Clobetasone butyrate landed on pharmacy shelves in the late 1970s, introduced as one of those topical steroid creams that promised strong anti-inflammatory punch without punishing the skin with too many side effects. Driven by the need for options that treat conditions like eczema, dermatitis, and even stubborn psoriasis patches, this molecule quickly caught the eye of dermatologists. Looking at the landscape at the time, potent topical steroids tended to damage skin with long-term use. Mild ones didn’t always provide enough relief for flare-ups. Enter clobetasone butyrate—a medium-strength solution that bridged the gap. Its arrival didn’t just mark another product launch; it opened doors for folks who needed daily control of skin troubles without trading off their skin’s integrity.
Clobetasone butyrate’s popularity stems from its Goldilocks approach: not too tough, not too gentle. It comes as creams, ointments, lotions, even eye drops in some markets. The prescription tube hiding in bathroom cabinets owes its versatility to a well-designed balance between strength and safety. What sets it apart boils down to the way it calms inflamed skin—slowing down the release of chemicals that trigger swelling, itch, and redness. You get the relief, skip the worst of the thinning that more aggressive steroids can bring. Folks dealing with childhood eczema or sensitive skin patches know the difference pretty quickly once they apply it.
On a lab bench, clobetasone butyrate crystals catch the light—a white to off-white appearance, mixing well into creams without hassle. With a molecular formula of C26H32ClFO5, it sports a unique steroid backbone, attached to a butyrate ester that ramps up its absorption where you need it most—the skin. Melting points hover around 220–225°C. Solubility profiles follow the norm for corticosteroids: nearly insoluble in water but dissolves smoothly in organic solvents, which helps formulators develop stable, effective products. Its moderate molecular weight and lipophilicity help it settle just beneath the surface of the skin, favoring action where inflammation sits.
Any box of clobetasone butyrate lays out a pretty straightforward list of details. Standard strengths run around 0.05% in creams and ointments, which gives doctors a consistent touchpoint for dosing. Most countries demand clear labeling—storage instructions, batch details, manufacturer address, expiration, and health warnings crowd the carton’s side. It’s mandated to display allergy cautions, reminders to use short-term only unless instructed by a healthcare provider, and instructions about avoiding eyes and mucous membranes. As with all steroids, a pharmacist will stress the hazards of broad, unsupervised use. Small print matters here, and with clobetasone butyrate, it’s not just red tape; these directions serve as a fence against the silent risks, especially thinning skin or secondary infections.
Manufacturers don’t reinvent the wheel, but the chemistry calls for careful hands. Synthesis begins with a parent steroid (often prednisolone or a close cousin), which undergoes selective esterification at the 17-hydroxyl group using butyric anhydride or a butyrate chloride reagent. This step attaches the butyrate, beefing up lipid solubility and making the steroid soak into the outer layers of skin better. Clinical-grade product demands strict purification, removing solvents and byproducts, followed by micronization. Getting that cream base right plays a big part—choose the wrong emulsifiers or preservatives and you either lose stability or risk skin reactions. Companies rely on time-tested protocols, frequent quality checks, and tight temperature controls along the way.
Clobetasone butyrate’s backbone leaves enough room for chemists to experiment with new derivatives. Most modifications tackle the ester group—swapping different fatty acid chains to find new balance in absorption or side effect profile. Some research projects look at halogen substitution, fiddling with the fluorine or chlorine atoms to tweak anti-inflammatory action or water solubility. Modifying the molecule’s lipophilicity can result in versions that pass through thicker or more damaged skin, or hold concentration for longer. Each tweak carries an eye toward improving safety or effectiveness, or for carving out new medical uses, from stubborn scalp conditions to allergic eye inflammations. Chemists, though, always circle back to the same challenge: boosting potency without crossing into dangerous territory.
