Product Name: Deflazacort Intermediate
Synonyms: Not provided for this intermediate; varies by manufacturer and synthesis pathway
Recommended Uses: Pharmaceutical manufacturing, raw material for corticosteroid synthesis
Manufacturer: Listed by the supplier, with full corporate address and emergency contact number required on all documentation
CAS Number: Provided as per batch specifics, traceable to raw material registers
Emergency Telephone Number: Available through the supplier's 24-hour response lines for calls regarding exposure or accidents
GHS Classification: Usually classified under skin irritation, eye irritation, and specific organ toxicity-dependent on exposure level
Signal Word: Warning (depending on regional regulations and hazard classes annotated on safety labels)
Hazard Statements: May cause respiratory tract irritation, skin irritation, or eye irritation; possible target organ effects with repeated exposure
Pictograms: Exclamation mark for irritants; consult actual packaging for full icons
Precautionary Statements: Avoid breathing dust, use protective gloves, wash skin thoroughly after handling, and seek fresh air if inhaled
Chemical Identity: Intermediate compound structure closely related to Deflazacort parent molecule, confidential structure
Purity: Usually above 98% unless otherwise specified by supplier test certificate
Impurities: Synthesis-related substances; identity and concentration available on batch-specific certificate of analysis
Other Components: Minimal water, trace solvents, possible residual raw material depending on batch conditions
Concentration: Deflazacort intermediate represents bulk of material; impurities under 2%
Inhalation: Move affected person into fresh air, support breathing, and seek immediate medical attention if symptoms such as coughing or difficulty breathing develop
Skin Contact: Wash area thoroughly with soap and water, remove contaminated clothing, and consult a physician if irritation persists
Eye Contact: Rinse with flowing water for at least 15 minutes, hold eyelids open to ensure thorough flushing, and get medical help without delay
Ingestion: Rinse mouth, do not induce vomiting unless instructed by medical professionals, seek prompt medical attention
Most Important Symptoms and Effects: Irritation of skin, eyes, respiratory system; possible delayed effects in sensitized workers
Suitable Extinguishing Media: Use water spray, foam, dry chemical or carbon dioxide extinguishers. Water jets not recommended due to potential dispersal of powder
Special Hazards Arising from Substance: May produce toxic smoke, carbon oxides, and other hazardous products when thermally decomposed
Protective Equipment and Precautions: Firefighters should wear full protective gear and self-contained breathing apparatus to avoid inhalation of breakdown products
Specific Methods: Remove containers from fire area if safe to do so; contain extinguishing water to prevent environmental contamination
Personal Precautions: Wear respirators, gloves, goggles, and disposable overalls; avoid dusting. Restrict access to those not involved in cleanup
Environmental Precautions: Prevent release into drains, groundwater, or surface waters; contain spillage using sand or inert absorbent
Methods for Clean-Up: Carefully collect powder using non-sparking tools, store waste in sealed, labeled containers for disposal by licensed contractor
Reference to Other Sections: For disposal considerations and personal protection, refer to the respective later sections in this sheet
Precautions for Safe Handling: Ensure ventilation sufficient to minimize dust exposure, use closed handling systems or containment whenever possible, and avoid contact with skin, eyes, and clothing
Conditions for Safe Storage: Keep in tightly sealed containers, protected from moisture, away from sources of ignition and incompatible substances such as strong oxidizers
Storage Temperature: Store at room temperature (15–25°C) unless otherwise specified by supplier
Incompatibilities: Segregate from strong acids, bases, and oxidizing agents to reduce risk of dangerous reactions
Occupational Exposure Limits: Not formally established; use internal guidelines based on dust limits for pharmaceutical manufacturing
Engineering Controls: Local exhaust ventilation required, process enclosures, and adequate general ventilation in workplaces
Personal Protective Equipment (PPE): Use disposable nitrile gloves, safety goggles, long-sleeved work garments, and approved dust respirators
Hygiene Measures: Remove contaminated clothing and wash hands before eating, smoking, or leaving the work area
Environmental Exposure Controls: Controls mandated to keep workplace air concentration as low as reasonably achievable to prevent accidental release and occupational exposure
