Pharmaceutical progress rarely follows a straight path. Looking at dutasteride, its backstory reflects an intersection of persistence in research and the willingness to challenge accepted treatments. Scientists initially searched for ways to address prostate enlargement and hair loss by digging into androgen metabolism. Researchers discovered that the enzyme 5-alpha reductase turns testosterone into dihydrotestosterone (DHT), a hormone closely linked with both issues. Finasteride hit the market in the early 1990s as the first real contender, but its limited activity against just one type of 5-alpha reductase left room for improvement. Dutasteride eventually emerged from the labs at GlaxoSmithKline, promising a broader inhibition against both type 1 and type 2 enzymes. The clinical trials stretched over several years, focusing on safety, reduction of prostate volume, and decreased risk of urinary retention. The FDA approved dutasteride for benign prostatic hyperplasia in 2001. This landmark marked a shift, giving clinicians a more complete tool to tackle prostate-related symptoms and sparking interest in other uses, including male pattern baldness.
Dutasteride shows how a single molecule can make a tangible difference for millions living with prostate issues. Available as soft gelatin capsules, usually in a 0.5 mg dose, it offers daily oral therapy for those managing the frustrating symptoms of an enlarged prostate. Its role expanded, as physicians started prescribing dutasteride off-label for androgen-driven hair loss. Beyond direct patient use, the molecule serves as a research standard in trials exploring hormonal pathways. Pharmacies worldwide stock the product, evidence of steady demand and broad clinical confidence in its benefits. Doctors rely on its predictable absorption and consistent dosing, which helps avoid unwanted swings in DHT suppression. Given its impact on quality of life for aging men, the place of dutasteride reaches beyond just drug shelves; it touches households, medical offices, and research centers chasing better hormonal therapies.
Chemists pay close attention to dutasteride’s dense molecular structure, which features a fused four-ring system typical for steroid frameworks. The compound appears as a white or nearly white powder, mostly insoluble in water but dissolves readily in organic solvents like ethanol and chloroform. This low water solubility might complicate some laboratory work but fits well for encapsulation and controlled oral delivery. Dutasteride’s molecular formula is C27H30F6N2O2, reflecting six fluorine atoms that add unique stability and pharmacological potency. The melting point sits around 242 to 250°C, offering a safe margin during processing steps. Its crystalline form and low volatility make handling straightforward in formulation development, even during large-scale manufacturing. These chemical properties also play a part in determining shelf life, pointing to manageable storage requirements in pharmacy or hospital settings worldwide.
Manufacturers package dutasteride with precise attention to labeling—critical for drugs that modulate hormone pathways. Bottles indicate the active ingredient clearly, followed by batch numbers, manufacturing dates, and the declared shelf life. Each gelatin capsule typically contains excipients such as mono- and diglycerides, and a shell material ensuring long-term stability. Labels warn against use by pregnant women due to risks of fetal harm, reflecting the drug’s teratogenic potential. Documentation lays out dosing guidance for benign prostatic hyperplasia: usually 0.5 mg per day, with adjustments depending on clinical response and patient risk factors. Crucially, packages cite the need to avoid blood donation for at least six months after use, a response to concerns about drug transfer through transfusions. All these specifics reinforce a commitment to patient safety and transparency, pairing up with regulatory documentation from FDA, EMA, and other agencies.
The story of dutasteride’s synthesis stands as a blueprint for modern drug creation. Production starts with multi-step organic synthesis, originating often from progesterone-like precursors. Chemists carefully introduce fluorine atoms—tricky but essential for enhancing potency and stability. The building process involves precise control over temperature, solvent choice, and timing. Phosphorus oxychloride acts as a reagent in one step, driving the construction of the final steroid backbone. The finished raw product goes through purification, usually by recrystallization and chromatography, to meet tight standards for pharmaceutical purity. Makers test every batch for contaminants, including residual solvents and potential byproducts; nothing gets ignored. These checkpoints appear more than just bureaucratic hoops—each step forms a layer of safety and reliability for every capsule someone swallows.
