Product Name: Estradiol
Chemical Name: 17β-Estradiol
CAS Number: 50-28-2
Synonyms: E2, Estra-1,3,5(10)-triene-3,17β-diol
Recommended Use: Pharmaceutical manufacturing, research, hormone therapy
Supplier Details: Name, address, emergency telephone
Product Code: Reported per supplier formulation
UN Number: Not assigned
GHS Classification: Reproductive toxicity, carcinogenicity, toxic to aquatic life
Signal Word: Danger
Hazard Statements: May cause cancer, suspected of damaging fertility or the unborn child, harmful to aquatic organisms
Pictograms: Health hazard, environment
Precautionary Statements: Avoid exposure, wear protective gear, avoid release to environment, obtain special instructions
Chemical Formula: C18H24O2
Purity: Typically ≥98%
Active Ingredient: Estradiol
Impurities: May contain trace related estrogens, water content, residual solvents
Eye Contact: Rinse immediately with water for at least 15 minutes, seek medical advice
Skin Contact: Wash thoroughly with water and soap, remove contaminated clothing, get medical attention
Inhalation: Move person to fresh air, provide oxygen if breathing is difficult, contact healthcare provider
Ingestion: Rinse mouth out, do not induce vomiting, seek immediate medical assistance
Notes for Doctors: Treat symptomatically; hormonal effects should be monitored
Extinguishing Agents: Water spray, foam, dry powder, carbon dioxide
Specific Hazards: Combustion may form carbon oxides, irritant fumes
Protective Equipment: Full protective suit, self-contained breathing apparatus
Special Procedures: Cool contaminated containers with flooding quantities of water until well after fire is out
Personal Precautions: Use personal protective equipment, avoid contact with skin and eyes, ventilate area
Environmental Precautions: Prevent entry into sewers or waterways
Methods for Cleanup: Sweep up and place in sealed containers for disposal, clean contaminated surfaces with appropriate solvents, avoid generating dust
Handling Precautions: Handle in well-ventilated area, avoid inhalation or direct contact, use biological safety cabinet if available
Storage Requirements: Keep container tightly closed in cool, dry, and well-ventilated area, away from heat, light, oxidizing agents
Specific Conditions: Recommended at 2–8°C for long-term integrity; labeled, secure access area to limit exposure
Engineering Controls: Fume hood, exhaust ventilation, local extraction
Respiratory Protection: Approved respirator for dusts or mists
Skin Protection: Chemical-resistant gloves, lab coat, long sleeves
Eye Protection: Safety goggles, face shield
Hygiene Measures: Wash hands and skin after handling, prohibit eating or drinking in the area
Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 173-179°C
Boiling Point: Not applicable (decomposes)
Solubility: Insoluble in water, soluble in ethanol, diethyl ether
pH: Not available
Molecular Weight: 272.39 g/mol
Vapor Pressure: Negligible at ambient temperature
Partition Coefficient: Log Kow ~4.01
Chemical Stability: Stable under recommended conditions
Thermal Decomposition: Produces carbon monoxide, carbon dioxide
Materials to Avoid: Strong oxidizers, acids
Hazardous Reactions: Negligible under normal conditions
Hazardous Decomposition Products: Irritating vapors, carbon oxides
Acute Toxicity: LD50 (oral, rat) >2000 mg/kg
Chronic Toxicity: Estrogenic effects documented, long-term low-dose exposure linked to hormone disruption
Carcinogenicity: Classified by IARC as possibly carcinogenic (Group 2A); evidence in animals and humans
Reproductive Toxicity: Known to affect fertility, fetal development
Other Effects: Allergic skin reactions, eye irritation, endocrine disruption
Ecotoxicity: Toxic to aquatic organisms, especially fish due to hormonal interference
Bioaccumulation: Evidence of persistence and accumulation in aquatic environments
Mobility: Not volatile, likely to adsorb to soil and sediments
Degradation: Readily degradable under some environmental conditions, but may persist due to low solubility
Aquatic Toxicity: LC50 (96h, fathead minnow): 85 μg/L
Waste Treatment Methods: Dispose of waste through a licensed chemical disposal contractor
Contaminated Packaging: Must be treated as hazardous; clean before disposal or incinerate under controlled conditions
Special Precautions: Prevent environmental discharge, comply with federal and local hazardous waste regulations
UN Number: Not classified as dangerous under transport regulations
Proper Shipping Name: Estradiol
Transport Hazard Class: Not regulated
Packing Group: Not assigned
Special Precautions for Transport: Secure tightly, prevent spillage, transport under cool and dry circumstances
OSHA Status: Regulated for workplace exposure as hazardous
TSCA Inventory: Listed
REACH Status: Registered/Introduced for relevant uses
SARA Title III: Not listed as an extremely hazardous substance
California Proposition 65: Listed as a chemical known to cause cancer and reproductive harm
Other Local/International Regulations: Subject to national controls on endocrine disruptors and pharmaceutical substances
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