Back in the late twentieth century, researchers searching for a way to combat stubborn skin inflammation figured out how to tweak the steroid backbone, landing on clobetasol propionate. This wasn’t just another cream on pharmacy shelves. It offered a level of potency doctors hadn’t dealt with before, especially against tough conditions like psoriasis and eczema. Scientists built on the growing body of corticosteroid chemistry, working out better selectivity and local activity by adding that propionate ester group. This brought significant skin absorption along with high anti-inflammatory punch—something sorely needed by folks stuck cycling through milder steroids with little relief. Over the years, patents expired and generic versions joined the branded options, cementing its spot in clinical dermatology.
Pharmacy drawers carry clobetasol propionate in several forms—creams, gels, foams, ointments, and shampoos. These finished products help capture a broad range of skin conditions. In real life, the cream ranks high with general dermatologists treating thick plaques, while foam and shampoo reach scalp trouble. Pharmacies stock both 0.05% strength and less common compounded versions. If you’ve ever tried scraping together an insurance claim for a branded tube, you know its reputation as a last resort stems from medical necessity and its cost.
This synthetic steroid turns up as a white to almost white crystalline powder inside manufacturing labs. Its solubility leans toward fat-loving solvents—perfect for creams, but almost non-existent in water. It weighs in at a molecular weight just over 467 g/mol and sports that characteristic cyclopentanoperhydrophenanthrene core skeleton. The propionate part attached on its twenty-first carbon atom helps the molecule glide across skin’s outer layers. In pharmacy storage, it needs to stay in a dry, cool place, away from harsh light, protecting it from degradation that could make it inactive.
United States Pharmacopeia and other national formularies require specific purity and potency ranges for any batch of clobetasol propionate bulk. Raw material certificates specify the melting range (around 196-201°C), residual solvents, enantiomeric purity, and particle size. Finished product labeling must highlight the 0.05% concentration, intended route, strict duration limits, and warnings about overuse. Allergy panels must list propylene glycol, alcohol, or any other excipient known to trigger reactions. Child-resistance tops the packaging guidelines due to risks with accidental ingestion. Legal controls restrict dispensing bottles to a maximum amount, discouraging use as a blanket treatment for all rashes.
Starting from the prednisolone or betamethasone backbone, chemical engineers direct the flow of functional groups using chlorination and oxidation steps. The process attaches a propionate ester at a chosen carbon atom, boosting absorption and duration on the skin. After reaction, purification involves crystallization and filtration, separating the API from unreacted starting material and by-products. In the final blending stage, mixers blend the API with the chosen base—petrolatum or water-based—for the intended moisturizer or topical delivery. Quality-control teams test each batch for strength, purity, and evenness before shipment.
The molecule puts up a strong shield against many breakdown reactions, though it can hydrolyze under extreme heat or light, splitting the propionate piece off its backbone. This reduces its activity, underlining why drugstore products come shrink-wrapped and kept out of sunlight. Advances in pharmaceutical chemistry involve swapping out different esters or ring positions, hunting for benefits like easier skin absorption, longer action, or fewer side effects. Some research looks into replacing the halogen at the ninth carbon with new groups, aiming for similar power with less skin thinning.
Ask a pharmacist and you’ll hear trade names—Temovate, Dermovate, Clobex, and others in global markets. The chemical world recognizes it as clobetasol-17-propionate, along with its INN and USAN labels. Search on supplier catalogs brings up names like 21-chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate. Rotational use in practice means most clinicians know it by the trade or generic name depending on country and insurance plans.
Staying safe with this drug means respecting its strength. Overuse leads to thinning skin, broken blood vessels, and even systemic side effects like elevated cortisol in rare cases, especially when used with occlusive dressings or on large surfaces. Labeling must address these risks, telling users to keep away from broken skin and eyes. Clinics implement checks to make sure it’s not renewed too often or given unsupervised to kids. Manufacturers protect assembly workers from powder dust with gloves and masks, and set up strong ventilation to avoid accidental exposure in the plant. Safety data sheets require quick wash procedures for spills and clear procedures for contamination incidents.
