Product Name: Dexamethasone-17-Acetate
Chemical Name: 9α-Fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-acetate
CAS Number: 1177-87-3
Synonyms: 9α-Fluoro-16α-methylprednisolone 17-acetate
Formula: C24H31FO6
Supplier: Medical laboratories, research facilities, chemical distributors
Recommended Use: Glucocorticoid for research, pharmaceutical manufacturing
Restrictions on Use: For laboratory, academic, and regulated industry only
GHS Status: Not classified under GHS as a hazardous substance
Route of Entry: Inhalation, skin and eye contact, ingestion
Potential Health Effects: Overexposure may cause endocrine disruption, immunosuppression, skin and eye irritation, possible reproductive toxicity, documented effects on the adrenal and pituitary systems
Signal Word: Warning
Hazard Statements: Possible allergen, suspected of damaging fertility or the unborn child, may cause skin and eye irritation
Pictograms: Exclamation mark, health hazard symbol
Chemical Identity: Dexamethasone-17-Acetate
Concentration: 98-100%
Impurities: Trace levels of related steroids possible, amounts insufficient to cause additional health hazards
Additives: None
Molecular Weight: 434.5 g/mol
Inhalation: Move the affected person to fresh air. Provide comfortable resting position. Seek medical attention for respiratory symptoms.
Skin Contact: Remove contaminated clothing. Rinse skin immediately with soap and plenty of water. Watch for delayed symptoms.
Eye Contact: Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Remove contact lenses if present. Get prompt medical advice.
Ingestion: Rinse mouth with water. Drink water in small sips if aware and alert. Never give anything by mouth to an unconscious individual. Seek immediate medical assistance.
Acute Symptoms: Irritation, headache, nausea, allergic reactions
Important Notes: Show SDS to treating physician, provide details of exposure route and duration
Suitable Extinguishing Media: Foam, carbon dioxide, dry chemical, or powdered extinguishers
Specific Hazards: Toxic fumes may develop (carbon oxides, hydrogen fluoride); avoid inhaling combustion residues
Protective Equipment: Full protective firefighting gear, self-contained breathing apparatus
Firefighting Instructions: Move containers away from fire if safe. Cool container with water spray. Keep out unnecessarily exposed personnel.
Unusual Fire or Explosion Hazards: No unusual hazards expected, substance is not volatile
Thermal Decomposition Products: Fumes of carbon dioxide, carbon monoxide, possibly hydrofluoric acid
Personal Precautions: Wear laboratory gloves, eye protection, lab coat, face shield for large spills
Environmental Precautions: Prevent substance from entering drains, sewers, or water sources
Spillage Cleanup Methods: Ventilate area, avoid dust formation, sweep up or absorb with inert material (vermiculite, dry sand). Place contaminated material in tightly sealed, labeled disposal containers.
Decontamination: Wash spill area thoroughly with detergent after material removal
Disposal: Dispose cleanup materials as hazardous waste according to local regulations
Handling Recommendations: Use in chemical fume hood. Wear standard safety gear. Keep away from eating, drinking, and smoking areas. Minimize dust and aerosol production.
Storage Conditions: Store in tightly sealed container. Keep in a dry, cool, well-ventilated area.
Incompatible Materials: Strong oxidizers, mineral acids
Special Handling Advice: Train personnel on safe handling. Label all storage and working containers clearly.
Temperature Range: Recommended storage between 2°C and 8°C.
Packaging Materials: Use inert, airtight containers, preferably amber glass
Engineering Controls: Work under local exhaust ventilation or in a certified laboratory hood
Occupational Exposure Limits: No specific OEL or TLV established. Recommended: Keep exposure as low as reasonably achievable.
Eye/Face Protection: Chemical splash goggles
Skin Protection: Nitrile or neoprene gloves, laboratory gown or disposable overall
Respiratory Protection: NIOSH-approved respirator for managing dust or aerosol risks
Other Protective Equipment: Use proper hygiene; wash hands after handling
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not determined
pH (aqueous solution): Not applicable
Melting Point: Approximately 233-237°C
Boiling Point: Not available (decomposes)
Flash Point: Not available
Flammability: Not flammable under standard conditions
Solubility: Insoluble in water; soluble in methanol, acetone, chloroform
Partition Coefficient (log Kow): Estimated 2.4–2.8
Vapor Pressure: Negligible at ambient conditions
Density: Approximately 1.3 g/cm³
Viscosity: Not applicable
Evaporation Rate: Not applicable
Decomposition Temperature: Above 240°C (with chemical decomposition)
Chemical Stability: Stable under normal laboratory and storage conditions
Reactivity: Inert under most anticipated storage and handling conditions
Possible Hazardous Reactions: Strong oxidizers may produce violent reactions, generation of toxic products (hydrogen fluoride gas in fire)
Conditions to Avoid: High temperatures, strong sunlight, incompatible chemicals
Decomposition Products: Carbon oxides, hydrofluoric acid, organic residues
Polymerization: Will not occur under standard handling
Acute Toxicity Data: No reliable LD50 data available; structurally similar glucocorticoids show potential for toxicity at high doses
Potential Health Effects: May suppress immune system, cause hormonal imbalances, affect reproductive and adrenal systems, irritate skin and eyes
Chronic Toxicity: May disrupt endocrine function, impact growth, potentially teratogenic, suspected carcinogen in rodents by analogy to related compounds
Routes of Exposure: Inhalation, skin and eye absorption, ingestion
Symptoms of Overexposure: Headache, nausea, drowsiness, skin eruptions, systemic glucocorticoid effects
Irritation/Corrosiveness: Mildly irritating to skin and mucous membranes
Allergic Reactions: Possible, particularly in sensitized individuals
Mutagenicity/Carcinogenicity: Limited data, structurally related compounds have produced adverse effects in animal studies
Toxicity to Aquatic Organisms: Data not available in detail, may be harmful based on glucocorticoid activity
Persistence and Degradability: Expected to persist in the environment, poorly biodegradable
Bioaccumulative Potential: Moderate, based on log Kow and steroid structure
Mobility in Soil: Low, substance binds strongly to soil particles
Other Ecological Effects: May disrupt aquatic ecosystems, hormone-active contaminants affect non-target species
Precautions: Prevent releases to surface or ground waters
Disposal Methods: Dispose as pharmaceutical, laboratory, or chemical waste according to regional, national, and local laws
Container Disposal: Triple rinse containers, puncture and dispose by incineration or as hazardous waste
Special Precautions: Do not flush to sewer, avoid uncontrolled disposal to environment
Reuse/Recycling: Not recommended
UN Number: Not assigned; not regulated under standard transport regulations for small laboratory quantities
Proper Shipping Name: Dexamethasone-17-Acetate
Transport Hazard Class: Not classified
Packing Group: Not classified
Environmental Hazards: Not a marine pollutant
Special Precautions: Protect from physical damage, spills, incompatible substances during transit
Regulatory Status: Not scheduled as a controlled substance in most jurisdictions, prescription/industrial drug regulations may apply
OSHA Hazards: Eye, skin, and respiratory irritant
TSCA: Not listed specifically
EU Regulation: Not covered by REACH Annex XVII restrictions
Other Regulatory Information: Subject to workplace exposure and environmental rules for pharmaceuticals and research chemicals
Labels Required: Appropriate hazard symbols and warning statements for laboratory chemical
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