Product Name: 21-Hydroxypregna-1,4,9(11),16-Tetraene-3,20-Dione-21-Acetate
Synonyms: Corticosteroid acetate derivative
CAS Number: 12345-67-8
Recommended Uses: Research, pharmaceutical synthesis
Supplier: Sigma Scientific Inc.
Contact Details: 555-123-4567, chemtech@sigma-scientific.com
Emergency Phone: 800-555-9111
GHS Classification: Acute Toxicity (oral), Skin Sensitizer, Reproductive Toxicant
Pictograms: Skull and crossbones, exclamation mark, health hazard symbol
Signal Word: Danger
Hazard Statements: Harmful if swallowed, causes skin irritation, may damage fertility or the unborn child
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, use only outdoors or in a well-ventilated area, wear protective gloves and eye protection
Routes of Exposure: Ingestion, inhalation, skin contact, eye contact
Symptoms: Nausea, headache, skin rash, dizziness, reproductive effects reported in chronic exposure cases
Chemical Identity: 21-Hydroxypregna-1,4,9(11),16-Tetraene-3,20-Dione-21-Acetate
Concentration: ≥99%
Molecular Formula: C24H30O5
Molecular Weight: 398.49 g/mol
Impurities: Typical pharmaceutical grade, traces of solvent residue below threshold limits
Additives: None known
Inhalation: Remove person to fresh air, keep comfortable for breathing, seek medical attention if symptoms persist
Skin Contact: Wash with water and soap for at least 15 minutes, remove contaminated clothing, consult a doctor if irritation continues
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, seek medical help
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical attention
Most Important Symptoms: Gastrointestinal discomfort, headache, persistent redness or irritation, hormonal symptoms
Note to Physician: Provide supportive therapy considering possible corticosteroid overdose
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Specific Hazards: Emits toxic fumes under fire conditions (carbon monoxide, carbon dioxide)
Protective Equipment: Self-contained breathing apparatus, full protective gear
Firefighting Instructions: Evacuate area, avoid breathing vapors, keep containers cool by spraying with water
Explosion Data: Low risk of explosion, does not pose significant dust explosion hazard
Personal Precautions: Wear gloves, eye protection, laboratory coat
Environmental Precautions: Prevent spillage from entering drains, surface water, soil
Cleanup Methods: Absorb spill with inert material, collect in suitable container for disposal, ventilate area
Exposure Controls: Avoid dust formation, use local exhaust ventilation
Decontamination: Wash contaminated area with soapy water after material pickup
Handling Precautions: Use in well-ventilated location, wear laboratory gloves and safety eyewear, wash hands after use, avoid ingestion or inhalation
Storage Conditions: Keep tightly sealed in original container, store at 2-8°C away from moisture and incompatible materials, segregate from oxidizers and acids
Packaging Materials: Store in amber glass bottle to protect from light
Special Instructions: Keep out of reach of unauthorized personnel, use secondary containment when storing bulk quantities
Occupational Exposure Limit: No values established; handle using best control practices for corticosteroids
Engineering Controls: Chemical fume hood or local exhaust ventilation required
Personal Protective Equipment: Nitrile gloves, splash goggles, laboratory coat, respiratory protection if airborne dust concentrations expected
Hygiene Measures: Avoid contact with skin and eyes, wash hands thoroughly after handling, remove contaminated clothing immediately
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Not applicable
Melting Point: 223-226°C
Boiling Point: Not determined
Flash Point: Not flammable
Vapor Pressure: Negligible at room temperature
Solubility: Sparingly soluble in water, soluble in ethanol, DMSO
Partition Coefficient: logP not established
Viscosity: Not applicable
Density: Approximately 1.187 g/cm³
Evaporation Rate: Not applicable
Decomposition Temperature: Above 230°C
Stability: Stable under recommended storage conditions
Reactivity: Unreactive under normal use, avoid contact with strong oxidizing agents
Conditions to Avoid: Elevated temperature, moisture, exposure to light
Incompatible Materials: Strong acids, oxidizers
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, possibly toxic fumes on decomposition
Acute Toxicity: No acute toxicity data available, based on class, ingestion may cause gastrointestinal, hormonal or neurological symptoms in large exposures
Chronic Effects: Prolonged exposure linked to hormonal changes, reproductive toxicity, immunosuppression
Skin Irritation: Causes moderate to severe irritation with prolonged contact
Eye Irritation: Dust causes eye irritation, potential for conjunctivitis
Respiratory Effects: Inhalation of dust or powder may lead to airway irritation
Carcinogenicity: No data supporting carcinogenic potential
Other Effects: No information available for mutagenicity or teratogenicity in humans; animal studies suggest reproductive toxicity
Aquatic Toxicity: Harmful to aquatic organisms with long lasting effects, avoid release to surface water
Persistence and Degradability: Limited biodegradability in soil and water
Bioaccumulation Potential: Potential to bioaccumulate in aquatic life
Mobility: Low volatility, unlikely to contaminate air, mainly persists in the terrestrial or water phase
Ecotoxicological Data: No specific LC50 or EC50 data available, expected effects on aquatic invertebrates at low concentrations
Disposal Methods: Dispose of contents and container in accordance with national, regional and local regulations
Waste Code: Consult local regulatory authorities; no universal waste stream identified
Contaminated Packaging: Rinse thoroughly, treat as laboratory chemical waste
Environmental Cautions: Do not pour into drains or waterways, incinerate at licensed chemical waste facility if possible
Recommendation: Keep out of municipal solid waste stream, track according to laboratory disposal log
UN Number: Not regulated as dangerous good
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Labeling Requirements: None mandated, label as laboratory chemical
Shipping Method: Securely packaged, protected from moisture and direct sunlight
Environmental Hazards: May pose hazard to aquatic environment in event of large spill during transit
TSCA: Not listed for commercial use in United States
REACH: Not registered, for research purposes only
OSHA: Not subject to specific OSHA standards; standard laboratory chemical handling protocols apply
WHMIS Classification: Not classified; treat as hazardous laboratory substance
Other Regulations: Handle according to institutional, state, and federal regulations for potent corticosteroids and hormone derivatives
Restrictions: For use by trained professionals in authorized research facilities only
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