Chemists working with dutasteride tackle a molecule already fine-tuned for biological activity. Chemical modification often targets the side chains or ring substitutions, mostly aiming for derivatives with altered half-life or selectivity. Reactions under controlled lab conditions allow small-scale substitution of fluorine or modification at other non-steroidal sites—yet the therapeutic index of dutasteride rarely benefits from radical change. Researchers might attach reporter groups for imaging or radio-label the molecule for tracing in metabolism studies. These adjustments help scientists map out drug action in tissues, expanding the base of evidence for efficacy and long-term safety.
Several synonyms and branded product names relate directly to dutasteride. Avodart stands as the original branded prescription, widely advertised and prescribed for prostate health. Generic options list only dutasteride as the active ingredient, a move shaped by patent expiration and increased market competition. Other international names or synonyms include GI198745 and duagen, though most healthcare professionals stick with the generic or brand name depending on their region. Pharmacy software, clinical trials, and insurance paperwork refer to these names interchangeably, yet each points back to the same proven compound.
Safe handling of dutasteride calls for both attention and routine. Personnel working in manufacturing or formulation labs rely on gloves and particle filters, especially during weighing and mixing. Facilities enforce standard operating procedures for cleanup, managing spills, and inspecting equipment for residue. The rules make sense, given the impact that even low-level exposure can have if absorbed through the skin or accidental ingestion, particularly among women of childbearing age. Health agencies reinforce these guidelines, and audited records track each batch from raw material to finished capsule. Consumer safety extends beyond the lab—patient leaflets detail side effects such as reduced libido, gynecomastia, or rare allergic reactions. The strict protocols built into every stage serve one goal: preventing harm while maximizing therapeutic gain.
Most people know dutasteride as a mainstay for managing benign prostatic hyperplasia, where its DHT-lowering effect shrinks prostate volume and clears up lower urinary symptoms. Clinical guidelines hit on these benefits, pointing to durable relief from troublesome nocturia, hesitancy, and the risk of sudden urinary retention. Off-label, dermatologists sometimes choose dutasteride to fight hair loss—a contentious but growing area, especially in cases where finasteride falls short. Researchers continue looking at its effect in treating androgen-driven skin disorders and even exploring roles in prostate cancer prevention. The consistent evidence underpinning these uses comes from years of patient data, multiple meta-analyses, and ongoing trials.
Ongoing research constantly redefines dutasteride’s potential. Scientists investigate tweaks in drug delivery through nanoparticles, aiming for targeted action and fewer side effects. Some groups explore combination therapies, pairing dutasteride with alpha-blockers to tackle both hormonal and muscle components of urinary trouble. Trials keep expanding into new patient populations, including investigations in women with rare androgen disorders, though data here grows slowly. Biomarker research chases methods for predicting which patients will respond best or risk developing side effects. The rigorous approach to research demands both experimental creativity and relentless attention to reproducibility.
Laboratories continually monitor for unexpected toxicity, aiming to protect everyone who encounters dutasteride, whether as patient, researcher, or manufacturer. Preclinical toxicology flagged reproductive and developmental effects early, leading to key safety warnings. Long-term patient monitoring reveals low rates of severe adverse reactions, supporting broad clinical confidence, but side effects such as altered mood or breast tenderness come up in some cases. Researchers test metabolites and look for genotoxicity, using both in-vitro studies and animal models to monitor long-range effects. Pharmacoepidemiologists scan prescription databases for trends in rare outcomes, providing early warning if any safety concerns shift with expanded or prolonged use. This constant feedback loop tightens the safety net for every person exposed to the molecule.
Dutasteride’s place in medicine feels secure, but its story is still evolving. There’s hope that new formulations will cut common side effects, letting more people benefit from its prostate-shrinking, DHT-lowering activity. With the spread of personalized medicine, genetic testing could someday steer physicians toward dutasteride for those most likely to benefit, while sparing others from unnecessary exposure. Colleges and industry teams continue to test the molecule in preventive roles—especially in high-risk men with worries about prostate cancer recurrence. With an aging male population, the demand for gentler, more potent therapies will keep rising. If researchers harness advances in drug targeting and patient selection, dutasteride may play a growing part in both preserving quality of life and keeping healthcare costs manageable in the years ahead.
