Danazol: A Deep Dive into Its Origin, Chemistry, and Place in Modern Medicine

Historical Development

Danazol appeared on the medical scene during the late 1960s as scientists searched for new ways to manage gynecological disorders. The motivation behind its development stemmed from the struggle to help women facing endometriosis, a problem that conventional hormone therapies couldn’t handle well. Early trials sparked both curiosity and caution. Reports trickled in showing promise in controlling pain and shrinking abnormal tissue, but researchers also noticed unexpected effects on lipid metabolism and liver function. As more data came in, medical professionals realized danazol reshaped the landscape for women needing options outside of surgery or high-dose estrogens. What began as a nearly experimental therapy grew into an FDA-approved treatment for not just endometriosis but also fibrocystic breast disease and hereditary angioedema, leaving its mark on reproductive health.

Product Overview

As a synthetic steroid, danazol sets itself apart from typical estrogens and androgens. This compound blunts the action of the pituitary gland on reproductive organs, which leads to a drop in estrogen levels in women. This effect can ease diseases powered by estrogen, like endometriosis. Danazol comes in oral capsule form, often available in 100 mg and 200 mg strengths, with preset dosing depending on diagnosis and patient needs. Switching from its origin in academic labs to mass-produced pharmaceuticals, danazol now shows up under different trade names, yet the basic molecule stays the same, ensuring predictable performance in the body. Its main customers are people who have not responded well to simpler treatments, or who want to avoid more invasive approaches.

Physical & Chemical Properties

Danazol carries the molecular formula C22H27NO2 and a molecular weight hovering near 337. Its structure reflects its ties to ethisterone and other steroids; a four-ring core, some strategic methyl substitutions, and an isoxazole group create a distinct profile. At room temperature, danazol forms a pale yellow, crystalline powder with poor water solubility but much better behavior in organic solvents. The powder melts at a temperature just above 220°C, underscoring its rigidity and resistance to breakdown under mild lab conditions. Mild odor and a neutral taste underscore its chemical independence from many flavor-tainted pharmaceuticals. Such stability matters during shipment, long-term storage, and countering the natural breakdown that plagues other steroidal agents.

Technical Specifications & Labeling

Packaging focuses on accuracy and safety. Capsules must contain precisely measured doses, matched by batch testing for impurities such as unreacted precursors or side products. Pharmacopeial standards like those from the USP and BP set tight rules for content, appearance, dissolution, and purity. Companies add clear labeling on box and bottle: batch number, expiration date, storage instructions (“room temperature, away from moisture”), and all active and inactive ingredients. Box inserts tell patients and medical professionals how to administer, monitor, and taper the drug. These steps not only guard patients against mishaps but also support trust in the supply chain, especially for those living far from point-of-manufacture.

Preparation Method

Preparing danazol draws on classic organic chemistry, particularly the manipulation of steroidal skeletons. Production typically starts with 17α-ethynyltestosterone. Chemists introduce an isoxazole ring through cyclization of precursor nitriles with hydroxylamine, leveraging selectivity so the skeleton locks into the danazol blueprint. Stepwise reactions, often at controlled temperatures and under nitrogen, whittle away side-products. Once the main reaction finishes, purification begins: solvents extract the key intermediate, while chromatography and recrystallization remove stubborn impurities. Finished danazol goes through drying and milling, leaving a powder ready for encapsulation. Modern methods include continuous batch monitoring and rapid quality control tools like NMR and infrared spectroscopy, pushing down costs while boosting yield.

Chemical Reactions & Modifications

Danazol does not exist in isolation; its synthetic template allows for further tweaking. Chemists have grafted different groups onto the molecule’s A- and D-rings, seeking to improve anti-gonadotropic power or reduce side effects. Some variants sell as research tools, shedding light on the way steroid molecules interact with androgen, estrogen, or progesterone receptors. Chemical modifications help in understanding drug-receptor fit and give insights into what portions of the molecule drive action versus toxicity. These explorations fuel the hunt for alternatives to danazol, with some products spinning off into patent filings or early-phase clinical candidates.

Synonyms & Product Names

The International Nonproprietary Name is danazol, with synonyms such as 17α-pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol or 2,3-isoxazoline-17-ethinyltestosterone. The medicine lands on pharmacy shelves labeled as Danocrine or Danol depending on region and manufacturer. Other less-common names crop up in medical literature and regulatory filings, but most pharmacists and clinicians stick to “danazol” for clarity. Generic versions sometimes use placeholder numbers linked to licensing or manufacturing codes, but the underlying chemical fingerprint does not shift between products, keeping both doctors and patients on solid footing.

