Material Safety Data Sheet for Fluorogestone Acetate

1. Identification

Product Name: Fluorogestone Acetate
Chemical Formula: C24H32FNaO5
Other Names: FGA
Recommended Use: Veterinary hormone, research chemical
Manufacturer: Contact relevant chemical supplier for details
Emergency Contact Number: Refer to local regulations or supplier number
CAS Number: 2529-45-5
UN Number: Not listed under the UN Dangerous Goods List
Synonyms: 17α-Acetoxy-9α-fluoro-11β-hydroxyprogesterone
Product Code: As assigned by manufacturer

2. Hazard Identification

GHS Classification: Reproductive toxicity (Category 2), Acute toxicity (Category 4, oral), Skin sensitization (Category 1), Eye irritation (Category 2A)
Hazard Statements: Harmful if swallowed, May cause an allergic skin reaction, Suspected of damaging fertility or the unborn child
Pictograms: Exclamation mark, Health hazard
Signal Word: Warning
Precautionary Statements: Avoid breathing dust, Wash hands thoroughly after handling, Wear protective gloves and eye protection, Use only outdoors or in well-ventilated area, Store locked up
Other Information: Exposure to this compound may disrupt endocrine function in humans and animals

3. Composition / Information on Ingredients

Chemical Name: Fluorogestone Acetate
Concentration: 100%
Molecular Weight: 422.50 g/mol
Impurities: No significant impurities expected that would impact classification
EC Number: 219-803-2
Active Ingredient: Fluorogestone Acetate
Other Ingredients: Not applicable to pure substance

4. First Aid Measures

Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, get medical attention if irritation persists
Skin Contact: Remove contaminated clothing, wash affected area with soap and water, seek medical attention for ongoing symptoms
Inhalation: Remove from exposure to fresh air, assist breathing if necessary, consult a physician
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical advice
Notes for Physician: Treat symptomatically, monitor for hormone effects
Indication of Immediate Medical Attention Needed: Hormonal disturbances, allergic reaction, persistent symptoms

5. Fire-Fighting Measures

Risk of Fire: Organic compound, combustible when exposed to flame or high heat
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: Direct water jet may spread powder
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, hydrogen fluoride, other toxic fumes
Special Protective Equipment for Firefighters: Self-contained breathing apparatus with full face shield
Fire/Explosion Hazards: Closed containers may rupture due to buildup of pressure
Firefighting Instructions: Cool containers with water spray, control runoff

6. Accidental Release Measures

Personal Precautions: Avoid contact with skin and eyes, avoid inhalation of dust
Protective Equipment: Gloves, eye protection, dust mask or respirator, lab coat
Environmental Precautions: Prevent entry into sewers, waterways, or soil
Cleaning Methods: Sweep up using damp cloth or absorbent material, transfer to secure container for disposal
Spill Area Ventilation: Ensure good air circulation
Disposal of Cleanup Materials: Treat as hazardous waste, dispose according to local regulations

7. Handling and Storage

Handling: Use only in well-ventilated areas, minimize dust generation and accumulation, avoid ingestion and inhalation, wear suitable protection
Hygiene Practices: Wash hands and face after handling, remove contaminated clothing
Storage Requirements: Store in original container, tightly closed, under cool, dry, and well-ventilated conditions
Incompatible Materials: Strong oxidizing agents, acids, and bases
Storage Temperature: 2-8°C recommended
Storage Location: Lock away from unauthorized access
Shelf Life: Refer to manufacturer’s expiry date guidelines

8. Exposure Controls and Personal Protection

Exposure Limits: No specific occupational exposure limits established, avoid exposure
Engineering Controls: Local exhaust ventilation, closed system operation
Personal Protective Equipment: Protective gloves (nitrile or neoprene), safety goggles or face shield, lab coat or coveralls, respiratory protection if dust generation likely
Respiratory Protection: NIOSH-approved respirator for dusts/mists
Skin Protection: Impervious gloves, long sleeves
Eye Protection: Chemical safety goggles
Environmental Controls: Prevent contamination of air, soil, water

9. Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless or faint chemical odor
Odor Threshold: Not determined
pH: Not applicable (insoluble in water)
Melting Point/Freezing Point: 240–244°C
Boiling Point: Not determined
Flash Point: Not determined
Evaporation Rate: Not determined
Flammability: Non-flammable but can burn
Solubility: Soluble in organic solvents (e.g., ethanol, chloroform), practically insoluble in water
Vapor Pressure: Not applicable
Density: ~1.3 g/cm³ (estimated)
Relative Vapor Density: Not applicable
Partition coefficient (Log Pow): Not determined
Decomposition Temperature: >240°C

10. Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Not reactive under normal conditions
Conditions to Avoid: High temperatures, sources of ignition, strong light
Incompatible Materials: Strong acids, alkalis, oxidizers
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, hydrogen fluoride, toxic vapors
Polymerization: Will not occur under standard conditions
Sensitivity to Static Discharge: Not anticipated

11. Toxicological Information

Routes of Exposure: Inhalation, ingestion, dermal, eye contact
Acute Toxicity: Harmful if swallowed, oral LD50 not precisely determined
Chronic Effects: May cause reproductive and endocrine disruption, prolonged exposure could alter hormonal balance
Skin Irritation: May cause irritation or sensitization after prolonged contact
Eye Irritation: May cause redness, tearing, or discomfort
Respiratory Irritation: Potential for nose, throat, or lung irritation with inhalation of dust
Carcinogenicity: Not classified as carcinogenic under current regulations
Mutagenicity: Data limited, mutagenic potential not fully evaluated
Reproductive Effects: Suspected reproductive toxin based on mechanism of action
Other Information: Long-term effects depend on dose and duration

12. Ecological Information

Ecotoxicity: Endocrine disruptor in aquatic and terrestrial organisms, chronic exposure may impact reproductive cycles
Persistence and Degradability: Not rapidly degradable, persists in soil and water
Bioaccumulation Potential: Tendency to bioaccumulate in tissues, especially in aquatic organisms
Mobility in Soil: Low mobility, binds to organic material
Aquatic Toxicity: Toxic to fish and aquatic invertebrates at low concentrations
Other Information: Dispose of waste carefully, avoid contamination of the environment

13. Disposal Considerations

Waste Disposal Methods: Dispose of as hazardous chemical waste using licensed contractor
Container Disposal: Triple rinse and dispose of containers as hazardous waste
Environmental Precautions: Do not allow to enter drains, waterways, or soil
Special Instructions: Follow local, regional, and national regulations for controlled substances, hormone-active compounds
Recycling Information: Not suitable for recycling; destruction by incineration preferred

14. Transport Information

UN Number: Not regulated as a hazardous material for transportation
Proper Shipping Name: Laboratory chemicals, n.o.s.
Transport Hazard Class: Not classified as dangerous under IATA, IMDG, ADR
Packing Group: Not applicable
Marine Pollutant: No
Special Precautions for Transport: Protect from excessive heat, moisture, and physical damage, mark containers clearly

15. Regulatory Information

U.S. TSCA: Not listed
EU REACH: Not specifically registered, controlled use under research and veterinary guidelines
OSHA Status: Not listed as hazardous chemical under OSHA HazCom standard; use controlled measures
SARA Title III: Not subject to reporting requirements
California Proposition 65: Not listed
WHMIS (Canada): Consult provincial regulations, hormones often require special handling
Other Regulatory Information: Check national and regional standards for controlled substances, hormone-handling requirements, workplace safety, and medical surveillance obligations