Product Name: Hydrocortisone Acetate
Chemical Name: 21-Acetoxy-11β,17-dihydroxy-pregn-4-ene-3,20-dione
CAS Number: 50-03-3
Molecular Formula: C23H32O6
Recommended Use: Pharmaceutical corticosteroid, anti-inflammatory agent
Manufacturer/Supplier Contact: Emergency phone number, street address, email, telephone number all provided on the manufacturer label or safety program
GHS Classification: Not classified as hazardous according to GHS
Label Elements: Not applicable
Signal Word: Not applicable
Hazards: May cause eye irritation, possible skin and respiratory irritation, may cause allergic skin reactions in sensitized individuals, avoid direct contact or inhalation
Precautionary Statements: Use only as directed, avoid unnecessary exposure, employ routine laboratory hygiene practices, appropriate for professional use only
Chemical: Hydrocortisone Acetate
Concentration: Pure substance, 100%
Impurities/Additives: No significant hazardous impurities above relevant thresholds
Synonyms: Cortisol 21-acetate, 11ß,17,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate
General Advice: Remove source of exposure, get medical help if symptoms persist
Inhalation: Move to fresh air, seek medical attention if respiratory symptoms occur
Skin Contact: Remove contaminated clothing, wash skin thoroughly with mild soap and water
Eye Contact: Flush eyes cautiously with water for several minutes, remove contact lenses if present, continue rinsing, seek medical help if irritation continues
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical attention
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, appropriate foam
Specific Hazards: May emit toxic fumes of carbon oxides and other unidentified combustion products
Protective Equipment: Firefighters wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Special Procedures: Cool exposed containers with water, move containers from fire area if safe
Personal Precautions: Evacuate unnecessary personnel, use personal protective equipment, ventilate area
Environmental Precautions: Prevent entry into drains, waterways, or soil
Clean Up Methods: Scoop up material avoiding dust formation, place in suitable closed containers for disposal, clean area with water and appropriate detergent
Handling: Wear appropriate personal protective equipment, minimize dust generation, work in a well-ventilated area or fume hood, avoid contact with eyes, skin, and clothing
Storage: Keep in tightly closed container, store in cool, dry, and well-ventilated area away from incompatible substances and direct sunlight, ensure restricted access, separate from oxidizers or strong acids
Control Parameters: No established occupational exposure limits, use local exhaust or general ventilation
Engineering Controls: Employ mechanical ventilation such as fume hoods
Personal Protective Equipment: Protective gloves made of nitrile or latex, safety goggles, laboratory coat, and respirator if exposure risk exists
Hygiene Measures: Wash hands, forearms, and face after handling
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Not applicable in solid form
Boiling Point: Decomposes before boiling
Melting Point: 226-229°C
Solubility: Practically insoluble in water, soluble in acetone and ethanol
Vapor Pressure: Negligible at ambient conditions
Molecular Weight: 404.5 g/mol
Partition Coefficient (log Kow): 1.6 (estimated)
Flash Point: Not available
Chemical Stability: Stable under normal handling and storage conditions
Reactivity: Not reactive under recommended conditions
Conditions to Avoid: Avoid excessive heat, sunlight, and sources of ignition
Incompatible Materials: Strong oxidizing agents, acids, bases
Hazardous Decomposition: Produces carbon monoxide, carbon dioxide, and possibly other toxic gases on combustion
Acute Toxicity: Low oral, dermal, and inhalation toxicity, more hazardous with chronic exposure
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Symptoms: Eye and skin irritation, possible allergic reaction, rare systemic corticosteroid effects with large exposure
Chronic Effects: Extended or repeated exposure may cause endocrine, metabolic, and immune changes
Carcinogenicity: Not classified as carcinogenic to humans by NTP, IARC, or OSHA
Reproductive Toxicity: No definitive evidence in humans, may impact when misused during pregnancy
Aquatic Toxicity: Not acutely harmful at low concentrations, persistent in the environment
Persistence and Degradability: Degrades slowly in soil and water; may bioaccumulate slightly
Bioaccumulation: Potential for limited bioaccumulation in aquatic organisms
Mobility in Soil: Slightly mobile due to low water solubility
Other Adverse Effects: May negatively impact aquatic organisms and microorganisms in high concentrations
Waste Treatment Methods: Dispose as hazardous chemical waste in accordance with local, regional, and national regulations
Disposal Containers: Use sealed, labeled containers resistant to chemical action, do not reuse
Precautions: Do not allow to enter drains, water bodies, or mainstream waste streams
Contaminated Packaging: Rinse and dispose of according to approved waste processing methods
UN Number: Not applicable for hydrocortisone acetate
Proper Shipping Name: Not classified as dangerous for transport
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Environmental Hazards: Not a marine pollutant
Transport Precautions: Ensure secure, upright packaging, protect from moisture
United States: Listed on TSCA Inventory; not subject to specific OSHA hazard communication standards for laboratory use
Europe: Listed in EINECS/ELINCS; regulated as active pharmaceutical ingredient
Labeling/Classification: Not classified as hazardous under current chemical safety laws in most territories
Other Regulations: Follow workplace exposure and good hygiene standards defined by local bodies, pharmaceutical handling guidelines apply
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