Methylprednisolone Acetate: Insight, History, Properties, and Prospects

Historical Development

Steroid research in the twentieth century transformed the way medicine handles inflammation, autoimmune diseases, and allergic reactions. In the 1950s, scientists at Upjohn advanced synthetic glucocorticoids, leading to methylprednisolone, a molecule tweaked for stronger anti-inflammatory action and fewer side effects than its ancestors. The acetate ester, known as methylprednisolone acetate, allowed for longer-lasting treatments. People with chronic illnesses like rheumatoid arthritis, asthma, and severe allergic reactions received real hope thanks to this stability and ease of depot (injectable slow-release) use. The pharmaceutical world kept up a steady demand, shaping both research and production priorities. Generations of doctors adjusted protocols based on results from real-world scenarios, not just lab data.

Product Overview

Methylprednisolone acetate stands as a cornerstone injectable steroid, designed for situations where oral steroids fall short or cause too many problems. Packaged as a cloudy suspension, not a clear solution, it gets injected into muscle, joint spaces, or tissues to control inflammation for weeks at a time. Some manufacturers offer pre-filled syringes. Each package spells out concentration—often 40 mg/mL—dosage info, proper handling, and expiration details. For clinics and hospitals, storage means refrigeration or cool, dry shelves. With generic versions on the market, doctors and buyers focus on quality, purity, and consistency much more than branding.

Physical & Chemical Properties

On the lab bench, methylprednisolone acetate appears as a white or slightly off-white crystalline powder—practically insoluble in water and sparingly soluble in alcohol. It melts between 215–220 °C, offering a clue to its stability during storage and formulation. The acetate piece attached to the methylprednisolone backbone makes it more lipophilic, so once injected, the body absorbs it slowly. This slow release underpins its use for lasting effect. Chemically, its backbone bears the hallmarks of a corticosteroid—rings, methyl groups, and precisely placed oxygens. Each piece contributes to how the compound interacts with steroid receptors inside human cells.

Technical Specifications & Labeling

Any reputable supplier lists technical details—purity (typically above 99%), moisture content, particle size, and known impurities. Labels show batch number, manufacture date, and storage advice, plus all excipients (such as polyethylene glycol, sodium chloride, and benzyl alcohol for preservation). Concentration matters, especially if a nurse grabs a 40 mg/mL vial instead of a 20 mg/mL one. Accurate labeling is not abstract paperwork: it’s direct patient safety. Mistakes or unclear listings can cause overdoses, allergies, or lost effectiveness. Everybody from pharmacists to transporters relies on these labels to avoid costly or tragic mistakes.

Preparation Method

Synthesis starts with prednisolone, a key building block. Chemists react it with acetic anhydride, catalyzed under mild conditions, to form the acetate ester. After reaction, purification steps remove unwanted byproducts by washing, recrystallizing, and filtering—in some cases, repeating for maximum purity. Getting a fine, clean powder allows precise dosing and good suspension in liquid form for injectables. This step-by-step lab work is still carried out in pharmaceutical factories, with every lot tested for quality before release. Every worker in this chain learns to appreciate the precise measurements and attention needed to keep errors at bay.

Chemical Reactions & Modifications

Chemists have explored changes to the methylprednisolone molecule for decades. Adding or shifting functional groups can affect how fast the body breaks the drug down, or change its side effect profile. The acetate modification slows absorption and extends duration, but other tweaks—like different esters—change solubility. Beyond the lab, research teams look for ways to switch out preservatives, reduce pain at injection sites, or decrease allergic reactions by swapping suspension agents. Such modifications demand rigorous clinical trials before they reach the market. Tweaking a corticosteroid isn’t guesswork; years of trial, error, and study shape each advance.

Synonyms & Product Names

Doctors, pharmacists, and patients might know methylprednisolone acetate by many names depending on brand, market, or generic labeling. “Depo-Medrol” stands as the classic brand in many regions, but generics carry a range of logos and colors—often just “methylprednisolone acetate injectable suspension.” The International Nonproprietary Name (INN) stays consistent across borders, but in some hospital charts, nurses jot down “MPA,” shorthand that can spark confusion in drug cabinets if not double-checked. In a busy practice, this web of names reminds everyone to always confirm a vial’s actual contents before every injection.

