Halobetasol Propionate walked into dermatology in the late 1980s, marking a turning point for those who struggle with tough, stubborn skin conditions that don’t flinch at milder steroids. It hit the shelves after scientists set out to address the frustration doctors felt with earlier corticosteroids that missed the mark for plaque psoriasis and contact dermatitis. Being born out of necessity means it wasn’t just about tweaking an old drug. Researchers pressed new ground in fluorination and propionate ester mods, giving this steroid real staying power on inflamed skin, and a rate of absorption that let doctors tame the worst rashes without jumping straight to systemic immunosuppressants. Experience shows that digging into the painful, persistent stories of patients, especially those cycling through weaker creams, fueled an urgent push for stronger, targeted formulas.
Halobetasol Propionate belongs to the very highly potent topical corticosteroids. Its profile looks different from older standards because it delivers powerful relief for thick plaques and hard-to-treat inflammation with thinner, faster-drying formulas. Typical over-the-counter options simply don’t cut it for lichenified lesions or chronic eczematous patches, but Halobetasol brings quick clearing when applied in the right dose and schedule. The product comes mainly as ointments and creams, though newer foams and lotions attract interest for covering large or hairy skin surfaces. Once it proved itself in dermatology offices, pharmaceutical companies quickly rolled out generics and brand alternatives, making it less of a luxury for insurance holders and more of a daily tool for managing recalcitrant skin.
Halobetasol Propionate stands out as a synthetic corticosteroid, appearing as a white to off-white powder. Its chemical structure, 21-chloro-6α,9-difluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione 17-propionate, lets it bind with high affinity to glucocorticoid receptors, which is the reason behind its high potency. It’s lipophilic, so it doesn’t just sit on the skin, it seeps in—delivering localized immunosuppression without the drawbacks of deep systemic drugs. Solubility remains low in water but ramps up in methanol and most organic solvents. Experience mixing and compounding this drug in a pharmacy tells me that it holds up well in well-made ointments without crystalizing or separating, and its stability score tops many of its rivals in real-world storage.
Concentration typically runs at 0.05%, a figure that dermatologists know by heart for this class. Most products come clearly labeled to avoid confusion—since exceeding the dose or schedule ramps up side effects. Packaging includes strong warnings against use on the face, groin, underarms, or in pediatric patients without close supervision. Documentation outlines proper usage—application to clean, dry skin, not under occlusion unless directed, and not for longer than necessary. The labeling pulls in detailed ingredient lists to ward off problems for folks with sensitivities to excipients. Even as a busy pharmacist, I’ve found that the inclusion of usage charts, expiration dates, and storage instructions on Halobetasol products beats the vague labeling we saw with older steroids, preventing lots of headaches for both doctors and patients.
Pharmaceutical companies manufacture Halobetasol Propionate by synthesizing the corticosteroid backbone with targeted halogenations and esterification. Organic chemistry in the lab means starting from corticosteroid precursors—adding fluorine and chlorine atoms at specific sites for greater activity, then esterifying with propionate to anchor potency into the final molecule. The process demands tight controls on reagent quality, temperature, solvent purity, and reaction time to chase high yields. Purification often follows by crystallization and careful drying. Preparing it for the market involves blending the active with emollients, emulsifiers, and sometimes penetration enhancers during compounding, so the final product spreads smoothly and penetrates skin efficiently. Industrial-scale production requires sterility, containment, and dedicated lines to prevent crossover contamination.
Making Halobetasol Propionate relies on selective halogenation—adding fluorine and chlorine to increase glucocorticoid receptor affinity. The core pregnadiene structure gets fine-tuned with substitutions to enhance topical activity and cut down on metabolic breakdown. The final propionate esterification serves both potency and stability. Chemists keep modifying these positions to hunt for even more potent drugs or ones with fewer side effects—recent research has looked into adding different ester groups or using other fluorination patterns, although none have yet matched Halobetasol’s unique blend of strength and skin compliance. At the bench, these tweaks open up new ways to target skin layers or modulate absorption, but every new idea gets tested against Halobetasol’s gold standard durability.
