The roots of methylprednisolone intermediates trace back to steroid research in the mid-20th century. Chemists were searching for synthetic alternatives to naturally occurring corticosteroids, driven by the need for more targeted treatments with fewer side effects. The journey involved painstaking organic synthesis—trial, error, and a huge reliance on empirical knowledge shared by lab teams in Europe and North America. The ambition to unlock new pharmacological pathways fueled a culture of discovery. Methylprednisolone intermediates became essential stepping stones, letting innovators bridge gaps between raw precursors and advanced steroids. These breakthroughs mattered not only to researchers in white coats but to patients waiting for solutions to autoimmune disorders and inflammatory conditions. Each improvement extended hope, not as academic progress, but as everyday impact for people struggling to manage disease.
Methylprednisolone intermediate has become a crucial material in preparing the final active pharmaceutical ingredient. It provides a vital link in manufacturing chains that shape key anti-inflammatory and immunosuppressive drugs. This intermediate is a dense, crystalline substance—created with precision, maintained with respect for purity standards that leave little room for shortcuts. The industry relies on this compound to launch production cycles that end with patient-ready medications. Quality in this intermediate shows up down the line—each gram matters, and manufacturers build trust through consistency and transparency. In my experience touring synthesis labs, technicians emphasize documentation and cross-lab checks, knowing their work’s significance ripples far beyond their benches.
Methylprednisolone intermediates show up as off-white solids, neither dusty nor sticky, each batch flowing with the right density. Chemical structure matters in every reaction step. Solubility stands in the moderate range for ethanol and acetone, creating a balancing act for process engineers. Molecular weight, melting point, and the presence of characteristic functional groups all demand attention. Even a faint excess of moisture throws off downstream yields, so facilities keep strict controls on humidity and temperature during storage. Any hint of impurity turns up quickly in quality control labs; gas chromatography and mass spectrometry track every little drift from the standard. The odd whiff of acetone or subtle earthy smell tells you the synthesis ran clean. Everyone handling these intermediates learns quickly how small variables shape outcomes in pharmaceutical chemistry.
Precision matters. Every vial or drum gets labeled with batch number, purity percentage, molecular formula, date of manufacture, shelf life, and maximum allowable storage temperature. Regulatory codes line the exterior, tracking each movement from synthesis to final use. The labeling acts both as a legal safeguard and as a logbook for future reference. Technicians demand clarity—no ambiguous terms or undocumented abbreviations. Analytical reports slip inside each shipment, usually attached to Certificates of Analysis. Compliance officers in the industry comment often on the importance of bridging good manufacturing practices and everyday safety. The clearer the paperwork, the fewer the mistakes, and the more confidence everyone feels down the line, from production to administration.
Chemists synthesize methylprednisolone intermediates through a well-planned combination of steroid backbone modifications: selective oxidation, reduction, and protection steps carried out in tightly controlled glass reactors. It starts from a core steroidal skeleton sourced from plant sterols. Operators load vessels according to strict standard operating procedures, reacting starting materials at defined temperatures and pressures using measured amounts of organic solvents and catalysts. Regular sampling gives a window into reaction progress—the right color shift, a reliable HPLC peak, a steady drop in reactant concentration. Crude product undergoes extra filtration, washings, and crystallization. Sometimes process bottlenecks mean tweaking reaction times or purities—decisions shaped by years of shared industry wisdom. Lab supervisors stress the need for disciplined cleaning and contamination prevention between shifts. The end result: a reproducible intermediate that lets downstream chemists focus on the finer synthetic steps ahead without wrestling with avoidable problems.
The magic of steroid intermediates comes from precise chemical manipulations. In methylprednisolone’s synthesis, chemists introduce alcohol and ketone groups at exact positions, shaping the molecule’s biological activity. Steps like selective reduction, halogenation, and protection of certain ring positions help define the unique attributes of the final active pharmaceutical. Each modification calls for careful reaction conditions: specific catalysts, reaction times, and purification techniques. These steps draw on decades of iterative development. Analytical teams rely on NMR spectroscopy, IR, and high-resolution LC-MS to pick up on even subtle by-products. Every cycle recognizes the molecule’s sensitivity to heat, light, and strong acids or bases. Modifications fine-tune the intermediate’s reactivity, enhancing its value for further industrial-scale synthesis and supporting the emergence of more effective steroids for clinical use.
