Product Name: Finasteride and Dutasteride Intermediate
Chemical Class: Pharmaceutical Intermediate
Synonyms: N/A
CAS Number: Available upon request
Recommended Use: For chemical synthesis in research and pharmaceutical manufacturing
Manufacturer: Refer to supplier’s documentation
Emergency Phone: Refer to facility or supplier emergency contact
Primary Risk: Respiratory and skin sensitizer; possible reproductive toxicity
Signal Word: Warning
Hazard Statements: May damage fertility; may cause skin irritation; toxic if inhaled in large amounts
Pictograms: Health hazard, exclamation mark
Precautionary Statements: Use protective gear, wash exposed skin after handling, avoid release to the environment
Component: Main constituent is a steroid-based organic compound
Concentration: 97-99% active intermediate, trace related substances
Impurities: Less than 1% process-related impurities by HPLC
Additives: No intentionally added additives
Molecular Formula: Provided on request for specific batch
Inhalation: Move affected person to fresh air; seek medical attention if symptoms develop
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing
Eye Contact: Rinse thoroughly with water for at least 15 minutes; seek medical advice
Ingestion: Rinse mouth, do not induce vomiting; consult a physician immediately
Notes for Physician: Symptomatic treatment and supportive care suggested
Suitable Extinguishing Media: Dry chemical, CO2, foam, or water spray
Special Hazards: May emit toxic fumes under fire conditions (carbon oxides, nitrogen oxides)
Protective Equipment: Self-contained breathing apparatus and full protective clothing recommended
Firefighting Instructions: Avoid runoff, keep unnecessary personnel away, cool nearby containers
Combustion Products: Harmful vapor and particulate matter possible
Personal Precautions: Wear suitable gloves, lab coat, and eye protection
Environmental Precautions: Prevent entry into waterways, drains, or soil
Spill Cleanup Methods: Scoop up solid spill and place in a labeled container, ventilate the area, clean residue with detergent and water
Disposal: Dispose material as hazardous waste following local regulations
Handling: Keep away from food and beverages; implement good industrial hygiene practices; use in well-ventilated area
Storage Conditions: Store in a tightly closed container at ambient or lower temperature away from heat, light, and moisture
Incompatibilities: Avoid strong oxidizing agents
Safe Handling Notes: Use tools and equipment that are chemical resistant
Protection Against Static Discharge: Contains no volatile solvents, but grounding minimizes risk
Engineering Controls: Work inside a fume hood; use local exhaust if needed
Personal Protective Equipment: Chemical-resistant gloves (nitrile or latex), protective laboratory coat, safety goggles, face shield if splashing is likely
Hygiene Measures: Wash hands before breaks; do not eat or drink during handling
Exposure Limits: No established OSHA or ACGIH exposure limits; minimize exposure from dust and powder
Respiratory Protection: Use approved respirator if ventilation is inadequate
Appearance: Off-white to pale yellow powder
Odor: Little to none
pH: Not applicable for solid powder
Solubility: Slightly soluble in organic solvents, practically insoluble in water
Melting Point: Typically 58-62°C (varies with intermediate)
Boiling Point: Decomposes before boiling
Vapor Pressure: Negligible at room temperature
Flash Point: Not easily flammable; specific value on request
Density: Around 1.2 g/cm3, varies with exact structure
Partition Coefficient (log Kow): Estimated value above 2, consistent with lipophilic compounds
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Reactivity: No significant reactivity under ordinary use and storage
Decomposition: Heating beyond melting point leads to thermal breakdown with possible noxious gases
Incompatible Materials: Strong oxidizers, acids
Polymerization: Not known to occur
Acute Toxicity: Low acute oral and dermal toxicity; inhalation of powdered form may irritate upper respiratory tract
Skin Irritation: Possible mild irritation after prolonged or repeated contact
Eye Irritation: May cause transient redness and discomfort
Chronic Effects: Extended exposure could affect endocrine system or reproductive organs; laboratory animal studies indicate adverse effects at high doses
Sensitization: Prolonged exposure may promote allergic skin reaction
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA
Reproductive Hazard: Caution advised for pregnant or breastfeeding individuals; fetal risk observed in animal studies
Ecotoxicity: May be toxic in aquatic environments over long periods
Persistence and Degradability: Organic structure shows slow biodegradation in soil and water
Bioaccumulation Potential: Likely to accumulate to some degree; high partition coefficient supports this
Mobility: Binds to soil; minimal mobility in aquatic environments
Additional Information: No data on long-term hazards, but prudent to prevent release to the environment
Waste Disposal: Treat as hazardous waste; incinerate or landfill in line with local, regional, and national regulations
Contaminated Packaging: Dispose packaging as hazardous waste; clean with approved solvent if recycling is planned
Special Instructions: Do not release into drains, surface water, or soil
Regulatory Codes: Refer to chemical waste codes applicable to pharmaceutical intermediates
UN Number: Not regulated as dangerous goods under most transport regulations (verify with current national standards)
Proper Shipping Name: Non-hazardous chemical; if above threshold, follow local authority guidelines
Packing Group: Not assigned unless classified hazardous by local regulations
Special Precautions: Protect from physical damage, store in secondary container during transit
Environmental Hazards: Avoid transport with food and animal feed; prevent accidental release
TSCA Status: Chemical may not appear on public inventory; for research or pharmaceutical use
SARA Title III: No SARA 313 chemicals present at reportable quantities
REACH Status: Pre-registered for use as pharmaceutical intermediate in the EU
Canada WHMIS: Subject to Non-Controlled Product classification if used in research
Other Regulations: Subject to workplace health and safety rules; follow local occupational protection laws
Labeling Requirements: GHS-compliant labeling with risk and safety phrases, supplier identification
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