Safety & Operational Standards

Experience in both pharmacy and hospital settings hammers home the significance of strict safety rules for danazol. Medical professionals must screen for history of liver disease, clotting issues, and even migraines before approving prescriptions, as danazol often worsens these conditions. Patients receive stern guidance about regular liver function testing, cholesterol monitoring, and contraceptive backup, since danazol can cause birth defects. Counting pills, matching patient records to barcodes, and tracking batch numbers lessen the odds of harmful errors. Facilities follow safety standards laid out by OSHA and local health agencies during capsule production, using gloves and fume hoods to keep airborne dust in check. Staff update safety data sheets on-site so that if a spill or mishap occurs, response teams get accurate information at speed.

Application Area

Doctors reach for danazol in cases where standard hormone or anti-inflammatory therapies don’t fully control gynecological pain or swelling. Its impact in hereditary angioedema—especially as a non-injectable, long-term stabilizer—gives people freedom from hospital visits and sudden attacks. Off-label use sometimes extends to rare blood disorders, stubborn mastitis, or even immune suppression in specialized clinics. Unlike many modern alternatives, danazol’s oral format suits patients managing chronic conditions from home, reducing the burden on clinics and emergency rooms. Experience shows that results can be hit or miss, with some women finding long-term relief while others tolerate side effects poorly, leading prescribers to tailor therapy carefully.

Research & Development

Research laboratories still probe danazol’s possibilities and pitfalls. Clinical studies compare it against newer hormone blockers, noting differences in risk, cost, and symptom control. Cell culture and animal models continue to map out new uses—maybe as a tool in fibromatosis, immune disorders, or even rare cancers. Some teams focus on optimizing dose forms, cutting out bitter flavors, and reducing digestive upset. Other projects drill down into metabolism, discovering how genetic differences steer outcomes from one person to another. Each fresh insight has real stakes: a safer, more potent derivative or clearer rules for genetic screening could change how patients with endometriosis or angioedema approach their long-term health.

Toxicity Research

Years of clinical practice underscore the tradeoff at the heart of danazol’s use. Its benefits often match up against troubling risks, such as weight gain, acne, hair growth, mood swings, and, less commonly, liver tumors or serious clotting events. Preclinical research on rodents and monkeys uncovered changes in blood lipids and liver enzymes—effects echoed in human trials. Ongoing studies outline the role of gender, age, and genetic mutations in risk, giving doctors sharper screening tools. Regular calls and lab checks form the backbone of safety for people taking this drug long-term. Industry-funded safety registries now cross-check data worldwide, exposing rare but severe complications and tightening advice as new data surfaces.

Future Prospects

Looking forward, danazol’s future hangs on both new formulations and fresh discoveries in hormone signaling. Compounds modeled on its blueprint or designed to adjust its interaction with receptors could power the next wave of therapies for endometriosis and beyond. Personalized medicine advances, such as routine genetic screening, may pinpoint which patients stand to gain most—and which should avoid danazol from day one. Pharmaceutical companies continue to study combinations with immune modulators, aiming to dial down dosages and limit side effects. Even with heavy competition from other drugs and surgery, classes of patients with stubborn disease or unusual biology will keep the window open for danazol, as long as science and experience steer its safe and effective use.



What is Danazol used for?

What Danazol Does and Why It Matters

Danazol stands out for its main role in treating endometriosis and fibrocystic breast disease. For women who find themselves sidelined by pain every month, this medicine can bring real relief. Endometriosis brings tissue similar to the lining of the uterus growing outside, causing pain, heavy periods, and sometimes infertility. Years ago, I saw a friend unable to keep a steady job because each month her pain knocked her flat. Regular painkillers didn’t touch it. After a round of options, her doctor gave her Danazol. She got her life back—enough to hold down regular work, go for walks, and catch up with old friends.

Doctors also turn to Danazol for inherited angioedema, a rare condition that causes swelling in the face, hands, or even the throat. At a busy hospital, I saw people arrive gasping for air, their faces distorted by sudden swelling. Danazol drops the risk of attacks by changing how certain hormones work. Life doesn’t wait for anyone, and having a tool to take the odds down makes all the difference.

