Corticosteroids have shaped dermatologic therapy since the middle of the twentieth century. Diflorasone, a synthetic fluorinated corticosteroid, emerged from efforts to deliver stronger anti-inflammatory effects with fewer side effects than older steroid creams. Drug chemists in the 1970s pushed to refine topical corticosteroids, tweaking both side chain and core modifications on the steroid skeleton. Diflorasone diacetate, the most widely prescribed ester variant, entered clinical practice in the 1980s after early research showed strong local anti-inflammatory properties. Its development followed a trend in dermatology: fluorination, acetylation, and esterification all used to heighten activity and reduce systemic absorption. Dermatologists demanded slimmer risks of skin thinning but still needed real power against stubborn eczema and plaque psoriasis. Generics arrived as patents expired, but the molecular structure stayed constant, speaking to the molecule’s lasting value.
Pharmaceutical shelves rarely display diflorasone products as over-the-counter creams. Its status as a high-potency corticosteroid means you’ll find it behind the prescription counter, in ointment, cream, and lotion forms. A dermatologist covers a range of stubborn inflammatory skin diseases with diflorasone: plaque psoriasis, chronic eczema, discoid lupus, and lichen planus that haven’t yielded to weaker options. Most drug labels assign diflorasone to “Class I or II” for topical steroids, matching clobetasol and betamethasone in strength. Some products use diflorasone diacetate as the active, blended with highly refined bases to spread smoothly and absorb well. Tubes usually contain 0.05% diflorasone diacetate, striking a balance between safety and aggressive action. Patients notice the texture—creams for oozing or moist rashes, ointments for tough, dry plaques—and doctors keep treatment courses short to dodge chronic side effects.
Diflorasone carries two fluorine atoms on its steroid backbone, boosting both stability and potency. As a white to off-white crystalline powder, it resists breaking down at room temperature but dissolves in alcohols and acetone better than water. Its chemical formula, C26H32F2O7, gives a hefty molecular weight near 494 g/mol, owing much to the two fluorines and assorted acetoxy groups. This lipophilic character allows it to slip into skin layers quickly, but it stays mostly local, which means systemic side effects appear less often when used as directed. Pharmaceutical manufacturers keep strict tabs on purity, using chromatography to nail down trace impurities below regulatory thresholds.
Regulatory agencies provide tight guidelines around topical corticosteroid packaging and use instructions. Pharmacy tubes and cartons label diflorasone diacetate by its concentration (typically 0.05%), along with batch numbers and expiry dates. Insert leaflets state storage below 25°C and stress short-term use in cycles. Instructions push patients to apply a thin film, once or twice daily depending on severity, and warn strongly against application to large surfaces or broken skin. Labels run through a roll call of possible side effects—thinning skin, stretch marks, easy bruising—especially near the face or in children. The FDA and other national agencies require manufacturers to include contraindications, ranging from viral skin infections to rosacea and perioral dermatitis. Child-proof closures show up even on small tubes to prevent accidental misuse.
The synthetic pathway to diflorasone diacetate starts from a corticoid core: usually prednisolone or hydrocortisone. Chemical engineers introduce fluorine at the 6α and 9α positions with selective fluorination, driving up glucocorticoid activity. Next, acetic anhydride brings about diacetylation at the 17 and 21 positions, increasing lipid solubility. The semi-synthetic process demands careful purification by crystallization and column chromatography since trace byproducts could affect both purity and safety. Scale-up in pharmaceutical environments uses automated batch reactors, inert gas atmospheres, and high-grade solvents to keep to good manufacturing practices.
Chemists look at corticosteroids and see dozens of places for molecular tinkering. For diflorasone, two main modifications provide its signature profile: fluorination and diacetylation. The 6α,9α-difluoro substitutions drive both anti-inflammatory punch and cut down on salt-retaining side activity. The esterification at the 17 and 21 positions increases skin penetration, while later hydrolysis inside skin cells reverts diflorasone to its active form. Research into analogues keeps targeting tweaks that boost local activity, blunt side effects, or limit breakdown by skin enzymes. Most other routes leave the rigid steroid structure intact, since changes at key rings often destroy glucocorticoid action.
Thanks to international approvals, diflorasone appears under several names, both generic and proprietary. The most common form, diflorasone diacetate, shows up as Psorcon in North America, and some local brands outside the US have unique branding. Pharmacopoeias recognize the same molecular entity under all these names, keeping doctors and pharmacists on the same page in global supply chains. Synonyms include 6α,9α-difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17,21-diacetate, but the mouthful rarely leaves chemistry books. On pharmacy shelves, packaging flags it as a “high potency topical corticosteroid.”