People around the world deal with hair loss and prostate issues, and one small capsule called dutasteride shows up in both conversations. This medicine isn’t some trendy supplement—it's a drug that changes how the body handles certain hormones. Doctors most often write scripts for dutasteride to deal with enlarged prostate, or what’s called benign prostatic hyperplasia (BPH). This isn’t just an "older guy" problem—families feel the strain when a loved one wakes up six times a night to use the bathroom, or can't sit through a grandkid’s soccer game without searching for the nearest restroom. Dutasteride helps shrink the prostate by stopping the body's conversion of testosterone into dihydrotestosterone (DHT), that hormone linked to prostate growth. Lower DHT, and in many men, the prostate shrinks, symptoms like poor urine stream or constant urgency slow down, and life sometimes gets a little less complicated.
Hair loss doesn’t just mess with vanity—it crushes confidence. Some men, facing this slow disappearance in the mirror, turn to dutasteride. This wasn’t its original job, but men started noticing that less DHT in the scalp meant less hair falling out and, for many, actual regrowth. Research in journals like the Journal of the American Academy of Dermatology points out that dutasteride packs a bigger punch than finasteride on this front, since it blocks more of the body’s DHT production. It’s not magic, but it changes both bathroom routines and how some men meet their own reflection.
Every medication comes with questions. Dutasteride isn't for everyone. Shrinking a swollen prostate brings relief, but the hormonal shifts sometimes cause low sex drive, trouble getting an erection, or breast tenderness. Some men talk about lingering depression. That’s tough to admit, but honesty matters more than pride or macho myth. Some families brush off these changes as "just the price of getting older," but doctors know the trade-off isn’t always that simple.
Safety matters too. Dutasteride can cause birth defects if a pregnant woman handles crushed pills—something every household needs to know. Blood tests may show lower prostate-specific antigen (PSA) levels, sometimes masking the early signs of prostate cancer. The U.S. Food & Drug Administration (FDA) and medical journals both warn doctors and patients to keep a close watch.
Anyone thinking about dutasteride has a right to understand the benefits and risks beyond the sales pitch. Open conversations about side effects, regular check-ups, and a thoughtful look at mental health can keep problems from getting worse. Some urologists suggest trying lifestyle changes—diet, weight loss, less alcohol—if the symptoms aren’t severe. Medications like tamsulosin sometimes work as well or even better for some men, especially for symptom relief without as many hormonal shifts.
Baldness and BPH aren’t just clinical terms—they shape real life. Doctors, patients, and families who talk honestly about these issues, study reliable research, and weigh each option together have the best chance to turn a prescription like dutasteride into something that truly helps. The best outcome goes beyond just tackling a symptom and leads back toward confidence and day-to-day comfort.
Dutasteride gets prescribed mostly for treating enlarged prostate, and sometimes for hair loss. Its main job is to block certain hormones called androgens, especially dihydrotestosterone. Blocking these hormones can bring clear changes in the body, and like other medications, dutasteride brings some risks along with its benefits.
One of the first things guys notice after taking dutasteride is a change in their sex life. A research piece from JAMA Dermatology found that about 5% of men noticed lower sex drive, trouble getting or keeping an erection, or less semen during ejaculation. The drop in sex drive and bedroom performance can be tough for anyone, especially if these symptoms don’t fade even after stopping the pills for a while. For men who are younger or thinking about starting a family, these side effects can weigh heavily on their minds. Open honest talk with one’s physician about reproductive plans before starting this drug matters more than many realize.
Other effects show up less dramatically —— breast swelling or tenderness, for example. Men don’t usually expect that, but enlarged or sore breasts happen to a small number. Fluid retention or puffiness may pop up, too. I’ve talked to a buddy who found himself shuffling through new shirts after noticing this breast change. He thought he was gaining weight, but it was likely a hormonal shift from the medication.