In the pharmaceutical trade, methylprednisolone intermediate sometimes appears under related synonyms and product codes. Terms like “11β-Hydroxy steroid intermediate,” “Prednisolone derivative intermediate,” or internal lab numbers surface in technical sheets and procurement orders. Most suppliers also reference the CAS number, allowing supply chain teams to cross-match regulatory submissions and technical files across borders. Chemical wholesalers watch for synonym fatigue—a vendor listing too many aliases raises questions about authentication. In my own review of procurement records, tight control over product identity keeps counterfeits and near-miss deliveries at bay.
Consistent safety standards define successful operations. Handling methylprednisolone intermediates means using gloves, goggles, and clean coats, with regular handwashing breaks. Production floors use vented hoods and dedicated spill kits. Material safety data sheets sit right next to reagent cabinets. Repeated exposure carries risk—dermatitis from skin contact or respiratory issues if powders aerosolize. Companies regularly retrain technicians on spill protocols and first-aid response, a routine that inspires lasting confidence. Safety audits come as part of any compliance package, watched closely by internal and external teams alike. Safe operations don’t just keep workers healthy; by preventing product cross-contamination, they also uphold the reliability of finished pharmaceuticals.
Methylprednisolone intermediates feed straight into the production of glucocorticoid drugs, particularly those prescribed for severe inflammation, allergies, and autoimmune conditions. Hospitals depend on these therapies for fast-acting relief—think acute asthma attacks or lupus flare-ups—with research pointing to improved outcomes over earlier steroid generations. Pharmaceutical firms incorporate these intermediates into both oral and injectable forms, widening access for patients worldwide. Regulatory filings list them as essential in creating methylprednisolone and allied medications, anchoring product portfolios for some major global drug manufacturers. Treatment providers value the reliability of source intermediates, as patient health sometimes rides on the rapid delivery of these drugs to emergency rooms and clinics.
R&D teams remain focused on streamlining synthesis routes, minimizing solvent use, and reducing hazardous by-products. At international conferences, experts share challenges and breakthroughs: greener chemistry, automated purification, higher yielding reactions. Research groups examine molecular analogues, aiming to uncover intermediates that produce less toxic metabolites or offer improved absorption in the body. Recent advances in solid-phase synthesis also support the precision creation of modified intermediates—unlocking custom steroids previously stuck as theoretical possibilities. Clinical feedback trickles back to the lab, guiding chemists toward intermediates both efficient to make and flexible enough for scale-up. Investments in up-to-date analytical equipment boost reproducibility, a trait prized by regulatory authorities and supply chain partners alike.
Toxicologists continually monitor both acute and chronic risk profiles linked to steroid intermediates, including methylprednisolone derivatives. Inhalation and skin-contact studies provide real-world insight into how accidental exposure plays out on the manufacturing line. Long-term animal studies shed light on organ-specific toxicity, especially for compounds close to the active pharmaceutical end products. Regulatory dossiers must include robust toxicity data, proven through independent third-party labs whenever possible. This process isn’t just regulatory theater—it has led to real workplace changes, like updated fume hood designs and stricter cleanroom entry rules. Even low-level contamination in waste streams sparks mitigation plans, as regulators globally enforce tighter environmental limits on pharmaceutical residues.
Looking ahead, the demand for methylprednisolone intermediates will rise alongside growth in autoimmune and inflammatory diagnoses, with population aging and greater diagnostic sensitivity both playing a role. Manufacturers explore biocatalytic processes, turning to engineered microbes to run specific reaction steps with lower emissions and higher selectivity. The quest for sustainable steroid synthesis draws new minds into the field, connecting synthetic chemists with bioengineers and process safety experts. Digital quality systems help track each intermediate from batch to finished drug, reducing waste and speeding up recalls if problems pop up. Industry discussions now include transparent supply chains, finer-tuned analogues for unmet medical needs, and expanded access in geographies that have long faced drug shortages. With strong frameworks for safety, innovation, and environmental control already in place, there’s plenty of room both for technical progress and greater patient benefit.
Methylprednisolone Intermediate often starts its journey in the hands of chemical manufacturers. These substances never reach the pharmacy shelf, but their impact travels far beyond the lab. They act as the building blocks for steroids like methylprednisolone, a drug known to many families who deal with inflammation, autoimmune disorders, or severe allergies. The more I read about people facing aggressive immune conditions, the more I realize how vital that starting step in manufacturing can be for everyday lives.