Tough Choices and Patient Realities

Any pill that messes with hormones can hit hard in other ways. Danazol is no exception. Weight gain, acne, voice changes, liver problems, and mood swings show up for many. Fact is, some people end up swapping one problem for a different set. A 2023 study in The Journal of Clinical Endocrinology & Metabolism checked outcomes in women taking Danazol for more than six months. Over a third stopped because side effects ramped up. The body works in messy, unpredictable ways—not just a neat checklist of symptoms.

It’s worth knowing Danazol can also raise cholesterol or affect how the liver works. Regular checkups matter. The U.S. Food and Drug Administration marks Danazol as a controlled med for a reason—it’s not the sort of drug to take on a whim. The information that women with a history of blood clots, liver problems, or certain cancers should skip this drug gets stressed by doctors for good reason.

Big Picture: Access, Stigma, and Smarter Care

The world doesn’t always hand people many choices. For some, birth control pills or newer hormone drugs work better with fewer risks. Insurance coverage can make matters harder. Generic forms of Danazol can cost less, but gaps in coverage stick around. Leaving people to patch together their care from emergency rooms or piecemeal clinics only drives up suffering.

Also, stigma around reproductive health keeps people quiet. I remember a cousin keeping her diagnosis hidden, afraid of “overreacting.” Changing the recipe means normalizing conversations about pain and treatment. Doctors listening without fast judgments land closer to what patients need.

There are potential ways forward. Stronger guidelines about who should get Danazol, more support for switching when side effects grow, and honest talks between doctors and patients can slow down the revolving door of failed treatments. Investment in safer options shouldn’t just stick with big hospital systems; community clinics need a seat at the table too. University research centers digging into alternatives, plus easier access to counseling about side effects, make life smoother for the folks counting on these medicines. Danazol’s story highlights why treatment is about people’s lives, not just molecules on a chart.

What are the common side effects of Danazol?

Understanding Danazol and Its Impact

Danazol comes up in doctor’s offices when someone has endometriosis, fibrocystic breast disease, or certain hereditary angioedema cases. Prescriptions like this can bring real relief, but the flip side is a list of possible side effects. No medication fits everyone perfectly, so walking into a treatment plan with clear eyes can help cut some surprises down the road.

Androgenic Effects: Changes in Appearance

Danazol stems from synthetic hormones. It tweaks the balance of male-type hormones, and these changes don’t stay invisible. Acne can pop up again, even if teenage years are long past. Hair starts showing up where it wasn’t before, often on the face or chest, which is called hirsutism. Hair loss from the scalp hits others instead. These changes can touch confidence. Some people stuck with oily skin and even deepening of the voice, which might stick around. For most of us, these shifts are more than cosmetic—they shape how we move through daily life.

Weight, Mood, and the Menstrual Cycle

Taking danazol often leads to weight gain. It's not always dramatic, but a few pounds each month can feel scary. Then the mood shifts come into play—some people face anxiety, depression, or sleeplessness. For many women, periods become lighter or disappear altogether. This might sound like a break for those with painful periods, but long gaps without periods can mean underlying changes that may matter in the long run.

More Than Skin Deep: Other Physical Changes

Because danazol lines up so closely with hormone levels, it shakes up a few physical processes, especially in women. Breasts sometimes shrink. Sometimes, muscle cramps or joint pain show up. Hot flashes, sweats, or vaginal dryness can rival menopause. Some patients tell their doctors about headaches, dizziness, and even rashes. The body sometimes reacts with fluid retention, swelling ankles or hands. These effects don’t affect everyone the same way, but they do crop up in clinic check-ins regularly.

Long-Term Concerns and Regular Checkups

Not all danazol side effects appear right out of the gate. Over time, liver strain may show up in routine blood tests. Doctors order regular liver function checks for this reason. Rarely, changes in cholesterol levels appear—especially increases in LDL (bad cholesterol) and drops in HDL (good cholesterol)—and these numbers can add quiet risks over months or years. In my own work, I’ve seen family members surprised by these results and grateful when a provider kept a careful watch.

Finding a Safer Path

Several ways exist to tackle side effects. Staying in close touch with a healthcare provider goes a long way. Reporting any changes, even ones that seem minor, matters because many symptoms fade with dose adjustments. In some cases, alternative non-hormonal therapies can carry fewer risks, especially for those at risk for heart or liver complications. Routine blood work—liver, cholesterol, hormone levels—catches trouble before it grows into damage. Patients shouldn’t ever feel frustrated alone; the side effect burden deserves honest conversation every step.

How should Danazol be taken or administered?

