Dexamethasone as a foundational corticosteroid claims a unique place in the annals of pharmaceutical history. Chemists in the 1950s, striving to fine-tune anti-inflammatory drugs and extend steroidal benefits, managed to tack on an acetate group at the 17th carbon. This tweak, simple as it looks on paper, expanded the medical toolkit. Before long, Dexamethasone-17-Acetate captured attention for its ability to regulate inflammation more precisely, offering clinicians improved ways to control allergy flare-ups, immune conditions, and even some hormone imbalances. Decisions in those days leaned heavily on trial, error, and intuition mixed with the growing rigor of emerging pharmaceutical science. Time has shown that these early bets on molecular adjustments delivered real-world benefits, especially with the search for steroids that work hard with reduced side effects.
Dexamethasone-17-Acetate stands out as a synthetic glucocorticoid. It’s often tailored for use in injectable suspensions and topical formulas. Its chemical backbone empowers the compound to dampen runaway inflammatory responses, suppress immune reactions in auto-immune disorders, and give relief to patients wrestling with severe allergies or adrenal insufficiencies. Through the years, I’ve seen its reach extend from inpatient hospital settings—where acute treatment is necessary—to specialized veterinary and dermatological clinics, where chronic care helps maintain daily function. In cancer therapy, Dexamethasone-17-Acetate sometimes steps in as a supportive agent, preventing nausea and reducing cerebral swelling. Yet, despite all these advances, persistent challenges show up in balancing the benefits with possible systemic side effects.
Dexamethasone-17-Acetate appears as a white crystalline powder, not much to look at but an achiever in the lab. The acetate modification increases the molecule’s lipid solubility, pushing absorption rates higher in certain formulations. Its empirical formula stands at C24H31FO6, with a molecular weight calculated at 434.5 g/mol, packing plenty of punch into a modest package. Solubility shows a marked improvement in organic solvents after esterification at the 17-position—a subtle yet impactful alteration on pharmacokinetics. As a seasoned observer, I’ve found that subtle changes in solubility often explain why a steroid sticks around in tissues longer or spares patients repeated dosing. Melting points, specific rotation, and UV absorbance all serve as quality signs that batch processes deliver what labels promise. These markers aren’t static trivia; they let regulators and users confirm safety batch by batch.
Technical specifications for Dexamethasone-17-Acetate get written with precision since minute impurities or wrong concentrations can mean poor outcomes. Pharmaceutical labeling must pin down concentration, recommended storage conditions, expiration, lot number, and sometimes pharmacodynamic details. In practice, I’ve learned regulations don’t just protect consumers—they give honest producers a fair playing field by rooting out substandard supply chains. Compliance teams routinely monitor for impurities, heavy metals, and even residual solvents, never assuming even a reputable source stays perfect without that scrutiny. Pharmacopeial monographs make this possible, and astute users always double-check for the batch certificate along with the bottle.
Producing Dexamethasone-17-Acetate isn’t just about buying Dexamethasone and adding some chemicals. Synthesis calls for selective acetylation—chemists protect the desired hydroxyl group at the 17th carbon, usually deploying acetic anhydride in an organic solvent under controlled conditions. For anyone familiar with the lab, it feels routine until you realize that every step, from pH balance to purification, changes the yield. Unintentional side reactions, residual solvents, or incomplete conversions haunt the process without careful validation. After acetylation, filtration and washing follow, with stringent drying ensuring shelf stability. Industrial-scale production leans on even tighter environmental and batch controls, tightening tolerances for impurity and residual solvent thresholds.
The classic reaction for synthesizing Dexamethasone-17-Acetate focuses on the introduction of an acetyl group at the steroid’s 17-hydroxyl position. One benefit of that modification: the molecule behaves differently in metabolic pathways, offering slower enzymatic hydrolysis and consequently longer action in tissues. Downstream, some synthetic steps allow the production of other esters, expanding the toolbox further for different release profiles. In practical terms, I’ve seen this chemical tweak convert a fast-acting solution into a depot-style injection, reducing patient visits and improving compliance. Researchers keep exploring alternative ester groups to vary half-life and tissue distribution, but acetates still deliver a reliable combination for storage and slow-release effects.