Hospital and retail pharmacy teams keep close management over products like diflorasone. Only trained staff dispense the medicine, since misuse causes a swath of chronic skin issues ranging from atrophy to pigmentation changes. Staff remind patients to avoid use on large body areas or beneath occlusive dressings, which can drive up absorption and side effects. Protocols call for scheduled drug inventory checks, temperature-monitored storage, and compliance with pharmacy licensing bodies. Disposal of expired material follows hazardous waste rules due to environmental and safety concerns with halogenated steroids. Medical guidelines recommend the shortest effective course—driven by good evidence that even strong steroids, when used correctly, don’t drive widespread harm—and providers check up on patients soon after starting a script.
Most patients learn about diflorasone during a seasonal eczema flare or a stubborn patch of psoriasis. Dermatologists turn to it only when medium- or low-potency creams haven’t worked, and only for small, thickened, or inflamed areas. Eye-area rashes, diaper dermatitis, and infective skin processes steer providers away from diflorasone’s high strength, in favor of milder options. Clinicians have even used diflorasone on lichen simplex or prurigo nodularis with impressive results, though these cases need monitoring. Online forums and patient support groups push strong advice on carefully following prescriber directions—stories abound of those who overuse high-potency steroids and deal with complications years later.
Drug development teams continue to probe new corticosteroid formulations that beat out older drugs for localized activity and less risk of atrophy or systemic absorption. Current research examines different vehicles (foams, gels, emulsions) that may boost skin tolerability or improve spread over awkward areas. Studies test diflorasone for off-label skin problems, but few trials move far past established chronic inflammatory dermatoses. Chemists aim to create prodrugs that remain inert in the bloodstream but become active only in diseased skin, though commercialized examples remain rare. Pharmaceutical scientists rely on clinical trials, patient diaries, and high-powered imaging to check for minute improvements that might justify a new generation of diflorasone-based creams.
Studies in laboratory animals and humans point to a familiar corticosteroid safety profile: suppression of local immune responses, skin thinning, and slowed wound healing all crop up with prolonged use, especially under occlusion or with inappropriate dosing. A surge in superinfections—fungal, bacterial, or viral—has cropped up in cases using diflorasone without a doctor’s supervision. Systemic toxicity rarely appears except with massive overuse, but blood tests sometimes pick up low cortisol or signs of hypothalamic-pituitary-adrenal suppression. Toxicity trackers rely on post-marketing pharmacovigilance, collecting patient reports on local and systemic reactions. Research in developing skin models provides a testbed for next-generation steroids that might dodge today’s risk profile.
The coming years sit poised for further advances in topical steroid science. Diflorasone and its analogues may lead to longer-lasting creams, new delivery patches, or sprays that stick only to targeted skin types. There’s work underway to map precisely how children, older adults, and those with complicated skin conditions process the drug—knowledge that could help doctors trim unnecessary risks. Artificial intelligence and machine learning drive hopes for highly personalized steroid regimens, matching molecular data to patient responses. The steroid backbone may stay, but side group modifications, smarter carriers, and improved regulatory frameworks could shape the use of diflorasone cream for another generation.
Living with relentless itching or irritated skin can turn daily routines into a test of patience. Skin conditions like eczema and psoriasis don’t just look uncomfortable—they feel that way, too. Flare-ups leave people searching for real relief, and that's where diflorasone finds a place in many medicine cabinets. This prescription-strength corticosteroid steps in as a strong option for easing inflammation, quieting redness, and dialing down that burning urge to scratch.
I’ve heard folks ask whether all steroid creams do the same thing—why pick one over the other? The truth is, potency varies tremendously. Diflorasone falls into the high-potency category. Doctors don’t hand it out for bug bites or the odd case of dry skin. Instead, they reach for it when less powerful creams haven’t cut it, or when the skin’s reaction has crossed from a minor nuisance to a real roadblock in someone’s life.
The science backs it up. Diflorasone tampers down the body’s immune response in the skin. That stops cells from sending out those signals that create swelling, heat, and itching. For folks dealing with plaque psoriasis, which turns elbows or knees downright scaly and inflamed, or with stubborn patches of eczema, diflorasone becomes a lifeline. It relieves symptoms so everyday activities don’t feel like running a gauntlet.