Safety & Operational Standards

Handling methylprednisolone acetate calls for vigilance. While the active drug treats many diseases, accidental exposure carries risk—especially for people with a history of allergies, diabetes, or suppressed immunity. Hospital staff use gloves, masks, and sterile syringes to reduce risk of contamination. Syringe and vial disposal goes in sharps bins, never trash cans, since the compound is potent and dangerous if mishandled. Storage regulations from agencies like the FDA and EMA push companies to log every shipment and keep vials out of kids’ reach. Pharmacovigilance tracking picks up on lot numbers if side effects cluster unexpectedly. Quality assurance isn’t a slogan—lives depend on each vial being exactly right.

Application Area

Doctors rely on methylprednisolone acetate for people coping with severe inflammation. Injections can calm flares in rheumatoid arthritis, quiet allergic cascades in asthma, and stop painful swelling in soft tissues or joints. Some ophthalmologists inject it behind the eye for retinitis or uveitis. In sports medicine, relief from tendonitis or bursitis can mean the difference between competing and months off. In veterinary medicine, the same compound soothes horses and dogs with conditions like hives or arthritis. Medical staff make decisions on dosing, frequency, and injection site depending on disease, age, co-morbidities, and past reactions. Experience and ongoing study guide every dose, beyond what textbooks suggest.

Research & Development

Pharmaceutical research into corticosteroids has evolved past the hunt for new drugs to focus on refining old giants like methylprednisolone acetate. Companies and university labs test new delivery systems—a microneedle patch, an improved biodegradable implant, or nanoparticle suspensions aiming to reduce pain and tissue damage at the injection site. Clinical trials in autoimmune and allergic diseases watch for improvements not just in effectiveness but in reducing known side effects—weight gain, infections, blood sugar surges. Real-world data now shapes research just as much as lab models. The story isn’t static; doctors and scientists still debate best uses, lowest effective doses, and where to swap in new therapies.

Toxicity Research

Methylprednisolone acetate, while life-changing for many, brings risk if used incorrectly or too long. High doses suppress the body’s own natural steroids, raising dangers if treatment stops suddenly. Researchers have tracked links to osteoporosis, slow wound healing, mood changes, and blood glucose spikes. Animal studies drive toxicity awareness, but long-term human follow-up often uncovers problems drug trials missed: kids on chronic steroids can stop growing as expected, adults may catch infections their immune system should beat. Tackling these problems, researchers suggest shorter courses, targeted injections, or slower tapering—tricks learned over decades, not overnight.

Future Prospects

The world’s need for anti-inflammatory treatments isn’t fading. Chronic diseases keep the demand for safe, reliable corticosteroids strong, but the game changes as biosimilars, biologics, and non-steroid anti-inflammatories enter the field. In big cities, you spot compounding pharmacies trying new formulations; rural clinics rely on methylprednisolone acetate’s steady profile. Researchers keep searching for ways to deliver it with fewer injections, less pain, and smaller risks—think long-acting patches, smart injectors, or combination drugs. Global health crises like pandemics remind us that proven drugs can anchor treatment, even as tomorrow’s science pushes forward. Lessons learned from this acetate form ripple into vaccine adjuvants, emergency kits, or even cancer care, as old chemistry meets new medical frontiers.



What is Methylprednisolone Acetate used for?

Understanding Its Role in Medicine Cabinets

Methylprednisolone acetate has carved out a spot as a go-to for many doctors handling stubborn inflammation. Walk into any orthopedic clinic or allergy center, you’re bound to hear this medication mentioned. It’s a corticosteroid—meaning, it borrows from the body’s own hormone system and turns down the noise on the immune response. The real advantage comes through its ability to calm body parts screaming with inflammation that just won’t quit.

Taming Pain and Swelling

Growing up with severe seasonal allergies and a close family member who wrestled with arthritis, I saw the misery out-of-control inflammation creates. Steroid shots were more than a last resort—they often meant the difference between sleeping at night and hours-wide awake. Methylprednisolone acetate is most often delivered as an injection, sending relief right to the troubled spot, like a swollen joint or a patch of irritated skin. Conditions like bursitis, rheumatoid arthritis, and gout flare-ups bring people to their knees. This medication can lift them off the mat.

Beyond joint and soft tissue issues, the shot finds use in treating troublesome allergic reactions, lupus, and sometimes asthma attacks that don’t listen to typical inhalers. Doctors also turn to it after organ transplants, hoping to keep rejection under control. Research from Mayo Clinic and Johns Hopkins supports these broader uses, pointing to anti-inflammatory benefits that ripple through many organ systems.