This is a steroid for the stubborn skin cases—plaque psoriasis, atopic dermatitis, lichen planus. Dermatologists value having it on hand, but limit its use to avoid problems linked to systemic steroid absorption. Scalp products help with thick hair or follicle-based irritation. It rarely serves as an eye medication due to its likelihood of causing glaucoma or cataracts. Some countries still see it in combination products with antimicrobials or antifungals, hoping to cover both infection and inflammation, but guidelines steer practitioners away from these cocktail creams.
Laboratories chase ways to deliver clobetasol propionate more precisely—microspheres, nanosuspensions, and liposomes all appear in recent journal articles. These tricks may someday help users avoid the skin thinning and stretch marks that follow long steroid courses. Research in skin pharmacokinetics looks at minimizing systemic uptake, possibly paving the way for even safer regimens. New base formulas using plant oils or silicone have reached the pipeline, hoping to win over patients tired of greasy ointments or sticky gels.
Animal and human testing in the early days showed clear danger signals—liver and adrenal effects appear after heavy use or on broken skin in high doses. Young children run the highest risk, since their thinner skin lets the steroid slip through more easily. Clinical studies documented how even adults picking up steroid creams for years can end up with brittle skin and hormonal imbalances. Regulatory bodies placed firm upper limits on daily, weekly, and total exposure. Modern reports continue to monitor for rare cases of abuse or accident, with detailed tracking systems now looking for long-term data.
Research points toward formulas designed to reduce unnecessary steroid contact, delivering medication just where the inflammation sits. Combinations with non-steroid anti-inflammatories could let patients stretch time between flare-ups, lessening the load of corticosteroid side effects. Biomarker-guided therapy, using a patient’s unique skin chemistry, could replace the trial-and-error approach, cutting out needless cycles of unsuccessful treatment. As patients push for relief without risks, the challenge for the next generation of scientists lies in creating treatments offering that deep itch relief without paying the price later in life.
Lots of people walk out of the pharmacy holding a tiny tube of clobetasol propionate. The doctor might have scribbled the name after hearing about rashes, red patches, or some itch that won’t give up. Clobetasol belongs to a family of medicines called corticosteroids. These creams don’t mess around—they bring serious punch for tough skin problems. Doctors save this option for more stubborn conditions.
Most people meet clobetasol when eczema, psoriasis, or dermatitis gets out of control. Eczema can cover skin in patches that feel raw and look angry. Psoriasis leaves stubborn silvery scales. I’ve seen folks lose sleep over the itching these things cause. Regular lotions or weaker steroids just can’t touch it. That’s where clobetasol steps in, delivering strong anti-inflammatory power. Instead of letting the skin stay inflamed, clobetasol quiets it down fast.
Dermatologists keep this medicine for short-term rescue missions. Too much use leads to skin thinning or color changes. I’ve watched patients get clear in two weeks—then spend months fixing the side effects after ignoring instructions. Always following a doctor’s advice makes a massive difference, because clobetasol can save skin, but shouldn’t become a habit.
Folks with chronic plaques of psoriasis often end up with clobetasol. It helps flatten the thick, scaly patches nothing else touches. For eczema, it’s a lifesaver during severe flares. I remember one parent, worried about her daughter’s constant scratching, who called clobetasol a “miracle tube.” Small doses, started and stopped as directed, kept that girl from going to school covered in bandages.
Other skin issues, like lichen planus or lupus spots, take a real toll on confidence. Appearance matters, especially for kids. Dermatologists sometimes use clobetasol for these cases. One father told me the medicine restored his child’s confidence before graduation pictures. Bad hair days come and go, but a visible rash steals joy. Clobetasol can give some of it back.
Powerful medicine always needs respect. Anybody using clobetasol should watch for side effects. Thinning skin sneaks up slowly. Broken blood vessels and stretch marks appear more easily. Using clobetasol on the face brings extra risks. I’ve seen folks wipe it on under the eyes, chasing wrinkles or redness, only to end up with worse problems.
Corticosteroid creams change how the skin handles infection. I’ve heard stories about fungus or bacteria taking advantage of thin skin. After all, skin is the body’s first defense. Only a few weeks of clobetasol makes a huge impact, but after problems calm down, switching to weaker creams or non-steroid options pays off over time.
No one likes medication for life. Lifestyle tweaks help prevent flare-ups, sometimes cutting down the need for strong creams. Humidifiers, gentle soaps, and basic moisturizers build up defenses. If clobetasol ends up in the medicine cabinet, keeping track of how often it’s used can prevent side effects before they start. Asking doctors for check-ins helps catch warning signs early.
