Product Name: Danazol
Chemical Name: 2,3-Isopropylidenedioxy-17α-pregna-2,4-dien-20-yn-17-ol
CAS Number: 17230-88-5
Uses: Pharmaceutical ingredient used mainly in treatment of endometriosis, fibrocystic breast disease, and hereditary angioedema
Manufacturer Supplier Details: Refer to packaging or responsible supplier for exact contact information and emergency telephone numbers, as these can change by country and facility
Emergency Contact: Refer to local emergency medical services or poison control for immediate help if exposure occurs
GHS Classification: Not classified as hazardous under GHS guidelines for most uses, but can interfere with hormone function and possible carcinogen concerns
Hazard Statements: May cause reproductive system interference, endocrine disruption, possible liver effects with prolonged exposure, risk for sensitive populations including pregnant women
Pictograms: Exclamation Mark (for acute toxicity), Health Hazard (for reproductive toxicity)
Precautionary Statements: Avoid unprotected contact, especially for pregnant or breastfeeding individuals
Potential Health Effects: Inhalation may create respiratory discomfort, ingestion can produce hormonal side effects, skin or eye contact may irritate sensitive users
Chemical Identity: Danazol
Concentration: Pure substance unless supplied as a formulation
Impurities: Minor processing impurities possible depending on manufacturing route, consult specific batch analysis
Molecular Formula: C22H27NO2
Molecular Weight: 337.45 g/mol
Inhalation: Move affected person to fresh air immediately. Seek medical attention if symptoms like dizziness, headache, or respiratory discomfort appear.
Skin Contact: Remove contaminated clothing. Wash affected area thoroughly with soap and water. If irritation persists, consult a healthcare provider.
Eye Contact: Rinse cautiously with plenty of water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Get medical advice if irritation continues.
Ingestion: Rinse mouth with water. Do not induce vomiting unless directed by a medical professional. Seek immediate medical attention for larger quantities or symptoms.
Advice for Physicians: Symptomatic and supportive care only, monitor for hormone-related symptoms. Specific antidote not available.
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Unsuitable Extinguishing Media: Direct water jet may spread powder or create contamination
Hazardous Combustion Products: Irritating or toxic fumes (carbon oxides, nitrogen oxides)
Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing to prevent skin and eye contact
Special Precautions: Prevent chemical runoff from entering drains or water sources, ventilate contaminated area during and after extinguishing
Personal Precautions: Use personal protective equipment, such as nitrile gloves, protective clothing, and safety goggles. Avoid creating dust. Do not breathe dust.
Environmental Precautions: Prevent substance from entering drains, surface and ground water. Notify authorities if contamination occurs.
Methods for Clean-Up: Carefully collect spillage using a damp cloth or HEPA-filtered vacuum. Dispose of all materials in a labeled hazardous waste container.
Decontamination Procedures: After clean-up, wash surfaces with suitable cleaning agent and water
Handling: Wear protective gear, handle in well-ventilated area or fume hood. Avoid handling near food, beverages, or smoking materials. Keep container tightly closed.
Storage Conditions: Store in cool, dry, well-ventilated area away from direct sunlight, heat sources, and incompatible substances such as strong oxidizers.
Storage Temperature: Recommended to keep below 25°C or as specified on product label
Additional Requirements: Restrict access to authorized personnel. Follow workplace control protocols for hormone-active agents.
Incompatibilities: Avoid contact with acids, bases, and strong oxidizing agents
Occupational Exposure Limits: Not established for Danazol, but handle according to standards for pharmaceuticals or hormone-active compounds
Engineering Controls: Employ local exhaust ventilation or work in fume hood to control airborne concentrations
Personal Protective Equipment: Use gloves (nitrile strongly recommended), lab coat, goggles, and (if risk of dust or aerosol) suitable respirator
Hygiene Measures: Do not eat, drink, or smoke while using. Wash hands and exposed skin after handling
Environmental Controls: Use spill containment and ensure no uncontrolled release to environment
Appearance: White to off-white crystalline powder
Odor: No significant odor
Odor Threshold: Not available
pH: Not applicable
Melting Point/Freezing Point: 224-228°C
Boiling Point: Not practicable as substance decomposes
Flash Point: Not available
Evaporation Rate: Not determined
Flammability: Not classified as flammable in solid form
Vapor Pressure: Very low at room temperature
Bulk Density: 0.5–0.7 g/cm³
Solubility: Slightly soluble in water; soluble in ethanol, methanol, and chloroform
Partition Coefficient: Log Pow approximately 4.5
Decomposition Temperature: Above 230°C
Viscosity: Not applicable (solid material)
Chemical Stability: Stable under recommended handling and storage conditions
Reactivity: Not particularly reactive under normal conditions
Hazardous Reactions: No dangerous reactions reported during intended use
Conditions to Avoid: Avoid excessive heat, contact with strong oxidizing agents
Hazardous Decomposition Products: Thermal decomposition may generate carbon monoxide, carbon dioxide, and nitrogen oxides
Incompatible Materials: Strong oxidizers, strong acids, strong bases
Acute Toxicity: Limited human data, large doses may cause headache, dizziness, altered menstrual cycle, androgenic effects
Chronic Effects: Possible endocrine disruption, liver function alterations with long-term use or excessive exposure
Routes of Exposure: Inhalation, skin contact, accidental ingestion
Carcinogenicity: Animal studies suggest potential risk, not classified as carcinogen by IARC
Mutagenicity: Negative in standard mutagenicity tests, though long-term reproductive risk needs caution
Reproductive Toxicity: Evidence of potential risk from interference with endocrine system; contraindicated in pregnancy
Target Organs: Liver, reproductive organs
Ecotoxicity: May present long-term effects for aquatic organisms due to hormone-like activity
Persistence and Degradability: Danazol is not readily biodegradable
Bioaccumulative Potential: Potential to bioaccumulate in aquatic organisms not ruled out due to log Pow value
Mobility in Soil: Limited mobility, binds to soil particles
Other Adverse Effects: Hormone disruption in wildlife possible if substance enters environment in significant quantities
Waste Disposal: Dispose of content or container as hazardous chemical waste in compliance with local, regional, and national regulations
Methods of Disposal: Incineration in approved facility preferred, do not discharge into drains, surface water, or soil
Contaminated Packaging: Decontaminate or dispose of in accordance with chemical waste regulations
Special Precautions: Prevent residue from entering mixed municipal waste streams
UN Number: Not regulated
UN Proper Shipping Name: Not dangerous for transport under most regulations
Transport Hazard Class: Not classified
Packing Group: Not applicable
Special Precautions: Avoid extreme temperatures, physical damage during transit, and transport only in well-closed, labeled containers
Environmental Hazards: Not classified as marine pollutant, but accidental large releases should be reported to relevant authorities
Labeling: Pharmaceutical agents like Danazol require specific labeling indicating prescription control and hormonal activity
Risk Phrases: May cause harm to unborn child, possible risk of hormone side effects
Safety Phrases: Keep out of reach of children, use only as directed by physician, wear protective gear during handling
Regulatory Status: Controlled substance for pharmaceutical uses; environmental and occupational handling subject to chemical safety regulations in most countries
Other Requirements: Facilities handling Danazol must follow applicable workplace safety, waste disposal, and environmental protection laws
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