Potent remedies sound fantastic until side effects enter the equation. People using this steroid for weeks on end can wind up with thinning skin, stretch marks, or even suppression of the body’s own hormones. My own family member landed in a spot where overdoing a steroid cream made regular cuts and scrapes heal slowly and left the skin fragile. The problem isn’t just overusing; not following the “use only as directed” rule can stack up long-term problems.
Experts, including dermatologists and the FDA, stress the point for a reason. Young children, for example, have a higher risk because their bodies soak up more of the medicine per pound. This is why proper guidance and check-ins with a doctor come with every tube.
Knowledge makes the difference. If you face a prescription, you shouldn’t treat it like a regular moisturizer. Doctors recommend applying only to affected spots and only for as long as necessary. Covering treated skin with airtight dressings without permission can cause problems. Mixing up which steroid cream goes where leads to confusion. Pharmacists play a role here, offering extra clarity during the pick-up so patients don’t unknowingly take risks.
One approach that’s gaining ground involves using these strong steroids for short “bursts” to knock down a flare, then switching to milder options or non-steroid creams to maintain control. This strategy, sometimes called steroid-sparing therapy, helps protect against side effects while delivering the serious punch needed up front. People with ongoing skin issues also benefit from tackling triggers—things like harsh soaps, allergens, or even stress—instead of leaning too much on creams alone.
Diflorasone serves a real purpose for those who feel like their skin is working against them. Proper use brings needed relief, but it’s not a cure-all. Staying in touch with a healthcare provider, asking questions, and keeping prescriptions up-to-date makes the most of what diflorasone offers, without letting the solution spill over into new trouble.
Diflorasone lands on pharmacy shelves as a strong corticosteroid, a medicine doctors reach for when the skin flares up with stubborn eczema, rash, or psoriasis. Many folks head into a prescription with nothing but a confused look at the tiny white tube. I remember feeling lost myself and wondering how to handle my own patch of stubborn rash, unsure if more cream really meant better relief.
A fingertip of diflorasone covers more ground than you think. Dermatologists stick to the “fingertip unit” rule – imagine squeezing out a line of cream from the tip of your finger to the first joint. That much will handle about two adult hands’ worth of skin. Piling on too much just invites trouble, like thinning skin, strange stretch marks, and, in rare cases, issues with internal organs when the medicine soaks in too deep.
Wash your hands: Clean hands before you touch your skin or the tube. Any leftover germs or dirt can make things worse.Start with clean, dry skin: Wipe away any sweat or soap. The medicine ought to meet just your skin, not old lotion or bacteria lurking about.Dot, then smooth: I learned to dab tiny spots over the rash or patch, then gently smooth them in the direction hair grows. Rubbing too hard might irritate or break the skin.Keep it light: A thin layer handles the job. Slathering on a thick blob doesn’t heal any faster and court more side effects.Skip the healthy skin: Focus diflorasone on the rash or itchy patches. The healthy skin on your arms or legs won’t benefit—just opens the door to dryness.Wash up after: Rinse off any leftover cream from your hands right away, unless your hands are the part you’re treating.
Using diflorasone too often has risks. The Food and Drug Administration warns that overuse—especially over large areas or on sensitive skin—can thin out the top layers, bruise more easily, or even cause strange hormonal issues if the body’s system picks up too much steroid. I’ve seen friends wrestle with skin that got weaker, more prone to paper cuts, after treating whole arms every day. This made them wish they used less right from the start.
The more you talk to a good dermatologist, the better your results. They stress short bursts—days or a week or two—then backing off as soon as the skin calms down. Don’t put diflorasone under tight wraps or bandages unless a doctor says so. Covering up skin can drive the medicine deep, and that’s where the trouble starts.
Keep the medicine out of reach of children. If kids need it, pediatricians usually recommend weaker steroids and less time using them. People who face repeated flare-ups find it helps to jot down when they use the cream and how the skin changes. This small practice makes it easier at follow-up appointments, where the doctor can fine-tune a plan that fits real-life bumps and down days.
Every strong steroid works best as part of a bigger health plan. Dermatologists push moisturizers, gentle soap, and sun protection. Planning around triggers like stress or harsh soaps can spare future flares and keep you from needing so much steroid cream in the first place.
Controlling my skin flare-ups often means weighing the good against the bad with every tube or cream. Diflorasone, a pretty strong topical steroid, promises relief from red, scaly patches that drive people nuts. Still, like most things in medicine, relief rarely comes free. No cream that packs a punch escapes trade-offs. Dermatologists speak plainly: even though the tube says “for skin only,” the whole body pays attention.