You see the white tablets or clear injections with long chemical names. Behind them, chemists pour years of expertise into fine-tuning intermediate substances. Think of these intermediates like the foundation for a solid house; without a reliable structure, everything else collapses. For methylprednisolone, the intermediate compounds allow for precise synthesis, purity, and safety. Each step in the process affects how well the final medicine works in acute asthma attacks, lupus treatments, and swelling after surgery.
People living with chronic conditions often feel grateful for relief, but the process is not always visible. The pharma industry depends on these building blocks to avoid deadly shortages. In 2023, there were headlines about global shortages of corticosteroids, which put people at risk of hospitalization from routine conditions. High standards in handling intermediates make the difference between consistent supply and empty pharmacy shelves.
I think about my own relatives with asthma and rheumatoid arthritis. During hard seasons, something as simple as one missed dose of a steroid can mean a trip to the ER. The dependability of methylprednisolone starts long before the doctor scribbles a prescription; it begins with these initial chemical steps.
Producing intermediates is not risk-free. Shortcuts in manufacturing create the potential for impurities, which can end up in the drugs taken by vulnerable people. Strict regulation helps but requires constant attention. In recent years, greater transparency and standardized checks have reduced major problems, but the threat doesn’t disappear. I have seen news about contamination making its way into medicines, causing recalls and public mistrust.
One clear step involves tighter collaboration between chemical plants and finished-product manufacturers. Open data reporting, batch traceability, and third-party audits help. In 2022, a handful of companies introduced blockchain to track the movement and changes in intermediates. The more accessible this technology becomes, the easier it gets for independent groups to verify purity. This kind of oversight protects both the end user and the reputation of the companies involved.
As demand for corticosteroids grows in countries facing rapid population changes, scalable and safe sourcing of intermediates plays a new role in public health planning. Forward-thinking companies have started training their chemists in specialized safety protocols and transparency. Smaller manufacturers often learn best practices directly from international forums or partnerships with university research teams.
Methylprednisolone intermediate remains mostly invisible to patients but stands as a silent pillar in modern medicine. A steady focus on quality, accountability, and investment in smarter systems transforms these chemical ingredients into the therapies people count on every day.
Taking steroids like methylprednisolone can change the way you feel both physically and emotionally. I’ve seen people use them to treat things such as asthma, arthritis pain, or severe allergic reactions. My own family turned to this medication after a rough ER visit for a flare-up. Relief came fast, but so did an awareness that the medication was doing more behind the scenes.
Most folks notice changes during the first days. Hungry? That appetite ramp goes way up. Many talk about stomach discomfort, that gnawing, unsettled feeling after every meal. Sleep can take a hit — lying awake, mind racing well past midnight. Some find themselves much more irritable or experience mood swings they can’t explain. Over time, these shifts can wear someone down, both at home and at work.
Fluid retention can leave people puffier, especially in the face and hands. If you’re keeping an eye on the bathroom scale, those extra pounds can creep up fast. It’s not just water weight but actual changes in how the body processes salts and sugars. Doctors will often mention the risk of blood sugar spikes, which matters a lot to anyone managing diabetes already. Infections tend to stick around longer due to how methylprednisolone keeps the immune system in check.
Extended or high-dose use brings a heavier load. I’ve read stories in medical literature and heard from patients about the jolt their blood pressure took, or just feeling their heart thumping harder than usual. Eyesight sometimes blurs, or people notice new headaches that feel nothing like what they had before. Bony aches set in, and long-term users need to look out for osteoporosis. The bones weaken, making falls dangerous.
For teens and kids, growth can slow down. These medications aren’t gentle on the body’s natural hormones, so the list includes rare but serious effects, like Cushing's syndrome, seen in those with extended use. That moon-shaped face and skin changes are hard to hide, both for adults and kids.
If anyone needs to use methylprednisolone, it pays to talk with a healthcare provider about the trade-offs. Ask what side effects could appear within days and which ones to watch out for months down the road. Blood work might need more frequent scheduling to catch shifts before they become a crisis.
