Product Name: Methylprednisolone Acetate
Chemical Formula: C24H32O6
CAS Number: 53-36-1
Recommended Uses: Pharmaceutical corticosteroid, anti-inflammatory agent
Manufacturer: Refer to package insert or labeling for full company information
Emergency Contact: Refer to company-supplied emergency numbers
GHS Classification: Not classified as hazardous under GHS for industrial quantities, though improper exposure brings health risks
Routes of Exposure: Inhalation, ingestion, dermal, ocular
Acute Health Hazards: Possible irritation of eyes, skin, respiratory tract; risk of hypersensitivity reactions; high-dose exposure can depress immune responses
Chronic Health Hazards: Prolonged or repeated exposure may result in hormonal imbalance, immunosuppression, delayed wound healing
Warning Statements: Risk of allergic reaction in sensitive individuals; misuse may aggravate existing infections
Active Ingredient: Methylprednisolone Acetate (concentration varies by formulation)
Inactive Components: May include polyethylene glycol, benzyl alcohol (as preservative), sodium chloride, polysorbate 80, water for injection
Purity: Above 98%, with pharmaceutical excipients defined in USP monograph
CAS listed substances: All main constituents comply with international regulatory requirements
Inhalation: Move affected individual to fresh air promptly; seek medical attention for continued respiratory distress
Skin Contact: Remove contaminated clothing. Wash skin with copious amounts of water and mild soap
Eye Contact: Irrigate eyes with clean water for at least 15 minutes. Get immediate medical evaluation if irritation continues
Ingestion: Do not induce vomiting. Rinse mouth. Obtain medical attention without delay, particularly in pediatric exposures
Flammability: Methylprednisolone Acetate is considered non-flammable; most excipients are not flammable at normal temperatures
Suitable Extinguishing Media: Use water, carbon dioxide, dry chemical, foam
Fire Hazards: On thermal decomposition, could emit carbon oxides and unidentified toxic fumes
Protective Equipment: Wear full protective gear including a self-contained breathing apparatus
Personal Precautions: Avoid contact with skin and eyes; prevent dust formation or inhalation of aerosols
Environmental Precautions: Prevent spill from entering drains, sewers, or waterways
Cleanup Methods: Absorb spills with inert material; clean area thoroughly with water and detergent. Dispose of contaminated materials according to regulations
Spill Response: Ensure adequate ventilation
Handling: Use in well-ventilated settings; avoid direct contact and use appropriate engineering controls; wear recommended protective gear
Storage: Maintain at controlled room temperature (20-25°C); protect from light and moisture; store in original container, tightly closed
Incompatibilities: Avoid exposure to strong oxidizers and high temperatures
Exposure Limits: Occupational exposure limit values are not established for pharmaceutical grade, but control via good laboratory practices
Respiratory Protection: Use NIOSH-approved respirator if airborne dust becomes an issue
Skin Protection: Chemical-resistant gloves required
Eye Protection: Safety glasses or chemical splash goggles
Engineering Controls: Use local exhaust or containment systems for bulk handling
Appearance: Fine, white to practically white, odorless, crystalline powder or suspension
Solubility: Practically insoluble in water; soluble in methanol, alcohol, chloroform
pH of Suspension: Typically ranges from 6.0 to 8.0 (depends on formulation)
Melting Point: 215–221°C
Molecular Weight: 416.5 g/mol
Vapor Pressure: Not appreciable at room temperature
Partition Coefficient (log P): 1.42
Stability: Stable under normal handling and storage conditions
Chemical Stability: Remains stable in original packaging away from heat, sunlight, moisture
Reactivity: Unreactive with most substances at room temperature
Hazardous Reactions: Does not undergo rapid dangerous reactions under standard use
Decomposition Products: Produces carbon monoxide, carbon dioxide, potentially toxic fumes on burning or decomposition
Incompatibilities: Strong oxidizing agents potentially degrade active compound
Acute Toxicity: LD50 data (specific animal models): Intravenous LD50 (mouse) estimated above 200 mg/kg
Possible Effects: Human overexposure linked to hyperglycemia, hypertension, mood changes, immune suppression, delayed growth in children
Sensitization: Reports of allergic and anaphylactoid reactions
Carcinogenicity: Not classed as carcinogenic by NTP, IARC, OSHA
Reproductive Toxicity: High doses may cause developmental toxicity and fetal growth restriction
Ecotoxicity: Methylprednisolone Acetate may cause harm to aquatic organisms at high concentrations
Persistence: Poorly biodegradable in water-based systems
Bioaccumulation Potential: Low to moderate in aquatic environments, does not significantly bioaccumulate
Mobility: Binds to particulate matter in soil and water, restricting movement
Aquatic Toxicity: Data suggest a no effect concentration at low parts per billion range in sensitive aquatic species
Waste Disposal: Dispose of unused product or waste by incineration or through a licensed pharmaceutical waste contractor
Container Disposal: Empty containers may retain product residue; dispose as hazardous waste
Environmental Precautions: Do not introduce into sewage systems, surface water, or soil
Special Instructions: Follow local, state, and federal regulations governing pharmaceutical disposal
UN Number: No specific UN designation under normal conditions
Shipping Name: Non-hazardous for transport under most regulatory frameworks
Transport Hazard Class: Not classified as dangerous goods
Packing Group: None assigned
Special Transport Instructions: Ship in secure, well-sealed packaging; protect from excessive heat and moisture; comply with carrier guidelines for pharmaceuticals
US Regulations: Listed as a prescription pharmaceutical under FDA oversight; subject to DEA controls depending on jurisdiction
International Inventory: Registered under appropriate pharmaceutical agency listings and international conventions
Workplace Controls: OSHA hazard communication standard applies where significant exposure possible; standard pharmaceutical handling procedures recommended
Labeling Requirements: Product labeling must provide complete safety and hazard information in accordance with FDA and international guidelines
Other Regulatory Status: Not subject to specific chemical hazard reporting under most environmental statutes; local variations may apply by state or country
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