Product Name: Diflorasone
Chemical Name: Diflorasone (C22H28F2O4)
Chemical Family: Corticosteroid
Molecular Weight: 394.45 g/mol
Synonyms: 9α-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
Use: Topical anti-inflammatory agent
Manufacturer: Details available on request
Emergency Contact: Local poison control center or healthcare provider
Recommended Use Restrictions: For external use only, avoid ingestion, shown to affect skin and eyes
Classification: Not classified as hazardous according to OSHA, but possible risks from improper handling
GHS Label Elements: Non-mandatory signal words usually not required, possible irritant pictogram
Acute Hazards: Skin irritation, possible sensitization on prolonged contact, temporary eye discomfort
Chronic Hazards: High exposure may depress local immune response, rare reports of Cushing’s syndrome with misuse
Routes of Exposure: Skin, eyes, accidental inhalation of powder or dust
Potential Health Effects: May cause skin thinning, bruising, or burning; rare risk of systemic toxicity with chronic use on large areas
Target Organs: Skin, mucous membranes
Hazard Statements: Avoid direct and prolonged contact; do not inhale dust
Diflorasone: 100% (active ingredient)
CAS Number: 2557-49-5
Impurities: Trace levels only, none classified as hazardous per SDS information
Formulation Additives: If present in product, typically non-active excipients or carrier cream base, details on request
Purity: Pharmaceutical grade material
Inhalation: Move to fresh air, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash exposed area with soap and water; medical consultation if rash or irritation remains
Eye Contact: Rinse with copious water for at least 15 minutes, seek professional attention if redness or discomfort develops
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical help or contact poison control
Most Important Symptoms: Local irritation, rare cases of systemic corticosteroid toxicity with extensive misuse
Advice to Physicians: Symptomatic and supportive care, monitor for adrenal suppression in rare overdose
Flammability: Not classified as flammable, burns if exposed to flame
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam
Hazards from Combustion: May release toxic fumes of carbon oxides and hydrogen fluoride if overheated
Protective Equipment: Full firefighting gear, self-contained breathing apparatus recommended
Special Procedures: Avoid breathing fumes, move product from fire area if safe to do so, cool exposed containers
Explosion Hazards: Dust generation may cause explosion risk in rare poorly ventilated cases
Personal Precautions: Wear gloves, safety glasses, gown or lab coat; ensure good ventilation
Environmental Precautions: Prevent spillage into waterways, use absorbent material for containment
Spill Clean Up: Mop or scoop up solid, clean affected surfaces with water and mild detergent, dispose as medical waste
Reporting: Notify health and safety management for significant spills
Handling: Use gloves, limit direct contact, avoid generating dust or aerosol, do not eat or drink while in use
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing immediately
Storage Conditions: Store tightly closed in cool, dry, well-ventilated area, protect from light and moisture
Incompatible Materials: Strong oxidizing agents, acids
Storage Containers: Original packaging recommended for best protection
Temperature Limits: Room temperature, 15-30°C for pharmaceutical formulations
Exposure Limits: No OSHA PEL or ACGIH TLV established specifically for diflorasone
Engineering Controls: Laboratory fume hood if handling bulk powder, general area ventilation
Personal Protective Equipment: Gloves (nitrile recommended), laboratory coat, eye protection, mask if powder is present
Skin Protection: Barrier creams do not substitute for gloves
Eye Protection: Safety glasses or goggles
Respiratory Protection: Dust mask if generating airborne particles during bulk handling
Other Controls: Emergency eyewash station and safety shower in proximity
Appearance: White to off-white powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Not determined (solid substance)
Melting Point: 265-268°C
Boiling Point: Not applicable (decomposes)
Flash Point: Data not available
Evaporation Rate: Not applicable
Flammability: Not flammable under normal conditions
Vapor Pressure: Negligible
Vapor Density: Not applicable
Solubility in Water: Practically insoluble
Partition Coefficient (log P): Approx. 2.2 (estimated)
Auto-ignition Temperature: Not established
Decomposition Temperature: Above 250°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not reactive under ordinary use and storage
Hazardous Reactions: Not known to polymerize or react violently
Conditions to Avoid: Excess heat, open flame, strong oxidizers
Incompatible Materials: Strong oxidizing agents, strong acids
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, hydrogen fluoride on combustion
Likely Routes of Exposure: Skin, eyes, inhalation, accidental ingestion
Acute Toxicity: No human LD50 established; animal data suggests low oral toxicity
Skin Irritation: Possible, especially on damaged or sensitive skin
Eye Irritation: Mild, transient
Inhalation: Unlikely unless powder is airborne, low risk of toxicity
Chronic Effects: Skin atrophy, adrenal suppression if misused or overused
Sensitization: Rare; monitor for rash or allergic reaction
CMR Status: Not considered carcinogenic, mutagenic, or reprotoxic by current data
Medical Conditions Aggravated by Exposure: Severe skin conditions, certain endocrine disorders
Special Notes: Use with caution in pediatric populations, monitor for systemic effects with large area exposure
Aquatic Toxicity: Data limited, corticosteroids may affect aquatic organisms if released in quantity
Bioaccumulation: Low potential, not persistent in the environment
Degradation: Gradually degrades, not expected to persist as an intact molecule
Soil Mobility: Low, minimal water solubility limits transfer
Other Effects: Avoid contamination of sewage, waterways, and soil to minimize impact
Product Disposal: Treat as pharmaceutical waste, incinerate in approved facility, consult local regulations
Packaging Disposal: Dispose containers and packaging as hazardous waste where applicable
Special Precautions: Do not flush into surface water, sewer, or drains
Regulatory Compliance: Follow guidelines for medication waste and hazardous chemicals per jurisdiction
UN Number: Not classified as dangerous goods by transport regulations
UN Proper Shipping Name: Diflorasone
Transport Hazard Class: Non-regulated
Packing Group: Not applicable
Environmental Hazards: None indicated for small quantities normally shipped
Transport Precautions: Secure tightly, keep away from incompatible items, do not ship with food
Special Precautions for User: Label clearly, carry documentation for customs or border inspection if needed
US FDA: Approved for topical pharmaceutical use
OSHA: Not specifically regulated as a hazardous chemical
TSCA: Listed for research and pharmaceutical use
WHMIS (Canada): Not classified as a controlled product
REACH (EU): Registered for pharmaceutical application
Other Regulations: Observe country, state, and local regulations regarding corticosteroids
Label Requirements: Pharmaceutical packaging labeling guidance applies
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