Product Name: Betamethasone Intermediate
Chemical Family: Corticosteroid intermediate
Recommended Use: Pharmaceutical synthesis
Manufacturer Information: Name, address, and contact details required by local authority
Emergency Contact: Include local and international emergency numbers for chemical exposure
SDS Number: Manufacturer’s unique identifier for the document
Synonyms: Common alternative chemical names or identifiers used across supply chains
CAS Number: 378-44-9 for reference in scientific registries
Classification: May cause skin and eye irritation, possible respiratory sensitizer, harmful if swallowed or inhaled
GHS Signal Word: Warning
Hazard Statements: H315: Causes skin irritation; H319: Causes serious eye irritation; H335: May cause respiratory irritation
Pictograms: Exclamation mark for acute toxicity, irritation
Precautionary Statements: Avoid breathing dust or fumes. Wash hands thoroughly after handling. Wear protective gloves and eye/face protection. Use only in well-ventilated areas.
Emergency Overview: Powder or crystalline solid, may form dust clouds capable of igniting under specific conditions. Exposure can irritate eyes, skin, and respiratory tract, producing symptoms such as coughing, redness, or rashes.
Chemical Name: Betamethasone Intermediate
Concentration: 96-99% by weight
Impurities: Byproducts or related steroids present at <4% by weight
Chemical Formula: C22H29FO5—or exact formula provided by manufacturer
Other Components: May include solvent residues, stabilizers below 1% if used during synthesis
Inhalation: Remove the person to fresh air. If breathing becomes difficult, give oxygen. Seek immediate medical assistance if symptoms persist.
Skin Contact: Wash with plenty of soap and water for at least 15 minutes. Remove contaminated clothing and shoes. Consult a physician for persistent irritation or allergic reaction.
Eye Contact: Flush with water for a minimum of 15 minutes, lifting eyelids occasionally. Seek prompt medical attention.
Ingestion: Do not induce vomiting. Rinse mouth with water if person is conscious. Get medical advice without delay.
Important Symptoms: Rash, burning, or itching sensation on contact sites; coughing or nasal irritation following inhalation.
Special Notes for Physicians: No specific antidote. Treat symptomatically. Monitor for delayed effects.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: Direct water jets on product powder can disperse dust clouds
Specific Hazards: Dust may form explosive mixtures with air. Fire may produce hazardous fumes containing carbon oxides and halogenated compounds.
Protective Equipment: Use full protective clothing and self-contained breathing apparatus. Avoid inhaling combustion products.
Special Procedures: Move containers from fire area if safe to do so. Cool fire-exposed containers with water spray. Prevent runoff from entering drains.
Personal Precautions: Wear appropriate protective equipment: gloves, goggles, suitable respiratory protection. Keep unnecessary personnel away.
Environmental Precautions: Prevent spill from entering waterways or soil. Limit spread of dust, avoid release to environment.
Methods for Containment: Cover spills with absorbent material. Collect and place into suitable, labeled waste containers. Minimize dust generation during clean-up.
Decontamination: Wash the contaminated area with water and detergent. Dispose of cleaning materials in compliance with local regulations.
Safe Handling Practices: Handle in chemical fume hood or well-ventilated area. Avoid dust formation and contact with skin, eyes, and clothing. Do not eat, drink, or smoke around open product.
Storage Requirements: Store in tightly closed containers in a cool, dry, well-ventilated space, away from heat, sparks, and open flames. Protect from sunlight and moisture.
Incompatibilities: Strong oxidizing agents, acids, alkalis. Keep separate from food and feedstuffs.
Hygiene Measures: Wash hands and surfaces after using product. Remove contaminated clothing and launder before reuse.
Occupational Exposure Limits: No established exposure limits for this intermediate. Minimize exposure by engineering controls.
Engineering Controls: Use local exhaust ventilation or fume hoods. Employ closed process systems where possible.
Respiratory Protection: NIOSH-approved respirators or particulate masks where dust is present.
Skin Protection: Impermeable gloves (nitrile or butyl rubber recommended), laboratory coats.
Eye/Face Protection: Chemical safety goggles or face shield for larger quantities.
Thermal Hazards: Not typically a concern under normal handling conditions.
Environmental Protections: Prevent uncontrolled emissions to air or water. Handle and store waste securely.