Benefits and Real-Life Outcomes

Steroid injections offer quick relief for many, cutting pain and swelling faster than pills. I watched my aunt enjoy weeks of pain-free gardening after her knee got a steroid injection, a welcome break from constant ache. Sports medicine clinics and pediatricians give similar stories—children with bad poison ivy turn a corner after one dose. The difference shows up not just on swelling charts, but in days spent back at work or school.

Doctors weigh this relief against side effects. Steroids, including methylprednisolone acetate, come with hurdles: elevated blood sugar, weight gain, thin skin, mood swings. Overuse can lead to brittle bones or immune system dips. No one likes relying on these shots long-term, but in short bursts, the quality-of-life payoff feels immediate.

Finding Safer Paths Forward

Every steroid prescription ought to come with a conversation about healthy limits. Steroid-sparing therapies and changes in daily habits deserve just as much focus. Physical therapists often teach patients new ways to move, hoping to delay or reduce the need for repeat injections. Diet can play a part too. Getting more omega-3s and less processed sugar often dials down inflammation behind the scenes.

For those living with autoimmune issues, methylprednisolone acetate is not a miracle, but it opens up breathing space—time to heal, plan next steps, and live more fully. Tools like this one matter, but so does thoughtful use, clear care plans, and regular check-ins. Nobody wins when relief comes at the cost of long-term health. Guided by the evidence, and honest talk in the exam room, this medication remains a lifeline for many facing pain and swelling that test their limits.

What are the possible side effects of Methylprednisolone Acetate?

Understanding the Drug’s Real-World Impact

Methylprednisolone acetate gets prescribed for all sorts of issues—joint pain, inflammation, immune problems. Anyone who’s had a stubborn rash or a flare-up of arthritis might recognize the name. With any steroid like this, though, the relief often comes with a trade-off. Knowing both sides of the story helps people make smarter decisions about their care.

Common Effects People Feel

Steroids change how the body manages inflammation and stress. With methylprednisolone acetate, some folks feel different right after a shot, or days later. Maybe there’s a flushed face, extra sweating, or they can’t settle down at night. Sleep trouble and mood swings often get overlooked, but they’re real. Fluid retention stands out—ankles swelling up after a few days, rings feeling tighter than usual. Many steroid users share stories about feeling hungry all the time, noticing weight that creeps up without diet changes. That hit me after my first round for joint pain—I raided the fridge at midnight more than once.

What Doctors Watch For

Some problems stay mild, but serious risks show up with higher doses or repeated use. Blood sugar can shoot up, even in folks without diabetes. Regular checks matter, especially for anyone with a family history of blood sugar issues. Immune changes play a big part too. Fighting off simple colds gets tougher. Cuts take longer to heal; infections hang around. After getting corticosteroid shots, a simple scratch from yard work turned into a two-week ordeal for my neighbor.

Long-term use triggers bone concerns: loss of density and easier breaks. One study from the Journal of Clinical Endocrinology and Metabolism links repeated steroid use to osteoporosis rates that climb over time. Eye pressure also catches up. Cataracts and glaucoma get more common, especially in folks crossing age 60 or dealing with other eye problems.

Unique Reactions and Allergic Problems

Everyone’s reaction to steroids plays out differently. Allergies, though rare, do happen. Itching, rashes, or trouble breathing after a dose signal big trouble and always mean a trip to urgent care. Localized reactions—like soreness or redness right at the injection site—show up in some people. They usually fade, but ongoing pain isn’t normal.

Finding Safer Ways to Use Methylprednisolone Acetate

Doctors now aim for the lowest possible dose that still gets results. Short bursts—just enough to tamp down a flare—usually mean fewer side effects. Combining the drug with a strong nutrition plan and regular movement helps manage weight gain and bone loss. It also pays off to check in with health professionals during a course of treatment; real-time feedback can catch problems early.

Big drug decisions shouldn’t be rushed. Anyone thinking about starting methylprednisolone acetate needs open, honest talk with a doctor, with a focus on both relief and risks. Experience from many patients shows how education, monitoring, and lifestyle choices directly shape outcomes, making the medicine more than just a quick fix.

How is Methylprednisolone Acetate administered?

Staring Down a Steroid Injection

The name “methylprednisolone acetate” sounds clinical on purpose. Ask someone who deals with autoimmune disorders, severe allergies, or bad inflammation about it, though, and you’ll hear stories that remind you healthcare gets personal fast. Doctors use this medicine because it’s one of the most reliable anti-inflammatories in the playbook. For someone who’s been through stubborn arthritis or a tough allergy flare, a shot of this steroid often sounds a whole lot better than another round of pills. But few folks walk into the clinic really knowing what’s about to happen.