Halobetasol Propionate goes by several trade names, helping providers recognize and prescribe it regardless of region or manufacturer. Names like Ultravate, Bryhali, and generic Halobetasol Propionate cream all carry similar warning labels, concentrations, and delivery forms. Its synonyms, such as 21-chloro-6,9-difluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate, double as identifiers in chemical registries and clinical studies—they matter mainly for pharmacists and researchers cross-referencing compounds, since those names don’t show up in typical patient conversations. Physicians often refer to products simply as “Halobetasol,” though knowing the various generic labels prevents prescription errors at the pharmacy counter.
Using Halobetasol Propionate safely depends on both patient education and healthcare oversight. Dosing restrictions are critical—no more than a few grams per week—since exceeding recommendations can thin skin, cause pigment changes, and allow drug to seep into the bloodstream, causing adrenal suppression. In my experience behind the counter, patients rarely read the fine print, so pharmacists and prescribers hold responsibility for spelling out risks, including not applying to the face, eyelids, or skin folds, and not using on children except as a last resort. Pharmacy staff store the drug at controlled room temperature, away from light, and inside child-proof packaging, meeting regulatory protocols for potent corticosteroids. Workplace safety for compounding means gloves, gowns, and fume hoods, as even small flakes can sensitize technicians over long exposure.
Doctors reach for Halobetasol when facing severe plaque psoriasis, recalcitrant eczema, lichen planus, and contact dermatitis that ignore weaker creams. It gets reserved for thick, scaly, or hyperkeratotic patches—especially on limbs or trunk. In practice, its high potency labels it “last line before oral immunosuppressants,” with strict caps on treatment duration and total body coverage. The real-world impact matches what’s promised: fast, visible improvement in angry, stubborn rashes that sap quality of life. Patients report relief in days, a game changer for those who have burned through milder options without success. Outside dermatology, use stays rare because of side effect concerns, but off-label adoption runs in hospital burn units or with severe allergic reactions, making it a critical, if carefully watched, tool.
Research on Halobetasol Propionate doesn’t coast on its approval. Investigators push for improved delivery systems—gels, foams, and sprays—aiming to stretch its benefit to broader patient groups, like those with hair-bearing areas or widespread plaques. Drug developers keep testing dual-action combos, pairing Halobetasol with antifungals, keratolytics, or even newer biologics, chasing ways to minimize steroid exposure. Papers in top journals keep tracking both short and long-term skin changes, barriers to adherence, and new biomarkers for predicting steroid response, all to sharpen when to use strong corticosteroids and when to pull back. Investments in digital monitoring tools let researchers capture real patient use in daily life, rather than just in six-week trials, and the results continue to refine clinical guidelines for safe, effective care.
Toxicity remains the shadow side of Halobetasol’s power—its high potency means real risk of skin atrophy, striae, and telangiectasia with overuse. Endocrinologists warn about hypothalamic-pituitary-adrenal (HPA) axis suppression from long-term misuse, an effect seen most often in children or people covering large body areas. Studies track how much drug gets absorbed at different sites, under occlusion, and in broken versus intact skin. Blood cortisol checks and ACTH stimulation tests get run on suspect cases. Case reports document both skin-damaging overuse and rare systemic side effects, including Cushing’s syndrome in extreme circumstances. Toxicologists call for more safety trials in special populations—elderly, pediatric, pregnant women—where traditional risk models don’t always predict real-world absorption. Long-term, the hope is formulations that limit systemic uptake while preserving local anti-inflammatory kick.