Pharmacies, research suppliers, and regulatory agencies carry different tags for Dexamethasone-17-Acetate. Some labels include terms like Dexamethasone acetate, 9α-Fluoro-16α-methylprednisolone 17-acetate, or even CAS numbers for absolute tracking. In my work, switching between technical synonyms and trade names sometimes leads to confusion or even procurement mix-ups, so double-checking certificates and product ID numbers stays essential. This patchwork of synonyms results from the overlapping vocabularies of chemistry, pharmacy, and international trade. Brand names, on the other hand, help clinicians spot specific formulations tailored to their intended route of administration or concentration, avoiding mix-ups at the point of care.
Dexamethasone-17-Acetate needs handling with respect, both in manufacturing and administration. Fine powders readily generate airborne particles, and direct skin contact, especially for formulation technicians, carries hazards. Eye and skin protection, approved ventilation systems, and dust collection define the baseline in a modern facility. Storage spaces must limit exposure to moisture and sunlight to avoid degradation or accidental contamination. On the pharmacy or clinical side, dosage errors invite risk—long-acting steroids can suppress adrenal function or trigger metabolic effects if protocols aren’t respected. I’ve seen firsthand that training dispensers and caregivers reduces those mistakes, but routine audits and compliance checks back up those personal lessons.
Innovation in glucocorticoid science rarely stands still. Research labs keep looking into new analogs and esters, trying to limit systemic side effects but still deliver the steroidal benefits that patients need. Dexamethasone-17-Acetate acts as a reference point for structure-activity relationships among synthetic corticosteroids. Studies compare new modifications against its time-tested performance, measuring inflammatory response, immune markers, and tissue retention. Advanced delivery techniques—nano-formulations, liposomal suspensions—try to fine-tune distribution and reduce dosages. New preclinical models and computational chemistry approaches help expedite the development pipeline, offering better safety profiles and reduced animal use. Funding trends and publication rates suggest that further enhancement of steroid specificity and reduction of glucocorticoid-induced complications remain major research priorities.
Steroid toxicity stays in the spotlight for any researcher working with Dexamethasone-17-Acetate. Acute exposures rarely provoke immediate danger, but cumulative dosing—especially without close oversight—invites a cascade of unwanted effects. Patients can face glucose intolerance, bacterial or fungal infection, osteoporosis, and the ever-present risk of adrenal suppression. Toxicity studies map out acceptable daily limits, often confirming safety at therapeutic doses but highlighting narrow windows between help and harm. Animal models help predict long-term sequelae, while patient registries and adverse event tracking help gauge real-world hazards. Over the years, clinicians have learned to taper steroid courses, monitor for secondary effects, and use the lowest effective dose to safeguard patient health.
The challenge for the future doesn’t just rest on improving chemistry—it calls for integrated strategies. Pharmaceutical developers look to enhance tissue targeting, reduce dosing frequency, and protect patients from endocrine disruption. New analogs or pro-drugs aim for more defined tissue distribution, less cross-talk with unintended receptors, and lower requirements for long-term administration. Solutions for safe use also involve better patient and provider education—clearer labeling, digital tracking of therapy courses, and transparency in adverse event reporting. High-quality research into long-term effects, both clinical and molecular, should inform updated guidelines. Investment in green chemistry synthesis methods brings another layer of progress, cutting waste and energy usage while maintaining purity. Dexamethasone-17-Acetate has served as a cornerstone for decades, but the story keeps evolving as patient needs grow, regulatory science becomes more robust, and research teams push for new heights in safety and specificity.
Dexamethasone-17-acetate shows up a lot in the world of medicine, but not everyone gets what it actually does. People often hear “dexamethasone” from their doctor, but the “17-acetate” part sounds like chemistry class jargon. It matters, though. This chemical version of dexamethasone, a corticosteroid, uses the acetate group to make it more suitable for certain ways doctors deliver medication to the body—think injections or skin creams instead of just pills.