Eating foods high in potassium and low in salt can make the process smoother. Bringing in a dietitian, if possible, helps with meal planning, especially with cravings running wild. Moderate exercise keeps bones and muscles in better shape, even during short bursts of treatment. Some people keep journals to notice patterns or mood changes, sharing them with their care team to spot trouble sooner.
Pharmacists stand as a solid resource. They pick up on patterns—mixing with other drugs, or reactions you might miss. Don’t feel shy about reaching out if anything feels off. Methylprednisolone does bring relief, but knowing about its baggage helps everyone handle surprises and stay in control of their health.
Every chemical compound brings its own set of quirks. Methylprednisolone intermediates are no different. They play an uncovered but crucial role in the manufacturing of certain corticosteroid medications. Laboratories and manufacturers rely on them to keep life-saving drugs rolling out of factories and into pharmacies. If these intermediates break down or lose potency, public health can take a direct hit. Years spent around labs have taught me that the devil really lurks in the details—most problems begin with something as ordinary as how a jar gets stored at the end of a shift.
Every reference guide and seasoned chemist points to temperature as the main culprit behind chemical instability. Methylprednisolone intermediates prefer cool, dry conditions. Warm, humid air shortens their shelf life and triggers unwanted reactions that no one wants during later drug synthesis. Simple investment in a climate-controlled storage area saves thousands in ruined materials, not to mention keeping drug quality consistent.
Humidity can sneak into containers and start changing the compound’s integrity without anyone noticing for months. Desiccators and silica gel packets turn into frontline defenders against moisture. Manufacturers place a high value on controlling water intrusion because I’ve seen the headaches it causes during quality checks.
Direct light, especially sunlight, speeds up chemical degradation. Many storage containers use amber glass or opaque plastics for a reason. Over the years, I’ve learned a lesson: It only takes a few hours of bright sunlight to ruin a batch. Shelving should never face a window. Even overhead lab lighting sometimes causes slow changes if storage goes on too long. So, a dark, enclosed storage system keeps the compound stable far longer.
Oxygen exposure acts as another quiet destroyer. Compounds with sensitive structures, like methylprednisolone intermediates, need tight lids and minimal headspace in their containers. In my years handling powder and liquid intermediates alike, I’ve watched oxidation slip in and compromise an otherwise perfect batch. Vacuum-sealed or nitrogen-purged bottles raise the game for long-term storage. Not every facility can spring for high-end systems, but even basic airtight containers beat open flasks every time.
Material choice for containers deserves attention. Glass rarely reacts with its contents, which keeps it the go-to option. Plastic sometimes makes sense if transportation matters more than longevity. Still, the goal always stays the same: keep the environment inside the container as unchanged as possible from day one to the day it's used.
Good habits matter just as much as fancy equipment. Labels with clear expiry dates, lot numbers, and storage instructions cut down on avoidable mistakes. Over the years, I’ve walked into storerooms where haphazard stacks and missing labels created confusion and waste. A digital inventory system brings order—at a glance, you see which batch needs to go next. Fewer errors mean a steady supply of high-quality materials ready for production.
Many facilities stick to what worked last year, even as best practices keep moving forward. Regular staff training on storage protocol does more than anything to cut down on loss. Monitoring for temperature spikes or accidental exposure to light picks up problems before materials get used in drug manufacturing. Adding some redundancy—a backup fridge, or two sets of humidity meters—keeps the operation moving even during equipment breakdowns.
Cutting corners with storage puts everyone at risk. Proper care for methylprednisolone intermediates underpins the reliability of important corticosteroid medicines. The effort spent getting this right never goes to waste; it supports the safety, potency, and availability of drugs millions rely on every day.
Methylprednisolone intermediate refers to an anti-inflammatory corticosteroid used for various conditions like asthma flare-ups, severe allergic reactions, and autoimmune disorders. This medication acts as a steroid that calms the immune system and eases symptoms. Clear, practical guidance about its dosage matters because even small variances in steroid doses affect both effectiveness and risk of unwanted effects. Without careful dosing, patients face serious concerns, including blood sugar swings, mood changes, and poor infection defense.
Doctors often prescribe methylprednisolone based on the condition being treated. For most adults dealing with moderate inflammation or allergic responses, daily doses range from 16 to 48 milligrams. Many physicians start higher for acute flares—say, 32 milligrams split twice a day, then step down to 4 to 8 milligrams per day. Short courses (three to five days) demand less caution about gradual tapering, but any plan longer than a week usually means slowly cutting back over time to let the body’s own steroid production recover.
