Dexamethasone Sodium Phosphate: More Than Just a Pharmaceutical Staple

Historical Development: The Story Behind The Molecule

Watching new medicines make their mark never gets old. Dexamethasone sodium phosphate began its journey during the relentless wave of mid-20th century drug discoveries. Researchers wanted steroids that worked better with fewer side effects. They spotted the glucocorticoid dexamethasone, which packed potent anti-inflammatory power. Converting this into its sodium phosphate form allowed for faster absorption, especially when it counted in emergencies. Hospitals around the world saw another step forward for injectable steroids. Over decades, dexamethasone sodium phosphate earned a reputation for reliability. Clinical breakthroughs—such as helping to keep COVID-19 patients alive—remind us that old medicines still have a big job to do.

Product Overview: What Sets This Drug Apart

Dexamethasone sodium phosphate solves a practical problem. Glucocorticoids can be tricky to give intravenously, yet doctors need that option when managing shock, brain swelling, or asthma that doesn't respond to inhalers. This drug dissolves easily in water, mixes well for injections, and gets to work quickly inside the body. It provides a bridge between speed and precision—giving doctors control in crisis, and patients a shot at better outcomes. Compared with traditional corticosteroids, it delivers more anti-inflammatory effect with a smaller dose. Such characteristics make it a mainstay in outpatient clinics, ambulances, and intensive care units.

Physical and Chemical Properties: Breaking Down The Details

Here’s what stands out: Dexamethasone sodium phosphate is a white or almost white crystalline powder. It dissolves well in water, much less so in alcohol or chloroform. That high solubility explains its use in quick-onset injections. Each molecule carries a glucocorticoid backbone plus the phosphate group, which boosts its compatibility with saline solution. Chemically, it clocks in at a molecular weight of about 516.41 g/mol. The powder resists breaking down if stored dry and shielded from light, but as soon as it hits liquid, stability drops and it needs to be used soon after mixing. Small details like this change how hospitals prepare and administer the drug, especially at scale.

Technical Specifications & Labeling: Reading What Matters

Walking down the aisles of a hospital pharmacy, every vial tells a story through its label. Dexamethasone sodium phosphate gets packaged in glass ampoules, pre-loaded syringes, or multi-dose vials. Common concentrations range from 4 mg/ml up to 10 mg/ml. Each label spells out the batch number, date of manufacture, and expiry. The sodium content becomes critical for patients with heart or kidney problems, so that often gets highlighted. Labels remind medical teams to store products at controlled room temperature and out of direct sunlight. Pharmacies maintain close oversight of their stocks, so traceability and fast recalls are possible, lessons learned from past contamination scares.

Preparation Method: Manufacturing Steps in Plain Language

Building dexamethasone sodium phosphate isn’t simple. Starting with dexamethasone base, technicians introduce phosphoric acid derivatives under carefully monitored conditions. The process needs clean rooms, filtered air, and expert staff with years of experience. Strict quality checks follow at every stage: from solvent purity to final crystal appearance. Once crystals form, factories filter, dry, and grind them, keeping everything shielded from rogue bacteria or chemical contaminants. Bulk powder then heads to sterile packaging facilities, where robotic arms fill glass ampoules in high-speed production lines. Throughout this chain, only a handful of missteps—from dirty equipment to inadequate filtering—could lead to failed batches. That risk keeps factory workers meticulous, often running double-checks before releasing a lot to market.

Chemical Reactions & Modifications: What Makes It Tick

Every chemical tweak alters a drug’s behavior. Adding a phosphate group to dexamethasone changes its properties in big ways. It improves water solubility, which means doctors don’t need to suspend the drug in oils or alcohols. That means fewer allergic reactions and faster onset in emergencies. In the body, special enzymes quickly snip the phosphate group, releasing the active steroid. Synthetic chemists can further modify the molecule, using safeguards so it delivers medicine fast but avoids triggering a crash in blood sugar or causing unwanted immune suppression. These modifications evolved based on real hospital feedback—clinicians sharing what worked, what failed, and what risked harm.

