Product Name: Ganciclovir
Chemical Name: 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine
Synonyms: DHPG, 2-Amino-1,9-dihydro-9-[(1,3-dihydroxy-2-propoxy)methyl]-6H-purin-6-one
CAS Number: 82410-32-0
Recommended Use: Antiviral agent, treatment of cytomegalovirus (CMV) infections
Manufacturer Information: Contact details of manufacturer or supplier must include address, contact phone, and emergency phone numbers
Emergency Contact: Local poison control center or manufacturer’s designated emergency contact
Relevant Identified Uses: For research, laboratory, and medical use
Not Recommended Uses: Not intended for food, cosmetic, or household purposes
GHS Classification: Acute Toxicity (Oral, Dermal and Inhalation), Reproductive Toxicity Category 1B, Specific Target Organ Toxicity (Repeated Exposure) Category 2
Signal Word: Danger
Hazard Statements: May damage fertility or the unborn child. Harmful if swallowed, inhaled, or in contact with skin. May cause organ damage through prolonged or repeated exposure.
Pictograms: Health hazard, exclamation mark
Precautionary Statements: Avoid breathing dust or powder. Wash face, hands, and exposed skin after handling. Use personal protective equipment as required. Obtain special instructions before use.
Other Hazards: Occupational exposure may cause eye and skin irritation. Occupational asthma and sensitization possible. Laboratory animal tests showed teratogenicity and carcinogenicity. May be harmful to aquatic life.
Chemical Name: Ganciclovir
Percentage: 98% or above (pharmaceutical grade)
CAS Number: 82410-32-0
EINECS Number: 620-301-1
Impurities/Additives: Trace process-related impurities, generally below 2% of total content; excipients if present in formulated product need specification.
Inhalation: Remove victim to fresh air, keep at rest in a position comfortable for breathing. Seek medical attention if symptoms persist such as shortness of breath or cough.
Skin Contact: Immediately wash skin with plenty of soap and water for at least 15 minutes. Remove contaminated clothing and wash before reuse. Seek medical attention if irritation or symptoms develop.
Eye Contact: Rinse cautiously with water for at least 15 minutes, lifting eyelids for thorough cleaning. Remove contact lenses if present and easy to do. Seek immediate medical advice for redness or pain.
Ingestion: Rinse mouth with water. Never induce vomiting. Give plenty of water to dilute in conscious patients. Immediate medical attention necessary.
Most Important Symptoms and Effects: Nausea, vomiting, abdominal pain, neurological symptoms, reduced white blood cell counts, fertility or developmental effects.
Advice for Medical Personnel: Symptomatic treatment; monitor blood cell counts and liver/renal function. Consider transport to hospital for advanced care.
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, alcohol-resistant foam
Unsuitable Extinguishing Media: Water jet can spread powders
Specific Hazards Arising from Chemical: Combustion can create hazardous vapors such as carbon oxides, nitrogen oxides, and hydrogen cyanide
Protective Equipment and Precautions: Firefighters use self-contained breathing apparatus and chemically resistant protective clothing. Approach from upwind to avoid hazardous fumes.
Special Methods: Avoid discharge of run-off into drains and watercourses. Cool exposed containers with water spray.
Personal Precautions: Avoid contact with spilled material. Wear chemically resistant gloves, goggles, protective clothing, and NIOSH-approved respirator in case of insufficient ventilation.
Environmental Precautions: Prevent further leakage or spillage. Do not discharge to drains, water courses, or onto the ground.
Methods for Containment and Cleanup: Sweep up or vacuum spilled powder using equipment with HEPA filtration. Place in suitable closed container for disposal. Wash contaminated surfaces with soap and water.
Other Information: Control dust generation. Thoroughly ventilate area.
Handling: Avoid dust formation. Do not breathe dust or vapors. Avoid contact with skin, eyes, and clothing. Wear suitable protective attire. Keep work area clean. Wash hands after use.
Storage: Store in tightly closed container. Keep in a cool, well-ventilated area protected from light and moisture. Store away from incompatible materials (strong oxidizers, acids, bases). Secure area against unauthorized access. Maintain at recommended temperature, typically 2-8°C for pharmaceutical stability.