Children pose a different challenge entirely. Their bodies process drugs at different rates, and steroids in growing children threaten bone health and normal growth. Pediatricians rely on weight-based dosing: around 0.5 to 2 milligrams per kilogram per day. It’s standard to give the dose in one or two divided administrations, not to disrupt the sleep cycle or cause behavioral troubles. Open communication with a pediatrician never fails—constant tracking lets families and doctors spot side effects and adjust as needed.
Older adults, people with diabetes, and anyone struggling with kidney or liver conditions fall into higher-risk categories. Methylprednisolone, like many steroids, lifts blood sugar and blood pressure unpredictably. For these groups, starting at the lowest effective dose usually wins the day. Doctors often ask for frequent check-ins and regular bloodwork, catching complications before they cause real harm. Lower starting doses—perhaps 16 mg per day or lower—can still bring improvement without excess risk.
Too much methylprednisolone causes trouble—weight gain, mood swings, weak bones, muscle loss, and brittle skin. Not enough means the drug won’t work. For those facing long-term use or high doses, daily habits deserve special attention. Ensuring plenty of calcium and vitamin D, staying active, and tracking blood sugar all lower the odds of steroid-related disease. It’s easy to fall into the trap of thinking that a higher dose speeds recovery, but decades of experience show that the lowest effective dose, for the shortest time possible, always lines up with fewer side effects and better quality of life.
Doctors choose methylprednisolone dosages based on factors like severity, age, body size, and existing conditions. Direct conversations, honest feedback about symptoms, and follow-up lab tests guide these choices. Trust in a doctor’s guidance changes the long-term outlook, helping patients steer clear of side effects and get the relief they need. Always ask questions and don’t adjust doses alone, no matter how the body feels on a given day. Responsible dosing, regular monitoring, and strong doctor-patient relationships turn this powerful drug into a reliable tool, not a risk.
Methylprednisolone is part of a family of steroids doctors reach for to reduce inflammation fast. Anyone with asthma or arthritis might know this name, since it often turns up on a prescription slip when something flares up. The 'intermediate' part points to how long the medicine acts in the body, not to any special access rules.
Walk into a pharmacy and ask for Methylprednisolone without a prescription, most pharmacists will shake their heads. Across the United States and many countries, steroids count as controlled substances. Regulators keep them behind the counter for good reason—taken without careful guidance, these drugs can trigger infection, high blood pressure, blood sugar swings, and mood changes. Some people might push against those rules, searching online or in less-regulated markets. This hunt puts health at risk, as pills from uncertified sources could turn out fake or contaminated.
This drug packs a punch. In my own circle, I've seen what a difference a short course can make for a friend with bad eczema. But that same fast-acting power means a doctor needs to monitor every dose. People sometimes forget that high-dose steroids can lead to withdrawal issues or cause bone thinning if abused over months. That's not just textbook talk; one relative grew dependent, taking leftover pills from a dental procedure, and had to work with her doctor for weeks to taper safely.
The digital age lets buyers sidestep traditional pharmacy walls, especially as websites spring up with claims that sound tempting. Yet the United States Food and Drug Administration warns that any seller offering prescription steroids without asking for a valid script breaks the law. In some countries, regulations appear looser—travelers have shared stories online about picking these up at pharmacy counters in parts of Asia or Latin America. Still, border customs can confiscate those pills, and doctors have no way to follow up on side effects or misuse.
Methylprednisolone is not Tylenol. Its effects run deep, influencing metabolism, immune response, and even mental health. The CDC and National Institutes of Health report that misuse adds to hospitalization rates and feeds antibiotic resistance through unintentional immune system suppression. Just a single error in self-dosing can cause blood pressure to spike or mask an infection planning to spiral out of control.
Expanding awareness about steroid safety should sit at the top of health priorities. Pharmacies and clinicians have started sharing clearer information about the risks for people juggling multiple medicines. Telehealth could help rural or mobility-challenged patients get supervised prescriptions instead of reaching for risky online sources. Insurance programs strengthening coverage for chronic conditions can limit the urge to hoard old medication. Supporting open communication ensures people know what’s in their pill, what dose works best, and when side effects should spark concern.