The name clobetasone butyrate crops up most often, but a thicket of brand names clutters pharmacy shelves. Popular ones like Eumovate, Eumosone, and Clobeg cream find their way into prescriptions almost everywhere. Having grown up in countries with public health formularies, it’s common to see a simple “clobetasone cream” generic sitting next to the pricier, branded tube. The molecule also carries a handful of synonym codes in the chemical trade: its CAS number (302-22-7) and abbreviations like CLOB or CB. For the patient, each version on the shelf promises the same ingredient between the lines, but prices and package inserts don’t always look alike.
Topical corticosteroids have a loaded history. Clobetasone butyrate’s moderate strength keeps it in the “safer” end, but that doesn’t mean the hazards vanish. Proper storage at room temperature (usually below 25°C), away from direct sunlight and moisture, keeps the drug stable. Regulatory authorities, including the US FDA and EMA, demand detailed documentation on every batch—residual solvents, microbiological counts, and stability data line the regulators’ checklists. In clinic settings, healthcare staff remind users about thin-skinned areas: face, groin, armpits. Instructions firmly suggest limited duration, scheduled reviews, and monitoring for common steroid side effects: thinning, striae, or even adrenal suppression if someone goes overboard. Kids and pregnant individuals need extra caution; doctors weigh the risks with real-life clinical need, not by rote.
Clobetasone butyrate shines most in dermatology. Its sweet spot blooms with eczema, atopic dermatitis, contact dermatitis, and sometimes nips at small outbreaks of inflammatory psoriasis. It isn’t designed for festering infections or open wounds—those require a different playbook. Eye drops containing minuscule doses come into play in the realm of ophthalmology, soothing mild allergic conjunctivitis. Its milder side effect profile makes it suitable for chronic use on delicate zones—faces, necks, or for young children whose skin can’t stand up to stronger steroids. Off-label, you hear stories about use in oral mucous patches, though these cases call for close monitoring and expert judgment.
Research teams push ahead, still asking: how much safer can a medium-strength steroid get? New studies focus on optimizing the vehicle—creams, foams, gels—to improve delivery and acceptance. Advances in nanotechnology catch attention, with nanoparticles potentially ferrying the molecule just where it needs to work, sparing the surrounding skin. Large surveys from teaching hospitals keep providing data on usage patterns, balance of benefit versus risk, and real-world outcomes in chronic inflammatory skin conditions. There’s growing interest in pairing clobetasone butyrate with antifungals or antibiotics in dual-action ointments, especially for folks prone to secondary skin infections. Every new formulation aims to squeeze out better benefit, cut down relapse rates, and prevent steroid phobia—people avoiding treatment out of worry for side effects.
Researchers have clocked thousands of patient-months watching for side effects. At low doses over short periods, most people skate past major trouble, but longer-term usage still pulls up caution flags: thinning of the skin, telangiectasia (those tiny blood vessels that show up with chronic steroid use), or contact allergy to the base chemicals. Very high usage, especially over a large body surface in young children or people with thin skin, brings risks such as skin atrophy or, in rare situations, suppression of the hypothalamic-pituitary-adrenal axis. It’s critical for researchers to tease out these thresholds, since what counts as “safe” for adults can fail kids or medicinally-fragile groups. Animal studies charted early toxicology signals, but years of vigilant tracking in real-world, diverse populations keep sharpening the margins of safe use.
Looking ahead, clobetasone butyrate’s future seems tied to increased personalization. New research might expand its role in combination products, bringing advanced vehicles that target delivery better or work alongside barrier repair agents. As the focus on skin microbiome and inflammation sharpens, new uses could sprout for less understood chronic skin diseases. There’s a push for lower-strength, over-the-counter versions tailored to sensitive groups under pharmacist guidance. Ongoing surveillance—real-world use data, longer-term safety studies, and global regulatory harmonization—promise to shape the next generation of how this familiar steroid relieves, soothes, and supports patients who just want their skin to behave. More options, better guidance, and a steady hand on safety all stack up to keep clobetasone butyrate relevant in ever-evolving dermatological care.