Doctors rely on dexamethasone-17-acetate when the body’s natural processes go haywire. One big example is inflammation. Anyone with asthma flare-ups, nasty skin conditions, or stubborn arthritis pain knows the frustration and exhaustion these problems bring. Dexamethasone-17-acetate helps by calming the body’s immune response, which often does more harm than good during these flare-ups.
The same goes for certain allergies. Breathe in too much pollen, get nasty hives or swelling, and sometimes over-the-counter pills won’t cut it. High-strength steroids like this one step in when traditional medications underperform.
Down in the trenches of cancer treatment, doctors turn to dexamethasone-17-acetate to reduce pain and tackle severe nausea linked to chemotherapy. The impact here isn’t just about science or test tubes. It’s about a patient getting a real chance to eat a meal or sleep through the night.
Nothing opens your eyes to medication quite like watching a family member struggle with an autoimmune disease. I remember seeing a relative, wracked with pain from lupus, finally get her symptoms under control—something that felt like a small miracle after weeks of swelling and soreness. This drug brought her relief when nothing else did.
Medical staff see its value all the time, especially for patients stuck in the revolving door of hospital visits. One nurse told me she relies on injectable dexamethasone-17-acetate to bring fast relief for severe allergic reactions. It works quickly and reliably, which matters during emergencies.
Anyone who’s taken strong steroids knows there’s a flip side. Stay on them too long, and risks start stacking up: weakened bones, mood swings, weight gain, blood sugar spikes. According to research published by the Mayo Clinic and National Institutes of Health, long-term steroid use can suppress the body’s ability to fight infection and even change blood chemistry. Doctors weigh these risks every day. They watch patients closely, monitoring blood, mood, and immune health, and try to keep doses small or intermittent.
People talk a lot about miracle cures, but the truth is, no magic bullet exists. Drugs like dexamethasone-17-acetate come as tools—sometimes necessary, never casual. More research means more options for patients, from improved non-steroid therapies to better understanding which patients benefit most and for how long. Government and private groups can step up funding for studies, and colleges can train new doctors to look past quick fixes. The real solution circles back to careful monitoring, honest conversation with patients, and teamwork among nurses, pharmacists, and specialists. That’s where hope grows.
Dexamethasone-17-Acetate comes up in hospital wards and research labs any time doctors tackle tough conditions like severe allergies, autoimmune flares, and certain cancers. Unlike over-the-counter meds, this corticosteroid packs a punch, so the question of “how much?” really matters. Striking the right dose not only keeps side effects at bay but also protects long-term health. Years spent in the pharmacy and on hospital floors have taught me that dosing isn’t about copying a chart—it demands respect for each patient’s unique story.
In medicine, people often expect a simple answer: take X milligrams Y times daily. Steroids, and especially specialized esters like Dexamethasone-17-Acetate, refuse to play by those rules. Usual adult starting doses (for the basic dexamethasone compound) hover between 0.75 to 9 mg per day, depending on what a doctor is treating. Because Dexamethasone-17-Acetate works as a long-acting ester, doses don’t always compare directly—even doctors often double-check their calculations. For example, treating an acute flare-up often means higher doses, tapered down as symptoms ease. When treating chronic illnesses, the lowest effective dose keeps side effects from stealing the show.
Too much, and you risk raising blood sugar, thinning bones, catching infections. Too little, and the underlying disease just keeps attacking. The fine line matters most for older patients, kids, or anyone already on several medicines. My own grandmother’s battle with vasculitis turned into a balancing act—enough steroid to stop the inflammation, but not enough to tip her into diabetes. Every extra milligram felt like gambling with her future health.
Different bodies break down drugs at different speeds. Weight, age, kidney health, even genetics rewrite the rulebook for each patient. Pregnant women and people with liver problems see steroids behave in unpredictable ways. Even experienced prescribers pause before deciding a steroid dose; often, doctors start on the low side, then “titrate” up or down while watching for side effects or signs of improvement. Self-experimenting or sharing a friend’s steroid bottle never ends well. I’ve lost track of stories where a shortcut backfired.
