Product Name: Meprednisone
Chemical Name: 6α-Methylprednisone
CAS Number: 1247-42-3
Molecular Formula: C22H28O5
Synonyms: Meprednisonum
Recommended Use: Pharmaceutical corticosteroid for anti-inflammatory and immunosuppressive therapy
Supplier Details: Pharmaceutical wholesalers, healthcare distributors, hospital pharmacies
Contact Number (Emergency): Refer to national poison control or medical emergency service
Product Identification Code: MEP1247423
Classification: Not considered hazardous under GHS guidelines for laboratory quantities
Main Hazards: May cause eye, skin and respiratory irritation; possible hormone disruption through repeated or prolonged exposure
Signal Word: Warning
Pictogram: Not required at typical handled volumes
Precautionary Statements: Avoid inhalation, contact with skin and eyes; handle using standard laboratory procedures
Routes of Exposure: Inhalation, ingestion, dermal, ocular
Potential Health Effects: Endocrine disturbance, immunosuppression, effects on adrenal gland function with chronic or high-level exposure
Target Organs: Immune system, endocrine system, eyes, skin
Environmental Hazards: May affect aquatic organisms—prevent release into waterways
Chemical Identity: Meprednisone
Concentration: 98–100% pure for pharmaceutical standards
Impurities: Less than 2%, typical process-related substances
Additives: None in pure solid or powder form; formulated tablets may contain excipients such as lactose, starch, microcrystalline cellulose, magnesium stearate, povidone
Inhalation: Move individual to fresh air, monitor for respiratory symptoms, seek medical advice if coughing, shortness of breath or dizziness develops
Skin Contact: Wash area with soap and warm water for at least 15 minutes, remove contaminated clothing, seek medical attention if irritation persists or rash develops
Eye Contact: Rinse eyes carefully with water for no less than 10 minutes, hold eyelids open, remove contact lenses if present and easy, seek immediate medical consult
Ingestion: Never induce vomiting; rinse mouth with water, seek medical evaluation, provide Material Safety Data Sheet to physician
Self-Protection by Responders: Use gloves, safety goggles, and lab coat while administering first aid to prevent accidental contamination
Suitable Extinguishing Media: Use water spray, dry chemical, CO2, or foam depending on surrounding materials
Unsuitable Extinguishing Media: High-pressure water jets may disperse powder
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, possibly hydrogen chloride and other toxic fumes
Protective Equipment for Firefighters: Self-contained breathing apparatus, protective clothing to prevent skin and eye exposure
Special Firefighting Instructions: Avoid inhaling smoke or fumes, isolate area until well ventilated
Personal Precautions: Wear gloves, lab coat, and respiratory protection if airborne dust expected
Environmental Precautions: Prevent spillage from entering drains or natural surface water
Cleanup Methods: Sweep up powder carefully to prevent dust formation, place in a labeled container for disposal per local regulations, wash spill area after material removal
Emergency Procedures: Isolate spill area, restrict access, ventilate the space if powder is airborne, and prevent further spillage using absorbent materials where necessary
Safe Handling: Use in well-ventilated area or fume hood, wear gloves and eye protection, avoid generating dust
Avoid: Inhalation, ingestion, contact with skin and eyes
Storage Requirements: Store tightly sealed at room temperature in dry, cool, well-ventilated place, away from incompatible substances (strong oxidizers, acids)
Equipment: Use grounded containers, handle with non-sparking tools
Storage Container Materials: Original pharmaceutical packaging or amber glass if repacking necessary
Exposure Limits: No established OSHA, NIOSH, or ACGIH limits; apply good laboratory hygiene practices
Engineering Controls: Fume hood or local exhaust ventilation in typical laboratory setting, closed handling for bulk process
Eye Protection: Chemical safety goggles
Skin Protection: Disposable nitrile gloves, long sleeves/lab coat
Respiratory Protection: Dust mask (P2/P3) if dust is generated or if handling quantities above a few milligrams
Hygiene Measures: Wash hands after handling, do not eat or drink while handling, remove and wash contaminated clothing
Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 227–231 °C
Solubility: Slightly soluble in water, freely soluble in methanol, ethanol, acetone, chloroform
Boiling Point: Not available
Vapor Pressure: Negligible at room temperature
pH: Not applicable as a solid
Partition Coefficient (log Kow): 1.7 (estimated)
Molecular Weight: 372.46 g/mol
Other: Stable under recommended storage conditions, slight risk of dust explosion if powder is dispersed in high concentrations in the air
Chemical Stability: Stable in dry, sealed containers at room temperature
Possibility of Hazardous Reactions: No hazardous polymerization
Conditions to Avoid: Moisture, prolonged exposure to light or heat, strong oxidizing agents, acids
Incompatible Materials: Strong oxidizers, reducing agents, strong acids
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, hydrochloric acid fumes, and other possibly toxic substances under fire conditions
Acute Toxicity: Data for meprednisone limited; in vivo/in vitro studies show moderate toxicity at high doses (LD50 oral rat >2,000 mg/kg)
Chronic Effects: Long-term use linked to suppression of hypothalamic-pituitary-adrenal axis, Cushingoid symptoms in humans exposed to pharmaceutical doses
Sensitization: Potential for allergic reaction in sensitized persons
Carcinogenicity: Not listed by IARC, NTP, OSHA as carcinogen
Mutagenicity: No evidence of genetic toxicity in standard assays
Reproductive Toxicity: Known animal studies indicate risk of foetal toxicity at high exposure
Routes of Exposure: Inhalation, dermal, ingestion
Symptoms: Irritation to eyes and skin, possible hormone disruption, immunosuppression, hyperglycemia, hypertension with repeated ingestion
Ecotoxicity: Harmful to aquatic life at high concentrations, long-term effects reported in aquatic environments for corticosteroids
Persistence and Degradability: Slowly biodegradable; may persist in water or soil for extended periods unless treated
Bioaccumulation Potential: Low to moderate potential for bioaccumulation in aquatic organisms based on chemical properties
Mobility in Soil: Limited data, potential for runoff if not suitably contained
Other Adverse Effects: Pharmaceutical residues detected downstream from municipal wastewater, possible effect on fish hormone regulation
Waste Treatment Methods: Dispose of unused or contaminated material through licensed waste disposal contractor following pharmaceutical waste guidelines
Product Disposal: Incinerate in approved facility or landfill in accordance with local, national, and international regulations
Contaminated Packaging: Treat as hazardous pharmaceutical waste
Preventative Measures: Do not release into drains or natural water bodies, avoid bulk disposal in regular landfill where possible
UN Number: Not classified as dangerous goods for transport by road (ADR), air (IATA), or sea (IMDG)
Proper Shipping Name: Not regulated
DOT Hazard Class: Not applicable
Packing Group: Not classified
Environmental Hazards: Not a marine pollutant
Special Precautions for User: Keep tightly closed during transport, protect from moisture and light, ensure correct labelling and documentation for pharmaceuticals
Global Inventory Status: Not listed as restricted substance by major regulatory agencies
Pharmaceutical Regulation: Controlled under medicinal products regulations in most jurisdictions; prescription only
OSHA Hazard Communication: Not hazardous as per OSHA Hazard Communication Standard 29 CFR 1910.1200 for small amounts
TSCA Status: Exempt as a pharmaceutical active ingredient
WHMIS Classification (Canada): Exempt under Drugs and Health Products category
REACH Status (EU): Pharmaceuticals exempted when used as intended for therapeutic use
Other Local/State Regulations: Comply with relevant country, state or provincial standards for controlled pharmaceuticals
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