For people struggling with tough skin conditions, clobetasol can be a life-changer. Yet respect goes hand-in-hand with relief. Education, open conversations with healthcare providers, and steady routines help keep skin healthy long after the tube runs out.
Clobetasol propionate gets pulled out of the cabinet for those rashes or flares nobody likes to talk about at dinner. Doctors prescribe it for angry red plaques, relentless eczema, and scalp psoriasis when nothing in the drugstore aisle cuts it. It carries a reputation for calming skin storms, so folks want quick results. The risk, though, comes from rushing the process or slathering it far and wide. That's where everyday caution matters a lot.
Picture this: skin burning and itching, someone desperate for relief. In a moment like that, squeezing out a thick line of this creamy medication offers hope. Over many years and a couple of frustrating flares, I've seen just how much skin can rejoice—or revolt—depending on the routine. Clean, dry skin gives this steroid a chance to work without extra bacteria causing problems. The fingertip rule, where a dab covers a hand-sized patch, helps people keep it in check. Patting it on gently instead of rubbing avoids even more irritation.
What makes the process tricky? Clobetasol acts strong and fast, but the temptation for "one more day" easily creeps in. The skin thins out fast if it gets overdosed—especially on the face or folds of skin. That leads to stretch marks or spider veins nobody wants to see.
Lots of folks think more cream gets the job done faster. Anecdotes from community groups and patient chats all echo the same regret: pushing past two weeks of daily use rarely ends well. Studies consistently flag skin breakdown and hormone problems with long, heavy use. The U.S. Food and Drug Administration and dermatology associations repeat this advice for a reason—few products soften inflamed skin quite like clobetasol, but poorly managed use often leaves a bigger mess than the rash itself.
No tube of clobetasol belongs beside the toothpaste. It comes with real health risks, not just from overuse, but from skipping follow-up appointments or ignoring warning signs. I watched one friend’s scalp go from flaky to steroid-thinned because she figured her regular shampoo could serve as a stand-in for medical monitoring. Direct communication—keeping the prescribing doctor in the loop and reporting side effects early—always worked better. Medical professionals push for the smallest effective dose for the shortest time, and with good reason.
Solid education shifts the story. Simple handouts, visuals, and pharmacy consultations build confidence and prevent quiet disasters. Safe practices also mean keeping the cream off baby skin, using gloves as needed, and washing hands quick after each use. Some health care teams encourage a diary for treatment courses, keeping both patients and clinicians on the same page about what the skin looked like before, during, and after. Notice something new—thinning, bruising, pimples popping up? Time to check in, not push on.
I’ve learned calm skin and good health come from teamwork—patient, doctor, and sometimes family all watching for early warning signs. Temporary power brings lasting comfort, but only if handled with respect. Safety steps up each time someone takes a breath, applies a thin layer, keeps it targeted, and tracks changes carefully. Less truly becomes more.
Clobetasol propionate treats a range of stubborn skin problems. Psoriasis, eczema, lichen planus, and even allergic rashes can calm down with just a thin layer of this ointment or cream. The temptation hits hard—red patches fade, angry skin quiets down, and the itch softens. That kind of relief can feel like magic after weeks of discomfort.
But there's always a flip side. Potent steroids like clobetasol tackle inflammation head-on, and in doing so, they often throw a few curveballs. Even after years as a pharmacist, I see people surprised by what happens after their skin clears up.
Many start to notice their skin feels different—almost fragile. The fancy word for this is “atrophy.” Frequent use of clobetasol can thin the top layer of skin, making it papery and stretchable. Cuts and bruises form easily. I’ve seen folks mention their skin tears during daily activities, and the healing process isn’t quick.
After a few weeks, especially over large body areas, stretch marks (striae) can sneak in. They turn purple or pink at first, then fade into pale streaks that don’t really disappear. This is more common on softer skin, like inner thighs, underarms, or sides of the abdomen.
Thicker, greasy ointments like clobetasol sometimes trigger “steroid acne,” which shows up as red pimples, especially on the face, chest, or back. Some folks get little inflamed bumps around hair follicles—folliculitis. It often stings and itches.
Light or dark patches can appear where the medicine’s used. Some people see lighter spots (hypopigmentation); others notice darkening (hyperpigmentation). For folks with darker skin, these changes can linger longer and sometimes never fully fade.