Few talk about mood changes from drugs like dutasteride. Some users mention feeling a bit more anxious or down. Anxiety and depression are no joke, and even a mild dip in mood can linger. While only a small slice of users mention this side, there’s strong value in checking in with yourself and sharing any mental health shifts at your regular checkups. Data on the link between these medications and mood is still growing, but it’s wise to keep the conversation open.
Like most prescription drugs, allergies can crop up suddenly. Rashes, hives, swollen lips or face — those need quick medical help. These don’t happen often, yet brushing them aside can get people in trouble. I’ve read about patients who didn’t connect sudden swelling or trouble breathing to their medication, so sharing all new symptoms with your care provider is crucial.
Some studies bring up questions on long-term prostate health. Dutasteride can lower PSA (prostate-specific antigen) readings. This number gets used by doctors to catch early warning signs of prostate cancer. If dutasteride hides real PSA levels, there’s a chance cancer gets missed for a while. The FDA also looked at a small jump in higher-grade prostate cancer among men on this type of medicine. Keeping regular checkups and being clear with doctors about your medication history helps avoid these risks.
Before starting dutasteride, have a blunt talk with a physician about family plans and personal worries. Routine labs help spot problems early. Any unexpected changes — whether in the bedroom, mood, or physical appearance — deserve attention. Patients have found switching drugs or lowering dosage brings relief. Extra exercise, support groups, or small changes in habits can help manage the subtle, lingering effects. Ultimately, informed choices and regular communication lead to the best outcomes, rather than just leaving things to chance.
Dutasteride shows up in a lot of conversations around hair loss. You hear some folks talking about dramatic changes in a few months, and you see others scratching their heads after almost a year with little to show. The truth sits somewhere in the middle, and it helps to keep expectations realistic before diving in.
This medication blocks the enzyme that converts testosterone to dihydrotestosterone (DHT). DHT plays a big role in male pattern baldness and prostate growth. By cutting back on DHT, dutasteride slows down hair loss and even opens the door for some regrowth. It works in a similar way to finasteride but packs a stronger punch, knocking out more of the DHT. That’s why it’s used for tough cases where hair loss doesn’t budge with milder options.
Anyone hoping for overnight miracles will end up frustrated. Both clinical studies and real-life users point to a steady, drawn-out process. Most people start seeing changes around three to six months. These aren’t usually drastic—think fewer hairs in the shower, less scalp peeking through in photos, or a bit of thickness returning at the edges.
Stronger regrowth may pop up after half a year, stretching into the twelve-month mark. Hair cycles move slow. Follicles that shrunk from DHT damage need time to wake up, produce thicker strands, and stick around long enough to make a visible difference. Some people get lucky and notice shifts faster, but most will have to wait the full six to twelve months to judge the real outcome.
People who jump from treatment to treatment before the year wraps up often miss out on the benefits. Consistency may sound boring, but it matters here more than any miracle shampoo. Skipping days or quitting early lets DHT climb back up and can wipe out months of steady progress.
Hormone-driven hair loss runs deep. Genetics, age, stress, and overall health chip away at the results. Someone in their early twenties with tons of thinning might catch a break sooner than a person who waited until their late forties to try medication. Diet, sleep, and even regular exercise give every follicle the fuel it needs to recover.
A study published in the Journal of the American Academy of Dermatology followed men on dutasteride for two years. Just over 70% noticed improvement by the end of twelve months. Around a third saw significant hair regrowth. These facts bring hope, but not guarantees—results still lean on individual biology.
While taking dutasteride, supporting the body with nutrient-rich food goes a long way. Iron, zinc, vitamin D, and protein create the raw materials for hair growth. A simple multivitamin or seeing a doctor for routine bloodwork can catch hidden deficiencies that slow down results.
Talking with a dermatologist can also clear up confusion and offer tools like minoxidil, laser devices, or PRP (platelet-rich plasma) injection. These options stack with dutasteride and give stubborn follicles an extra nudge.