Halobetasol Propionate stands at the crossroads of tradition and innovation in topical steroids. Companies chase new delivery routes—microneedles, nanoparticles, and slow-release patches—in hopes of stretching its benefits and shrinking side effects. Layering the steroid with anti-itch molecules or novel moisturizers could extend its reach for difficult skin patterns, or even bring it to milder cases without the risk profile of full-strength applications. Regulatory pressure and patient demand drive the search for safer, smarter steroids—either with modified structures or paired with digital adherence trackers that spot overuse before patients notice harm. I expect the next decade to bring tighter guidelines around maximum use, clearer patient education, and a more nuanced understanding of who truly benefits from high-potency topicals. Researchers continue lining up against steroid phobia with new safety studies, and patients look for less risky ways to clear their toughest skin battles. As someone who’s watched the tide turn in dermatology, I see Halobetasol staying relevant, but with the spotlight once again on balanced, cautious, and personalized use.
Living with chronic skin problems pulls daily life into a cycle of discomfort, embarrassment, and endless cream trials. People battling psoriasis, stubborn eczema, or lichen planus often reach a point where standard steroid creams just don't cut it. Years back, I watched my neighbor wrestle with red, itchy, thick plaques on her arms that stole her sleep and her comfort. She used over-the-counter options to little effect. Her dermatologist finally recommended halobetasol propionate, turning out to be a real game changer.
Halobetasol propionate falls in the group of ultra-potent topical steroids. It works by suppressing the over-activity of immune cells that cause swelling, redness, and flaky patches. Dermatologists tend to prescribe it for short bursts—adults generally use it for no longer than two weeks in one area. This is not a cream for general dry skin or everyday use; it tackles tough spots that refuse to heal with lighter prescriptions. The World Health Organization classifies halobetasol among the highest strength topical corticosteroids, and its results back that up in studies.
People often spot an improvement within a few days; the angry plaques flatten, and the itch fades. In clinical research, more than half the patients with severe plaque psoriasis cleared up significantly after two weeks of twice-daily halobetasol treatment. Fast action brings relief but also demands caution. Doctors always remind patients not to cover large areas or keep the cream on for months. Long-term or excessive use could thin the skin or lead to hormone problems by suppressing the adrenal glands.
Following instructions goes beyond reading the leaflet. I’ve seen cases where people tried to stretch the benefits by sneaking an extra application or using it over wide patches. That’s risky. Applying a thin layer, avoiding broken skin, steering clear of the eyes, and sticking to the prescribed course keeps things safe. Surprising as it sounds, kids rarely get this drug, and only under strict medical supervision. Safety comes from respecting the power behind these formulas, not from using more or longer.
Halobetasol propionate is just one tool. Lifestyle changes matter. Moisturizers keep skin barriers intact, while stress management and avoidance of triggers reduce flair-ups. Light therapy, non-steroid creams, and systemic medicines also play a role for some folks. Patients who get relief from halobetasol often switch to milder medications for maintenance, reducing the risks that come with potent steroids over the long run.
Trust builds between patients and healthcare teams through honest conversations. No one wants to trade one problem for another, so the best outcomes come from balancing relief with responsibility. If you’re dealing with stubborn skin inflammation and nothing else seems to work, halobetasol propionate can provide real hope. The key lies in careful use, ongoing follow-up, and looking beyond quick fixes by working together on a plan that protects both skin and overall well-being.
Halobetasol Propionate cream often gets prescribed for stubborn cases of eczema, psoriasis, or other rashes where itchy, inflamed skin just won’t heal up with weaker ointments. Facing any skin issue can feel frustrating, especially when earlier treatments haven’t given much relief. The struggle to find something that calms red, angry patches is real. In that search, using a strong steroid cream might sound both promising and a little worrying.
If your doctor’s written out a prescription for this cream, it helps to remember that Halobetasol packs quite a punch. It’s much stronger than over-the-counter hydrocortisone, and the results can appear fast. My own experience, dealing with chronic hand eczema, taught me that patience, care, and following instructions go a long way toward safely getting clear skin again.