Anyone who has tangled with itchy, flaky, red skin patches knows those outbreaks for what they are: maddening, embarrassing, sometimes downright painful. Years ago, right out of college, I started my first job at a newspaper and woke up one day with a mottled strip of red, scaly skin on my elbow. Afternoons at my desk left me scratching without even realizing it. Turns out, I wasn’t alone—eczema and dermatitis hit millions in big and small ways, making every handshake or short-sleeve shirt a little bit of a risk.
Clobetasone butyrate steps into these daily frustrations as a topical corticosteroid—something stronger than over-the-counter hydrocortisone but not so heavy that doctors hesitate to reach for it. It’s often prescribed for eczema, dermatitis, and psoriasis. As a mid-strength steroid cream, it takes on swelling, controls redness, and helps those angry patches calm down. Unlike the potent creams with big side effect lists, clobetasone gives relief for moderate problems where constant flare-ups aren’t responding to weak ointments.
Clobetasone provides a way to tackle inflammation without jumping straight to the tough stuff that can thin the skin. I remember sitting in a dermatologist’s office and talking about my own skin woes. She explained how steroid creams work by blocking some of the substances that trigger swelling and itching. Clobetasone, being milder than its cousins like betamethasone, offers a safer bet for sensitive spots—think eyelids, face, kids’ arms. Doctors like it because it helps avoid scars from scratching and won’t hit you with the heavy risks unless you use it long-term or on large body patches.
That tube in the medicine cabinet acts more like a firefighter, not a builder. It quiets the blaze, but it doesn’t build new skin or prevent what triggered the flare in the first place. Managing eczema means paying attention to triggers: scented soaps, hot showers, wool sweaters, or even job-related stress. Using clobetasone alongside these lifestyle changes gives the skin space to heal.
Doctors don’t just throw out steroid creams like candy. Overuse thins the skin, causes stretch marks, and sometimes leads to infections. Some people want to slather it on thick and often, chasing instant relief, but that’s trouble we can avoid. Clobetasone butyrate creams usually come with a prescription so a professional can keep watch, especially for kids or on the face. I found that sticking to the ‘fingertip rule’—applying just enough to cover the affected patch—meant fewer worries about side effects.
Living with tough skin problems can make every day a bit harder, but treatments like clobetasone make the load lighter. Healthcare professionals rely on trustworthy clinical studies. One review in the British Journal of Dermatology described clobetasone as effective and relatively safe for mild to moderate eczema, confirming that real-world use lines up with what patients and dermatologists experience. It’s still important to see a professional for lasting or severe problems, since clear skin often requires a plan that’s bigger than any single cream.
I’ve seen many folks struggle with itchy skin or angry red rashes. Some try over-the-counter remedies. Others pick up prescription creams, like clobetasone butyrate, after visiting a doctor. People usually get this steroid cream for eczema, dermatitis, or allergic reactions. It brings hope—relief from those patches that just won’t clear up. But without a solid approach, the relief doesn’t always last or side effects sneak in.
Parents sometimes swipe too much cream over a child’s rash, thinking more means better or faster healing. Friends tell each other to “rub it in well.” In truth, precision matters more than enthusiasm. Doctors prescribe these creams for a reason—they work, but only as part of a bigger plan. Always read the leaflet that comes in the box, because it includes guidance tailored to the product strength and your needs.
Pharmacists often speak about the “fingertip unit”—the amount squeezed from the end of an adult’s finger, enough to cover a patch the size of two adult palms. Slathering on generous globs won’t deliver faster results. Instead, it boosts the risk of thinning the skin or triggering acne and stretch marks. People sometimes forget: topical steroids travel into the bloodstream, especially if applied thickly, often, or over large areas. Children have thinner skin, so overuse carries even greater risk.