This steroid shrinks inflammation. In my experience, it also brings a host of side effects under that calm surface. Skin thins faster than expected, especially if used beyond a couple of weeks. Sometimes, even the veins underneath start to show up, blue and snake-like. Bruising gets easier, so just brushing against a table can leave marks. The area around treated patches loses pigment sometimes, creating pale spots that stick around for months. Maybe worse, hair grows more in some places, leading to uncomfortable stares or questions nobody wants to answer.
I’ve seen older relatives struggle with fine lines around their eyes from softer steroids, let alone something as strong as diflorasone. Stretch marks pop up on arms or legs just from a few rounds of strong steroid cream. That’s not just talk at the pharmacy counter—these marks don’t shrink away once they show up.
Doctors warn about big problems when steroids get absorbed into the body. Diflorasone is no different. When people put it over large patches, the chances of absorption jump. Suddenly, a topical medication turns into a full-body issue. Kids, especially little ones, can end up with big hormone changes. Growth slows, mood changes, and older adults notice muscle weakness. There are stories about folks whose blood sugar goes up, or who start to look puffy in the cheeks from fluid retention.
Even immune responses can take a hit. I caught more colds one year after months of using strong steroids. My doctor pointed out that steroids knock down the natural skin barriers, letting all sorts of bacteria in. That means more skin infections and slower healing after scratches or cuts. Fungal infections, which used to be rare for me, became a usual suspect during my flare-ups.
Pregnant or breastfeeding folks have special concerns. Since diflorasone can slip into the system, nobody wants even a trace of it affecting developing babies. Patients with diabetes already fight with blood sugar, so adding another variable feels risky to a lot of families. The strongest advice I ever got was to talk straight with my healthcare provider about every medication, especially the ones that can change more than just my skin.
Limiting the area and duration turns out to be the most straightforward move. My doctor insists on short bursts instead of daily, year-round use. Moisturizing the skin before and after treatment also gives an extra buffer. For most folks, spreading a little less on each spot helps avoid thinning and pale patches. Using the lowest strength steroid that still works makes a real difference. If a tube stays in the cabinet for more than a month, it’s time to ask if another plan makes more sense. Routine skin checks and honest conversations with doctors are keys that keep small problems from turning into big ones.
At the end of the day, diflorasone works in some of the toughest skin battles, but nobody wins if the solution creates its own string of new problems. Every tube comes with a conversation worth having—one that weighs comfort, safety, and skin that stands a chance at lasting health.
Diflorasone, a potent topical corticosteroid, steps in when the skin throws a fit. Doctors reach for it in the face of stubborn eczema, psoriasis, and a handful of other inflammatory skin conditions. The relief comes fast, but it also brings strong medicine right to the surface. This punch of potency draws questions, especially from parents and folks suffering from facial rashes.
Facial skin puts up less of a fight than other parts of the body. It’s thinner and much more likely to throw a tantrum from strong steroids. Diflorasone can drag sledgehammers when a gentle tap is needed. If you swipe it across cheeks or forehead, there’s a real shot it will leave behind streaks of skin thinning, pimples, and sometimes even tiny blood vessels that don’t vanish.
Doctors, especially those with years in dermatology, wave the red flag before writing for diflorasone on the face. The American Academy of Dermatology points to safer, lower-potency options for routine use on sensitive areas. They’ve seen what happens: folks end up with more problems than they started, trading itch for permanent changes in how their skin looks and feels.
Young skin acts like a sponge. Kids soak up medications more easily, pulling more steroid into their system through skin than adults ever could. High-potency drugs in small bodies raise the odds of real problems—things like slowed growth, adrenal issues, and long-term skin changes no parent wants for their child.
The FDA stamped a warning across potent steroids like diflorasone, telling practitioners and pharmacists to steer clear for kids, unless a specialist insists and keeps a close watch. These warnings didn’t appear overnight; they came after years of reports showing too many young patients ran into trouble. The National Eczema Association gives broad advice to start as gentle as possible, use the least amount for the shortest time, and always check with a pediatric dermatologist before thinking about prescription steroids in kids.
Milder creams can often calm down rashes—hydrocortisone at the drugstore, or lower-potency prescription steroids, help more than hurt when used smartly. Skin on the face and children’s bodies bounce back better with these options. Sitting down with a board-certified dermatologist beats internet guesswork every time, especially with delicate patches or young patients.
Reading about medication is step one. Coming across warnings and scary stories shows you care, but those with formal training carry knowledge you just can’t get from package inserts or forums. Specialists look out for the early signs that side effects are knocking, and they adjust treatments before small issues snowball.