I always start by washing my hands and the area getting treatment. Soap and lukewarm water get rid of dirt and oil. After gentle drying with a towel, I squeeze out just a thin line of cream. Doctors usually say “a thin film” for a reason: more cream won’t speed healing, but it can bring more side effects. Rubbing a small dab over the area and stopping as soon as it blends in gives the skin just enough medicine without wasting any.
For cracked or broken skin, it stings less to apply the medicine gently. No need for rubbing or scrubbing. Halobetasol should only go on skin — never the face, never near the eyes, and definitely not inside the mouth or nose. It works best on thick plaques or rashes, and it should never touch delicate, thin skin. Doctors say to avoid using it on wide swaths of skin or for longer than three weeks. From my own use, short bursts with clear breaks in between kept my skin from thinning or bruising later on.
Any strong steroid can trade quick results for side effects if used too long or on the wrong spots. After about a week, most rashes start to settle down. If scales don’t vanish or irritation gets worse, calling the dermatologist always beats guessing. I learned the hard way that using too much led to skin that bruised easily later, so I take those label warnings seriously now.
Doctors keep a close watch for thinning skin, stretch marks, or even signs the body is absorbing the steroid. Kids are especially sensitive, which is why pediatricians give out this cream only in rare cases and under strict instructions. After finishing a course, I always let my skin rest. No more cream, only gentle moisturizer, unless told otherwise.
Real relief takes more than medicated cream. Dry air, harsh soaps, and frequent hand washing can all trigger flares. Switching to fragrance-free body wash and daily moisturizing changed my skin for the better. Identifying triggers turned out more valuable than just reacting each time a rash showed up. Speaking up with doctors and reporting every new symptom helps catch problems before they can start. Even if a tube of Halobetasol sits in the medicine cabinet, it’s a tool, not a cure-all. Working with a medical team and not skipping moisturizing made a long-term difference for me, even during stressful times.
Doctors sometimes reach for halobetasol propionate for skin conditions that just won't calm down. I’ve used it for my own stubborn eczema flares, and the stuff works fast. It quiets the itching and redness like few other creams do. That’s the good part. The flip side is, after using it every day for a while, I noticed some changes in my skin. Thinner patches, a bit of discoloration, and tiny lines I didn’t have before. I started looking closer at what halobetasol propionate actually does — and the risks that come with its power.
Halobetasol propionate works as a super-potent steroid. This strength means it can calm inflammation in record time, but it also comes with a long list of possible side effects. Thinning of the skin stands out as one complaint from people who have used this cream for longer than a few weeks. With the skin thinning out, blood vessels underneath start to show up more. Stretch marks and easy bruising follow if someone keeps applying it to the same spot.
Steroids, especially strong ones, can cause something called perioral dermatitis. This shows up as little bumps and redness around the mouth — frustrating since people use these creams to get rid of rashes, only to trade one problem for another. There is also the risk of steroid acne; the follicles get clogged and pimples pop up where folks never had problems before.
Doctors warn that using halobetasol over large areas, or for a long time, can let the drug slip through the skin into the body. In rare cases, this can suppress your adrenal glands. These glands help keep your hormones balanced and respond to stress. Symptoms sneak up: fatigue, weakness, headaches. Kids face even more risk since their bodies absorb medicine more fully, so pediatricians stick to the lowest dose for the shortest stretch possible.
Infections can show up more often. The cream weakens the body’s normal immune defense in the skin. Cuts take longer to heal, and small blisters or sores can stick around. There are stories about fungal infections flaring up after people use halobetasol on itchy skin that turns out to be a yeast infection. The steroid makes the infection worse since it weakens the local immune response.
Strong prescription creams have a place, especially for people who have struggled with psoriasis, eczema, or lichen planus for years. Patients and doctors need to be honest about expectations. Short bursts of treatment, followed by breaks, work better than long stretches without stopping. Only use on thick, stubborn patches — not on your face, fragile skin, or large sections of your body.