Synonyms & Product Names: Navigating The Landscape

Few drugs carry more aliases. Doctors and pharmacists juggle trade names like Decadron, Dexasone, or Hexadrol. In the literature, you’ll spot references to Dexamethasone 21-Phosphate disodium or Oradexon. Each pharmaceutical company brands it differently to carve out market share, but the core ingredient stays the same. Patients sometimes get confused by these names, picking up prescriptions under one brand and refilling with another. This doesn’t usually cause trouble beyond a moment’s hesitation, yet pharmacy staff frequently cross-check with electronic records to keep safety front and center. Consistency in branding helps, but education weighs in as the best way to prevent mix-ups.

Safety & Operational Standards: Meeting The Bar

Keeping dexamethasone sodium phosphate safe depends on detailed protocols. Handling involves gloves, face masks, and frequent hand washing to cut back on infection risk. Vials and ampoules need to be inspected for cracks or particles before use. Nurses and pharmacists double-check concentrations to avoid dosing errors, especially where decimal points decide between help and harm. Stock gets rotated to respect shelf-life limits and prevent using expired drugs. Storage away from heat and light ensures potency does not dip prematurely. Regulatory authorities—like the FDA or EMA—audit production sites, reviewing test results, documentation, and incident logs. During crisis moments, emergency use authorizations speed the drug into the field but require added vigilance, as happened during COVID surges.

Application Area: Beyond Just One Disease

Dexamethasone sodium phosphate finds its way into IV lines and syringes for a variety of reasons. In cancer wards, it relieves brain swelling from tumors. Emergency rooms rely on it when allergy-induced shock threatens lives. Asthma attacks, croup in kids, MS flare-ups, arthritis, and eye inflammation all fall within its reach. During the COVID-19 pandemic, it ended up saving lives by dampening the immune system’s runaway response. Its quick action and predictable effects also made it a backbone for pre-surgical antiemetic protocols. Physicians remain keenly aware of its immune dampening, making decisions with a risk/benefit mindset for each case. Hospital stockrooms keep it ready because sudden need remains a reality across medical fields.

Research & Development: Science Moves Forward

Drug innovation never stands still. Even after decades on the market, teams keep probing how dexamethasone sodium phosphate could work better or safer. Recent research looks for ways to reduce side effects like bone loss, high blood sugar, and mood swings. Trials explore new dosing outlines for chronic illnesses, or combine it with biologic agents to tame severe inflammation. Scientists in university labs try to tweak the molecule so it lingers at disease sites and not healthy tissues. Some research groups have published promising animal studies focusing on targeted delivery, hinting at a new era where steroids heal without collateral damage. The wealth of published papers attests to the continuing drive for improvement—building on the backbone of proven molecules with new chemistry and delivery science.

Toxicity Research: Protecting Patients

Dexamethasone sodium phosphate walks a fine line between relief and risk. Decades of clinical use allowed safety researchers to map out danger zones. High doses, even for short bursts, raise blood sugar and suppress immune function enough to leave patients open to infection. Long-term use thins bones, weakens muscles, and raises blood pressure. Pregnant women and children face special risks, since steroids can harm growth or unborn babies. Animal studies backed up these concerns, while early patient monitoring helped confirm safe dosing ranges. Toxicologists measure how long the drug sticks around after injection, track breakdown products, and watch for rare genetic reactions. Every new study adds to the picture, helping clinicians treat with confidence but also healthy respect for the risks.

Future Prospects: What Lies Ahead

Looking ahead, dexamethasone sodium phosphate seems poised to remain in the toolkit, but with smarter guardrails. Biotech companies invest in formulations that last longer or hit disease targets more precisely. Hospitals want dose calculators that slash human error, paired with bar-coded vials to trace every step from factory to bedside. Artificial intelligence now sifts through millions of patient records, flagging those at increased risk for steroid side effects so clinicians can adjust doses in real time. The relentless pressure of new diseases and antibiotic resistance keeps corticosteroids front-page news. As medical teams learn from pandemic playbooks and advance digital monitoring, the future holds promise for using this familiar steroid with greater wisdom and fewer side effects. The challenge isn’t just new chemistry, but smarter systems that keep the balance between fast relief and long-term safety.