Occupational Exposure Limits: No established OSHA or ACGIH limits, but minimize exposure as a suspected carcinogen and teratogen.
Engineering Controls: Work in a chemical fume hood. Use local exhaust ventilation in areas handling powder or dust. Provide eyewash stations and emergency showers.
Personal Protective Equipment: Wear chemical-resistant gloves (nitrile, latex), impervious protective clothing, safety goggles or face shield, and NIOSH/MSHA approved respirator suited to particulate hazards.
Hygiene Measures: Wash hands before eating, drinking, or smoking. Remove contaminated clothing. Do not eat, drink, or smoke in work area.
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: 9.2 - 10.2 (2% solution)
Melting Point/Freezing Point: Decomposes before melting at approximately 250°C
Boiling Point: Not available
Flash Point: Not flammable
Evaporation Rate: Not applicable
Flammability: Not classified as flammable
Vapor Pressure: Negligible
Vapor Density: Not available
Relative Density: 1.66 g/cm³
Solubility in Water: 2.6 mg/mL at 25°C
Partition Coefficient (log Kow): -1.18
Autoignition Temperature: Not available
Decomposition Temperature: > 250°C
Viscosity: Not applicable
Stability: Stable under recommended storage and handling conditions.
Reactivity: No known hazardous reactions under normal conditions.
Conditions to Avoid: Excessive heat, light, moisture, open flames
Incompatible Materials: Strong acids, bases, oxidizing agents
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen cyanide (at high temperatures or combustion)
Polymerization: Not expected to occur.
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral LD50 (rat): 1000–1500 mg/kg. Low acute toxicity by skin and inhalation.
Skin Corrosion/Irritation: May cause mild irritation.
Serious Eye Damage/Irritation: May cause mild to moderate irritation.
Respiratory or Skin Sensitization: May cause allergic reaction in susceptible individuals.
Germ Cell Mutagenicity: Evidence of mutagenicity in animal studies.
Carcinogenicity: Animal studies suggest possible carcinogenicity. Not classified by IARC.
Reproductive Toxicity: Clear evidence of reproductive and developmental effects in animal studies.
STOT (Single Exposure): Potential effects include mild transient symptoms, mainly respiratory.
STOT (Repeated Exposure): Target organs: Hematopoietic system, reproductive organs.
Aspiration Hazard: Not considered an aspiration hazard.
Symptoms: Nausea, vomiting, fatigue, headache, leukopenia, neutropenia, teratogenic effects, and decreased fertility.
Ecotoxicity: Low to moderate aquatic toxicity. Fish and invertebrate LC50 data generally in the mg/L range.
Persistence and Degradability: Limited biodegradability in water and soil, persistent in environment.
Bioaccumulative Potential: Low potential for bioaccumulation (log Kow -1.18).
Mobility in Soil: Likely moderate due to water solubility.
Other Adverse Effects: No data available for ozone depletion, endocrine disruption.
Waste Treatment Methods: Dispose of as hazardous chemical waste in accordance with local, regional, and national regulations.
Contaminated Packaging: Empty containers and packaging should be triple-rinsed and then disposed of as hazardous waste.
Special Precautions: Avoid discharge into sewers, soil, or waterways. Use authorized waste disposal contractor. Incineration may be recommended for large quantities.
UN Number: Not regulated as dangerous goods in most standard forms
UN Proper Shipping Name: Not applicable
Transport Hazard Class: Not classified
Packing Group: Not classified
Environmental Hazards: Avoid release to environment
Special Precautions for User: Protect packages against physical damage, moisture, and excessive heat. Ship in accordance with applicable regulations for pharmaceuticals or chemicals.
TSCA: Not listed for commercial distribution in the USA
OSHA Hazard Communication: Classified as hazardous based on reproductive toxicity and acute effects
EU REACH Status: Not registered; subject to REACH Annex exemption for pharmaceuticals
WHMIS Classification (Canada): D2A, D2B - Toxic and mutagenic
SARA/Title III (USA): Not listed
California Proposition 65: Not listed, but consult state regulations for updates.
Inventory Lists: Consult local chemical inventory regulations to confirm current status.
Other Information: This MSDS complies with requirements of OSHA 29 CFR 1910.1200, GHS, and other global standards where applicable.
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