Product Name: Ethinyl Estradiol
Chemical Name: 19-nor-17α-pregna-1,3,5(10)-trien-20-yne-3,17-diol
CAS Number: 57-63-6
Formula: C20H24O2
Intended Use: Synthetic estrogen for research, pharmaceutical applications, hormonal contraceptives
Manufacturer’s Contact: Provided by supplier
Emergency Phone Number: Refer to safety coordinator details supplied with order
Classification: Reproductive toxicity (Category 1B), Carcinogenicity (Category 2), Specific Target Organ Toxicity – repeated exposure (Category 2), Acute aquatic toxicity (Category 1)
Pictograms: Health hazard, exclamation mark, environment
Signal Word: Danger
Warning Statements: Suspected of causing cancer, may damage fertility or the unborn child, may cause damage to organs through prolonged exposure, very toxic to aquatic life
Symptoms of Exposure: Nausea, vomiting, headache, risk of blood clots, hormonal disturbances
Routes of Exposure: Inhalation, ingestion, skin absorption, eye contact
Main Ingredients: Ethinyl Estradiol 98–100%
Impurities: Less than 2%, including degradation products
EINECS Number: 200-342-2
Molecular Weight: 296.4 g/mol
Other Components: None intentionally added
Inhalation: Move exposed person into fresh air. Keep warm and at rest. Seek medical advice if symptoms persist.
Skin Contact: Immediately remove contaminated clothing. Wash affected area with plenty of soap and water. Medical attention required for irritation or signs of allergic reaction.
Eye Contact: Rinse thoroughly with plenty of water for at least 15 minutes. Remove contact lenses if present. Obtain medical attention, especially if redness or pain persists.
Ingestion: Rinse mouth. Do not induce vomiting unless directed by medical personnel. Give small quantity of water if person is conscious. Seek immediate medical assistance.
Advice for Doctors: Provide symptomatic and supportive treatment. Antidote not available.
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, appropriate foam
Unsuitable Media: Strong water jets may spread fire
Special Hazards: Combustion releases toxic fumes: carbon monoxide, carbon dioxide, possibly unidentified organic compounds
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Firefighting Instructions: Isolate area, stay upwind, keep out unnecessary personnel, prevent water run-off from contaminating water supplies and drains
Personal Precautions: Wear approved respirator, protective gloves, eye protection. Avoid dust formation. Avoid inhalation, ingestion, skin and eye contact.
Environmental Precautions: Prevent further leakage or spillage if safe. Do not allow product to reach drains, sewers, or water courses.
Cleanup Methods: Pick up and arrange disposal without creating dust. Sweep up, shovel or vacuum material into labeled containers for disposal. Clean contaminated surface thoroughly.
Disposal of Collected Material: Dispose of in accordance with local regulatory requirements.
Safe Handling: Use in a well-ventilated area. Wear suitable gloves and protective equipment. Avoid contact with skin, eyes, and clothing. Prevent inhalation of dust. No eating, drinking, or smoking in work area.
Storage Conditions: Store in tightly closed original container. Keep away from light, moisture, and sources of ignition. Recommended storage temperature is 2–8°C.
Incompatibility: Strong oxidizing agents, strong bases
Engineering Controls: Work in closed process systems if possible, use local exhaust ventilation. Handle substance in fume hood when solid or powder.
Control Parameters: No occupational exposure limits established in the US or EU; handle using good laboratory practices
Personal Protective Equipment: Chemical resistant gloves, safety goggles, protective clothing. Respiratory protection if dust or aerosols generated.
Hygiene Measures: Wash hands, forearms, and face thoroughly after handling. Remove contaminated clothing and equipment before entering eating areas
Form: White to off-white crystalline powder
Odor: Odorless
Melting Point: 182–184°C
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Sparingly soluble in water, soluble in alcohols and organic solvents
pH: Not applicable
Vapor Density: No data available
Other Properties: Stable under normal conditions; sensitive to light and heat
Chemical Stability: Stable under recommended storage conditions
Hazardous Reactions: No polymerization expected
Conditions to Avoid: Excess heat, sunlight, moisture, strong oxidizers or bases
Decomposition Products: Carbon oxides, acrid smoke, other hazardous organic compounds possible on combustion
Acute Toxicity: LD50 (oral, rat): 800 mg/kg (literature data)
Chronic Effects: Repeated and prolonged exposure may cause reproductive effects, hormone disturbances, increased risk of some cancers
Routes of Exposure: Inhalation, ingestion, dermal, ocular
Symptoms: Nausea, vomiting, headache, blood clots, liver dysfunction, possible allergies
Carcinogenicity: IARC: Possible human carcinogen (Group 2B)
Reproductive Toxicity: Known risk of birth defects, fetal toxicity, hormonal disruption
Sensitization: Skin and respiratory sensitization possible for sensitive individuals
Aquatic Toxicity: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Poorly biodegradable, persistent in water and soil
Bioaccumulative Potential: Has potential for bioaccumulation in aquatic organisms
Mobility in Soil: Moderate mobility through soil, poses risk to groundwater
Other Adverse Effects: Interferes with hormone systems in wildlife, especially aquatic vertebrates
Waste Treatment Methods: Incinerate in suitable facility with flue gas cleaning, or deliver for chemical destruction. Do not flush into surface water or sanitary sewer. Avoid release to the environment.
Contaminated Packaging: Dispose of as unused product, according to local environmental regulations.
Legal Compliance: Waste code and handling requirements generally determined by local, regional, national authorities; follow detailed disposal guidelines
UN Number: Not regulated under IATA, IMDG, ADR as a hazardous substance
Proper Shipping Name: Not listed as dangerous goods for transport
Packing Group: Not applicable
Hazard Class: Not classified
Other Requirements: Good industrial practice suggests securing container to prevent movement, avoid spillage, follow recipient country’s transport rules
OSHA Status: Not specifically regulated
TSCA: Not listed
EU Classification: Reproductive Toxicity, Category 1B; Carcinogenic, Category 2
Labelling in Accordance with Regulation (EC) No. 1272/2008 (CLP): Pictograms, signal word Danger, H statements for reproductive toxicity and carcinogenicity
California Proposition 65: Listed as chemical known to cause cancer or reproductive toxicity
Other Standards: Subject to regional/national controls for pharmaceutical or research use only
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