Wash your hands well before and after application. Clean the affected area gently, pat dry, and dab on a thin layer. Rubbing forcefully irritates the skin—gentle, brief dabs matter more than pressure. Cover only the spots that show symptoms. Don’t apply clobetasone butyrate as a moisturizer across unaffected skin.
Some patients want to quit as soon as improvement appears, fearing side effects. Others keep using the cream long after the rash fades. Both habits miss the mark. Listen to your prescriber’s recommendation, and follow the prescribed schedule—usually once or twice a day, never more, and often just for a few days up to a couple of weeks. Longer use demands follow-up checks, since the risks grow over time. Doctors may sometimes suggest “weekend therapy,” where the cream is used on just two days each week to prevent flare-ups.
Redness, burning, or worsening rash might pop up—don’t shrug it off. Discuss these reactions with a pharmacist or doctor before continuing. Itchy, weepy patches, especially around the mouth or eyes, may signal overuse or a skin infection, not simple inflammation.
Using clobetasone butyrate in a careful, measured way can help avoid the complications that give topical steroids a bad reputation. Take time to learn about proper application. Trust established sources: doctors, pharmacists, and official NHS or FDA guidelines. Steer clear of online myths or advice from well-meaning neighbors. Steroid creams, handled thoughtfully, can mean the difference between ongoing discomfort and days filled with relief. That’s something worth getting right.
Standing in front of a mirror, tube in hand, I've wondered about the silent trade-offs behind each dab of medicated cream. Clobetasone butyrate sits among those steroid treatments that people turn to when standard moisturizers and over-the-counter options just can't tame persistent skin rashes or eczema. You want relief, but there's a catch: side effects.
Stinging or burning doesn’t just exist in the package leaflet; those happen. After a few days' use, skin can feel a tight burn, especially where it's thinnest—face, eyelids, or even the creases of elbows. Long-term application can thin the skin itself. Folks see visible blood vessels or find cuts and scrapes heal slower. Steroids used on delicate areas or slathered under dressings amplify these risks. In a rush to clear up my own eczema, I pushed “just a bit more”—regretting the fragile aftermath that took months to resolve.
You'd expect a prescription product to solve problems, not hide them. Yet that's one oddball effect: skin infection symptoms slow down or go undercover under a steroid. That gentle-looking patch of skin could host a fungal or bacterial party, but the cream dulls the signs. I’ve seen how tricky this becomes: by the time the true problem surfaces, it’s already taken root. A study published in the British Journal of Dermatology notes that misusing topical steroids can transform harmless infections into stubborn cases.
Steroid creams like clobetasone absorb into the bloodstream in small amounts. Frequent, broad, or long-term application increases this risk, especially for children. Some people notice changes, like weight gain, mood swings, or longer-term growth impacts for kids. Cases like these appear less often with clobetasone than with potent steroids, but they aren’t unheard of. The National Health Service (NHS) underscores that too much for too long risks suppressing natural hormone production.
A handful of users learn their skin can't tolerate these steroids; rashes worsen, or everything flares unexpectedly. I’ve seen uneven bleeding of pigment—patches that lose color or darken, sometimes sticking around even after treatment stops. The face remains the most common trouble zone for these kinds of shifts.
Good skin health mixes everyday habits and common sense with medical care. Using clobetasone butyrate only as long as needed lowers risks. Dermatologists push for thin, short applications—just enough to calm the flare, then switching to milder products or plain moisturizer. For kids, and anyone with sensitive or broken skin, a doctor should check in early and often. If an infection pops up or the area worsens, it's smart to pause treatment and get a professional opinion. Pharmacy staff can flag signs too—no shame in asking plenty of questions about what’s coming out of that tube. Healthy skin, I’ve learned, relies on honest conversations, close monitoring, and never ignoring the body's signals.
Everyone knows how a rash can make a kid miserable. Parents often scramble for something that actually calms the itching and redness. Clobetasone butyrate, a mild steroid cream, often pops up on pharmacy shelves for eczema and certain types of dermatitis. The question hangs in every parent’s mind: can a cream designed for adults really be safe on young, sensitive skin?