Understanding Why Care Matters

Danazol isn’t a drug to take lightly. Doctors turn to it for treating endometriosis, fibrocystic breast disease, and a few rare conditions like hereditary angioedema. As a synthetic steroid, danazol can spark a whole list of body changes, so just grabbing a bottle and swallowing pills doesn’t make sense. Dosage, timing, and instructions play a big part in how well, or how poorly, this therapy turns out.

The Right Way Starts at Prescription

My first run-in with a steroid prescription came during college, when a close friend managed endometriosis. She described meeting her gynecologist every month at the start. Doctors often begin with a lower dose before raising it, tracking any changes in symptoms, mood swings, or side effects. Skipping this step can mean strong reactions, or worse, it could make serious health problems harder to catch. Taking danazol without medical guidance, or using someone else’s dose, can lead to bone density problems, liver strain, or weird shifts in hair growth and voice changes.

Following Instructions: Not Just Doctor’s Orders

Danazol usually comes in capsules taken by mouth, once or twice a day. Swallowing a capsule with water after a meal helps the gut handle the medicine better. Food sometimes helps prevent stomach upset. Setting a routine — same time every day — reduces missed doses and swings in hormone levels. From watching my friend juggle classes, work, and medication, I saw that alarms or pill organizers can make a difference.

Missing a Dose: It Happens, but Don’t Double Up

Worry sets in after a missed pill, that’s human. But taking two capsules later almost never helps. Doctors say skip and take the next scheduled dose, unless they laid out different instructions. Doubling up can cause uneven changes in blood levels, nudging the side effects up a notch.

Keep Track of Side Effects and Regular Checkups

Danazol impacts liver enzymes, cholesterol, and blood cell counts. So, regular blood tests — every few months — matter for anyone on this therapy. Most clinics check liver function and lipids. From my own experience shadowing a nurse, patients often think mild effects aren’t worth mentioning — like a raspy voice or oily skin. But small symptoms signal how the body handles the drug. Logging symptoms in a journal, even on a phone, gives the next doctor visit more value. Reporting changes early prevents bigger problems down the road.

Talking Openly With Doctors

Side effects can worry anyone, especially with stories about steroids and body changes all over social media. Trusting relationships with doctors matter here. No question is too minor, whether it’s about birth control, drug interactions, or diet choices. Patients with liver disease, history of blood clots, or ongoing migraine issues need a different plan. My friend learned that drinking alcohol and danazol don’t mix well; liver care is a big deal with this med.

Supporting Safe Medicine Use at Home

Family and friends should understand what’s at stake. A supportive environment encourages patients to stick with the plan, report real concerns, and avoid shortcuts. If you spot mood changes, swelling, or sudden bruising, a doctor’s visit can’t wait. Many folks do best when the circle around them treats this process as important — not a burden.

Weighing Risks and Making Choices

Danazol’s benefits can show up quickly, but so can its risks. Getting the best out of this medicine means respecting the routine, keeping up with healthcare visits, asking honest questions, and building awareness at home. From lived experience and expert data, the advice remains the same: follow the instructions, watch for changes, and put safety first.

Are there any contraindications or precautions for using Danazol?

Why Doctors Think Twice Before Prescribing Danazol

Danazol steps in where pain and certain hormone problems refuse to let up. It’s mainly used for endometriosis, fibrocystic breast changes, and some rare genetic conditions like hereditary angioedema. It works, but with a heavy hand. This isn’t the sort of medication you toss into a plan without a good reason.

Trouble starts with liver concerns. Danazol can stress the liver to the point of permanent damage—folks with liver disease or abnormal liver function shouldn’t be anywhere near it. Doctors check liver enzymes before handing out a prescription and run regular tests after that. I’ve seen folks try to tough out strange fatigue or yellowing skin because they thought the medicine was managing their symptoms. In reality, that was the cue to stop and run tests: ignoring changes makes things worse.

Women, Pregnancy, and Hormones: More Than an Afterthought

Danazol tweaks hormone levels, which opens the door to unique risk for women of childbearing age. The drug can harm developing fetuses, especially baby girls. Birth defects aren’t just a fine-print risk—they’ve shown up before. Discussing birth control isn’t a footnote; it’s at the front of the conversation for anyone even possibly able to get pregnant. Missing that detail can change lives in ways no one bargained for.

Hormonally, Danazol acts like testosterone. Women taking it see changes like acne, weight gain, changes in voice, and sometimes hair loss where they don’t want it and hair growth where they haven’t seen it before. Some of these effects linger, even after stopping the drug. This reality doesn’t show up much in glossy marketing but becomes obvious once people start taking it.