Appearance: White to off-white crystalline powder
Odor: Odorless or faint chemical aroma
Odor Threshold: Not determined
Melting Point: Approximately 220°C (428°F)
Boiling Point: Not applicable (decomposes before boiling)
Density: 1.3 g/cm³ approx.
Solubility: Insoluble in water; soluble in acetone, ethanol, or common organic solvents
pH Value: N/A (not available in aqueous form)
Flash Point: Not determined
Vapor Pressure: Not significant at room temperature
Partition Coefficient (log Kow): Not available, expect to be lipophilic
Evaporation Rate: Not applicable
Explosive Properties: Dust may pose explosion hazard in heavy concentrations
Vapor Density: Not applicable
Chemical Stability: Stable under standard storage and handling conditions. Sensitive to light and moisture with long-term exposure.
Reactivity: Does not react strongly under normal laboratory conditions.
Incompatible Materials: Powerful oxidizers (like peroxides), strong acids, and bases may cause decomposition.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, hydrogen fluoride, and other toxic gases may form under fire or thermal decomposition.
Polymerization: No risk of hazardous polymerization.
Conditions to Avoid: Excessive heat, sparks, sources of ignition, exposure to sunlight.
Acute Toxicity: Harmful by inhalation or ingestion in sufficient quantities. Data for the intermediate itself may be limited, but corticosteroid intermediates often show low acute toxicity in animal models.
Chronic Effects: Prolonged or repeated contact can cause sensitization, skin, and mucous membrane irritation. Long-term laboratory data suggest increased risk of systemic symptoms for high or prolonged exposures.
Routes of Exposure: Dermal, ocular, inhalation, ingestion
Potential Health Effects: May produce local rash, redness, or discomfort with repeated skin contact. May trigger respiratory symptoms if inhaled at high levels. Harmful if swallowed in quantity.
Carcinogenicity: No internationally recognized data for carcinogenic potential of this intermediate.
Mutagenicity: No mutagenic effects reported in standard laboratory testing.
Reproductive Toxicity: Data on reproductive effects are not available. Pharmacologically active steroids can present fetal risks if systemically absorbed.
Ecotoxicity: Limited information available. Potential to cause adverse effects on aquatic organisms if large quantities are released. Laboratory studies show some corticosteroid intermediates persist in water and could affect fish at high exposures.
Persistence and Degradability: Not readily biodegradable—remains intact for extended periods in soil or water unless treated by advanced filtration or oxidation.
Bioaccumulative Potential: Possible accumulation in aquatic environments given the lipophilic structure, though specific quantitative data are lacking.
Mobility in Soil: Low mobility expected due to limited water solubility.
Other Adverse Effects: Inform local authorities of significant release to water bodies, given the unknowns about impacts on local ecosystems.
Waste Treatment Methods: Dispose of material, residues, or leaked product as hazardous pharmaceutical waste according to official regulations.
Contaminated Packaging: Triple rinse containers before disposal or send to licensed drum reconditioner. Do not reuse original packaging for other materials.
Disposal Precautions: Remove all traces of the material from waste before general disposal. Keep waste separate to prevent reactions with incompatible wastes.
Special Considerations: Avoid incinerating chemical in open air without advanced emissions controls. Use only permitted chemical or pharmaceutical destruction sites.
UN/NA Number: Not assigned for this specific intermediate under current transport regulations
Transport Hazard Class: Not regulated for land, sea, or air; still prudent to classify as “chemical substance, not otherwise specified” for internal documentation
Packing Group: Not classified
Environmental Hazards: None known for this intermediate, but avoid accidental release during shipment
Special Precautions: Secure packaging to prevent dust generation and limit physical damage in shipment. Label parcels with chemical name and handling precautions.
Transport in Bulk: Not applicable due to unit shipment size typical for intermediates.
Global Inventories: Check presence on regional chemical inventories such as TSCA (US), REACH (EU), DSL (Canada), ENCS (Japan)
Workplace Safety: Subject to occupational health and safety regulations in country of use—ensure workers are trained in handling pharmaceuticals and intermediates.
Labeling: Meets local and regional labeling requirements for industrial chemicals, including hazard and precaution statements.
Control of Substances: May be covered by controls for pharmaceutical manufacturing and good laboratory practice protocols.
Other Requirements: Import/export may require notifications or permits under restricted substance regulations. Keep all safety documentation on-site and accessible for regulatory review.
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