What is Dexamethasone Sodium Phosphate used for?

What Makes This Medicine Matter in Real Life?

Dexamethasone sodium phosphate doesn’t turn heads in the pharmacy, yet it’s the kind of drug doctors count on during tough cases. Pulled from experience supporting loved ones through chemotherapy and seeing hospitals struggle during COVID-19 surges, this medication’s role goes far past lab numbers or package inserts. Raised in a family with chronic illness, I’ve watched relief wash over patients who finally felt a break in ongoing pain or swelling, and dexamethasone often played a part.

Combatting Inflammation and Allergic Reactions

People bring up steroids and often think of muscle-bound athletes, but dexamethasone sodium phosphate’s real value comes from fighting serious inflammation. It stands out in cases of severe asthma attacks, where quick action means someone breathes easier. Doctors also reach for it during severe allergic reactions that go beyond ordinary antihistamines. More times than I’d care to count, it showed up in emergency rooms and pediatric wards, standing between life and disaster, especially when allergies spiral out of control.

Essential Support Through Cancer Treatments

Cancer changes everything for a patient and those around them. Chemotherapy throws the immune system out of balance and nausea turns every meal into a challenge. Used as part of treatment plans, dexamethasone sodium phosphate helps cut back swelling near tumors and stops severe nausea in its tracks. Years back, sitting in waiting rooms as friends dealt with chemo, the difference before and after a dose was clear—less vomiting, a touch more energy, and a chance to feel human again, even if just for a day.

Key Player During COVID-19

Pandemics lay bare the limits of modern medicine. During the early days of COVID-19, researchers found this medication curbed deadly inflammation in some of the sickest patients. It wasn’t a miracle cure, but it trimmed down the worst symptoms and helped hospitals buy time. The weight of watching ventilators fill up brought fierce debates: supplies ran thin, and doses got rationed. Yet as studies published by respected groups like the WHO showed, deaths fell in patients needing extra oxygen. This practical outcome drove global health recommendations and prompted countries to stockpile the medicine.

Potential Downsides and Responsible Use

All medicines carry risks. Long-term use of dexamethasone can weaken bones, raise blood sugar, and peel away protections against infection. Abuse during minor illnesses doesn’t help, either. One fix lies in honest conversations: doctors need open lines of communication with their patients, so drug use stays smart and targeted. Growing up in a rural community, I watched elders fall through the cracks because clear follow-up care wasn’t an option. Investing in local clinics and ongoing patient education makes safe steroid use possible, even outside big cities.

Conclusion Isn’t Enough—Action Is Key

Dexamethasone sodium phosphate won trust because it brought relief when patients had few choices. This isn’t just chemistry or a bottle on the pharmacy shelf; it’s a lifeline. As long as care providers keep an eye on the risks, this tool will keep making life easier for those caught in medical storms. It deserves attention not as a miracle fix, but as a dependable helping hand where few exist.

What are the possible side effects of Dexamethasone Sodium Phosphate?

Understanding the Realities of Dexamethasone

Dexamethasone sodium phosphate helps doctors manage many health issues, including inflammation, allergies, and certain auto-immune conditions. In hospitals, patients might receive it through an IV or as an injection. At lower doses, it often controls symptoms without much trouble. At higher doses, or over long periods, it can throw the body’s normal balance off track.

What People Might Feel Right Away

Users sometimes talk about feeling jittery or restless after getting dexamethasone. Sleep can turn upside down — with people saying they can’t wind down at night. Anyone who’s ever missed a night’s sleep knows how rough that can feel. Stomach pain shows up now and then, along with heartburn or feeling queasy. The immune system may take a backseat, leading to a higher chance of picking up infections that would not bother most folks.