Friends sharing amazing before-and-after photos rarely mention how long they stuck with the routine, or how rough the first months looked. Dutasteride takes time—often half a year or longer—to show results that feel worth it. Committing long-term, sticking to doctor guidance, and supporting the whole body lay the groundwork for visible change.
People start worrying about thinning hair pretty early these days. It’s hard not to, given all the pressure to stay young-looking. Folks reach for shampoos, supplements, lasers, and more. Some land on prescription options like finasteride, the classic name in hair loss treatment. Then dutasteride came along, with promises to offer even greater results. Dutasteride blocks both types of the enzyme 5-alpha reductase, reducing the hormone DHT that shrinks hair follicles. Finasteride only blocks one. That sounds technical, but the real concern boils down to this: does that extra punch translate to more hair?
Clinical trials show dutasteride appears to regrow hair more effectively for many men, especially those with moderate to severe pattern baldness. In direct comparisons, participants using dutasteride often saw thicker regrowth and less shedding than those on finasteride. Hair count measurements back that up, so the numbers look promising. Anyone browsing hair loss forums or Reddit will find anecdotes from men crediting dutasteride for big improvements—reversing receding hairlines or filling in bald spots that hadn’t seen growth in years.
I’ve talked to dermatologists who follow this research closely. They stress dutasteride isn’t an instant fix. It can take 6-12 months before meaningful results show up in the mirror. Like most prescription medications, dutasteride only keeps working if you keep taking it. Stopping means risking a return to baseline—sometimes with a fast shed that feels scary if you aren’t prepared.
Bigger guns come with bigger risks. Dutasteride blocks more DHT, and with less circulating DHT, effects spread further than just the scalp. Some men report lower libido, erectile issues, breast tenderness, or mood changes. These side effects scared off plenty of would-be patients, especially younger guys who feel healthy otherwise. For a subset, those symptoms just do not subside. Studies suggest the rate of these effects is a bit higher than with finasteride, though both drugs carry the risk. Long-term safety isn’t fully understood, especially for folks who start early and take it for decades.
An honest talk with a trusted doctor matters before starting dutasteride. Bloodwork might uncover other causes for hair loss, like thyroid or iron issues, that could be fixed without medication. Doctors who see hair loss daily know how to track for side effects over time and suggest switching or stopping the drug if problems develop. Some guys feel fine on a tiny dose, once or twice a week, instead of every day. Finding the right approach is personal and works best under the care of a medical professional.
Dutasteride isn’t cheap. Insurance rarely covers it purely for treating hair loss, since the FDA did not approve it for that purpose. Doctors prescribe it “off-label,” so persistence may be needed at the pharmacy counter. Generic versions help a little with the price, but it still adds up each month. Some people get creative—buying the capsules used for prostate treatment and splitting the contents—but there’s no guarantee of even dosing that way.
Everybody’s biology responds differently. Some respond best to dutasteride. Some see enough on finasteride or prefer no medication at all. Others put more effort into scalp care, nutrition, or hair styling and accept gradual thinning as part of their story. Talking it through, weighing the real data, and knowing personal tolerance for risk shape the right call. Dutasteride stands as a serious option for those who want to make a big push against hair loss, but it’s not for everyone, and it works best with honest guidance instead of blind optimism.
Dutasteride often enters conversations around hair loss and prostate health. Many men use it to slow down hair thinning, since it blocks the enzyme that turns testosterone into dihydrotestosterone (DHT), a hormone linked to both enlarged prostates and male-pattern baldness. Some doctors and patients discuss using dutasteride for women, especially those struggling with certain types of hair loss. Before jumping in, it's important to go beyond surface-level headlines and look at what’s really involved.
I remember the first time a friend asked if the “men’s hair pill” could help her. Her dermatologist said dutasteride isn’t officially approved for women in most countries. That’s largely because studies have flagged serious risks. According to both the FDA and European Medicines Agency, dutasteride can cause birth defects if taken during pregnancy. This small pill can interfere with hormones that shape a developing fetus, including altering formation of reproductive organs for an unborn child. That warning alone makes most doctors hesitate to prescribe it to anyone who might become pregnant.
