Product Name: Dexamethasone Intermediate
Chemical Family: Corticosteroid Intermediate
Synonyms: Glucocorticoid precursor, steroid intermediate
CAS Number: 50-02-2
Manufacturer: Provided upon request
Recommended Use: Pharmaceutical synthesis
Emergency Phone: Provided upon request
Address: Provided upon request
Classification: Harmful if inhaled, hazardous to organ systems upon repeated exposure
Signal Word: Warning
Hazard Statements: May cause irritation to eyes, skin, respiratory tract; risk of allergic skin reaction; prolonged exposure could damage adrenal gland function and immune response
Precautionary Statements: Avoid breathing dust; wash hands thoroughly after handling; wear protective gloves, clothing, and eye protection; do not eat, drink, or smoke while handling product
GHS Labels: Exclamation mark for irritation risk
Chemical Name: Dexamethasone Intermediate
Concentration: Greater than 98%
Impurities: May contain precursor and byproduct compounds under 2% each
Molecular Formula: C22H29FO5
Molecular Weight: 392.461 g/mol
Inhalation: Move to fresh air, monitor for breathing difficulty, consult medical help if symptoms persist
Skin Contact: Remove contaminated clothing; rinse skin with soap and water for at least 15 minutes; medical attention if irritation persists
Eye Contact: Flush eyes gently with clean water for 15 minutes; consult medical advice if pain or redness continues
Ingestion: Rinse mouth, drink water to dilute substance, receive medical evaluation; do not induce vomiting
Suitable Extinguishing Media: Water mist, dry chemical, carbon dioxide, foam
Unsuitable Media: Direct high-pressure water jets
Hazards: Releases fumes under fire conditions including carbon oxides, hydrogen fluoride
Protective Equipment for Firefighters: Full protective gear and self-contained breathing apparatus
Special Procedures: Fight fire from safe distance, cool containers with water spray, avoid inhalation of combustion products
Personal Precautions: Wear respiratory protection, gloves, chemical-resistant clothing
Environmental Precautions: Prevent powder from entering drains, waterways, or soil
Methods for Cleanup: Ventilate area, sweep up carefully to avoid dust, place in suitable closed container for disposal
Spill Handling: Avoid creating dust, use HEPA-filtered vacuum or damp methods
Handling: Work in well-ventilated space, use local exhaust, avoid skin and eye contact, prevent dust buildup, wash after handling
Storage: Store tightly sealed in original container, cool and dry location, keep away from incompatible materials such as strong oxidizers and acids
Storage Temperature: Below 25°C recommended
Incompatible Materials: Strong acids, alkali, oxidizers
Control Parameters: No established exposure limits for dexamethasone intermediates; follow general pharmaceutical handling precautions
Engineering Controls: Enclosed process systems, local exhaust, laminar flow hoods
Personal Protective Equipment: Nitrile gloves, lab coat, closed footwear, chemical splash-proof goggles, NIOSH-approved respiratory protection if dust or aerosols present
Hygiene Measures: Remove contaminated clothing, do not eat or drink in work area, wash thoroughly after handling
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Not applicable for solid
Melting Point: 220-230°C approximate
Boiling Point: Decomposes before boiling
Flash Point: Data not available, non-flammable under ambient conditions
Solubility: Soluble in organic solvents like ethanol, poorly soluble in water
Vapor Pressure: Negligible at room temperature
Partition Coefficient (n-octanol/water): Not determined
Auto-Ignition Temperature: Not determined
Evaporation Rate: Not relevant (solid material)
Explosive Limits: Not determined
Chemical Stability: Chemically stable under recommended storage and handling
Reactivity: Non-reactive under normal use
Hazardous Reactions: May react with strong oxidizers or acids
Decomposition Products: Toxic fumes of carbon monoxide, carbon dioxide, fluoride compounds
Polymerization: Will not occur under normal storage
Acute Toxicity: Data limited, based on dexamethasone—LD50 (oral, rat) estimated >3000 mg/kg
Chronic Effects: Risk of adrenal suppression, immune modulation, skin and mucous membrane sensitization from repeated exposure
Irritation: Causes eye, skin, and respiratory tract irritation
Carcinogenicity: No sufficient data, not listed by IARC, NTP, or OSHA
Reproductive Effects: Glucocorticoid drugs linked to reproductive toxicity in animal studies, intermediates may carry similar risks
Mutagenicity: Not expected based on ingredient profile, evaluation ongoing
Other Effects: Prolonged overexposure connected to hypokalemia, hypertension, and glucose metabolism changes in finished steroids
Ecotoxicity: Information on aquatic toxicity limited; corticosteroids have shown possible adverse effects in water-dwelling organisms
Persistence and Degradability: Not readily biodegradable; slower breakdown in soil and water than many organic chemicals
Bioaccumulation Potential: Low for intermediate, but finished compounds may accumulate in aquatic life over time
Mobility in Soil: Slow migration, likely to bind to organic matter
Other Adverse Effects: Discharge into the environment may disrupt aquatic hormonal systems—always avoid uncontrolled release
Waste Treatment Methods: Dispose as hazardous pharmaceutical waste in accordance with local, regional, and national regulations
Container Disposal: Triple rinse containers before recycling or disposal; do not reuse uncleaned containers
Special Instructions: Incinerate at licensed facility with proper air pollution controls, prevent any release to natural waters
UN Number: Not classified as dangerous under current transport regulations
UN Proper Shipping Name: Non-regulated
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Environmental Hazards: None identified for transport
Special Precautions: Avoid generation of dust, handle in sealed primary packaging, transport in secondary container
TSCA: Not listed as a pure substance; pharmaceutical intermediates reviewed under drug regulations
ECHA REACH: Intermediate substances might fall under specific registration—users must verify with their supplier
US OSHA: Not regulated as hazardous in pure form but workplace controls required for good practice
SARA Title III: Not identified as extremely hazardous, not subject to Section 313 reporting
California Proposition 65: Not listed
Other Regulations: Always check for applicable national pharmaceutical or chemical control frameworks in user’s region
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