Product Name: Halcinonide Cream
Chemical Name: 21-chloro-9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone
Synonyms: Halog, Halcinonide Acetone Acetal, Norflurane
CAS Number: 56816-01-4
Recommended Use: Prescription topical corticosteroid for dermatological use
Manufacturer: Identified on packaging label, contact details provided with product
GHS Classification: Not classified as hazardous for supply or transport in most jurisdictions
Health Hazards: Skin irritation, eye irritation, potential endocrine disruption, allergic reactions in sensitized persons
Environmental Hazards: May pose risk with persistent use that enters water systems; not readily biodegradable
Signal Words: Warning
Pictograms: Exclamation mark for irritation
Precautionary Statements: Avoid contact with eyes and mucous membranes, wash hands after handling, do not ingest
Active Ingredient: Halcinonide (0.1% by weight in typical formulations)
Other Ingredients: Propylene glycol, mineral oil, white petrolatum, cetostearyl alcohol, sodium lauryl sulfate, emulsifying wax, purified water
Impurities: Trace pharmaceutical manufacturing by-products, not considered hazardous under normal use
Inhalation: Move person to fresh air if aerosolized material is inhaled, seek medical advice if symptoms occur
Skin Contact: Wash with soap and water if irritation occurs; discontinue exposure, get medical attention for persistent redness or rash
Eye Contact: Flush eyes with running water for at least 15 minutes, seek prompt medical attention
Ingestion: Do not induce vomiting, rinse mouth with water, seek medical help promptly; product designed for topical use only
Notes for Physicians: Symptomatic treatment, monitor for adrenal suppression with extensive or prolonged exposure
Suitable Extinguishing Media: Carbon dioxide, dry chemical, foam, or water spray
Specific Hazards Arising from the Chemical: Combustion may produce toxic fumes including hydrogen chloride, hydrogen fluoride, carbon monoxide, and oxides of nitrogen
Protective Equipment and Precautions for Firefighters: Wear self-contained breathing apparatus and protective clothing, use water spray to cool containers exposed to fire
Personal Precautions: Wear gloves, safety glasses, avoid skin and eye contact
Environmental Precautions: Prevent large releases from entering drains or watercourses
Methods for Clean-Up: Absorb with inert material, sweep up, transfer to suitable containers for disposal, wash area thoroughly after clean-up
Safe Handling: Handle with care to avoid spills; avoid inhaling vapors or direct contact; wash hands thoroughly after use
Storage Conditions: Store at 20°C to 25°C, keep away from heat, direct sunlight, and incompatible materials (oxidizers)
Packaging Materials: Store in original, tightly closed container, protect from physical damage and moisture
Exposure Limits: No established permissible exposure limits for halcinonide
Engineering Controls: Use with adequate ventilation in workspace
Personal Protective Equipment: Nitrile gloves, protective eyewear, lab coat or apron; respiratory protection not required for routine dermal use but recommended for large-scale manufacturing exposure
Appearance: White to off-white cream
Odor: Mild, characteristic
pH: 4.5–6 (as formulated in cream)
Melting Point: Approximately 220°C (pure compound)
Boiling Point: Not applicable
Solubility: Practically insoluble in water, soluble in methanol and chloroform
Flash Point: Not readily flammable in finished form
Vapor Pressure: Negligible
Partition Coefficient: Log P approximately 2.6 (octanol/water)
Chemical Stability: Stable at recommended storage temperatures
Reactivity: Not reactive under normal storage and use conditions
Incompatible Materials: Strong oxidizers, strong acids
Hazardous Decomposition Products: Possible formation of corrosive and toxic compounds during fire; avoid combustion conditions
Acute Toxicity: Low acute oral and dermal toxicity in animal studies
Chronic Effects: Dermal overuse or misuse may cause atrophy of skin, suppression of hypothalamic-pituitary-adrenal axis, contact allergies
Carcinogenicity: Not listed as a carcinogen by NTP, IARC, or OSHA
Reproductive and Developmental Effects: High doses associated with potential birth defects in animal studies, caution advised for pregnant users
Routes of Exposure: Skin contact is primary exposure in therapeutic use; accidental ingestion and eye contact possible with misuse
Ecotoxicity: No data available for halcinonide specifically; corticosteroids in general may affect aquatic organisms’ endocrine function
Persistence & Degradability: Not readily biodegradable
Bioaccumulation Potential: Not expected to bioaccumulate in organisms due to low environmental mobility
Mobility in Soil: Limited data, but poor water solubility suggests low mobility
Other Adverse Effects: Use and disposal should prevent release to surface waters or municipal sewage to minimize ecological impact
Disposal Methods: Incinerate in compliance with local, state, and federal regulations; do not flush unused product or large amounts into drains
Container Disposal: Empty containers should be disposed of as regulated medical waste
Special Precautions for Landfill or Incineration: Follow local guidelines to protect groundwater and avoid environmental contamination
UN Number: Not regulated
UN Proper Shipping Name: Not applicable
Transport Hazard Class: Not classified as hazardous under most international transport regulations
Packing Group: Not applicable
Environmental Hazards: Product not considered marine pollutant
Special Precautions for User: Secure to prevent leaks during transport, avoid heat and open flames
OSHA: Not specifically regulated under Hazard Communication Standard
EPA: Not listed as hazardous waste; pharmaceutical disposal best practice recommended
FDA: Prescription drug, subject to labeling and approval requirements
State Regulations: Subject to additional requirements in select US states regarding disposal and environmental protection
Other Regulations: Users should consult applicable local and international regulations for safe use, storage, and disposal
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