The Realities of Administration

It’s one thing to read that methylprednisolone acetate comes as an injectable, but a whole other thing to sit in an exam room, sleeve rolled up or pants leg hiked, and wait for that syringe. Most of the time, nurses or doctors aim for a muscle — the upper outer part of your butt or arm gets picked because it can handle medication without much fuss. They use a fresh, sterile syringe, and the medicine itself looks milky or cloudy. Nobody wins popularity contests for sticking a needle in someone else, but most providers try to talk patients through the whole thing.

Sometimes methylprednisolone acetate goes straight into a sore joint or the soft tissues where the pain lives. People with rheumatoid arthritis or severe tendon inflammation get familiar with this process. It can sting or burn a bit — healthcare workers never sugarcoat that. A lot of patients find the payoff is worth it, since local injections target relief right where it’s needed most.

Why Injections Instead of Pills?

Some might ask why not just offer a tablet or liquid, and honestly, that’s a fair question. I’ve watched family try both, and the answer’s always about the speed and strength of what’s needed. Methylprednisolone acetate given as a shot works fast and lasts longer than a quick oral dose. Pills flood your whole system, but a single injection keeps things more focused. For people who can’t swallow medication well or have stomach problems, an injection keeps the process simple.

There’s another reason doctors like the injectable version: it avoids the daily reminder of being sick. Instead of remembering a pill bottle, a person can get an injection at the clinic, then move on with life. For chronic flare-ups, this makes a world of difference.

Safety Measures That Matter

Given the power packed in these steroids, providers stay careful. Before giving a shot, they ask about allergies, recent infections, or other medicines that might mix poorly. People with diabetes notice blood sugars go up, so close monitoring follows every dose. Anybody on multiple injections gets liver, kidney, and bone checked, since long-term steroids treat but also stress the body.

Sterile technique isn’t just for show — avoiding infection matters as much as the medicine itself. I’ve sat in waiting rooms where folks swap stories about home remedies, but nothing replaces a sterile needle, a trained set of hands, and some real medical know-how.

Making It Work For Real Life

Patients want comfort, and clinics want results without extra risks. Clear communication builds trust. Handouts help, but the best advice comes from practitioners who listen, warn about what a person might feel, and stick around for questions after the injection. Sometimes it’s not the shot that leaves an impression, but the calm, practical care that comes with it.

Can Methylprednisolone Acetate interact with other medications?

The Real-Life Puzzle of Mixing Medications

Nobody wants to feel worse when they’re expecting relief. Methylprednisolone acetate (people recognize this as a steroid shot or pill) gets used for everything from arthritis to allergies. As a parent dealing with a child’s asthma and having taken steroids myself for joint flare-ups, I’ve experienced those “read the fine print” moments in the pharmacy. Drug interactions don’t top everyone’s mind, though doctors and pharmacists warn about them daily.

From the FDA to Mayo Clinic, experts agree that methylprednisolone acetate doesn’t live in a bubble. It influences blood sugar, suppresses immunity, and kicks up blood pressure. Some drugs amplify these effects, making things unpredictable. Blood thinners like warfarin don’t always play nice with steroids. Both can make your stomach lining vulnerable, raising bleeding risks. People on blood pressure pills may watch readings climb, even with their usual routine. I know someone with diabetes who’s seen their blood sugar jump into scary territory after a steroid injection, even after sticking with their insulin plan.

Negative Surprises: What Really Happens

Steroids don’t just add extra “umpf” to your system. They demand that your body pay attention. People who rely on vaccines or antibiotics for protection can see those medicines lose their punch. Steroids turn down the body’s defense system, so folks catch infections easier and heal slower.

Nonsteroidal anti-inflammatory drugs like ibuprofen or naproxen lead to duo trouble—pairing them with methylprednisolone acetate strains stomachs and kidneys. Watch out if you’ve got stress ulcers or kidney disease in the family. Living in a household with three generations, we’ve learned the hard way that mixing up grandpa’s arthritis meds means everyone needs to double-check the pill box.

Anti-seizure drugs and antifungals shake things up, too. Some make steroids break down faster, going from “helpful” to “ineffective” overnight. Others put a damper on the body’s response, so it’s like the steroids aren’t even there. Even vaccines for flu or pneumonia fade faster if someone’s running a steroid cycle because the immune system’s blunted.