More Than Just a Hormone Issue

Some folks end up with changes in cholesterol, putting them at bigger risk for heart disease. People with existing heart issues or high cholesterol might find the drug tips the scales the wrong way. There’s no skipping over regular blood tests—watching cholesterol swings is part of the routine.

Danazol can pile onto existing problems for those with kidney trouble or blood clots in the past. There’s more risk for dangerous clots, especially in people who already have those problems in their medical chart. In the clinic, this means going over medical history together, looking for anything that adds up to more risk.

Solutions and Smarter Choices

Doctors and pharmacists don’t just hand out advice for fun—they know Danazol’s side effects kick in quietly or show up with a bang. People already juggling thyroid problems, diabetes, or medications that stress the liver may not mix safely with Danazol. This isn’t just checking boxes on a form. Sharing every medication and health concern upfront is where safety starts. If there’s doubt, safer drugs often exist, especially for issues like endometriosis or breast pain.

Relying on blood tests and frequent follow-ups isn’t overkill—it’s part of making sure Danazol does more good than harm. For anyone feeling lost or worried, pushing for more information and honest conversations with health professionals makes all the difference. Risks around Danazol aren’t theoretical; they’ve played out in real lives. Being informed and staying alert is what keeps those stories from repeating.

Can Danazol interact with other medications?

Why Medication Interactions Matter with Danazol

Many folks have never heard of Danazol unless they or someone close gets a prescription for endometriosis or hereditary angioedema. Danazol helps because it changes hormone levels and has a direct effect on the way the body handles certain proteins. Once a medication changes how hormones—or any key system—works, risk of interaction with other drugs turns real. I have watched people confused in the pharmacy aisle by the list of “do not take with” warnings. Danazol provides no exception.

Understanding the Common Interactions

Every time someone brings a medication list to the clinic, one eye always lands on steroids, blood thinners, and diabetes medications. Danazol can change the effect of warfarin, a common blood thinner. Blood becomes slower to clot, or sometimes it clots too quickly. One old friend had her clinic visits doubled for bloodwork checks after her Danazol started. Diabetic patients sometimes find their insulin or oral diabetes medications losing their grip, requiring dosage changes and extra sugar checks every day. Because Danazol affects hormones, women using birth control (especially those relying on estrogen) lose some protection, sometimes ending up with unplanned surprises. Cholesterol drugs can become inconsistent, pushing bad cholesterol up for no good reason.

Too Many Cooks in the Liver

Despite the body’s best attempts to process chemicals in the liver, adding Danazol can gum up the works. I learned early that “liver enzymes” shape how drugs leave the body. Danazol competes with medications like statins and anticonvulsants processed by the same enzymes. The next thing people know, their anticonvulsant drug levels spike, side effects show up, and someone is hunting for a new plan. On top of that, Danazol can raise blood levels of cyclosporine and tacrolimus—two immune-suppressing drugs—not in a gentle way. Patients may risk toxic reactions, kidney problems, or even hospitalization.

Who Pays the Price?

Testing isn’t perfect. Older adults—already juggling a basket of pills—run the highest risks of very serious outcomes. A teenager might bounce back after a wonky lab value, but someone with fragile health or a weak immune system could end up in the hospital from one misstep. Side effects from drug interactions rarely announce themselves with full drama. Dizziness, unexplained bruises, nosebleeds, mood swings, or headaches can float by, easy to write off—until something big happens.

Building a Safe Plan Together

Real safety comes down to honest conversations. Write up every pill, spray, patch, and herbal supplement before heading to the doctor. Technology helps but never replace old-fashioned listening. Pharmacists often catch dangerous combinations, so never skip asking questions at the pharmacy window. If something feels off—swelling, headaches, changes in energy or appetite—never wait to see if it gets worse. Regular check-ups and bloodwork can catch problems before they snowball. Most cases of trouble with Danazol happen because nobody connected the dots between prescriptions. Technology now tracks drug interactions better than ever, but face-to-face conversations still keep people safe.

Helping Patients Out

Better awareness comes from stories and simple advice. Print out that meds list, update it at every medical visit, and check with a trusted pharmacist or doctor before adding new over-the-counter medicine. Watching friends recover from medication missteps reminds us no system replaces basic vigilance and honest communication across everyone involved in patient care. Every patient deserves active, ongoing support when taking a drug like Danazol—not just instructions at the start.

