Product Name: Estriol
CAS Number: 50-27-1
Synonyms: 1,3,5(10)-Estratriene-3,16α,17β-triol
Recommended Use: Pharmaceutical synthesis, hormone research, laboratory reagent
Supplier Details: Typically provided by laboratory chemical suppliers. Contact details and emergency phone numbers appear on purchase documents. Physical location refers to secure chemical storage in an institutional lab setting, monitored by qualified staff.
Product Code: Often varies with supplier inventory system.
GHS Classification: Not classed as hazardous under current GHS criteria. Prolonged exposure and misuse present health concerns in research settings.
Risk Phrases: May cause skin and eye irritation. Reproductive hazard. Potential endocrine disruptor. Chronic exposure might affect hormone-regulated biological processes.
Routes of Entry: Inhalation, ingestion, dermal absorption.
Pictogram(s): No mandatory GHS pictogram. Use caution due to its hormonal activity.
Target Organs: Endocrine system, reproductive system.
Label Elements: Not regulated for pictogram display, but warnings about reproductive effects should be clearly visible.
Chemical Identity: Estriol
Purity: Usually exceeds 98% as supplied for laboratory use.
Molecular Formula: C18H24O3
Molecular Weight: 288.38 g/mol
Impurities: Residual solvents and synthesis byproducts occur at low ppm levels depending on supplier and process control.
Component Concentration: Single-ingredient material; trace impurities not expected to change handling requirements.
Inhalation: Move affected person to fresh air. Provide accessible medical evaluation, especially if symptoms like headache or dizziness develop.
Skin Contact: Wash thoroughly using soap and water for several minutes. Remove contaminated clothing. Seek medical consideration if irritation or rash persists.
Eye Contact: Rinse cautiously with clean water for at least 15 minutes. Keep eyelids open. Get medical support if burning or vision changes continue.
Ingestion: Rinse mouth extensively using water. Do not induce vomiting. Obtain medical advice right away, and provide SDS to medical staff.
Symptoms and Effects: Prolonged contact risks reproductive effects, especially in women, as well as headaches and skin irritation for sensitive individuals.
Recommended Medical Attention: Hospital-based observation aligns with best practice after large exposure or if symptoms persist beyond initial decontamination.
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide to douse area.
Specific Hazards: Heating results in emission of irritating smoke and vapor. Decomposition at high temperatures can give off hazardous fumes such as carbon oxides.
Protective Equipment: Firefighters require self-contained breathing apparatus and full protective gear.
Special Procedures: Control runoff from high-volume water use, as downstream contamination affects water treatment plants.
Personnel Precautions: Laboratory staff should wear gloves, safety goggles, and fitted laboratory coats. Avoid raising dust and limit leakage beyond immediate area.
Environmental Precautions: Estriol is a hormonally active substance and should not reach drains, natural waters, or waste streams used for aquatic farming.
Cleaning Methods: Ventilate affected area well. Collect solid or powder using wet method with absorbent materials, then transfer waste to sealed chemical waste containers.
Disposal: See section on chemical disposal below.
Notification Requirements: Report spills to campus or company safety officers and, if released beyond facility control, notify authorities as required by law.
Handling: Conduct all operations in controlled laboratory environments using chemical fume hoods for powder manipulation. Direct contact and inadvertent inhalation must be prevented.
Storage Conditions: Estriol needs to be refrigerated (2–8°C) in airtight, light-resistant containers. Limit access to qualified personnel.
Incompatibilities: Strong oxidizers degrade product. Keep away from acids and bases which can accelerate breakdown.
Hygiene Practices: Wash hands thoroughly after handling. Do not eat, drink, or smoke near chemical processing.
Engineering Controls: Fume hoods and local exhaust ventilation provide necessary reduction of airborne particles. Use secondary containment.
Personal Protection: Wear chemical-resistant gloves (nitrile or latex), snug safety goggles, and lab coats. In case of risk of splashes or dust, use face shields and disposable respirators rated for particulates.