Clobetasone butyrate belongs in the corticosteroid family. Among these, it's considered relatively mild. Doctors sometimes reach for it in cases where the rash isn’t getting better with simple moisturizers and the need for relief outweighs the risk. In my practice, I’ve met many worried parents who reach for this cream hoping to avoid something stronger.
Research backs up its use for stubborn eczema in children older than one year. The National Institute for Health and Care Excellence supports short-term use when other remedies aren't cutting it. It’s important not to use stronger products meant for adults on children, because a child’s skin absorbs medicine in a different way. Mild steroids like clobetasone offer a safer route if the doctor is guiding the process.
A tube of clobetasone butyrate can seem like a magic solution when a child is scratching until they bleed. Yet, no cream solves every problem without bringing new risks. Prescription guidelines stress using it only for the shortest time possible on the smallest area needed. Long-term use can thin a child's skin, making it fragile. Sometimes, parents have copied what they saw work elsewhere, treating ringworm or infected rashes with steroid creams, which causes more trouble. I’ve seen children who developed worse skin infections because steroids lowered their skin defenses.
Another issue comes from the way the cream gets used over-the-counter in some countries. Without a doctor’s advice, people miss the real diagnosis behind the rash. Eczema might need clobetasone, but psoriasis or fungal infections do not. Finding out what exactly is going on before starting with steroids helps avoid the cycle of short-term relief followed by long-term chaos.
Doctors recommend applying clobetasone with the “fingertip unit” method—a safe measure that prevents overuse. Moisturizers still do most of the heavy lifting, creating a barrier that lets the skin repair itself. I always show parents how to use these together, with steroid cream reserved for flare-ups only. For children under one year, experts stay away completely and try other options.
Supporting families means teaching them when to ask for help. New rashes, broken skin, or strange patterns call for medical attention before picking up any medicine. Hospitals and pediatricians should keep educating caregivers on when a cream is part of the answer—and when it isn’t. This goes far beyond handing over a prescription; it shapes how families handle flare-ups for years.
Every parent wants relief for their child, fast. Clobetasone butyrate can bring that comfort, as long as it comes along with the right diagnosis and clear guidance on its use. Plenty of facts and years of experience say it’s safe—if families and doctors respect the small print. That partnership keeps kids’ skin healthy and parents less anxious the next time a rash shows up.
Clobetasone butyrate steps into the lives of many who struggle with eczema, dermatitis, and similar skin troubles. This topical corticosteroid shines when red, itchy patches flare up. A little tube in the medicine cabinet promises relief, and for most, it delivers. Yet, the more you lean on it, the more you start to wonder about safety—especially if weeks stretch into months.
Doctors and pharmacists warn against using clobetasone butyrate for too long, and not without reason. Steroids calm irritated skin, but they don't fix what triggers the problems in the first place. Keep reaching for steroid creams each day, and your skin can grow thin, bruise easily, or develop stretch marks. These changes aren’t just on paper; they show up after regular use. I’ve seen patients walk in with ghostly pale, almost see-through spots after a year of using mid-strength steroids like clobetasone on the same areas—especially the face, eyelids, and hands.
Suppressed skin isn’t the only risk. Absorbed steroids can sneak into the bloodstream, especially if you cover broad areas or use dressings. In rare cases, the body’s own hormone production slows, causing trouble far beyond the skin. In children, growth can fall behind. For all ages, fighting off infections grows harder. The British National Formulary urges against applying clobetasone for longer than seven days unless a doctor reviews the situation. The warning’s there because these risks don’t wait politely in the background—they show up, even after careful use at times.