Navigating Safety: What Actually Helps

Best practice starts with talking, not hoping. Pharmacists are a goldmine for real-world advice. They see lists of medications all day—so let them weigh in before adding prescription steroids to the regimen. Handy tools sit online, like drug interaction checkers from reputable sources such as Drugs.com or WebMD. I’ve pulled out my phone at the doctor’s office just to double check, and doctors appreciate the thoroughness.

Clear communication beats confusion every time. Bringing an updated medication list to appointments flags issues before they pop up. After getting a steroid shot myself, I made a habit of listing every medicine, supplement, and even herbal teas with the clinic nurse. This tiny act gives professionals the context they need to spot risk.

Short-term steroids and one-off treatments rarely stack up problems, but regular users or folks on several meds at the same time can’t afford to leave it to chance. Keeping tabs on mood, blood sugar, blood pressure, and sleep puts you in the driver’s seat. Even a basic notebook gets the job done.

Methylprednisolone acetate helps countless people get back to living, but nobody sails these waters alone. Ask questions, compare notes, watch for signals from your body, and trust the health team to catch what you might miss. Real life is more forgiving when everyone pays attention before mixing things up.

What precautions should be taken when using Methylprednisolone Acetate?

The Importance of Respecting Steroids

Methylprednisolone acetate stands among those strong medicines doctors turn to for serious health challenges—things like severe allergies, certain autoimmune problems, and flare-ups in chronic issues. My years of talking with pharmacists and working with patients remind me that steroids, helpful as they can be, demand careful handling because their effects ripple far beyond the first injection or the first pill.

Not All Conditions Suit Steroids

Some folks expect a quick fix with these injections, hoping for instant relief from joint pain or inflammation. I’ve seen people push for quick solutions, but taking shortcuts with steroids can cause more harm than good. A doctor must check the risks—people struggling with active infections, especially fungal infections, cannot safely take this medicine. The body’s defenses drop whenever these steroids enter the system, so letting an infection slide in isn't worth it.

Keeping an Eye on Blood Sugar and Blood Pressure

People living with diabetes or high blood pressure often face bumps in the road when they start on steroids. Injecting methylprednisolone can send blood sugar soaring or push blood pressure higher. In my experience, these shifts sneak up unless the patient checks levels at home or gets follow-up labs. Regular monitoring gives everyone—patients and providers—a better shot at catching problems early.

Bones, Stomach, and Mental Health—Risks Aren’t Always Obvious

Steroids can thin bones, especially with repeated doses. I know several older adults with osteoporosis who needed extra calcium, vitamin D, or even medicine just because steroids left their bones more fragile. The stomach can get hit too, and ulcers aren’t rare. Doctors often give protective medicines or check for history of stomach troubles in patients they've treated.

For folks prone to mood swings, depression, or anxiety, steroids sometimes stir up emotional storms—insomnia, agitation, or even mood changes that catch families by surprise. Honest conversations before injections or prescriptions matter. Sometimes it's better to warn someone than to watch them struggle in silence afterward.

Vaccines and Other Medicines: Watch for Trouble

Whenever someone takes methylprednisolone acetate, getting vaccines calls for a careful plan. Steroids soften the immune response, so live vaccines can become unsafe or might not work as expected. If someone’s on blood thinners or heart medicine, interactions may throw off lab values or cause bleeding risks during injection. Telling the full truth about your complete medicine list isn’t just wise—it can stop an emergency.

Simple Steps for Safer Use

Using steroids safely means listening closely to the healthcare team, reading instructions, and showing up for follow-ups. Even with a hectic life, coming back for appointment checks or updating your doctor about new symptoms can make a big difference. A plain notebook helps track blood pressure, side effects, sugar swings, or anything out of the ordinary.

I've learned that honest conversations about goals and worries pay off. Some people fear these medicines and others want them too often. Realistic expectations and a strong partnership with your care team offer the best protection for your health.