Danazol
Names
Preferred IUPAC name (1S,2R,10R,11S,14S,15S)-2,15-dimethyl-5,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthrene-1,14-diol-3-one
Other names Danocrine
Danol
Danazolum
Cyclomen
Pronunciation /ˈdæn.ə.zɒl/
Preferred IUPAC name (1S,2R,10R,11S,14S,15S)-2,15-dimethyl-17-oxa-13-azatetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-ene-14-carbonitrile
Other names Danocrine
Danol
Gonol
Azol
Danoval
Cyclomen
Pronunciation /ˈdæn.ə.zɒl/
Identifiers
CAS Number 00017230-88-5
Beilstein Reference 3118738
ChEBI CHEBI:4330
ChEMBL CHEMBL1399
ChemSpider 1043
DrugBank DB01406
ECHA InfoCard 100.021.327
EC Number EC 200-334-9
Gmelin Reference 95844
KEGG C06928
MeSH D003601
PubChem CID 2995
RTECS number GV4375000
UNII QGK4Y6FI79
UN number UN2811
CompTox Dashboard (EPA) DTXSID3023756
CAS Number 17230-88-5
Beilstein Reference 3689793
ChEBI CHEBI:4338
ChEMBL CHEMBL724
ChemSpider 2172
DrugBank DB01406
ECHA InfoCard 13b176ec-7f50-4c76-9517-0973a6365c81
EC Number EC 3.4.4.-
Gmelin Reference 85736
KEGG C07052
MeSH D003622
PubChem CID 3009
RTECS number GV7875000
UNII 9B1GFOR43A
UN number UN2811
Properties
Chemical formula C22H27NO2
Molar mass 337.447 g/mol
Appearance White to pale yellow crystalline powder
Odor Odorless
Density 1.07 g/cm³
Solubility in water Insoluble
log P 4.53
Vapor pressure 6.77E-06 mmHg at 25°C
Acidity (pKa) 4.65
Basicity (pKb) 8.65
Magnetic susceptibility (χ) -80.0·10^-6 cm^3/mol
Refractive index (nD) 1.616
Dipole moment Dipole moment of Danazol: 2.95 D
Chemical formula C22H27NO2
Molar mass 337.44 g/mol
Appearance White to pale yellow crystalline powder
Odor Odorless
Density 0.94 g/cm³
Solubility in water Insoluble
log P 4.53
Vapor pressure 1.33E-04 mmHg at 25°C
Acidity (pKa) 4.26
Basicity (pKb) 10.71
Magnetic susceptibility (χ) -83.5e-6 cm³/mol
Refractive index (nD) 1.162
Viscosity Viscous liquid
Dipole moment 5.08 Debye
Thermochemistry
Std molar entropy (S⦵298) 322.2 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -231.6 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -8297.8 kJ/mol
Std molar entropy (S⦵298) 354.6 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -189.6 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -7632.6 kJ/mol
Pharmacology
ATC code G03XA01
ATC code G03XA01
Hazards
Main hazards May impair fertility, cause liver toxicity, and pose a risk of thromboembolic events.
GHS labelling GHS02, GHS07
Pictograms Cardiovascular, Exclamation Mark
Signal word Warning
Hazard statements Hazard statements: H361 Suspected of damaging fertility or the unborn child.
Precautionary statements Precautionary statements: Store below 30°C. Protect from light. Keep out of reach of children.
Flash point > 210°C
Lethal dose or concentration LD50 (rat, oral): >4,370 mg/kg
LD50 (median dose) LD50 (median dose) of Danazol: 5 g/kg (oral, rat)
NIOSH Not established
PEL (Permissible) PEL: Not established
REL (Recommended) 200–400 mg daily
IDLH (Immediate danger) Not listed
Main hazards May damage the unborn child. Causes serious eye irritation. May cause damage to organs through prolonged or repeated exposure.
GHS labelling GHS02, GHS07
Pictograms {"Pictograms": "D"}
Signal word Warning
Hazard statements H351: Suspected of causing cancer.
Precautionary statements P201, P202, P281, P308+P313, P405, P501
NFPA 704 (fire diamond) Health: 2, Flammability: 1, Instability: 0, Special:
Flash point 113°C
Lethal dose or concentration LD50 (oral, rat): >4,750 mg/kg
LD50 (median dose) LD50 (median dose): Mouse oral LD50 = 8600 mg/kg
NIOSH NN3675000
PEL (Permissible) PEL: Not established
REL (Recommended) 200 mg
Related compounds
Related compounds Ethisterone
Oxymetholone
Related compounds Ethisterone
Testosterone
Oxandrolone
Stanozolol
Norethisterone