Doctors point out swelling in the hands, feet, or face as a common sign that the body’s holding extra water. This puffiness can make shoes feel tighter or leave people unhappy with how they look. Blood sugar sometimes climbs, even for people who never had diabetes. If that goes unnoticed, more serious problems can follow.

The Long Game: What Repeated Use Brings

Bones don’t fare so well under the long-term strain of dexamethasone. The drug saps bone mineral, making fractures more likely. The risk stands out for older adults or anyone who can’t move around much. Muscles can lose strength, and skin may thin out, showing bruises from even minor bumps.

Eye health matters, too. Dexamethasone can bump up eye pressure or cloud the lens, raising the odds of cataracts or glaucoma. High doses may tangle with mood and thinking — bringing on feelings of sadness, anxiety, or noticeable changes in behavior. Personal stories from patients talk about emotional swings that friends and family notice right away.

What the Evidence Shows

The United States Food and Drug Administration highlights these risks in public information sheets on dexamethasone. A recent review in The Lancet stresses the risk of severe infections and blood sugar spikes in hospital patients. The World Health Organization relates how these side effects force doctors to monitor patients closely, especially if the drug is helping someone fight off a tough illness.

Data suggest that about one in ten long-term users of corticosteroids like dexamethasone will experience bone loss or problems like steroid-induced diabetes. Most people taking short courses face only mild symptoms, but the risks climb when therapy drags on.

Managing the Risks

Doctors and nurses keep a close watch for early hints of these issues. Regular blood tests flag changes in sugar or salt. Bone scans help doctors catch early signs of osteoporosis. Talking about sleep, mood, or stomach troubles with providers ensures side effects don’t sneak up unnoticed.

Sometimes a lower dose or a shorter course can bring symptoms under control without making these side effects so likely. Teamwork between patient and provider lets problems get caught before they grow. People using dexamethasone should not skip doses or stop the drug too quickly, as the body gets used to the medicine and may need time to adjust.

How is Dexamethasone Sodium Phosphate administered?

Why This Steroid Stands Out in Medical Treatment

Dexamethasone sodium phosphate plays a role in medicine that anybody who’s ever spent time in the hospital recognizes. Doctors and nurses rely on it to calm intense swelling, quiet an overactive immune system, and help patients breathe easier during crises. I’ve sat across from patients’ families in the ICU, answering their worried questions. They wanted plain talk, not a string of medical jargon: Is the medicine helping? Can they give it at home? Are there risks? The way this drug gets into a patient’s system matters just as much as what it does once it gets there.

Routes of Administration: More Than Just a Shot

This steroid isn’t one of those things you pick up at the pharmacy to swallow with breakfast. Dexamethasone sodium phosphate usually arrives in a small vial—ready for a syringe, not a spoon. Doctors can inject it directly into a muscle or, for faster results, straight into a vein with an IV. Emergency rooms count on this speed during allergy attacks or severe asthma. Patients with swelling from brain tumors or spinal injuries get it by IV, too, since oral pills wouldn’t act fast enough.

In eye clinics, I’ve watched specialists use dexamethasone sodium phosphate to ease inflammation by injecting tiny amounts around the affected eye. Some ear, nose, and throat cases call for drops containing this medicine so that the anti-inflammatory effect zeroes in where it’s needed most. Hospital pharmacies also prepare solutions for use in nebulizers for people whose lungs need direct relief.

Necessity of Skilled Hands and Careful Monitoring

There’s a reason most people never give themselves this medicine at home. Not all injections are equal—missing the right muscle, vein, or tissue spot can mean less relief and more problems. Nurses check the dosage closely since steroids can do harm if the numbers run too high for too long. Blood sugar and blood pressure can rise. Wounds heal slower. Children might experience slowed growth. My own family has dealt with these side effects in the treatment of autoimmune disease, so the importance of oversight isn’t theoretical to me.

Seeking the Right Use in the Right Patients

Dexamethasone sodium phosphate means hope for patients in crisis, but its power requires responsibility. Researchers continue to publish long-term studies. COVID-19 cases brought the drug back into headlines, as doctors saw it help the sickest patients breathe easier. But they also discussed dosing, timing, and ways to cut the risk of infection or other problems. Guidelines from groups like the World Health Organization and the American College of Physicians shape how doctors use this steroid worldwide.