The U.S. Food and Drug Administration flags that glucocorticoid dosing requires “individualization.” Large studies and decades in practice back this up: one-size-fits-all approaches lead to side effects or poor disease control. Long-acting esters demand even more caution, since they hang in the body and can’t be taken away after the shot is given.
Doctors and pharmacists double-check patient charts for reasons. Electronic records help flag risky combinations, and close follow-up catches problems early. If a patient gets jittery, develops a rash, or starts losing sleep after a new steroid shot, this info gets to their doctor fast. More patient education helps, too—clear talk about what to expect from a new drug or how to taper off slowly.
Medicine never gets simpler, but attention to the details keeps real people safer. Dexamethasone-17-Acetate, in skilled hands, treats what needs treating, and leaves the rest of life untouched.
Dexamethasone-17-Acetate falls under the strong steroid medication category. Doctors usually reserve it for conditions that need firm anti-inflammatory action or when other options bring little relief. More than a decade working with patients has shown me that people tend to look past the possible trade-offs of a prescription, trusting the promise of relief. Steroids, though, have a habit of asking for something back.
Dexamethasone-17-Acetate tones down the immune system. Folks notice they catch colds easier, and wounds seem to stick around longer than expected. It blocks immune cells from doing their usual job, so both bacteria and viruses can settle in places they’re not wanted. I remember an older patient who faced repeated lung infections after a year-long steroid course. These risks call for extra hand-washing, more cautious contact with sick friends, and sometimes vaccines before starting the steroid.
The brain sits in the crosshairs, too. A number of people report mood swings, trouble falling asleep, or even periods of feeling down. It’s not just mild irritability—some struggle with severe anxiety or agitation. Research from the Mayo Clinic ties steroid use to higher chances of depression, especially for those who stick with them long term. Checking in on mental health and flagging emotional changes with a care team makes a real difference.
For many, dexamethasone-17-acetate brings changes in the mirror. The most common shift is weight gain. Faces round out, and fat settles in new places—especially cheeks and the belly. This can shake how people feel about themselves, even if the steroid helps their illness. Some start to see stretch marks or thin skin that bruises at the slightest bump. One teenager I knew felt less social because of these changes, showing how steroids impact more than just the inside of the body.
Osteoporosis creeps up on long-term users. Dexamethasone, like its cousin prednisone, pulls calcium out of bones. In my clinic, I met patients who lost inches off their height from weakened vertebrae. Muscle weakness also sneaks up, turning daily tasks into slow, careful movements. Studies from Johns Hopkins show higher fracture rates in folks using steroids year after year.
Steroids play havoc with blood sugar. Diabetics might need more insulin, and some without previous problems learn they now have diabetes. Dexamethasone tends to raise blood pressure as well, often driving people back to their doctor for extra medications. The stomach doesn’t appreciate steroids either. Many complain of acid reflux, heartburn, or stomach ulcers. Eating before taking each dose and sometimes pairing with antacids helps a bit, but doesn’t erase the risk entirely.
Doctors prefer using dexamethasone at the lowest effective dose, for the shortest time possible. Getting a second opinion on whether alternative treatments work just as well can spare people from many of these issues. Those who need longer courses benefit from routines that include bone scans, regular blood pressure checks, and extra vigilance for infection. Building meal plans with more calcium and less simple sugar, and keeping up with gentle weight-bearing exercise, can slow bone loss and blunt the weight gain that comes with steroids. Talking openly with a healthcare team—about physical, mental, and social changes—makes a tough treatment journey much more bearable.
Corticosteroids like Dexamethasone-17-Acetate can truly work wonders for inflammation and immune problems, but they come with a fair share of risks worth considering. As somebody whose family has relied on steroid treatment for asthma and arthritis, I’ve seen the upsides along with the hazards. These medications may offer relief, yet they also carry warnings that every patient and caregiver ought to know.