If possible, switch to gentler options once the worst is over. Plenty of non-steroid creams help calm itch and redness for the long haul. Moisturize often, keep up with regular skin checks, and pay attention to any new reactions. Check in with your dermatologist every few months. Sometimes, all it takes is a reminder to use less cream, or to swap in something safer when symptoms settle down.
Halobetasol propionate has its uses for stubborn rashes, but applying it without a plan can lead to more trouble in the long run. Skin is quick to show changes when things aren’t right. Listen to your body, work closely with your care team, and stay alert to shifting patches, colors, or textures. Sharing what works—and what causes weird side effects—lets others steer clear of the same pitfalls.
Halobetasol propionate packs a punch among topical steroids. It treats stubborn eczema and psoriasis where milder creams can’t touch the itch. You see red, inflamed, scaly patches start to clear, often after a few days. Many people reach for that tube and feel hope settle in their chest—final relief after endless scratching. But that power comes at a steep price, especially if it’s used too freely.
Doctors and pharmacists learn early: thick skin fares better with strong steroids. Elbows, knees, even the palms tolerate some strength. The face and groin? Not so much. Skin around eyes or in the folds absorbs medicine fast and doesn’t protect itself well.
Medical research and years of case reports show why caution matters here. Folks who’ve smeared halobetasol on their eyelids or groin for days, sometimes just from following old advice or out of desperation, often end up back in the office. Problems pop up fast. The skin thins, blood vessels become more visible, and sometimes the skin tears open at the slightest friction. Steroid-induced rosacea, pimples, or a perioral dermatitis rash turn into another uphill battle. CDC and Mayo Clinic both warn against applying strong steroids on sensitive areas for just these reasons.
Pharmacies stock halobetasol because some rashes defeat mild steroids. Insurance companies, especially in the U.S., push back against expensive, newer, or non-steroidal creams, and not every patient sees a dermatologist. People want fast fixes. Some have little guidance, or they save old prescriptions and dab that cream anywhere a patch appears. Marketing and social media posts don’t help, either.
A patient once told me he tried halobetasol on his face, hoping to fade a patch of eczema before a job interview. He didn’t see me until after he saw a new flare-up and thinner skin around his nose.
Steroid stewardship matters. Harvard’s medical faculty say, quite simply, “Use the least potent strength, for the shortest period, on the smallest patch.”
Doctors prescribe milder cream like hydrocortisone for faces or groin. These do the job for many cases and cause fewer problems. If that doesn’t work, a dermatologist might try non-steroidal anti-inflammatory creams—tacrolimus or pimecrolimus. These target inflammation without thinning the skin, even with months of use. Moisturizers—ceramide-rich and fragrance-free—lock in healing and soothe stinging. Sometimes, switching laundry detergents or cutting back on hot showers makes a big improvement, especially for eczema.
Everyone deserves a break from itchy, stubborn rashes. But that relief shouldn’t cost the skin’s natural structure its safety. Reading the directions, contacting a healthcare provider, and asking clear questions protects skin, confidence, and long-term health. Every cream, even from the pharmacy shelf, deserves a second thought—especially when it meets your face.
Halobetasol propionate packs quite a punch as far as topical corticosteroids go. Doctors often turn to it for stubborn skin conditions—plaque psoriasis, eczema, dermatitis—that won’t budge with weaker creams. Many people feel relief within days, enough to stir hope after patches of inflamed skin chip away at their self-esteem and sleep. The itch stops. Skin smooths out. It feels like a miracle in a tube.
Stronger steroids bring faster results but also carry a greater load of side effects. For those of us who’ve relied on creams like halobetasol, the worry grows: what happens after months, or even years, of use? Reports pour in about thinning skin or sudden new stretch marks. I remember a neighbor whose skin became fragile—almost translucent—after relying on high-strength creams for her psoriasis. Research backs up these stories. The FDA approves halobetasol for short bursts—generally two weeks. Most clinical trials on this medication look at safety for that window, not for months or longer.