People crave fast solutions to long-suffering skin problems. I remember one patient embarrassed by red, oozing eczema behind her knees. Clobetasone transformed her skin in days. She wanted to keep using it, believing it kept flare-ups away. Six months later, she sat in my office, shocked at the paper-thin skin and new spider veins. Her situation isn’t unique. Clobetasone can feel like magic—until the hidden costs creep in.
Science backs up the cautious approach. Dermatologists published in The Lancet show side effects climb with stronger, longer steroid use. Most countries’ guidelines agree: limit the time. Short bursts for sudden flare-ups, then switch to gentler care. Talk of “steroid-sparing” routines isn’t just for severe cases. Moisturizers, antihistamines, smart lifestyle shifts, and, if needed, non-steroid anti-inflammatories (like tacrolimus) can help keep skin calm between topical steroid treatments.
Open communication matters. Anyone using clobetasone more than a couple times a week in the long term deserves a realistic chat. Pint-sized tubes run out faster than people expect, and “just in case” soon leads to daily routines. Tracking how much you use, noting side effects, and coming back for check-ins help stop small issues before they grow big.
Steroid creams have their place, but a long-term strategy asks for variety. Emollient use soothes dryness and itch all day, not just in crisis. Allergies and harsh soaps play a role, too. Simple changes—like showering with cooler water or using fragrance-free products—reduce the need for strong creams. In clinics, we sometimes switch to non-steroid creams or give "weekend-only" steroid schedules once the skin settles. This approach gives the body a break, cutting down risks.
Clobetasone butyrate serves those in need, but leaning on it every day isn’t a free ride. People owe it to themselves to follow safe use, talk openly with their doctor or pharmacist, and remember: strong skin means more than calm skin—it means healthy layers, too.
| Names | |
| Preferred IUPAC name | S-(11β,16β)-21-chloro-9α-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl butanoate |
| Other names |
Eumovate
Clobetasol butyrate Clobetasone butyrate topical Clobevate |
| Pronunciation | /kləʊˈbiːtəˌsoʊn bjuːˈtɪəreɪt/ |
| Preferred IUPAC name | (11β,16β)-21-chloro-16-methylpregna-1,4-diene-3,20-dione 17-butanoate |
| Other names |
Eumovate
Clobetasone 17-butyrate Clobivate Trimovate Clobetasone |
| Pronunciation | /kləˈbiːtəˌsəʊn bjuːˈtɪəreɪt/ |
| Identifiers | |
| CAS Number | 25122-46-7 |
| Beilstein Reference | 3832321 |
| ChEBI | CHEBI:93112 |
| ChEMBL | CHEMBL1407 |
| ChemSpider | 218868 |
| DrugBank | DB00253 |
| ECHA InfoCard | 100.070.392 |
| EC Number | 3.1.1.1 |
| Gmelin Reference | 77829 |
| KEGG | D03574 |
| MeSH | D003001 |
| PubChem CID | 636396 |
| RTECS number | GL7830000 |
| UNII | EHX44XPY4X |
| UN number | UN2811 |
| CompTox Dashboard (EPA) | DTXSID7031402 |
| CAS Number | 25122-46-7 |
| Beilstein Reference | 3082294 |
| ChEBI | CHEBI:3787 |
| ChEMBL | CHEMBL1201347 |
| ChemSpider | 16115 |
| DrugBank | DB00295 |
| ECHA InfoCard | 1000416 |
| EC Number | EC 3.1.1.31 |
| Gmelin Reference | 603304 |
| KEGG | D03585 |
| MeSH | D003003 |
| PubChem CID | 636398 |
| RTECS number | UB5412500 |
| UNII | TZV841J50S |
| UN number | UN2811 |
| CompTox Dashboard (EPA) | DTXSID7033747 |
| Properties | |
| Chemical formula | C26H32ClFO6 |
