Product Name: Estrone
Chemical Formula: C18H22O2
Chemical Family: Steroidal Estrogen
CAS Number: 53-16-7
Recommended Use: Laboratory uses, hormone replacement research, reference material
Synonyms: Folliculin, E1
Manufacturer/Supplier: Major chemical distributors or pharmaceutical companies
Emergency Contact: Local Poison Control Center, Company Emergency Number
Classification: Reproductive toxicity, Category 2; Acute Toxicity (oral), Category 4
Hazard Statements: May damage fertility or the unborn child; Harmful if swallowed
Pictograms: Health hazard, exclamation mark
Signal Word: Warning
Precautionary Statements: Wear protective gloves, avoid breathing dust, use in well-ventilated area, wash hands thoroughly after handling
Potential Health Effects: Skin absorption possible; eye, skin, respiratory tract irritation; endocrine disruption possible
Environmental Hazards: Toxic to aquatic organisms
Chemical Name: Estrone
CAS Number: 53-16-7
Concentration: ≥99% (pure form)
Impurities: Trace byproducts of synthesis, less than 1%
Inhalation: Move person to fresh air, seek medical advice if symptoms develop
Skin Contact: Rinse with plenty of water for several minutes, remove contaminated clothing, get medical help if irritation persists
Eye Contact: Rinse with water for several minutes, remove contact lenses, get medical attention
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical advice
Acute Symptoms: Nausea, headache, dizziness, allergic reactions, hormone-related effects
Suitable Extinguishing Media: Carbon dioxide, dry chemical, foam
Unsuitable Extinguishing Media: Water jet
Specific Hazards: May produce toxic fumes including carbon oxides on combustion
Protective Equipment: Full protective gear including self-contained breathing apparatus
Special Procedures: Use water spray to cool containers, avoid inhaling smoke or fumes
Personal Precautions: Wear gloves, lab coat, goggles, and mask
Environmental Precautions: Prevent spillage from entering drains, watercourses, or soil
Cleanup Methods: Use inert absorbent (sand, vermiculite), collect into labeled containers, ventilate area, wipe surfaces with damp cloth, dispose as hazardous waste
Decontamination: Clean area thoroughly, avoid raising dust during cleanup
Handling: Use with local exhaust, handle in chemical fume hood, avoid dust formation, minimize exposure, practice good hygiene
Storage Conditions: Keep in tightly sealed container, store in cool, dry, and well-ventilated area, avoid direct sunlight, segregate from incompatible substances (strong oxidizers)
Incompatibilities: Strong acids and bases, oxidizing agents
Storage Life: Stable under recommended conditions, store below 25°C
Exposure Limits: None established by OSHA or ACGIH for estrone
Engineering Controls: Chemical fume hood, eye wash station, safety shower
Personal Protective Equipment: Chemical-resistant gloves, safety goggles, lab coat, mask or respirator (if dusts or aerosols are generated)
Hygiene Measures: Wash hands after handling, do not eat or drink in work area, remove contaminated clothing
Appearance: White to off-white crystalline powder
Odor: Odorless
Molecular Weight: 270.37 g/mol
Melting Point: 254-261°C
Boiling Point: Not available (decomposes)
Solubility: Slightly soluble in water, soluble in ethanol, acetone, ether
Vapor Pressure: Negligible at room temperature
pH: Not applicable
Partition Coefficient (log Kow): 3.13
Chemical Stability: Stable under normal laboratory conditions
Reactive Hazards: Reacts with strong oxidizing agents
Decomposition Products: Produces carbon monoxide, carbon dioxide, other organic compounds on thermal decomposition
Polymerization: Will not polymerize under normal conditions
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Acute Toxicity: LD50 (oral, rat): ~2000 mg/kg
Chronic Effects: Potential reproductive toxicity, disruption of hormonal balance, possible carcinogen based on animal studies
Symptoms: Altered menstrual cycle, dizziness, headache, nausea, risk of hypersensitivity
Carcinogenicity: Not listed by IARC, NTP, OSHA as a confirmed carcinogen, but similar estrogens carry increased risk of certain cancers with long-term exposure
Ecotoxicity: Harmful to aquatic organisms, may disrupt endocrine systems in wildlife
Persistence and Degradability: Resistant to biodegradation, possible persistence in water and soil
Bioaccumulation: Potential for bioaccumulation in aquatic organisms
Mobility in Soil: Low mobility, binds to soil particles
Other Ecological Hazards: Estrogenic effects possible even at low concentrations
Waste Treatment Methods: Dispose as hazardous waste through approved chemical waste contractor
Incineration: Possible with regulated equipment, comply with local, state, federal requirements
Container Disposal: Rinse, puncture, and render unusable before discarding, follow hazardous waste label requirements
Precautions: Do not release into environment, avoid landfill disposal
UN Number: Not classified as dangerous for transport
Proper Shipping Name: Estrone, solid
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Special Precautions: Protect containers from physical damage, avoid sources of ignition, keep separated from food and feedstuffs during transport
Labels Required: As mandated for laboratory chemicals or hazardous substances, if shipped in bulk
US Regulations: Not listed specifically by TSCA, SARA Title III, CERCLA; may be subject to state-level reporting
EU Regulations: Subject to REACH authorization, classified as endocrine disruptor, workplace restrictions may apply
WHMIS Classification (Canada): D2A (very toxic: reproductive hazard)
GHS Classification: Reproductive Toxicity Category 2, Acute Toxicity Category 4
Other International Info: Seek national chemical authority database for country-specific regulations or restrictions
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