Methylprednisolone Acetate
Names
Preferred IUPAC name (6α,11β,16α)-21-(acetyloxy)-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
Other names Depo-Medrol
Medrol Acetate
Pronunciation /ˌmɛθ.ɪl.prɛdˈnɪs.əˌloʊn əˈsiː.teɪt/
Preferred IUPAC name (6α,11β,16α)-11,17-Dihydroxy-6-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate
Other names Depo-Medrol
Medrol Acetate
Solu-Medrol
M-Pred
Methylpred acetate
Pronunciation /ˌmɛθ.ɪl.prɛdˈnɪs.əˌloʊn ˈæs.ɪ.teɪt/
Identifiers
CAS Number 53-36-1
Beilstein Reference 1305072
ChEBI CHEBI:6834
ChEMBL CHEMBL1200827
ChemSpider 16213277
DrugBank DB00959
ECHA InfoCard echa.infocard.100.000.097
EC Number 3.2.1.21
Gmelin Reference 390263
KEGG C07258
MeSH D008770
PubChem CID 441335
RTECS number XN9450000
UNII 58YRXQ5ZAS
UN number UN2811
CompTox Dashboard (EPA) DTXSID7034303
CAS Number 53-36-1
Beilstein Reference 1761046
ChEBI CHEBI:6843
ChEMBL CHEMBL1200699
ChemSpider 205093
DrugBank DB00959
ECHA InfoCard ECHA InfoCard: 100.033.404
EC Number 3.2.1.10
Gmelin Reference 8695
KEGG C07247
MeSH D008770
PubChem CID 441320
RTECS number OA1750000
UNII 78R6JE864D
UN number UN2811
Properties
Chemical formula C24H32O6
Molar mass 416.497 g/mol
Appearance White, odorless, crystalline powder
Odor Odorless
Density 1.33 g/cm³
Solubility in water Insoluble in water
log P 1.94
Vapor pressure Negligible
Acidity (pKa) 12.43
Basicity (pKb) 7.94
Magnetic susceptibility (χ) -7.3e-6
Refractive index (nD) 1.487
Viscosity White suspension
Dipole moment 2.06 D
Chemical formula C24H32O6
Molar mass 432.497 g/mol
Appearance White or almost white crystalline powder
Odor Odorless
Density 1.33 g/cm³
Solubility in water Insoluble in water
log P 1.52
Acidity (pKa) 12.53
Basicity (pKb) 12.96
Magnetic susceptibility (χ) -7.9e-6 cm³/mol
Refractive index (nD) 1.485
Viscosity White suspension
Dipole moment Dipole moment: 2.24 D
Thermochemistry
Std molar entropy (S⦵298) 576.8 J·mol⁻¹·K⁻¹
Std molar entropy (S⦵298) 576.6 J·mol⁻¹·K⁻¹
Pharmacology
ATC code H02AB04
ATC code H02AB04
Hazards
Main hazards May cause allergic reactions; immunosuppression; increased risk of infection; may cause endocrine, cardiovascular, gastrointestinal, musculoskeletal, ophthalmic, and psychiatric effects.
GHS labelling GHS07, GHS08
Pictograms !["health hazard", "exclamation mark"]
Signal word Warning
Hazard statements H302: Harmful if swallowed. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
Precautionary statements Keep out of reach of children. For intramuscular or intra-articular use only. Not for intravenous use. Use only as directed by a physician. Store at controlled room temperature. Protect from light. Discard unused portion.
NFPA 704 (fire diamond) 1-1-0
Flash point Flash point: 222.1 °C
Lethal dose or concentration Lethal dose or concentration not established.
LD50 (median dose) LD50 (median dose): Mouse (intraperitoneal): 1950 mg/kg
NIOSH N0149260622
PEL (Permissible) Not Established
REL (Recommended) 40 mg/ml
Main hazards May cause allergic reactions; may cause immunosuppression; may increase risk of infections; may cause hyperglycemia; may cause hormonal imbalance; may cause osteoporosis with long-term use.
GHS labelling GHS07, GHS08
Pictograms GHS07, GHS08
Signal word Warning
Hazard statements H302, H315, H319, H335
Precautionary statements Keep out of reach of children. For intramuscular or intra-articular use only. Do not administer intravenously. Use only as directed by a physician. Discard unused portion. Store below 25°C (77°F) and protect from light.
NFPA 704 (fire diamond) 1-1-0
Flash point Flash point: 224.8°C
Lethal dose or concentration LD50 (rat, oral): >2000 mg/kg
LD50 (median dose) LD50 (median dose): Mouse (intravenous) 273 mg/kg
NIOSH 83-43-2
PEL (Permissible) Not Established
REL (Recommended) 40 mg/mL
Related compounds
Related compounds Prednisolone
Prednisone
Hydrocortisone
Methylprednisolone
Triamcinolone
Dexamethasone
Related compounds Prednisolone
Prednisone
Methylprednisolone
Hydrocortisone
Dexamethasone
Betamethasone
Triamcinolone
Fludrocortisone