People who treat their families’ skin ailments, or worry about their own faces, do well to keep diflorasone off their list unless their doctor says otherwise. Risk stays lower with milder medicine, close monitoring, and sticking to short courses. Long term, we want skin healthy enough not to need rescue, and kids reaching adulthood without baggage from the treatments meant to help.
Regulations and medical advice evolve because faces and small hands deserve as little risk as possible. Medical experience, patient caution, and a focus on wellness—not just quick fixes—point the way forward.
Diflorasone is a topical corticosteroid many people look for when their skin flares up — rashes, eczema patches, or stubborn itch. Before anyone walks up to the drugstore expecting to grab it off a shelf, they’ll need to know that diflorasone sits behind the counter for a reason: in the United States, this is a prescription-only medication.
Diflorasone isn’t some light lotion. It’s a high-potency steroid. That puts it in the same strong category as clobetasol or halobetasol. There’s no over-the-counter corticosteroid in the country that matches this strength. Regulatory bodies like the Food and Drug Administration set this policy because strong steroids can create big problems if used wrong — thinning skin, worsening infections, or causing body-wide side effects.
Anyone who’s battled rashes knows the desperation to feel relief. I remember dealing with stubborn eczema as a teen, reaching for anything in the house to take the edge off. Even for milder steroids like hydrocortisone, doctors warn against overuse. If I’d had direct access to something as strong as diflorasone, I might have spread it on every patch, unknowingly risking complications. Prescription-only access makes sure a qualified professional assesses the risk, explains safe application, and checks for proper duration.
Facts back up the caution: misuse of potent topical corticosteroids can lead to side effects like skin atrophy, stretch marks, or even hormonal disruption with prolonged use. Children face bigger risks because their skin absorbs more medication. Without a check-in with a healthcare provider, people might apply diflorasone in ways that blur its benefits into harm.
A 2020 review in the Journal of the American Academy of Dermatology emphasized a growing trend of steroid overuse driving problems like topical steroid addiction and withdrawal. Countries struggling with over-the-counter steroid creams have seen increased cases of damaged, fragile skin and other severe adverse effects. Prescription policies aren’t just bureaucracy — they come from real evidence.
For someone who really needs diflorasone, the route is straightforward: meet with a dermatologist or primary care physician. These appointments allow a professional to decide on the right treatment, checking for hidden infections or other conditions masquerading as something simple. A doctor can also lay out a plan: how much to apply, which areas to avoid, and for how long. Following this advice builds trust in treatment and limits the risk of long-term issues.
Access to care is another story. Not everyone can easily book a visit, and the cost of appointments and prescriptions keeps some people from getting help. Telemedicine offers a bit of relief, giving remote consultations for those who live in medical deserts or have tight schedules. Advocacy for expanded insurance coverage and lower drug prices could help more people safely obtain medications like diflorasone when truly needed.
Anyone who has struggled with eczema, psoriasis, or other persistent skin problems knows the toll these conditions can take. It’s not just the itching or discomfort — it’s the stigma and self-consciousness that follow. While powerful medications can make a world of difference, their use belongs under medical oversight, not self-navigation. Some think of prescription-only status as a barrier, but often it’s the protection that keeps more harm from happening. Tough as it may be to wait for an appointment, having that expert guide can be the best tool for healthier skin in the long run.