Addressing Challenges in Access and Training

Some patients across smaller towns or in resource-limited settings don’t get quick access to injectable forms or expert help. This creates gaps in care. Solutions show up in telemedicine, training programs for rural nurses, and measures to improve medication storage and tracking. Hospitals invest in ongoing staff education. High-quality, science-based information for both professionals and patients helps prevent errors, waste, and unnecessary harm.

Moving Forward with Open Conversation and Reliable Science

If you or a loved one faces a situation where dexamethasone sodium phosphate enters the picture, ask questions. Confirm who’s preparing and giving the injection, how they monitor for side effects, and what plans exist for follow-up. Science, not guesswork, makes the biggest difference here. By insisting on clear communication and basing care on real evidence, we help this drug reach its purpose—relief, control, and safety for people who need it most.

Are there any precautions or contraindications for using Dexamethasone Sodium Phosphate?

Looking at the Bigger Picture

Dexamethasone sodium phosphate gets attention in hospitals for a reason. This corticosteroid packs a punch against inflammation and overactive immune responses. People dealing with swelling from allergies, strong autoimmune reactions, or certain cancers often depend on it. Still, experience around hospital wards and clinics keeps teaching the same lesson: such a powerful drug can cause trouble in the hands of the unwary.

Who Should Not Use This Medication

Some people carry more risk with dexamethasone than others. Folks with serious fungal infections should avoid it entirely. This comes down to the way steroids like dexamethasone mop up immune reactions, giving infections a chance to flourish. Anyone with a known allergy to the drug or to other corticosteroids has to stay well away, too. Anaphylactic reactions, while rare, can pop up fast and require urgent care.

Underlying Conditions Raise Red Flags

Doctors ask about health history for good reasons. Individuals with peptic ulcers, osteoporosis, or psychiatric issues can see their symptoms get worse after starting dexamethasone. Blood sugar jumps up in people with diabetes. Eyes can get in trouble too—glaucoma patients may notice pressure spikes, while cataract-prone folks have to be extra mindful. People living with tuberculosis, herpes eye infections, or other lurking infections risk a flare-up since steroids suppress defenses the body relies on.

Everyday Interactions Add Risks

Daily routines often include over-the-counter medicines and supplements. Mixing nonsteroidal anti-inflammatory drugs, blood thinners, some vaccines, or antifungals with dexamethasone can spell problems. Even antibiotics sometimes clash. Simple grapefruits or licorice can join the list, changing how the liver processes the drug. Not mentioning these details to a healthcare provider invites avoidable trouble.

Serious Side Effects—Not Just the Obvious Ones

No one can ignore steroid side effects. Mood swings, trouble sleeping, and swelling around the face or belly crop up in clinic after clinic. Bone density drops, infections can slip by under the radar, and the body’s own hormone production starts shutting down. I’ve seen teenagers put on steroids for asthma gain weight quickly, then face real struggles with acne and self-image. Even adults can get thrown off by sudden shifts in energy, frequent bruising, or muscle weakness.

Mitigation and Safer Use

Physicians narrow down the dose, cut treatment time, and review all prescriptions each time steroids come into play. Tapering off the drug gives the adrenal glands a fighting chance to start back up. A team approach helps—pharmacists catch drug interactions and primary care doctors keep an eye out for bone thinning, rising blood sugars, or signs of infection. Patients benefit from direct, honest talk about risks, so they know to report headaches that don’t quit, vision blurring, or new fevers right away.

Learning Together

Corticosteroids like dexamethasone can turn a bad flare-up around, but the trade-offs never disappear. Open conversations and a clear plan between patient and healthcare team keep the balance—relief from illness without paying too high a price elsewhere. No one can afford shortcuts with drugs this strong, not in the real world where side effects touch daily life.