Exposure Limits: No national or international occupational exposure limits established for estriol. General institutional standards recommend minimizing exposure, especially for pregnant and lactating workers.
Monitoring: Regular surface contamination monitoring reduces cross-contact within multi-user labs.
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Not applicable (insoluble in water)
Melting Point: 280–282°C
Boiling Point: Decomposes before boiling
Flash Point: No data available; solid at ambient temperature
Water Solubility: Practically insoluble; slightly soluble in alcohol and organic solvents
Vapor Pressure: Not significant at room temperature
Density: Approx. 1.4 g/cm³
Partition Coefficient (Log P): 2.45 (measured in octanol/water system for lipid solubility)
Chemical Stability: Stable under ambient laboratory conditions when kept dry and sealed.
Reactivity: No risk of violent reaction with air or water; reacts with strong acids, bases, and oxidizers.
Hazardous Decomposition: Forms carbon oxides, water vapor, and unidentified aldehydes upon heating.
Polymerization: No known risk of dangerous self-polymerization.
Storage Controls: Avoid exposure to excessive light and humidity.
Potential Effects: Estriol acts as a weak estrogen. Exposure over time can affect reproductive systems, especially in women working with the substance during pregnancy.
Acute Toxicity: Oral LD50 in rodents estimated above 2,000 mg/kg based on scientific literature.
Chronic Effects: Prolonged exposure affects reproductive hormones, causes discomfort like headaches, and may irritate mucous membranes and skin.
Sensitization: Some individuals develop allergic skin reactions.
Carcinogenicity: Not classified as a carcinogen by IARC, ACGIH, NTP, or OSHA.
Mutagenicity: No known evidence of mutagenic or genotoxic potential.
Reproductive Toxicity: Strong concern for effects on female fertility and embryo development with repeated occupational exposure.
Aquatic Toxicity: Estriol disrupts endocrine processes in aquatic organisms. Even diluted discharge can reduce fish fertility and development.
Persistence and Degradability: Poorly degradable under standard wastewater conditions. Risk of persistence in water bodies.
Bioaccumulation Potential: Tendency to accumulate in aquatic food chains shown by peer-reviewed research; long-term monitoring recommended.
Mobility in Soil: Minimal; usually adsorbs to soil particles, but leaching increases in highly permeable ground.
Other Adverse Effects: Institutional releases subject to regulatory reporting. Limit waste volume and contain workplace discharge.
Disposal Methods: Collect waste in properly labeled, tightly closed chemical containers. Treatment through incineration in licensed facilities remains preferred.
Contaminated Packaging: Rinse and dispose as hazardous waste or according to approved local protocols.
Restrictions: Do not discharge into waterways or public sewers. Comply with campus, municipal, or federal hazardous waste programs.
SDS Reference: Keep a copy of the corresponding SDS document on file for any workplace exposure event or occupational inquiry.
UN Number: Not assigned; not classified as a hazardous material for transport.
Transport Hazard Class: Not regulated.
Packing Group: Not assigned for standard packaging.
Environmental Hazards: Avoid accidental leakage during shipment to protect against potential waterway disruption.
Special Provisions: Package securely in sealed containers inside secondary containment for intercity or international deliveries.
Worldwide Regulations: Not named on any international chemical control list as a restricted substance, though regulations on estrogen-like compounds exist in environmental and drug manufacturing law.
Workplace Restrictions: Universal laboratory safe work practices apply, with enhanced consideration for reproductive-age and pregnant workers.
Labelling Requirements: Warnings about reproductive and developmental hazards required under OSHA Hazard Communication Standard in the United States, and similar requirements apply in EU and Canada.
Inventory Listings: Included on TSCA, EINECS; not subject to special restrictions as a pure research compound.
Reporting Obligations: Institutional releases into the environment may trigger environmental review and reporting under national or state disposal control statutes.
Recordkeeping: Retain usage logs and SDS records for regulatory compliance and medical follow-up.
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