Appearance: Solid, off-white to pale yellow powder
Odor: Weak, often negligible
pH: Not applicable (insoluble in water)
Melting Point/Range: Data provided by manufacturer; generally above 120°C, consulting the latest certificate of analysis is crucial
Boiling Point: Decomposes before boiling
Flash Point: Not readily flammable in ambient laboratory conditions; dust explosion risk may exist
Solubility: Practically insoluble in water, sparingly soluble in some organic solvents such as ethanol or DMSO
Vapor Pressure: Negligible at room temperature
Partition Coefficient (n-octanol/water): Data available with compound characterization
Density: Vendor-specific; typically 1.2–1.3 g/cm³
Chemical Stability: Stable under standard laboratory conditions, does not rapidly degrade at room temperature
Possibility of Hazardous Reactions: Contact with strong oxidants or reducing agents could trigger hazardous chemical changes
Conditions to Avoid: Excessive heat, moisture, and sources of ignition threaten the compound’s stability
Materials to Avoid: Reactive toward bases, strong oxidizers, and acids; combining these should be avoided to prevent hazardous byproducts
Hazardous Decomposition Products: Burning may release toxic carbon monoxide, carbon dioxide, and possibly halogenated or nitrogenous compounds
Acute Toxicity: Limited direct data; relevant information derived from related corticosteroids and comparable intermediates
Skin Corrosion/Irritation: Evidence of irritation in in-vitro and in-vivo studies on structurally related compounds
Serious Eye Damage/Irritation: Direct exposure may provoke tearing, redness, or pain
Respiratory or Skin Sensitization: Prolonged handling can lead to sensitization and allergic responses among susceptible workers
Carcinogenicity, Mutagenicity, Reproductive Toxicity: No long-term studies available for this specific intermediate, relate to data on final drug where possible
Other Effects: Long-term or repeated exposure may impact organs targeted by corticosteroids, requiring ongoing occupational health surveillance and medical checks for exposed staff
Ecotoxicity: No comprehensive data available; conservative approach suggests potential risk to aquatic environments, consistent with steroid class
Persistence and Degradability: Stable in the environment, persistence likely without natural rapid degradation
Bioaccumulative Potential: Predicted to have low-moderate potential due to structure; lab studies pending
Mobility in Soil: Binds moderately to soil particles, minimal leaching anticipated, but avoid uncontrolled releases
Other Adverse Effects: Not tested, should treat as potentially hazardous waste requiring containment and careful disposal
Waste Treatment Methods: Collect spillage and unused powders in sealed, labeled containers approved for hazardous chemical waste, hand over to licensed waste processors
Disposal of Packaging: Containers that held Deflazacort intermediate should be triple-rinsed and incinerated or disposed of in line with hazardous waste protocol
Special Precautions for Disposal: Avoid environmental contamination, comply with national and regional laws for chemical substance disposal. Disposal methods must consider potential impact on water, soil, and air
UN Number: Established by competent authority, consult shipping records and current regulatory classification
UN Proper Shipping Name: Based on precise identification, often declared as “chemical, n.o.s.” if not further classified
Transport Hazard Class: Consult shipping label; typically not assigned to routine APIs without clear hazards, but might be classified depending on batch and impurity profile
Packing Group: Determined by packaging robustness and nature of intermediate
Environmental Hazards: Not labeled as marine pollutant unless specified by authorities
Special Precautions for User: Personnel should use gloves and avoid inhalation of dust during transport and handling, especially during container opening and decanting
Safety, Health, and Environmental Regulations/Legislation Specific: Compliance with REACH/OSHA/WHMIS or relevant local occupational safety laws required
Chemical Inventory Status: Must be listed or exempt in major chemical inventories relevant to destination country
SDS Availability: Up-to-date material safety data sheet must be accessible to all workers and transport personnel in native language and English
Other Required Labeling: Precautionary and hazard labeling to match GHS and local standards; must include emergency contact, supplier identification, and batch traceability
Worker Training: Mandatory instruction on handling procedures, emergency response, PPE usage, spill containment and proper waste disposal
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