Some conditions throw up red flags right away. People with serious infections should tread carefully. Dexamethasone-17-Acetate weakens the body’s defense systems. When my neighbor got a lung infection, the doctor refused steroids because they can let infections thrive unchecked. Patients fighting tuberculosis, fungal infections, or herpes simplex in the eye face clear dangers.
Uncontrolled diabetes serves as another warning sign. Steroids push blood sugar higher—something my uncle with type 2 diabetes quickly learned as his levels shot up after just a short course of steroid pills. Anyone with heart problems, high blood pressure, or peptic ulcers should look for safer options since steroids add strain to weakened hearts and inflame the stomach lining.
Mixing medications can spark trouble. Blood thinners, some seizure drugs, and vaccines do not play well with Dexamethasone-17-Acetate. I remember a friend who ended up with bruises all over from minor bumps while taking steroids and warfarin at the same time. Steroids can wreck the immune response to live vaccines, so vaccinations deserve careful timing.
Mental health matters, too. Not everyone expects steroids to affect their mood, yet anxiety, sleep trouble, and even psychosis can pop up. It’s not rare to hear from patients who felt their personality change or struggled to sleep through the night on these meds.
Giving steroids to kids brings up concerns about growth. Doctors told my cousin’s family to weigh short-term benefits against possible stunted growth or weaker bones. Pregnant women face tough decisions, too. Steroids can cross the placenta and may affect fetal development, so obstetricians and moms talk through every option. Adults over 65 stand at risk for bone thinning and muscle loss, making falls and fractures much more likely.
Keeping an eye out for side effects makes a big difference. Regular blood tests for sugar, pressure, and bone density turn up problems before they spiral. People with infections, mental health issues, or pregnancy should always talk openly with their health team before starting these medicines.
Doctors often start with the lowest possible dose and short bursts, rather than months on end. Tapering off—never stopping suddenly—can ward off adrenal crashes and withdrawal symptoms, something my own family experienced in the past.
Open conversations save lives. Sharing medical history and talking through every medication and supplement helps doctors spot risks early. Real-world vigilance, paired with smart choices, goes much further than any warning label could.
No one takes medicine hoping to add new problems. Yet piling up prescriptions gets tricky. Ask someone juggling three or more pills; things can go sideways fast. Dexamethasone-17-acetate, a corticosteroid, shows up in clinics for all sorts of reasons—from allergy flare-ups to autoimmune rumbles. Not everyone realizes this compound can change how other drugs work in the body, sometimes in ways that cause real trouble.
I still recall an aunt who needed steroids for chronic inflammation. She figured doubling up with her usual meds shouldn’t matter. Pretty soon, afternoon naps turned into restless nights and blood sugar started rising. Her story pops up again and again for folks combining drugs without advice. Pharmacists mention this all the time: corticosteroids like dexamethasone tweak how the liver processes medicine. That colorless pill can turn up metabolism, slow it down, or put the kidneys on notice.
The mix matters. Blood thinners like warfarin lose their edge or swing the other way, upping the risk of clots or bleeding. Diabetics see glucose swinging on them without warning. Add on anti-seizure meds, antifungals, or certain antibiotics, and suddenly hoses cross. The interactions are not rare footnotes; millions of patients get corticosteroids each year, and many combine them with other prescription or even over-the-counter drugs.
Asking about painkillers? Nonsteroidal anti-inflammatory drugs (NSAIDs) raise the odds of stomach ulcers or bleeding if taken with dexamethasone-17-acetate. Thinking of getting vaccinated? Steroids can weaken the immune response, making those vaccines less effective. Scripts for high blood pressure? Diuretics used together can disturb potassium and sodium, making heart issues worse. Even herbal remedies can surprise here; St. John’s Wort lowers steroid levels, while some supplements throw off electrolytes.
It doesn’t take medical school to look at a new prescription and ask some good questions. Pharmacists pick up details others miss: half-lives, dose timing, food effects. Skipping that five-minute conversation doesn’t save much time if a drug interaction sends someone to the ER.
