Product Name: Flumethasone
Chemical Name: 6-alpha,9-alpha-Difluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione
Synonyms: Flumethasone, Flumetasone, Flumethasonum
CAS Number: 2135-17-3
Molecular Formula: C22H28F2O5
Molecular Weight: 410.45 g/mol
Recommended Use: Pharmaceutical corticosteroid, research chemical, veterinary medicine
Manufacturer/Supplier: Refer to the latest label or procurement document for supplier details
Emergency Contact: Poison Control: 1-800-222-1222 (US), local emergency services as appropriate
Hazard Class: Acute toxicity (oral, dermal, inhalation – Category 4), Eye Irritation (Category 2), Carcinogenicity (Category 2)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, may cause eye and skin irritation, suspected of causing cancer, suspected of causing genetic defects
Precautionary Statements: Avoid contact with eyes, skin, and clothing. Do not breathe dust or fumes. Wash hands thoroughly after handling. Use only in well-ventilated areas.
Routes of Exposure: Inhalation, ingestion, dermal contact, eye contact
Health Effects: Long-term exposure may produce hormonal changes, adrenal suppression, or immunosuppression. Short-term exposure can irritate skin, eyes, or respiratory tract.
Target Organs: Liver, kidneys, adrenal glands, skin, eyes, immune system
GHS Pictograms: Exclamation mark, Health Hazard
Other Hazards: May be harmful to the unborn child. Flumethasone can affect human health at low doses due to its potency.
Substance: Flumethasone
Chemical Formula: C22H28F2O5
Concentration: 100% in pure powder
Impurities/Additives: Not typically present in pharmaceutical grade. Trace solvents or residuals may be present depending on supplier.
EC Number: 218-347-0
Relevant Impurities Contributing to Classification: N/A
Stabilizing Additives: None expected for reference standards or pharmaceutical form
General Advice: Seek medical attention for any exposure.
Inhalation: Remove victim to fresh air. Keep at rest in a position comfortable for breathing. If not breathing, give artificial respiration. Call a poison center or doctor.
Skin Contact: Take off contaminated clothing. Rinse skin with water for at least 15 minutes. Seek medical advice for persistent irritation or allergic reaction.
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes. Remove contact lenses, if present. Continue rinsing and get medical attention.
Ingestion: Rinse mouth with water. Do not induce vomiting unless directed by medical personnel. Drink water if conscious. Get immediate medical help.
Most Important Symptoms/Effects: Nausea, headache, dizziness, allergic reactions, suppression of immune response, hormonal disturbances, adrenal effects.
Notes to Physician: Treat symptoms and provide supportive care. Flumethasone’s effects may be delayed after exposure.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray, foam
Unsuitable Extinguishing Media: None known for small laboratory quantities
Special Hazards: Decomposition produces toxic gases including hydrogen fluoride, carbon monoxide, carbon dioxide
Protective Equipment for Firefighters: Full protective clothing and self-contained breathing apparatus
Fire/Explosion Risks: Dust can form explosive mixtures with air under some conditions. Containers can burst under heat.
Advice for Firefighters: Move containers away from fire area if safe to do so. Eliminate all ignition sources. Use caution when fighting chemical fires in confined spaces.
Personal Precautions: Evacuate area except for trained personnel with suitable protective equipment. Avoid breathing dust. Avoid contact with skin and eyes.
Environmental Precautions: Prevent entry to drains, sewers, or waterways. Notify authorities if product enters the environment. Flumethasone is hazardous to aquatic and terrestrial life.
Spill Containment: Isolate spill area. Ventilate area. Use non-sparking tools.
Cleanup Methods: Collect spilled powder mechanically and place in a suitable, labeled waste container. Clean area with damp cloth, avoiding dust formation. Wash contaminated surfaces.
Disposal: Dispose with hazardous pharmaceutical waste, following local, regional, and national regulations.
Handling: Use chemical fume hood for weighing and manipulating powder. Wear personal protective equipment including gloves, lab coat or coveralls, eye protection, and a respirator as needed. Minimize dust generation. Label containers clearly.
Storage: Store in tightly closed container in a cool, dry, well-ventilated area, away from incompatible substances such as strong acids or bases. Keep out of reach of children, pets, and unauthorized personnel. Protect from light.
Incompatible Materials: Strong oxidizers, strong acids, bases.