| Molar mass | 466.043 g/mol |
| Appearance | White or almost white cream |
| Odor | Odorless |
| Density | 1.1 g/cm³ |
| Solubility in water | Practically insoluble in water |
| log P | 1.95 |
| Vapor pressure | 0.0000000897 mmHg at 25°C |
| Acidity (pKa) | 12.68 |
| Basicity (pKb) | pKb = 12.64 |
| Magnetic susceptibility (χ) | -79.8e-6 cm^3/mol |
| Refractive index (nD) | 1.58 |
| Viscosity | Viscous liquid |
| Dipole moment | 2.78 D |
| Chemical formula | C26H32ClFO6 |
| Molar mass | 466.040 g/mol |
| Appearance | White or almost white cream |
| Odor | Odorless |
| Density | 1.09 g/cm3 |
| Solubility in water | Practically insoluble in water |
| log P | 1.99 |
| Vapor pressure | 8.8E-10 mmHg at 25°C |
| Acidity (pKa) | 12.59 |
| Basicity (pKb) | 1.98 |
| Magnetic susceptibility (χ) | -95.5×10⁻⁶ cm³/mol |
| Refractive index (nD) | 1.576 |
| Viscosity | Viscous liquid |
| Dipole moment | 2.61 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | Std molar entropy (S⦵298) of Clobetasone Butyrate is 576.6 J·mol⁻¹·K⁻¹ |
| Std enthalpy of combustion (ΔcH⦵298) | -7889 kJ/mol |
| Std molar entropy (S⦵298) | 786.6 J·mol⁻¹·K⁻¹ |
| Std enthalpy of combustion (ΔcH⦵298) | -7625 kJ/mol |
| Pharmacology | |
| ATC code | D07AB01 |
| ATC code | D07AB01 |
| Hazards | |
| Main hazards | Causes skin irritation, may be absorbed through skin, harmful if swallowed, may cause allergic reactions, avoid contact with eyes and mucous membranes. |
| GHS labelling | GHS07, GHS08 |
| Pictograms | G, S2 |
| Signal word | Warning |
| Hazard statements | H410: Very toxic to aquatic life with long lasting effects. |
| Precautionary statements | Keep out of reach of children. For external use only. Avoid contact with eyes. Do not use on broken or infected skin without medical advice. Discontinue use if irritation or sensitization occurs. Use only as directed by a physician. |
| NFPA 704 (fire diamond) | NFPA 704: 1-1-0 |
| Flash point | Flash point: 226.2±27.9 °C |
| Lethal dose or concentration | LD50 (rat, oral): >3000 mg/kg |
| LD50 (median dose) | LD50 (median dose): >3000 mg/kg (rat, oral) |
| PEL (Permissible) | Not Established |
| REL (Recommended) | 30 g CREAM |
| IDLH (Immediate danger) | Not Established |
| Main hazards | Causes skin and eye irritation; may suppress the immune response; prolonged use can lead to skin thinning and adrenal suppression. |
| GHS labelling | GHS07, GHS08 |
| Pictograms | Clobetasone Butyrate" pictograms: `"H315, H319"` |
| Signal word | Warning |
| Hazard statements | No hazard statements. |
| Precautionary statements | Keep out of reach of children. For external use only. Avoid contact with eyes. Do not use on broken or infected skin unless directed by a doctor. If irritation occurs, discontinue use and consult a healthcare professional. |
| NFPA 704 (fire diamond) | Health: 2, Flammability: 1, Instability: 0, Special: - |
| Flash point | Flash point: 195.1 °C |
| LD50 (median dose) | LD50 (median dose): >3000 mg/kg (rat, oral) |
| PEL (Permissible) | Not Established |
| REL (Recommended) | 0.05% |
| IDLH (Immediate danger) | Not established |
| Related compounds | |
| Related compounds |
Clobetasol
Clobetasol propionate Betamethasone Fluticasone propionate Hydrocortisone Prednisolone Mometasone furoate |
| Related compounds |
Clobetasol propionate
Betamethasone valerate Hydrocortisone butyrate Fluocinolone acetonide Mometasone furoate |
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