As strange as it sounds, medicines designed to soothe irritation can leave a burning or stinging sensation. Sometimes the first few doses produce itching and redness. If that happens, it’s smart to talk with your provider right away—sometimes the base ingredients trigger a small allergic reaction.
A strong steroid can soak in through the skin, especially where the skin’s thin, like the face or folds. If someone uses it for long periods, or covers wide areas, a bit of that steroid slips into the bloodstream. People have reported weight gain, trouble sleeping, and even signs of adrenal suppression—fatigue, dizziness, and low mood. Cushing’s syndrome, which involves puffiness and facial swelling, can develop in rare cases.
Doctors use the fingertip rule to limit overapplication: nobody needs more clobetasol than what covers the affected spot. Taking breaks, choosing weaker steroids for the face and folds, and steering clear of long-term use all go a long way to reducing risk. Mixing in fragrance-free moisturizer helps buffer side effects, too. Asking questions at the pharmacy can help untangle dose, schedule, and how to spot warning signs.
Unchecked, side effects from clobetasol can turn a useful medicine into a problem of its own. Regular skin checks, short courses, and open conversations with healthcare teams help keep things on track.
I’ve watched friends and family reach for the strongest solution in the medicine cabinet when a rash pops up on the face or eyelids. Some people figure, “If it works on my arm, surely it does the job anywhere.” I’ll be honest, I used to think the same way. Until I learned that skin doesn’t react the same everywhere, especially when a steroid like clobetasol propionate enters the conversation.
Clobetasol propionate ranks as one of the most powerful topical steroids out there. It’s favored for tackling tough psoriasis patches and stubborn eczema on thicker skin like knees or elbows. Faces, eyelids, groin, and other delicate areas don’t have those protective layers. Strong steroids zip straight into thinner skin, cranking up the chance of side effects like thinning, bruising, panda-like rings around the eyes, and even steroid-induced acne or rosacea. These can stick around long after you’ve tossed the tube back in the drawer.
I’ve seen cases where someone uses clobetasol on the eyelids just two nights, only to end up needing treatment for inflamed, peeling skin. The face draws in more of the active ingredient than, say, the back—a fact confirmed by dermatology research. Long-term use, even just a few days here and there, can trigger permanent changes, like visible capillaries or loss of natural color. It’s not a risk most folks want to take without guidance.
If a doctor says it’s okay to use clobetasol on a sensitive area, usually they have a strategy in mind: extremely short-term, on a tiny patch, and followed up with less potent creams. For example, some severe skin conditions leave no choice but to pull out the big guns. The key lies in strict direction—how much, how often, and how long. Medical teams often check progress with follow-up visits, sometimes swapping out the ointment altogether at the first sign of trouble.
For garden-variety facial rashes or itching, doctors stick to milder steroids or steroid-free products. Hydrocortisone 1%—much weaker than clobetasol—gets the nod for limited facial use, and only with a plan to stop within a week or less. Beyond creams, many rashes respond to gentle cleansing, fragrance-free moisturizers, and targeted non-steroid therapies like calcineurin inhibitors. These come with a much smaller risk of scarring or pigmentation changes.
I get the urge to fix a rash with the first thing at hand, especially if it promises fast relief. It saves hassle and time, and sometimes it feels like the only option. Yet, speaking from experience—and what I’ve seen in the dermatology world—it rarely pays off to treat facial irritation with the strongest stuff. The damage left behind can outlast the relief. If it’s on your face or a sensitive spot, talk to someone with real skin expertise. Don’t play pharmacist with potent steroids on the parts of yourself you’d rather not damage.
SummaryClobetasol propionate does a lot of good for certain skin problems, but faces and sensitive areas call for extra caution. Strong steroids belong in a long-term care plan, not a quick fix. Check with a qualified dermatologist before reaching for a strong steroid where your skin is its thinnest.
Clobetasol propionate shows up in many medicine cabinets after a trip to the dermatologist. Redness, itching, stubborn rashes—this cream handles tough skin flare-ups that don’t budge with weaker steroids. Pharmacists measure it out with care for good reason. This cream is among the strongest steroids doctors write prescriptions for, and that strength means there’s both power and risk.