Occupational Exposure Limits: No established OSHA, ACGIH, or NIOSH exposure limits for flumethasone; minimize exposures
Personal Protective Equipment: Chemical-resistant gloves (nitrile or latex), safety goggles or face shield, lab coat or coveralls, NIOSH-approved respirator in case of dust generation
Engineering Controls: Use only in chemical fume hood, provide eyewash and safety shower in area, ensure ventilation is sufficient
Hygiene Measures: Wash thoroughly after handling and before eating, drinking, or using the bathroom. Remove contaminated clothing and wash before reuse.
Environmental Controls: Prevent release to environment. Use spill control materials and procedures appropriate for potent corticosteroids.
Appearance: White or off-white crystalline powder
Odor: Odorless
Odor Threshold: Not determined
pH (aqueous solution): Not available
Melting Point: Approximately 258-262°C
Boiling Point: Not established
Flash Point: Not applicable (solid material)
Evaporation Rate: Not determined
Flammability: May form combustible dust concentrations in air
Vapor Pressure: Not applicable
Vapor Density: Not available
Solubility: Insoluble in water, sparingly soluble in ethanol and organic solvents
Partition Coefficient: Log Kow ≈ 2.6
Auto-ignition Temperature: Not determined
Decomposition Temperature: Not available
Viscosity: Not applicable to solid form
Chemical Stability: Stable under normal laboratory and storage conditions
Reactivity: Not reactive under standard handling
Hazardous Reactions: Can react violently with strong oxidizers
Conditions to Avoid: Heat, light, moisture, sources of ignition, uncontrolled dust formation
Incompatible Materials: Strong oxidizing agents, acids, bases
Decomposition Products: Hydrogen fluoride, carbon oxides, and other toxic fumes.
Acute Toxicity: Harmful if inhaled, swallowed, or absorbed through skin
LD50 (oral, rat): Estimated 200-500 mg/kg
Potential Effects from Exposure: Headache, nausea, skin and eye irritation, hormone imbalance, adrenal suppression, immune suppression
Repeated Dose Effects: Possible adrenal insufficiency, Cushingoid symptoms, immunosuppression, osteoporosis
Carcinogenicity: Not listed by IARC, NTP, or OSHA. Long-term steroid exposure may increase risk of some cancers
Mutagenicity: Limited evidence of genotoxicity. Monitor for long-term health impacts
Reproductive Toxicity: May harm fetus. Avoid use during pregnancy unless specifically prescribed
Other Toxic Effects: Allergic reactions, impacts on glucose metabolism, delayed wound healing possible with chronic exposure.
Toxicity (Aquatic): Hazardous to aquatic organisms, may cause long-term effects in aquatic environment
Persistence and Degradability: Biodegradation in environment expected to be slow
Bioaccumulative Potential: Moderate; Log Kow supports potential for accumulation in aquatic life
Mobility in Soil: Low water solubility, expected moderate mobility in soil
Other Adverse Effects: Corticosteroids can disrupt endocrine systems in wildlife; avoid any release into environment.
Ecological Precautions: Dispose of unused or waste flumethasone through approved hazardous waste facilities
Waste Treatment Methods: Incinerate at approved hazardous waste facility, in accordance with local and national regulations
Container Disposal: Dispose of contaminated packaging as hazardous waste. Do not reuse containers.
Disposal Precautions: Avoid release into environment. Follow all relevant national, regional, and local regulations.
Special Disposal Instructions: Contact licensed waste disposal company for collection and disposal. Document all disposal actions.
UN Number: Not regulated for transport under ADR/RID/IMDG/IATA for pharmaceutical quantities
Proper Shipping Name: Not classified as hazardous for transport
Hazard Class: Not applicable for small or finished pharmaceutical forms
Packing Group: Not applicable
Special Precautions: Ship in strong, tightly sealed containers, protected from light and moisture
Environmental Hazards: Not classified as marine pollutant
Transport in Bulk: Not applicable (pharmaceutical/chemical)
US Regulations: Not listed on the US TSCA inventory. Regulated as a prescription pharmaceutical. Subject to FDA and DEA oversight in some applications.
EU Regulations: Not classified as dangerous substance under Regulation (EC) No 1272/2008 in finished medicinal forms. Subject to REACH pre-registration.
Other Country-Specific Regulations: Restricted use outside of controlled environments, veterinary, and prescription applications. Controlled under various health authority regulations worldwide.
Label Requirements: Follow GHS/OSHA/CLP labeling for laboratory preparations. Pharmaceutical packaging may vary.
Safety Review Date: Refer to container or Safety Data Sheet version date for current revision. Annual review recommended.
Additional References: ICH, USP, EMA, and WHO guidelines for pharmaceutical manufacturers.
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