| Names | |
| Preferred IUPAC name | S-((6α,11β,16α)-6,9-difluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione-16-yl) acetate |
| Other names |
Difluorasone
Difluorasona Diflorasona |
| Pronunciation | /daɪˈflɔːrəˌsoʊn/ |
| Preferred IUPAC name | S-fluoro(6S,8S,9R,10S,11S,13S,14S,16R,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-6,10,13,16-tetramethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-17-carbothioate |
| Other names |
Diflorasone diacetate
Difluoroprednate Florone |
| Pronunciation | /daɪˈflɔːrəˌsoʊn/ |
| Identifiers | |
| CAS Number | 2557-49-5 |
| Beilstein Reference | 1501696 |
| ChEBI | CHEBI:31698 |
| ChEMBL | CHEMBL1200309 |
| ChemSpider | 4547 |
| DrugBank | DB00223 |
| ECHA InfoCard | 1007003 |
| EC Number | EC 246-357-3 |
| Gmelin Reference | 88339 |
| KEGG | D01238 |
| MeSH | D004071 |
| PubChem CID | 32045 |
| RTECS number | DT1750000 |
| UNII | 7V8A09UFJF |
| UN number | UN2811 |
| CAS Number | 1175-19-5 |
| 3D model (JSmol) | `/legacy/jmol/jmol.php?model=CC1(C2CCC(C1(C3=CC(=O)C=C(C3F)F)C(=O)COC(=O)C)C(F)(F)F)O2` |
| Beilstein Reference | 2082539 |
| ChEBI | CHEBI:31463 |
| ChEMBL | CHEMBL1535 |
| ChemSpider | 11906 |
| DrugBank | DB00223 |
| ECHA InfoCard | 1000040 |
| EC Number | EC 244-839-7 |
| Gmelin Reference | 24211 |
| KEGG | D07821 |
| MeSH | D004049 |
| PubChem CID | 3033869 |
| RTECS number | DJ3480000 |
| UNII | NQX6R1KE6E |
| UN number | UNII:VIF8YP18R7 |
| CompTox Dashboard (EPA) | DTXSID2021635 |
| Properties | |
| Chemical formula | C22H28F2O6 |
| Molar mass | 452.522 g/mol |
| Appearance | White to off-white cream |
| Odor | Odorless |
| Density | 1.1 g/cm³ |
| Solubility in water | Practically insoluble in water |
| log P | 2.8 |
| Vapor pressure | 9.5E-12 mmHg |
| Acidity (pKa) | 12.49 |
| Basicity (pKb) | 1.98 |
| Magnetic susceptibility (χ) | -79.1·10^-6 cm^3/mol |
| Refractive index (nD) | 1.654 |
| Dipole moment | 3.34 D |
| Chemical formula | C22H28F2O6 |
| Molar mass | 532.576 g/mol |
| Appearance | White to off-white crystalline powder |
| Odor | Odorless |
| Density | 1.1 g/cm³ |
| Solubility in water | Practically insoluble in water |
| log P | 3.74 |
| Vapor pressure | 7.97E-14 mmHg |
| Acidity (pKa) | 12.53 |
| Basicity (pKb) | 2.82 |
| Magnetic susceptibility (χ) | -85.6·10^-6 cm³/mol |
| Refractive index (nD) | 1.677 |
| Dipole moment | 3.1771 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | Std molar entropy (S⦵298) of Diflorasone is 683 J·mol⁻¹·K⁻¹ |
| Std enthalpy of combustion (ΔcH⦵298) | -6770 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -6491 kJ/mol |
| Pharmacology | |
| ATC code | D07AC06 |
| ATC code | D07AC05 |
| Hazards | |
| Main hazards | May cause skin irritation, allergic reactions, and systemic absorption leading to adrenal suppression with prolonged use. |
| GHS labelling | GHS labelling of Diflorasone: "No known GHS classification. |
| Pictograms | 💊💠🧴 |
| Signal word | Danger |
| Hazard statements | H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation. |
| Precautionary statements | Keep out of reach of children. For external use only. Avoid contact with eyes. If irritation develops, discontinue use and consult a physician. Do not use on broken or infected skin without medical supervision. |
| NFPA 704 (fire diamond) | 1-3-0 |
| Flash point | Flash point: 94.6°C |
| Lethal dose or concentration | LD50 (rat, dermal) >3,000 mg/kg |
| LD50 (median dose) | LD50 (median dose): >3,000 mg/kg (rat, oral) |
| PEL (Permissible) | PEL (Permissible) for Diflorasone: Not established |
| REL (Recommended) | 0.05% |
| IDLH (Immediate danger) | Not listed |
| Main hazards | May cause skin irritation, allergic reactions, and systemic absorption leading to adrenal suppression with prolonged use. |
| Pictograms | 💊🧴🔵👨⚕️ |
| Signal word | Warning |
| Hazard statements | No hazard statements. |
| Precautionary statements | Keep out of reach of children. For external use only. Avoid contact with eyes. If irritation develops, discontinue use and consult a physician. Do not use on broken or infected skin. Use only as directed by your healthcare provider. |
| Flash point | > 327.2°C |
| Lethal dose or concentration | LD50 (rat, oral): >3000 mg/kg |
| LD50 (median dose) | LD50: >3000 mg/kg (rat, oral) |
| PEL (Permissible) | Not established |
| REL (Recommended) | 0.05% cream |
| Related compounds | |
| Related compounds |
Fluocinolone acetonide
Fluocinonide Diflorasone diacetate |
| Related compounds |
Fluocinonide
Fluocinolone acetonide Fluorometholone |
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