Can Dexamethasone Sodium Phosphate interact with other medications?

Mixing Medications Can Get Complicated

People rely on dexamethasone sodium phosphate to tame inflammation, especially during allergic reactions, asthma attacks, or for autoimmune conditions. This steroid helps a lot, but the catch is, it does not stand alone. Most real-life patients—myself included—don’t just take one drug. Someone with asthma might reach for inhalers, antibiotics, and even anxiety medication. It’s so easy for things to get tangled.

Real Risks Behind Forgotten Details

I’ve seen patients go to different doctors, each adding something new—a blood pressure pill, a diabetes medicine, maybe something for pain. The truth is, dexamethasone pushes liver enzymes into high gear, flooding your bloodstream with other drugs faster than usual. You get less effect from some meds that just get broken down and flushed away. On the other hand, it can slow down how your body clears certain blood thinners or antivirals, making them linger and leading to dangerous side effects.

Common Problem Areas

One big worry is with blood thinners like warfarin. Dexamethasone messes with how warfarin leaves your body. Even a tiny change in warfarin levels can mean too much bleeding or too little protection from clots. Diabetics see their blood sugar climb thanks to steroids, so diabetes pills or insulin often need adjustment. I remember seeing elders get rushed to the ER because their sugar spiked out of control after starting steroids. Not everybody expects stress hormones to run wild.

A friend with epilepsy once told me her seizures almost doubled after she got a steroid shot for her lungs. Turns out, dexamethasone actually lowers levels of some anti-seizure drugs. There’s science behind that—liver enzymes burn through them. Antifungals and certain antibiotics—think erythromycin or ketoconazole—have the opposite effect, making steroids hang around longer, which raises the risk for infections and even mood swings.

Tackling the Real Challenge: Communication

Too often, doctors don’t know every pill a person is taking. Sometimes, folks forget to update everyone. When I visit my own doctor, I bring a written list. That list keeps everyone on the same page and helps avoid surprises in the pharmacy aisle. Pharmacists stand as important allies here—they notice drug combinations slip through the cracks and can flag dangerous pairs on the spot.

Better Solutions in the Clinic and at Home

Smart medication management hinges on regular reviews. Doctors checking up on all prescriptions, over-the-counter remedies, and even herbal supplements can spot trouble early. Electronic health records, if kept up to date, help teams see the bigger picture. Patients need clear instructions on what symptoms mean trouble: severe headaches, changes in blood sugar, bruising, or confusion. If side effects kick in, fast calls to the prescriber can literally save lives.

The promise of a medicine like dexamethasone often rests on trust. That trust grows when everyone on the healthcare team works together, cross-checks medicines, and encourages patients to be open. As someone who has seen the downside of medication interactions, I tag every new prescription with questions—and I encourage others to speak up, too.

