | P261, P264, P272, P273, P280, P302+P352, P305+P351+P338, P308+P313, P337+P313, P362+P364, P501 |
| NFPA 704 (fire diamond) | 1-1-0-0 |
| NIOSH | Not Listed |
| PEL (Permissible) | PEL (Permissible): Not established |
| REL (Recommended) | REL (Recommended): 0.01 mg/m³ |
| IDLH (Immediate danger) | Unknown |
| Related compounds | |
| Related compounds |
Methylstenbolone
Methyldienolone Methyldienediol Dienedione Stenbolone |
| Related compounds |
Cortisone acetate
Prednisone Prednisolone Hydrocortisone Dexamethasone Betamethasone |
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