Product Name: Budesonide Intermediate
Chemical Formula: C25H34O6 (example – confirm with actual lot)
Synonyms: Budesonide precursor, corticosteroid intermediate
Recommended Use: Pharmaceutical manufacturing, research and development
Manufacturer Details: Supplier information and emergency contact phone numbers
CAS Number: 51333-22-3
UN Number: Not classified as hazardous for transport
Product Code: Reference internal catalogue
Classification: Eye irritation, skin irritation, possible respiratory effects if inhaled
Signal Word: Warning
Hazard Statements: Can cause moderate eye and skin irritation, may provoke respiratory tract irritation, ingestion harm not established
Pictogram: Exclamation mark (GHS07) recommended
Precautionary Statements: Use protective equipment, prevent eye and skin contact, avoid inhaling dust
Hazards Not Otherwise Classified: Not classed as carcinogenic but corticosteroids present special warnings if misused
Emergency Overview: Dust clouds may explode in presence of ignition sources; keep away from ignition
Main Ingredients: Budesonide intermediate, purity >97%
Chemical Name: Report specific IUPAC name on product lot
Impurities: Less than 2%, includes possible residual solvents
Other Ingredients: No additives or stabilizers claimed
CAS Number: 51333-22-3
EC Number: As stated for specific batch
Eye Contact: Rinse eyes with plenty of water for 15 minutes; seek medical attention if irritation persists
Skin Contact: Wash skin thoroughly with soap and water; remove contaminated clothing; use lotion if irritation continues
Inhalation: Move person to fresh air, monitor for respiratory distress, seek medical care if coughing or shortness of breath continues
Ingestion: Rinse mouth with water; call for medical advice; do not induce vomiting
Most Important Symptoms and Effects: Temporary irritation, redness, headache from dust exposure, rare allergic response
Immediate Medical Attention and Special Treatment: Administer oxygen for respiratory symptoms, treat symptomatically
Suitable Extinguishing Media: Water spray, dry chemical, CO2, or foam
Unsuitable Media: Do not use direct high-pressure water streams
Specific Hazards: May emit toxic fumes including carbon monoxide, carbon dioxide, possible oxides of steroidal base
Special Protective Equipment: Self-contained breathing apparatus (SCBA), chemical suit, gloves
Firefighting Instructions: Remove containers from zone, cool surroundings with water spray
Explosion Data: Powder may form explosive dust-air mixtures, control all ignition sources
Personal Precautions: Wear gloves, goggles, dust mask or respirator
Emergency Procedures: Evacuate unnecessary personnel, restrict access
Methods for Containment: Sweep up carefully without generating dust, transfer to sealable container
Clean-up Procedures: Wash affected area with water and detergent, ventilate area well
Environmental Precautions: Keep out of drains and surface water
Disposal: Dispose as hazardous chemical waste per local law
Precautions for Safe Handling: Avoid dust generation, use in well-ventilated areas, wear PPE, keep away from food or feed
Hygiene Practices: Wash hands before eating, remove contaminated clothing before leaving work
Safe Storage Conditions: Store in tightly sealed container, keep in cool, dry, well-ventilated place away from light
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Storage Class: Chemical storage, preferably with other APIs and intermediates
Specific End Use: For controlled industrial and laboratory use only
Occupational Exposure Limits: No specific OEL set for this intermediate; treat with caution
Engineering Controls: Fume hood, local exhaust ventilation
Personal Protective Equipment (PPE): Safety glasses, chemical resistant gloves (nitrile or latex), lab coat, dust mask or respirator
Environmental Controls: Prevent product escape into environment
Other Protective Measures: Emergency eyewash and safety shower available near workspace
Appearance: White to off-white powder
Odor: Odorless or faint chemical smell
Melting Point: 224 – 232°C (confirm for each batch)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Slightly soluble in water, soluble in organic solvents like ethanol, methanol, DMSO
pH: Not applicable (solid form)
Flash Point: Not determined
Density: Approx. 1 g/cm³
Partition Coefficient: Log Kow available upon request
Stability: Stable under normal temperatures and dry storage
Reactivity: No known rapid hazardous reactions
Conditions to Avoid: Heat, moisture, strong light, open flames
Incompatible Materials: Strong acids, strong oxidizers
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, possible volatile organic compounds
Polymerization: Will not occur under recommended handling conditions
Acute Toxicity: Not fully characterized, corticosteroidal intermediates can cause irritation with prolonged exposure
Chronic Effects: Extended exposure may affect adrenal gland function, immunosuppression possible
Routes of Exposure: Inhalation, dermal, ingestion possible
Symptoms: Eye and skin irritation, coughing, headache, rarely allergic reactions
Carcinogenicity: Not listed as carcinogenic by OSHA, NTP, IARC, or ACGIH
Mutagenicity / Teratogenicity: Not established for intermediate; use full protective gear during handling
Ecotoxicity: Not thoroughly tested; potential harm to aquatic organisms from active pharmaceutical ingredients
Persistence and Degradability: Poorly biodegradable, may linger in soils and sediments
Bioaccumulation: Data not available but possible based on structure
Mobility in Soil: Limited mobility in groundwater based on powder form
Other Adverse Effects: Prevent uncontrolled environmental release, pharmaceutical residues need close management
Disposal Methods: Incinerate in accordance with local, regional, or national regulations
Contaminated Packaging: Dispose of container as hazardous waste; do not reuse
Special Precautions: Never dispose via wastewater or municipal waste stream
Consult: Environmental safety officer or local waste contractor for detailed guidance
UN Number: Not classified under UN transport regulations
Transport Hazard Class: Non-hazardous for air, sea, and road
Packing Group: Not applicable
Special Precautions: Keep container sealed, dry and upright during transport
Environmental Hazards: Avoid release into environment at any stage of logistics
Transport in Bulk: Not regulated, package in accordance with internal SOP
Labelling: Standard chemical label with product and producer information
Global Inventories: Check listing on TSCA, REACH, DSL, EINECS
Labelling Requirements: GHS compliant, manufacturer address visible
Workplace Classification: Controlled substance for industrial/laboratory use
SARA Title III: Not listed as reportable
California Proposition 65: No warning required based on current evidence
OSHA Regulations: This product should be handled in accordance with general safety and health precautions
Local Laws: Always refer to specific national or state requirements for updated restrictions and notifications
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