Chemical Name: 4-Aza-5Alpha-Androsta-1-En-3-One-17Beta-Carboxylic Acid
Synonyms: Finasteride Carboxylic Acid, 17β-Carboxyfinasteride
CAS Number: 98319-26-7
Recommended Use: Pharmaceutical intermediate
Manufacturer Contact: Refer to product label for supplier name, address, emergency telephone
Product Code: Highlighted on packaging or catalog details
Emergency Contact: Local poison control, 24-hour hazardous material response numbers
Classification: No comprehensive GHS classification data for all hazards; may cause skin and eye irritation, respiratory tract discomfort on inhalation
Signal Word: Not established; exercise caution
Hazard Statements: Irritating to eyes and skin, prolonged or repeated exposure may cause allergic reactions, dust may cause mild respiratory irritation
Pictograms: Exclamation mark (if available)
Precautionary Statements: Avoid breathing dust; use protective gloves; wash thoroughly after handling; seek medical examination if symptoms present
Other Hazards: Combustible as fine particles; avoid open flames and ignition sources
Chemical Formula: C20H28N2O3
Concentration: 100% (when supplied as pure substance)
Impurities/Additives: None noted for pharmaceutical-grade material
Molecular Weight: 344.45 g/mol
Inhalation: Move exposed person to fresh air, support breathing if necessary, seek medical attention for persistent symptoms
Skin Contact: Remove contaminated clothing, wash affected area with soap and water, consult a healthcare professional if irritation develops
Eye Contact: Rinse eyes gently and thoroughly with water for at least 15 minutes, keeping eyelids open, seek medical attention if irritation persists
Ingestion: Rinse mouth, drink water if conscious, never induce vomiting without medical instruction, get medical help immediately for large exposures
Most Important Effects: Irritation, potential for mild allergic response
Protection for Rescuers: Avoid direct contact, use gloves and mask
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray for larger fires
Unsuitable Media: Direct water jet; risk of dust dispersal
Specific Hazards: Combustion may produce COx, NOx, toxic organic vapors
Special Protective Equipment: Wear self-contained breathing apparatus and suitable fire gear
Firefighting Procedures: Do not enter space without protection, avoid inhalation of smoke and fumes, remove containers from hazard zone if possible without risk
Personal Precautions: Use proper PPE (mask, gloves, safety goggles), minimize dust, ventilate area
Environmental Precautions: Prevent material from entering drains, surface water, soil
Cleanup Methods: Sweep or vacuum up spill using non-sparking tools, avoid raising dust, place in labeled, sealed container for disposal
Decontamination: Wash spillage area with water and mild detergent
Handling: Use in well-ventilated areas, avoid generation of dust, keep containers sealed when not in use, practice standard lab hygiene
Storage Conditions: Store in a cool, dry, well-ventilated place, away from incompatible chemicals, protect from light, secure containers to prevent damages
Incompatible Materials: Strong oxidizers, acids, bases
Packaging: Use leak-proof containers, clearly labeled
Occupational Exposure Limits: No established limits (TLV, PEL); minimize exposure
Engineering Controls: Local exhaust ventilation, handle in chemical fume hood if possible
Respiratory Protection: Dust mask (NIOSH-approved) if dust present
Skin Protection: Chemical-resistant gloves (nitrile, latex), lab coat
Eye Protection: Safety goggles
Hygiene Measures: Wash hands after handling, do not eat or drink during use, remove contaminated clothing
Appearance: White to off-white crystalline powder
Odor: Odorless or faint organic scent
Odor Threshold: Not determined
pH: Not applicable (solid)
Melting Point/Freezing Point: 220–225°C (measured values may vary slightly)
Boiling Point: Decomposition before boiling
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Combustible when finely divided
Explosive Limits: Not established
Vapor Pressure: Negligible
Vapor Density: Not applicable
Relative Density: ~1.2–1.3 g/cm³
Solubility: Poor solubility in water, soluble in organic solvents (methanol, DMSO)
Partition Coefficient (log Kow): Not established
Auto-Ignition Temperature: Not determined
Decomposition Temperature: >220°C
Viscosity: Not applicable
Chemical Stability: Stable under normal storage conditions
Reactivity: Inert at ambient temperature; avoid strong acids, bases, oxidizers
Hazardous Reactions: No hazardous polymerization
Conditions to Avoid: Excessive heat, light, moisture
Incompatible Materials: Oxidizing agents, acid chlorides
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, other toxic fumes
Acute Toxicity: Limited human data, not acutely toxic at low exposures
Potential Health Effects: Irritation of eyes, skin, mucous membranes; may trigger mild sensitization in predisposed persons
Symptoms of Overexposure: Redness, itching, coughing, headache
Chronic Effects: No significant chronic effects documented at occupational exposure levels
Carcinogenicity: Not classified by IARC, NTP, OSHA
Reproductive Toxicity: No indication in standard references for this compound
Mutagenicity: No evidence in standard in vitro or in vivo systems
Additional Data: Based on structural similarity to finasteride, theoretical risk for reproductive effects for those handling bulk quantities; proper controls reduce exposure risk
Ecotoxicity: No measured data for fish, algae, or invertebrates; expected to present low aquatic toxicity in small quantities
Persistence and Degradability: Expected to be only slowly biodegradable due to steroidal core
Bioaccumulation Potential: Low, based on poor water solubility and moderate log Kow
Mobility in Soil: Low mobility, high binding to organic matter
Other Adverse Effects: Avoid uncontrolled release to surface water or groundwater
Waste Disposal: Collect waste in tightly closed, labeled containers, dispose through licensed chemical waste contractor, never pour into drains
Contaminated Packaging: Dispose of as unused product
Recycling: Not applicable
Special Precautions: Follow local, regional, and national regulations for hazardous laboratory waste
RCRA Status: Not a listed waste, but treat as hazardous laboratory waste
UN Number: Not assigned
Proper Shipping Name: Laboratory chemical, solid, n.o.s. (not otherwise specified)
Transport Hazard Class: Non-hazardous for land, sea, or air transport under most conditions
Packing Group: Not assigned
Special Precautions: Use sealed primary and secondary containers, label in compliance with local regulations
Environmental Hazards: Not a marine pollutant
Bulk Transport: Not regulated in bulk
TSCA: Not listed (intended only for research or pharmaceutical use)
REACH Status: Not registered, for R&D only
OSHA Hazards: No specific classification, observe general laboratory chemical rules
SARA Section 313: Substance not listed
California Proposition 65: Substance not on Proposition 65 list
Other Regulatory Listings: Comply with local and national workplace safety laws, consult updated references for regional restrictions
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