For women not planning pregnancy, especially those with persistent hair loss, the desperation for answers pushes some to try off-label options. Some dermatologists in places like the United States or the UK will prescribe dutasteride to select women, usually if they've tried other medications such as spironolactone or minoxidil with little success. The few studies that exist suggest dutasteride could slow certain types of hair thinning in women after menopause. Even then, many experts prefer finasteride—another DHT blocker with a safer record for women—because dutasteride is stronger and stays in the body longer.
I keep running into patient stories scattered across forums. Some say they had mood changes, decreased libido, or breast tenderness. These aren’t unique to men; women report them too. Unlike aspirin or allergy pills, dutasteride wasn’t built for women’s metabolism or hormones. That means research can't fully predict how each person might react. Also, dutasteride lingers in the body for months, which means risk doesn’t vanish after stopping the medication.
Women struggling with stubborn hair loss can feel isolated, but alternatives exist. Talking with a dermatologist helps sift through options backed by real science: topical minoxidil, anti-androgen medicines, low-level laser therapy, nutrition checks, or even platelet-rich plasma treatments. A good doctor will help weigh risks against benefits, take into account medical history, and never push a prescription just because something worked for someone else online.
All medicines carry trade-offs, but dutasteride’s risks have more weight for women. The focus should land on both safety and well-being, not only hopes for thicker hair. Getting accurate information and speaking frankly with a doctor helps avoid mistakes that could have lasting effects. I’ve seen friends get steered away from dangerous choices by a careful health professional who had their best interest at heart. The hope for a quick fix rarely leads to a safe or healthy outcome.
| Names | |
| Preferred IUPAC name | (5α,17β)-N-{2,5-bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-1-ene-17-carboxamide |
| Other names |
Avodart
Duodart Jalyn |
| Pronunciation | /duːˈtæs.tə.raɪd/ |
| Preferred IUPAC name | (5α,17β)-N-{2,5-bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-1-ene-17-carboxamide |
| Other names |
Avodart
Duagen Dutas Duprost Nobel |
| Pronunciation | /duːˈtæstəraɪd/ |
| Identifiers | |
| CAS Number | 164656-23-9 |
| 3D model (JSmol) | `/JSmol/getModel.cml?modelid=30564` |
| Beilstein Reference | 3774532 |
| ChEBI | CHEBI:50629 |
| ChEMBL | CHEMBL1200969 |
| ChemSpider | 388372 |
| DrugBank | DB01126 |
| ECHA InfoCard | 03b9e8c2-8064-4f07-8ce4-dbfeea65e8cf |
| EC Number | EC 5.3.3.9 |
| Gmelin Reference | 1092369 |
| KEGG | D03566 |
| MeSH | D004361 |
| PubChem CID | 6918293 |
| RTECS number | YF5692420C |
| UNII | UR0UPX40A6 |
| UN number | UN number not assigned |
| CAS Number | 164656-23-9 |
| 3D model (JSmol) | Here is the **JSmol 3D model string** for Dutasteride: ``` CCC(=O)N1CC(CN1C(=O)[C@H]2CC[C@H]3[C@H]2CCC4=CC(=O)CCC34C)C5=CC=CC=C5F ``` This is the **SMILES** string representation, used to generate 3D models in JSmol. |
| Beilstein Reference | 3630521 |
| ChEBI | CHEBI:50622 |
| ChEMBL | CHEMBL1200969 |
| ChemSpider | 387401 |
| DrugBank | DB01126 |
| ECHA InfoCard | 03e98e7a-c593-42ad-bd05-34a87de3e9b0 |
| EC Number | EC 5.3.3.3 |
| Gmelin Reference | 8212182 |
| KEGG | D04022 |
| MeSH | D000068882 |
| PubChem CID | 6918295 |
| RTECS number | EI9459800 |
| UNII | TZK0ZL3K1O |
| UN number | UN2811 |
| Properties | |