Keeping an updated medication list pays off, including any vitamins, supplements, or occasional painkillers. Show the list during every clinic visit. Doctors rely on patients’ honesty to prevent surprises. Electronic health records help, but only if everyone logs the right info. If a steroid gets added to your regimen, ask straight out—could this make my other pills stronger or weaker? Am I at risk for higher blood sugar, blood pressure, or stomach trouble now?
Taking steps at home helps, too. Track symptoms: insomnia, mood swings, weird swelling, jitters. Contact the clinic sooner, not later, when side effects creep in. Many pharmacies offer medication reviews; a 15-minute check can catch a lot.
In my experience, the patients who fare best share every detail with their care team. They don’t just accept “take this and go.” They ask questions, read the pamphlet, and use pill boxes to keep things straight. Regular bloodwork and blood pressure checks spot changes before things volcano. If a doctor mentions adding dexamethasone-17-acetate, a little extra vigilance saves trouble down the line.
Corticosteroids play a big role in healthcare, but they mix best with open communication and some healthy skepticism. Anyone adding dexamethasone-17-acetate to their prescription basket owes it to themselves to double-check those combinations.
| Names | |
| Preferred IUPAC name | 2-[(1R,2R,4aS,4bS,6aS,6bR,9aR,10aS,10bS)-1-Fluoro-1,4a,6a,7,8,9,9a,10,10a,10b-decahydro-6b-hydroxy-1,2,4a,6,6b,9a-heptamethyl-5-oxo-phenanthro[1,2-b]furan-2-yl]ethyl acetate |
| Other names |
Dexamethasone 17-acetate
Dexamethasone acetate Decadron acetate Hexadecadrol acetate Fluormethylprednisolone acetate |
| Pronunciation | /ˌdɛk.səˌmɛ.θəˌsoʊnˌsɪv.ənˈæ.sɪ.teɪt/ |
| Preferred IUPAC name | (8S,9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-11,17-dihydroxy-17-acetyl-10,13,16-trimethyl-6,7,8,10,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one |
| Other names |
Dexamethasone 17-acetate
Decadron acetate Hexadrol acetate NSC 34510 17-Acetoxy-9α-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione |
| Pronunciation | /ˌdɛk.səˌmɛ.θəˌsoʊn ˈsɛv.ənˈtiːn əˈsiː.teɪt/ |
| Identifiers | |
| CAS Number | 1177-87-3 |
| Beilstein Reference | 3417205 |
| ChEBI | CHEBI:4463 |
| ChEMBL | CHEMBL1200333 |
| ChemSpider | 123596 |
| DrugBank | DB14644 |
| ECHA InfoCard | 100.011.320 |
| EC Number | EC 200-351-1 |
| Gmelin Reference | 82259 |
| KEGG | C02176 |
| MeSH | D005188 |
| PubChem CID | 10755 |
| RTECS number | DQ1750000 |
| UNII | OK3C6ZZ13P |
| UN number | UN2811 |
| CompTox Dashboard (EPA) | DTXSID1039211 |
| CAS Number | 1177-87-3 |
| 3D model (JSmol) | `3D model (JSmol)` string for **Dexamethasone-17-Acetate**: ``` 13 10 Dexamethasone-17-Acetate C1CC2(C(C1(C(=O)CO2)C3=CC(=O)C4C(C3=O)C(=C(C(=C4C)O)F)C)OC(=O)C)C ``` Above string represents the molecule for loading in JSmol or similar software. |
| Beilstein Reference | 1423153 |
| ChEBI | CHEBI:4466 |
| ChEMBL | CHEMBL1200329 |
| ChemSpider | 146405 |
| DrugBank | DB14643 |
| ECHA InfoCard | 13d1e380-0d53-415d-8d77-354ebd34a3c8 |
| EC Number | EC 200-352-9 |
| Gmelin Reference | 108259 |
| KEGG | C01915 |
| MeSH | Dexamethasone-17-Acetate |
| PubChem CID | 6542 |
| RTECS number | DH8050000 |
| UNII | VOU0UKX14M |
| UN number | Dexamesathasone-17-Acetate does not have a UN number |
| Properties | |