Dexamethasone Sodium Phosphate
Names
Preferred IUPAC name disodium (11β,16α)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate)
Other names Decadron Phosphate
Dexasone
Dexone
Hexadrol Phosphate
Maxidex
Dexamethasone Phosphate
Pronunciation /ˌdɛk.səˈmɛθ.əˌsoʊn ˈsoʊ.di.əm ˈfɒs.feɪt/
Preferred IUPAC name Disodium (11β,16α)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate)
Other names Decadron Phosphate
Dexasone
Hexadrol Phosphate
Dexona
Maxidex
Millicorten
Neodex
Dexone
Dexpak
Pronunciation /ˌdɛk.səˌmɛ.θəˌsoʊn ˌsoʊ.di.əm fəˈs.feɪt/
Identifiers
CAS Number 55203-24-2
Beilstein Reference 1070485
ChEBI CHEBI:3165
ChEMBL CHEMBL1200696
ChemSpider 83637
DrugBank DB01234
ECHA InfoCard 03e8e615-0611-4e23-aa1e-ccb13ee9c9ca
EC Number 215-540-4
Gmelin Reference 49924
KEGG D07862
MeSH Dexamethasone Sodium Phosphate
PubChem CID 441436
RTECS number QM9450000
UNII 7S5I7G3JQL
UN number UN2811
CompTox Dashboard (EPA) DTXSID8030083
CAS Number 2392-39-4
Beilstein Reference 14275374
ChEBI CHEBI:31344
ChEMBL CHEMBL1200693
ChemSpider 2157
DrugBank DB01234
ECHA InfoCard 03b6b8b3-8fd2-470a-9a4c-c634b976c09b
EC Number 262-967-7
Gmelin Reference 16236
KEGG D00836
MeSH Dexamethasone Sodium Phosphate"[MeSH]
PubChem CID 441436
RTECS number QS4550000
UNII 7S5I7G3JQL
UN number UN2811
CompTox Dashboard (EPA) DTXSID7044361
Properties
Chemical formula C22H28FNa2O8P
Molar mass 516.40 g/mol
Appearance A white or almost white, crystalline powder
Odor Odorless
Density 1.45 g/cm³
Solubility in water Freely soluble in water
log P -1.73
Acidity (pKa) 1.98
Basicity (pKb) 1.42
Magnetic susceptibility (χ) -67.5×10⁻⁶ cm³/mol
Refractive index (nD) 1.420
Viscosity Clear, colorless liquid
Dipole moment 13.2418 D
Chemical formula C22H28FNa2O8P
Molar mass 516.404 g/mol
Appearance White or almost white, crystalline powder
Odor Odorless
Density 2.13 g/cm³
Solubility in water Very soluble in water
log P -3.2
Acidity (pKa) 1.72
Basicity (pKb) 1.32
Magnetic susceptibility (χ) -74.0e-6 cm³/mol
Refractive index (nD) 1.427
Viscosity Viscous liquid
Dipole moment 5.82 D
Thermochemistry
Std molar entropy (S⦵298) 319.5 J·mol⁻¹·K⁻¹
Std molar entropy (S⦵298) 334.6 J·mol⁻¹·K⁻¹
Pharmacology
ATC code H02AB02
ATC code H02AB02
Hazards
Main hazards May cause allergic skin reaction; causes serious eye irritation.
GHS labelling GHS05, GHS07, Danger, Causes serious eye damage, Causes skin irritation, May cause respiratory irritation
Pictograms Rx, Rx only, ℞
Signal word Warning
Hazard statements H302, H319
Precautionary statements Use personal protective equipment as required. If medical advice is needed, have product container or label at hand. Keep out of reach of children. Read label before use.
Lethal dose or concentration LD50 (intravenous, rat): 94 mg/kg
LD50 (median dose) LD50 (median dose): Mouse intravenous LD50 = 794 mg/kg
NIOSH WN3625000
PEL (Permissible) PEL (Permissible Exposure Limit) for Dexamethasone Sodium Phosphate: Not established.
REL (Recommended) 0.8 mg/kg daily
IDLH (Immediate danger) Not established
Main hazards May cause allergic skin reaction; causes serious eye irritation.
GHS labelling GHS07, GHS08
Pictograms GHS07,GHS08
Signal word Warning
Hazard statements Hazard statements: Causes serious eye irritation. May cause respiratory irritation.
Precautionary statements Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Avoid contact with eyes. For external use only unless otherwise directed by physician. Use only as directed by your doctor.
Autoignition temperature > 370°C (698°F)
Lethal dose or concentration LD₅₀ (mouse, intravenous): 794 mg/kg
LD50 (median dose) Mouse (IV) LD50: 794 mg/kg
NIOSH NT8050000
PEL (Permissible) Not established
REL (Recommended) 0.1%
Related compounds
Related compounds Betamethasone
Hydrocortisone
Prednisolone
Methylprednisolone
Triamcinolone
Fludrocortisone
Related compounds Dexamethasone
Betamethasone Sodium Phosphate
Prednisolone Sodium Phosphate
Hydrocortisone Sodium Phosphate
Dexamethasone Acetate
Dexamethasone Phosphate
Dexamethasone Disodium Phosphate
Dexamethasone Sodium Sulfate