Long-term exposure doesn’t just hit the skin. Steroids can seep through, affecting the rest of the body. One major worry is suppression of the adrenal glands. If the body stops producing enough natural corticosteroids, energy drops, and response to stress plummets. Some patients have wound up needing blood tests and adrenal function checks, and kids are especially at risk. Skin may bruise easily, tear with simple scratches, or show spider veins. Hair can thin. People living with chronic skin disease walk a tricky path—flares bring pain, but heavy creams bring side effects.
Most dermatologists don’t want people stuck in a cycle of strong creams, infection risk, and anxiety about side effects. From what I’ve seen, education goes further than just handing over another prescription. Patients who ask questions and understand their medication gain better control. Rotating different treatments—sometimes using gentler steroid creams, non-steroid options like calcineurin inhibitors, or moisturizers—allows skin to recover. One friend with lichen planus, for example, switched from daily steroid use to intermittent treatment plus diligent moisturizing. Her flares shrank, and her skin felt thicker within months.
Support for chronic skin conditions doesn’t have to rely solely on high-strength steroids. Today, there’s renewed interest in ultraviolet light therapy or newer non-steroid creams, like crisaborole or topical JAK inhibitors. A recent 2022 meta-analysis pointed out that proactive dermatology care—regular check-ins, education, lifestyle support—keeps more people off strong creams long-term. For those who need halobetasol, using it “as needed” rather than every day helps the most. Doctors sometimes suggest “weekend therapy”—using the cream only on weekends, never daily, to minimize risk.
Talking honestly with doctors goes a long way. If side effects sneak up, stopping the cream or switching to a gentler option can make a big difference. Keeping a skin diary, using fragrance-free moisturizers, and layering other therapies helps people stay in control. For children, parents ought to press for alternatives before starting strong steroids. Regular follow-up and lab checks, especially for people who’ve used halobetasol for more than a few weeks, spot trouble early.
Halobetasol propionate changes lives when skin disease gets out of hand. With good communication, alternative treatments, and a steady partnership with health professionals, the benefits outshine the risks—without leaving skin or health in the lurch.
| Names | |
| Preferred IUPAC name | (6α,11β,16β)-21-Chloro-6,9-difluoro-11,17-dihydroxypregna-1,4-diene-3,20-dione 17-propionate |
| Other names |
Ulobetasol Propionate
Halobetasol Delovart Ultravate Bryhali Halox Eznate |
| Pronunciation | /heɪˌloʊˈbɛtəˌsɒl proʊˈpiːəˌneɪt/ |
| Preferred IUPAC name | (6α,11β,16β)-21-Chloro-6,9-difluoro-11,17-dihydroxypregna-1,4-diene-3,20-dione 17-propionate |
| Other names |
Ulobetasol
Halobate Bryhali Lexette Ultravate |
| Pronunciation | /ˌheɪ.loʊˈbɛ.tə.sɒl proʊˈpɪə.neɪt/ |
| Identifiers | |
| CAS Number | 66852-54-8 |
| 3D model (JSmol) | `3D model (JSmol) string for Halobetasol Propionate:` ``` CC(C)(O)[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)CCl)C)Cl)F)C)C(=O)O ``` |
| Beilstein Reference | 3931151 |
| ChEBI | CHEBI:31600 |
| ChEMBL | CHEMBL1201191 |
| ChemSpider | 121349 |
| DrugBank | DB01388 |
| ECHA InfoCard | InfoCard: 1000022 |
| EC Number | 602-882-4 |
| Gmelin Reference | 104992 |
| KEGG | D01733 |
| MeSH | D017025 |
| PubChem CID | CID54680681 |