| Chemical formula | C24H31FO6 |
| Molar mass | 434.497 g/mol |
| Appearance | White to practically white crystalline powder |
| Odor | Odorless |
| Density | 1.31 g/cm3 |
| Solubility in water | Slightly soluble in water |
| log P | 2.6 |
| Vapor pressure | 5.97E-14 mmHg at 25°C |
| Acidity (pKa) | 12.45 |
| Basicity (pKb) | 13.57 |
| Magnetic susceptibility (χ) | -7.7e-6 |
| Refractive index (nD) | 1.552 |
| Viscosity | Viscous liquid |
| Dipole moment | 9.6154 Debye |
| Chemical formula | C24H31FO6 |
| Molar mass | 434.497 g/mol |
| Appearance | White or creamy white crystalline powder |
| Odor | Odorless |
| Density | 1.32 g/cm³ |
| Solubility in water | Slightly soluble in water |
| log P | 2.56 |
| Vapor pressure | 2.7 x 10^-9 mm Hg |
| Acidity (pKa) | 12.61 |
| Basicity (pKb) | 13.46 |
| Magnetic susceptibility (χ) | -7.8e-6 |
| Refractive index (nD) | 1.571 |
| Viscosity | Viscous oil |
| Dipole moment | 7.82 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 567.6 J/mol·K |
| Std enthalpy of formation (ΔfH⦵298) | -726.8 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -6695 kJ/mol |
| Std molar entropy (S⦵298) | 576.8 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -789.7 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -7112 kJ/mol |
| Pharmacology | |
| ATC code | H02AB02 |
| ATC code | H02AB02 |
| Hazards | |
| Main hazards | Harmful if swallowed. Causes serious eye irritation. Causes skin irritation. May cause respiratory irritation. |
| GHS labelling | GHS02, GHS07 |
| Pictograms | GHS06, GHS08 |
| Signal word | Warning |
| Hazard statements | H302: Harmful if swallowed. H361: Suspected of damaging fertility or the unborn child. |
| Precautionary statements | P261, P264, P272, P280, P302+P352, P304+P340, P305+P351+P338, P312, P332+P313, P337+P313, P362+P364 |
| NFPA 704 (fire diamond) | 1-1-1-0 |
| Flash point | Flash point: 9°C |
| Lethal dose or concentration | Lethal dose or concentration (LD50) for Dexamethasone-17-Acetate: "LD50 (oral, rat): >3,000 mg/kg |
| LD50 (median dose) | mg/kg (Rat) 1660 oral |
| NIOSH | WV7G1U41GB |
| PEL (Permissible) | Not established |
| REL (Recommended) | 0.3 mg daily |
| IDLH (Immediate danger) | Not listed |
| Main hazards | Causes damage to organs through prolonged or repeated exposure. |
| GHS labelling | GHS07, GHS08 |
| Pictograms | GHS06, GHS08 |
| Signal word | Warning |
| Hazard statements | H361: Suspected of damaging fertility or the unborn child. |
| Precautionary statements | P280, P305+P351+P338, P302+P352, P332+P313, P337+P313, P362 |
| NFPA 704 (fire diamond) | 1-1-1-0 |
| Flash point | > 280 °C |
| Autoignition temperature | 400 °C |
| Lethal dose or concentration | LD50 (rat, oral): 1660 mg/kg |
| LD50 (median dose) | LD50 (median dose): 16 mg/kg (intravenous, mouse) |
| NIOSH | FQ8Y76VD1N |
| PEL (Permissible) | Not established |
| REL (Recommended) | 0.01–0.1% |
| IDLH (Immediate danger) | Not established |
| Related compounds | |
| Related compounds |
Dexamethasone
Dexamethasone acetate Dexamethasone 21-acetate Dexamethasone sodium phosphate Dexamethasone valerate Betamethasone Prednisolone Hydrocortisone |
| Related compounds |
Cortisone acetate
Prednisolone acetate Hydrocortisone acetate Dexamethasone Betamethasone Triamcinolone acetate Methylprednisolone acetate |
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