Many people trust topical creams without a second thought. The tube looks harmless, no complicated warnings like the ones for heart medication. But doctors, including dermatologists, know that clobetasol can stir up trouble if used week after week. Reports show thinned skin, stretch marks that don’t fade, easy bruising, and slow wound healing with long-term use. That’s not all—clobetasol can slip through the skin and affect the rest of the body. Too much applied for too long drains the body’s own steroid hormone supply, sometimes leading to adrenal suppression. In rare cases, glucose control in people with diabetes worsens and blood pressure ticks up.
Medical studies, including those published in journals like JAMA Dermatology and the British Journal of Dermatology, confirm these side effects. It’s not theory—it’s reality in clinics. Cases in kids especially stand out; their skin absorbs medicine in greater quantities, so the risk jumps even higher. One child using clobetasol for eczema developed Cushing’s syndrome, a sign their natural cortisol dipped dangerously low.
Dealing with severe eczema or psoriasis can drain a person’s patience. It’s not always fair to compare a doctor’s understanding to the battles faced by people trying to sleep through the night without scratching. Creams like clobetasol bring quick relief. The trouble usually starts when temporary use quietly turns into a routine. Anyone who’s had relentless plaques knows the temptation to stretch out each prescription, searching for normal-looking skin. That’s how trouble sneaks in.
Doctors suggest clobetasol for targeted, short courses, usually under two weeks. After that, they look for milder solutions or recommend using steroids just twice a week to keep symptoms at bay. This “weekend-only” method reduces side effects, allowing the skin time to repair. Finding non-steroid options—like moisturizers with ceramides or medicines like calcineurin inhibitors—can make it easier for people to break free from the cycle.
Patient education shapes everything. Pharmacists and doctors should take a moment at every refill to review the right way to use this medication. People who try to mix advice from friends, online forums, or old habits often end up with trouble. It’s wise to take photos of affected skin and track changes, so conversations with health professionals stay honest and clear.
Trust builds the best outcomes. A good doctor listens and offers options, not just warnings. From personal experience, firm instructions matter less than feeling supported—a dermatologist who helped my family worked with us to step down the clobetasol, mixing in UV therapy and heavy-duty moisturizers. Skin slowly healed, nobody felt scolded, and long-term steroid risks faded into the background. Real care means working out a plan that protects both comfort and long-term health.
| Names | |
| Preferred IUPAC name | S-[(11β,16β)-21-chloro-9-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl] propanoate |
| Other names |
Clobetasol
Clobetasol-17-propionate Clobetasolum Clobex Dermovate Temovate Olux Cormax |
| Pronunciation | /kləˈbiːtəˌsɒl prəˈpəʊni.eɪt/ |
| Preferred IUPAC name | S-((11β,16β)-21-chloro-9-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl) propanoate |
| Other names |
Clobetasol
Clobetasol-17-propionate Dermovate Temovate Clobex Olux Immunosuppressant corticosteroid |
| Pronunciation | /kləʊˈbiːtəˌsɒl proʊˈpaɪəˌneɪt/ |
| Identifiers | |
| CAS Number | 25122-46-7 |
| Beilstein Reference | 3562145 |
| ChEBI | CHEBI:3784 |
| ChEMBL | CHEMBL1438 |
| ChemSpider | 202224 |
| DrugBank | DB01013 |
| ECHA InfoCard | 100.066.816 |
| EC Number | CAS 25122-46-7 |
| Gmelin Reference | 1871815 |
| KEGG | D03571 |
| MeSH | D017207 |
| PubChem CID | 6917714 |
| RTECS number | GN5220500 |
| UNII | 6RSX9L8KJ4 |
| UN number | UN2811 |
| CompTox Dashboard (EPA) | DTXSID5022210 |
| CAS Number | 25122-46-7 |
