Product Name: Dexamethasone Sodium Phosphate
Chemical Family: Glucocorticoid
Synonyms: Dexamethasone disodium phosphate; Phosphate dexamethasone sodium salt
CAS Number: 2392-39-4
Intended Use: Pharmaceutical corticosteroid for anti-inflammatory and immunosuppressive treatments
Manufacturer: Listed on product packaging or by supplier
Emergency Contact: Refer to local poison control center or national health authority
GHS Classification: Not classified as hazardous under GHS for typical pharmaceutical use
Label Pictograms: No pictograms required for normal handling
Signal Word: None required
Health Hazards: Possible allergic reactions, endocrine disruption with repeated exposure, immunosuppression, risk of adverse effects with accidental ingestion or overexposure
Precautionary Statements: Avoid eye and skin contact. Refrain from inhalation of dust. Employ suitable control measures.
Emergency Overview: Non-flammable, may cause irritation, accidental ingestion or injection increases health risks
Chemical Identity: Dexamethasone Sodium Phosphate
Concentration: Pure substance typically formulated up to 100% in pharmaceutical-grade materials
Impurities and Stabilizers: None of toxicological significance listed
Molecular Formula: C22H28FNa2O8P
Molecular Weight: 516.4 g/mol
Eye Contact: Rinse cautiously with plenty of water for at least 15 minutes, remove contact lenses if present and easy to do, seek medical attention if irritation persists
Skin Contact: Remove contaminated clothing, wash the affected area with mild soap and water, seek medical advice if symptoms develop
Inhalation: Move person to fresh air, loosen tight clothing, monitor for respiratory distress, obtain medical help for persistent symptoms
Ingestion: Rinse mouth thoroughly with water, do not induce vomiting, call poison control or physician for guidance
Note for Physicians: Treat symptomatically, monitor electrolyte balance and adrenal function
Most Important Symptoms/Effects: Irritation, allergic reactions, potential adrenal suppression with significant exposure
Suitable Extinguishing Media: Water spray, foam, dry powder, carbon dioxide
Unsuitable Media: High pressure water jet may spread product
Special Hazards from Fire: Emits toxic fumes including carbon oxides, phosphorus oxides, sodium oxide, and hydrogen fluoride
Protective Equipment for Firefighters: Use self-contained breathing apparatus and full protective gear
Evacuation Procedures: Remove personnel from immediate area if possible, prevent exposure to smoke and combustion gases
Personal Precautions: Wear gloves, safety goggles, and laboratory coat to avoid contact
Spill Handling: Avoid formation of dust, ventilate area, use HEPA-filtered vacuum or wet methods for cleanup
Environmental Precautions: Prevent entry into drains, surface or groundwater; use absorbent material for large spills
Cleanup Methods: Collect spilled product into sealable containers for disposal as hazardous pharmaceutical waste
Decontamination: Wash surface with suitable cleaning agent and water after removal
Precautions for Safe Handling: Handle in well-ventilated spaces, employ engineering controls if significant powder is used, keep containers tightly closed
Hygiene Measures: Wash hands before eating, smoking, or using restroom; do not handle with food or beverages nearby
Storage Conditions: Store at a controlled room temperature, protect from excessive heat, moisture, and light
Compatibility: Keep away from strong oxidizers, acids, and bases
Special Packaging: Use pharmaceutical-grade containers labeled with product details and hazard precautions
Occupational Exposure Limits: No legally established limits; minimize inhalation and skin contact due to pharmacological effects
Engineering Controls: Local exhaust ventilation or fume hood for large-scale or repeated handling processes
Personal Protective Equipment: Laboratory gloves, safety glasses or goggles, laboratory coat or gown
Respiratory Protection: Dust respirator when handling powder in bulk or cleaning spills
Environmental Exposure Controls: Prevent accidental releases from entering environment, follow standard pharmaceutical waste protocols
Appearance: White to off-white crystalline powder
Odor: Odorless
pH (1% Solution): Approximately 7.0—9.0
Melting Point: Decomposes above 230°C
Solubility: Freely soluble in water, practically insoluble in alcohol
Partition Coefficient (log Pow): Not readily available
Vapor Pressure: Not significant
Flash Point: Not flammable
Relative Density: Not specified, generally less than 2 g/cm³ for organic solids
Chemical Stability: Stable under recommended storage conditions
Reactivity: No dangerous reactions under normal conditions of use
Compatible Materials: Avoid contact with strong acids, strong oxidizers
Hazardous Decomposition Products: May produce toxic oxides of carbon, phosphorus, sodium, fluorine
Polymerization: No hazardous polymerization expected
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: LD50 (oral, rat) greater than 3000 mg/kg; low acute toxicity in small doses
Chronic Effects: Suppression of hypothalamic-pituitary-adrenal function, osteoporosis, increased infection risk with repeated exposure
Sensitization: Allergic skin reactions possible
Carcinogenicity: Not classified as carcinogenic by IARC or NTP
Mutagenicity: No evidence from available data
Reproductive Toxicity: Embryotoxic and teratogenic effects reported at high doses in animal studies
Symptoms: Irritation, headache, adrenal suppression, immune effects with chronic exposure
Aquatic Toxicity: Harmful to aquatic organisms in high quantities
Persistence and Degradability: Slowly biodegradable in the environment, potential for bioaccumulation is low
Mobility in Soil: May be mobile in aqueous solution; risk of groundwater contamination with improper disposal
Other Adverse Effects: Interferes with endocrine function in wildlife in significant concentrations
Precautionary Measures: Avoid release to the environment; treat as hazardous pharmaceutical waste
Waste Treatment Methods: Dispose of unused or contaminated product as hazardous pharmaceutical waste according to local, state, and federal regulations
Recommended Disposal: Incineration in controlled facility; do not dispose of via drains or regular trash
Contaminated Packaging: Treat emptied containers as hazardous, recycle according to regulations if permitted
Precautions: Keep incompatible waste streams separate, label clearly, minimize risk of exposure for all handlers
UN Number: Not regulated for transport under current international regulations for finished pharmaceutical products
Proper Shipping Name: Not dangerous for transport
Hazard Class: None
Packing Group: None
Special Precautions: Protect from moisture, extreme heat, and mechanical damage during shipping
Environmental Hazards: Check bulk shipments or spills for additional national or regional requirements
International Inventories: Listed on national drug databases where regulated for pharmaceutical use
OSHA Status: Not classified as hazardous under US OSHA Hazard Communication Standard for pharmaceutical finished products
TSCA: Exempt as a pharmaceutical finished product
WHMIS (Canada): Not controlled for routine handling in final pharmaceutical dosage
EU Regulation: Not classified as hazardous under European CLP Regulation for pharmaceutical use
Safety Assessment: Usage requires regulated medical oversight; available only by prescription in most jurisdictions
Other Requirements: Strict adherence to pharmaceutical waste handling and worker safety protocols for all operations involving bulk material
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