| Chemical formula | C27H30F6N2O2 |
| Molar mass | 528.528 g/mol |
| Appearance | White to off-white powder |
| Odor | Odorless |
| Density | Dutasteride has a density of 1.1 g/cm³ |
| Solubility in water | Practically insoluble |
| log P | 2.92 |
| Vapor pressure | 9.05E-10 mmHg |
| Acidity (pKa) | 12.52 |
| Basicity (pKb) | pKb = 12.25 |
| Magnetic susceptibility (χ) | -1019.0e-6 cm^3/mol |
| Refractive index (nD) | 1.150 |
| Viscosity | 23.6 cP |
| Dipole moment | 5.5341 Debye |
| Chemical formula | C27H30F6N2O2 |
| Molar mass | 528.529 g/mol |
| Appearance | White to pale yellow powder |
| Odor | Odorless |
| Density | 1.0 g/cm³ |
| Solubility in water | Practically insoluble in water |
| log P | 2.84 |
| Vapor pressure | 3.39E-12 mmHg |
| Acidity (pKa) | 12.13 |
| Basicity (pKb) | pKb = 12.3 |
| Magnetic susceptibility (χ) | -90.4e-6 cm^3/mol |
| Refractive index (nD) | 1.130 |
| Viscosity | 129.9 cP |
| Dipole moment | 5.72 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 395.6 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -523.2 kJ/mol |
| Std molar entropy (S⦵298) | 354.5 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -511.7 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -1090 kJ·mol⁻¹ |
| Pharmacology | |
| ATC code | G04CB02 |
| ATC code | G04CB02 |
| Hazards | |
| Main hazards | May cause reproductive toxicity, suspected of damaging fertility or the unborn child, harmful if absorbed through skin, may cause harm to male fetus. |
| GHS labelling | GHS07, GHS08 |
| Pictograms | **"Pictograms": "Pregnancy warning | Health hazard | Environment hazard"** |
| Signal word | Warning |
| Hazard statements | H361: Suspected of damaging fertility or the unborn child. |
| Precautionary statements | Keep out of reach of children. Women who are pregnant or may become pregnant should not handle crushed or broken tablets. Store at room temperature away from moisture and heat. Only for use by men. Dispose of properly according to local regulations. |
| Flash point | > 267.3 °C |
| Autoignition temperature | > Autoignition temperature: 400°C |
| Lethal dose or concentration | LD₅₀ (rat, oral) > 150 mg/kg |
| LD50 (median dose) | LD50 (median dose): 576 mg/kg (Rat, oral) |
| NIOSH | Not assigned |
| PEL (Permissible) | Not established |
| REL (Recommended) | 0.5 mg daily |
| IDLH (Immediate danger) | Not established |
| Main hazards | May cause harm to unborn children, risk of absorption through skin, may affect male reproductive system, possible liver effects. |
| GHS labelling | GHS07, GHS08 |
| Pictograms | medication, prescription, oral-use, capsule, not-for-pregnant-women, keep-out-of-reach-of-children |
| Signal word | Warning |
| Hazard statements | H361fd: Suspected of damaging fertility. Suspected of damaging the unborn child. |
| Precautionary statements | Keep out of reach of children. Women who are pregnant or may become pregnant should not handle crushed or broken Dutasteride capsules. Store at room temperature away from moisture and heat. Use only as directed by your doctor. |
| Flash point | 250.7±31.5 °C |
| Lethal dose or concentration | LD50 (rat, oral): > 2,000 mg/kg |
| LD50 (median dose) | LD50 (median dose): >400 mg/kg (rat, oral) |
| NIOSH | Not Assigned |
| PEL (Permissible) | Not established |
| REL (Recommended) | 0.5 mg once daily |
| IDLH (Immediate danger) | Not established |
| Related compounds | |
| Related compounds |
Finasteride
4-azasteroids Testosterone Dihydrotestosterone |
| Related compounds |
Finasteride
Epristeride Abiraterone Bicalutamide Cyproterone acetate |
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