| 3D model (JSmol) | `3D model (JSmol)` string for **Clobetasol Propionate**: ``` C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)C)OC(=O)CCC(=O)O ``` This is the SMILES string representing the 3D model usable in JSmol. |
| Beilstein Reference | 136514 |
| ChEBI | CHEBI:3738 |
| ChEMBL | CHEMBL1436 |
| ChemSpider | 54652 |
| DrugBank | DB01180 |
| ECHA InfoCard | echa-info-card:100.045.441 |
| EC Number | CAS 25122-46-7 |
| Gmelin Reference | 85936 |
| KEGG | D01278 |
| MeSH | D017021 |
| PubChem CID | 6917714 |
| RTECS number | GM2510000 |
| UNII | 4M16R0NH7T |
| UN number | Not assigned |
| CompTox Dashboard (EPA) | DTXSID5025091 |
| Properties | |
| Chemical formula | C25H32ClFO5 |
| Molar mass | 467.0 g/mol |
| Appearance | White to almost white crystalline powder |
| Odor | Odorless |
| Density | 1.2 g/cm³ |
| Solubility in water | Practically insoluble in water |
| log P | 3.6 |
| Vapor pressure | 6.5 x 10⁻¹⁰ mmHg |
| Acidity (pKa) | 12.52 |
| Basicity (pKb) | 2.84 |
| Magnetic susceptibility (χ) | -94.1e-6 cm³/mol |
| Refractive index (nD) | 1.63 |
| Dipole moment | 2.49 D |
| Chemical formula | C25H32ClFO5 |
| Molar mass | 467.0 g/mol |
| Appearance | White or almost white cream |
| Odor | Odorless |
| Density | 1.185 g/cm³ |
| Solubility in water | Practically insoluble in water |
| log P | 3.7 |
| Vapor pressure | 7.8 x 10^-10 mmHg at 25°C |
| Acidity (pKa) | 12.7 |
| Basicity (pKb) | '12.62' |
| Magnetic susceptibility (χ) | -94.5e-6 cm³/mol |
| Refractive index (nD) | 1.622 |
| Viscosity | Viscous liquid |
| Dipole moment | 2.63 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 303.4 J·mol⁻¹·K⁻¹ |
| Std enthalpy of combustion (ΔcH⦵298) | -6824 kJ/mol |
| Pharmacology | |
| ATC code | D07AD01 |
| ATC code | D07AD01 |
| Hazards | |
| Main hazards | Causes skin irritation, may be harmful if swallowed, may cause allergic skin reaction, suspected of damaging fertility or the unborn child. |
| GHS labelling | GHS07, GHS08 |
| Pictograms | Clobetasol Propionate: Rx; G; C; D |
| Signal word | Warning |
| Hazard statements | Hazard statements: May cause eye irritation. May cause skin irritation. |
| Precautionary statements | Keep out of reach of children. For external use only. Avoid contact with eyes. Do not use on broken or infected skin. Use only as directed by your healthcare provider. Discontinue use if irritation or sensitivity occurs. |
| NFPA 704 (fire diamond) | NFPA 704: 2-1-0 |
| Flash point | 145.7°C |
| Lethal dose or concentration | Lethal dose or concentration (LD50, oral, rat): 50 mg/kg |
| LD50 (median dose) | > 131 mg/kg (rat, oral) |
| REL (Recommended) | 0.05% |
| IDLH (Immediate danger) | Not established |
| Main hazards | Causes skin irritation, may be harmful if swallowed or absorbed through skin, causes eye irritation. |
| GHS labelling | GHS05, GHS07, GHS08 |
| Pictograms | Rx-only, Topical-use, Avoid-eye-contact, Not-for-oral-use, Do-not-use-on-broken-skin, Short-term-use, Keep-out-of-reach-of-children |
| Signal word | Warning |
| Hazard statements | H410: Very toxic to aquatic life with long lasting effects. |
| Precautionary statements | Keep out of reach of children. For external use only. Avoid contact with eyes. Do not use on broken or infected skin. Discontinue use if irritation or sensitivity occurs. Use only as directed by a physician. |
| NFPA 704 (fire diamond) | Health: 2, Flammability: 1, Instability: 0, Special: - |
| Flash point | > 226.2 °C |
| Lethal dose or concentration | Mouse oral LD50: >2000 mg/kg |
| LD50 (median dose) | > 1310 mg/kg (rat, oral) |
| NIOSH | Not Listed |
| PEL (Permissible) | PEL (Permissible Exposure Limit) for Clobetasol Propionate: "Not established |
| REL (Recommended) | 0.05% |
| IDLH (Immediate danger) | Not Listed |
| Related compounds | |
| Related compounds |
Betamethasone
Betamethasone dipropionate Betamethasone valerate Clobetasol Cortisol |
| Related compounds |
Betamethasone
Betamethasone dipropionate Betamethasone valerate Clobetasone Corticosteroids |
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