| RTECS number | MI6633000 |
| UNII | JSD7F63GOC |
| UN number | UN number not assigned |
| CompTox Dashboard (EPA) | DTXSID3046422 |
| CAS Number | 66852-54-8 |
| Beilstein Reference | 3572232 |
| ChEBI | CHEBI:142755 |
| ChEMBL | CHEMBL2104703 |
| ChemSpider | 22538812 |
| DrugBank | DB01218 |
| ECHA InfoCard | 1000349 |
| EC Number | 61788-85-0 |
| Gmelin Reference | Gmelin Reference 109104 |
| KEGG | D01708 |
| MeSH | D017025 |
| PubChem CID | 10076921 |
| RTECS number | UF1530000 |
| UNII | 5W7SML3A6B |
| UN number | UN number not assigned |
| CompTox Dashboard (EPA) | urn:cpp:0032b6de-3df6-4b3d-82b9-2d6e9f1f4372 |
| Properties | |
| Chemical formula | C25H31ClF2O5 |
| Molar mass | 494.572 g/mol |
| Appearance | White to off-white cream |
| Odor | Odorless |
| Density | 1.2 g/cm3 |
| Solubility in water | Insoluble in water |
| log P | 3.7 |
| Acidity (pKa) | 12.52 |
| Basicity (pKb) | 12.65 |
| Magnetic susceptibility (χ) | -7.9e-6 |
| Refractive index (nD) | 1.570 |
| Viscosity | Viscous |
| Dipole moment | 2.78 D |
| Chemical formula | C25H31ClO5 |
| Molar mass | 485.0 g/mol |
| Appearance | White to off-white cream |
| Odor | Odorless |
| Density | 1.11 g/cm³ |
| Solubility in water | Practically insoluble in water |
| log P | 4.3 |
| Acidity (pKa) | 12.59 |
| Basicity (pKb) | 8.56 |
| Magnetic susceptibility (χ) | -7.3e-6 cm³/mol |
| Refractive index (nD) | 1.572 |
| Viscosity | Viscous liquid |
| Dipole moment | 2.78 D |
| Pharmacology | |
| ATC code | D07AC14 |
| ATC code | D07AC14 |
| Hazards | |
| Main hazards | May cause skin irritation, hypothalamic-pituitary-adrenal (HPA) axis suppression, allergic reactions, and risk of systemic absorption leading to adverse effects. |
| GHS labelling | GHS labelling of Halobetasol Propionate: `"Warning; H315: Causes skin irritation; H319: Causes serious eye irritation; H335: May cause respiratory irritation"` |
| Pictograms | 🔥⏳🚫🩸🧴 |
| Signal word | Warning |
| Hazard statements | H410: Very toxic to aquatic life with long lasting effects. |
| Precautionary statements | Keep out of reach of children. For external use only. Avoid contact with eyes. If irritation develops, discontinue use and consult a physician. Not for ophthalmic, oral, or intravaginal use. |
| NFPA 704 (fire diamond) | NFPA 704: 1-1-0 |
| Flash point | > 234.8 °C |
| LD50 (median dose) | > 1.0 to > 2.5 g/kg (rat, dermal) |
| NIOSH | PB4025000 |
| PEL (Permissible) | PEL: Not established |
| REL (Recommended) | 0.05% |
| IDLH (Immediate danger) | Not established |
| Main hazards | May cause skin irritation, HPA axis suppression, allergic reactions, and delayed wound healing |
| GHS labelling | GHS05, GHS07, Danger, Causes serious eye damage, Causes skin irritation, May cause respiratory irritation |
| Pictograms | GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H373: May cause damage to organs through prolonged or repeated exposure. |
| Precautionary statements | Keep out of reach of children. For external use only. Avoid contact with eyes. If irritation develops, discontinue use and consult a physician. |
| LD50 (median dose) | > > 1500 mg/kg (rat, oral) |
| NIOSH | Not Listed |
| PEL (Permissible) | PEL (Permissible) for Halobetasol Propionate: Not established |
| REL (Recommended) | 0.05% |
| IDLH (Immediate danger) | Not established |
| Related compounds | |
| Related compounds |
Betamethasone
Clobetasol propionate Halcinonide Fluocinonide Fluocinolone acetonide |
| Related compounds |
Betamethasone
Clobetasol Halcinonide Fluocinonide |
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