Product Name: Cyproterone Acetate
SYNONYMS: Androcur, CPA
CAS Number: 427-51-0
Manufacturing Company: Provided by the supplier or distributor
Recommended Use: Pharmaceutical, research and laboratory reagent
Emergency Telephone: Listed on supplier’s documentation
Address: Provided by manufacturer or distributor
Email: Contact included with packaging or company website
Risk Phrases: Harmful by inhalation, ingestion or skin absorption
GHS Classification: Reproductive toxicity (Category 2), Carcinogenicity (Category 2), Skin irritation, Eye irritation
Signal Word: Warning
Hazard Statements: May damage fertility, suspected of causing cancer, causes skin and eye irritation
Pictograms: Health hazard, exclamation mark
Precautionary Statements: Use protective gear, avoid breathing dust, wash hands thoroughly after handling, avoid release to the environment
Symptoms of Exposure: Nausea, vomiting, reproductive effects, headache, skin rash, respiratory discomfort
Routes of Exposure: Inhalation, ingestion, dermal contact, eye contact
Component: Cyproterone Acetate
Chemical Formula: C24H29ClO4
Concentration: 98% or higher as supplied
Impurities: Traces of related steroidal compounds, residual solvents from synthesis
Additives: None required in pure form
General Information: Move affected individual from exposure, keep at rest, seek medical attention
Inhalation: Remove person to fresh air, monitor breathing, administer oxygen if needed, get medical help fast
Skin Contact: Wash with abundant soap and water, remove contaminated clothing, consult a healthcare professional
Eye Contact: Rinse eyes carefully with plenty of water for at least 15 minutes, lift eyelids, seek prompt medical care
Ingestion: Do not induce vomiting, rinse mouth with water, call a physician or poison control immediately
Most Important Symptoms: Hormonal effects, nausea, headache, gastrointestinal pain
Note to Physician: Treat symptomatically, monitor for hormone-related effects
Suitable Extinguishing Media: Use dry chemical powder, carbon dioxide, or foam
Unsuitable Extinguishing Media: Do not use water jets directly on substance
Special Hazards: May generate hazardous fumes including chlorine and carbon oxides
Protection for Firefighters: Self-contained breathing apparatus and full protective clothing
Fire Precautions: Avoid inhaling smoke, move containers from fire if safe, evacuate to upwind areas
Hazardous Combustion Products: Hydrogen chloride, carbon dioxide, carbon monoxide
Personal Precautions: Wear gloves, face protection, and dust mask, stay upwind, evacuate unnecessary personnel
Environmental Precautions: Prevent product from entering drains, sewers, or surface water
Spill Cleanup Methods: Scoop up loose powder carefully, use disposable towels, avoid creating dust, ventilate area well
Decontamination: Wash area with suitable detergent and ample water, gather waste in a labeled container
Disposal: Follow hazardous waste procedures, consult local regulations for proper disposal
Personal Safety: Always wear suitable PPE including gloves, lab coat, and protective eyewear
Safe Handling: Only open containers in well-ventilated areas or fume hoods, avoid dust formation
Minimize Exposure: Use the smallest quantity necessary for work performed, keep container tightly sealed
Storage Conditions: Store in a cool, dry, well-ventilated place, protect from light, keep away from incompatible materials like strong oxidizers
Separation from Incompatibles: Do not store near acids, alkalis, or materials generating reactive gases
Shelf Life: Follow expiry date from supplier, monitor for changes in appearance or odor
Permissible Exposure Limit: No occupational exposure limit established
Engineering Controls: Work inside chemical fume hood or use local exhaust ventilation
Personal Protective Equipment: Chemical-resistant gloves (nitrile recommended), safety goggles, laboratory coat, dust mask or respirator if airborne particles are generated
Hygiene Measures: Wash hands and face before eating, drinking, or leaving the laboratory, never touch eyes or face during handling
Environmental Controls: Use appropriate measures to avoid emissions to the environment, monitor air and surface levels as appropriate
Appearance: White or off-white crystalline powder
Odor: Odorless
Melting Point: 210-213°C
Boiling Point: Not applicable (decomposes)
Solubility in Water: Insoluble
Solubility in Solvents: Slightly soluble in ethanol, chloroform, acetone, ethyl acetate
pH: Not relevant (non-aqueous solid)
Vapor Pressure: Negligible
Relative Density: 1.29 g/cm3
Partition Coefficient (log P): 3.3–3.5
Evaporation Rate: Not measurable for solids
Flash Point: Not available
Chemical Stability: Stable under recommended storage conditions
Thermal Decomposition: Begins to decompose above 200°C
Possibility of Hazardous Reactions: No self-reactivity under normal use, but contact with strong oxidizing agents poses significant hazard
Conditions to Avoid: Heat, direct sunlight, strong oxidizers, acids, bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, hydrogen chloride, chlorine gas
Polymerization: Does not occur
Acute Toxicity: Data not widely available, expected harmful if swallowed, inhaled, or absorbed
Skin Corrosion/Irritation: Causes mild to moderate skin irritation upon contact
Serious Eye Damage/Irritation: Possible irritation, redness, tearing
Respiratory or Skin Sensitization: May induce allergic reactions in sensitive individuals
Carcinogenicity: Potential carcinogen based on animal testing and mechanism
Reproductive Toxicity: Evidence for reduced fertility, feminization, and hormone disruption
Chronic Exposure: Endocrine disruption, liver effects, abnormal hormone levels
Other Information: No confirmed mutagenicity, no confirmed risk of genetic damage at low concentrations
Environmental Toxicity: Long-lasting effects possible in aquatic environments
Aquatic Toxicity: Limited data, likely toxic to fish and aquatic invertebrates due to hormonal activity
Mobility in Soil: Expected low mobility due to low solubility in water, possible persistence
Persistence and Degradability: Not readily biodegradable, may remain in environment
Bioaccumulative Potential: Moderate to high, based on partition coefficient
Other Adverse Effects: Endocrine disruption in aquatic life, potential effects on soil organisms
Waste Treatment Methods: Use certified chemical disposal company for destruction
Incineration: Preferred method when approved by authorities, use high-temperature incinerators equipped with scrubbers
Disposal of Containers: Rinse with suitable solvent, consider contaminated, follow hazardous waste guidelines
Local Regulations: Consult local, regional, and national regulations for suitable disposal
Prevent Contamination: Never empty into drains, sewers, or water bodies
UN Number: Not assigned specifically for cyproterone acetate
Proper Shipping Name: Pharmaceutical chemical, non-hazardous for transport under most regulations
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Environmental Hazards: Avoid release to surface water during transport
Special Precautions for User: Ensure packaging remains sealed and undamaged, clear labeling as per IATA/IMDG where required
Transport in Bulk: Not recommended, limited to packaged forms only
US TSCA: Not listed for use as general industrial chemical, use restricted to pharmaceuticals
European Union REACH: Listed for registered pharmaceutical use, restricted for other purposes
OSHA Hazard Communication: Meets the definition of a hazardous chemical under the standard
California Proposition 65: Consult latest list for status, reproductive or carcinogenic effects may be referenced
WHMIS (Canada): Classified as toxic and harmful substance
Labeling Requirements: Health hazard pictograms, warning statements, and supplier contact information required
Other Countries: Each jurisdiction has unique controls for pharmaceuticals, consult local Drug Administration authority
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