While a quick fix looks appealing, the lasting impact of steroid misuse isn't worth that gamble. Methylprednisolone earns respect and a gatekeeper for good reason. Smart use follows clear guidance, respectful of both the body’s power and what modern medicine can offer.
| Names | |
| Preferred IUPAC name | (6α,11β)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione |
| Other names |
6α-Methylprednisolone
6α-Methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione |
| Pronunciation | /ˌmɛθ.ɪl.prɛdˈnɪs.əˌloʊn ɪn.təˈmiː.di.ət/ |
| Preferred IUPAC name | (6α,11β)-11,17,21-Trihydroxy-6-methylpregn-1,4-diene-3,20-dione |
| Other names |
Methylprednisolone EP Impurity M
6α-Methylprednisolone |
| Pronunciation | /ˌmɛθɪlprɛdˈnɪsəˌloʊn ˌɪntərˈmiːdiət/ |
| Identifiers | |
| CAS Number | 63731-95-7 |
| Beilstein Reference | 3984442 |
| ChEBI | CHEBI:6930 |
| ChEMBL | CHEMBL1201290 |
| ChemSpider | 172905 |
| DrugBank | DB00959 |
| ECHA InfoCard | ECHA InfoCard: 100.007.328 |
| EC Number | 211-861-5 |
| Gmelin Reference | Gmelin Reference: 83238 |
| KEGG | C00214 |
| MeSH | D008789 |
| PubChem CID | 12044404 |
| RTECS number | OA1750000 |
| UNII | T666739B6D |
| UN number | UN3272 |
| CAS Number | 14899-36-6 |
| 3D model (JSmol) | `6-chloro-11β,17-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione` |
| Beilstein Reference | 2361040 |
| ChEBI | CHEBI:6888 |
| ChEMBL | CHEMBL1200693 |
| ChemSpider | 21809137 |
| DrugBank | DB00959 |
| ECHA InfoCard | echa.europa.eu/substance-information/-/substanceinfo/100.033.303 |
| EC Number | 211-234-5 |
| Gmelin Reference | Gmelin Reference: 83355 |
| KEGG | C07176 |
| MeSH | D008770 |
| PubChem CID | 12560 |
| RTECS number | OA1750000 |
| UNII | RC7Z5Y384O |
| UN number | 2811 |
| CompTox Dashboard (EPA) | DTXSID5020462 |
| Properties | |
| Chemical formula | C22H30O5 |
| Molar mass | 416.49 g/mol |
| Appearance | white or almost white crystalline powder |
| Odor | Odorless |
| Density | 1.32 g/cm³ |
| Solubility in water | Insoluble in water |
| log P | 1.96 |
| Acidity (pKa) | 12.59 |
| Basicity (pKb) | 12.75 |
| Refractive index (nD) | 1.506 |
| Dipole moment | 2.56 D |
| Chemical formula | C22H30O5 |
| Molar mass | 374.47 g/mol |
| Appearance | White or almost white crystalline powder |
| Odor | Odorless |
| Density | 1.32 g/cm³ |
| Solubility in water | Insoluble in water |
| log P | 1.87 |
| Acidity (pKa) | pKa = 12.59 |
| Basicity (pKb) | 13.96 |
| Magnetic susceptibility (χ) | Magnetic susceptibility (χ): -7.5e-7 |
| Refractive index (nD) | 1.527 |
| Dipole moment | 3.1072 Debye |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 311.2 J·mol⁻¹·K⁻¹ |
| Std molar entropy (S⦵298) | 386.5 J·mol⁻¹·K⁻¹ |
| Pharmacology | |
| ATC code | H02AB04 |
| ATC code | H02AB04 |
| Hazards | |
| Main hazards | May cause respiratory irritation. May cause damage to organs through prolonged or repeated exposure. |
| GHS labelling | GHS05, GHS07 |
| Pictograms | GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H319: Causes serious eye irritation. |
| Precautionary statements | P264, P270, P272, P280, P302+P352, P333+P313, P362+P364, P501 |
| Flash point | 135°C |
| Lethal dose or concentration | LD50 (Rat, oral): > 2000 mg/kg |
| LD50 (median dose) | 1898 mg/kg (Rat, oral) |
| NIOSH | DNF |
| PEL (Permissible) | 15 mg/m³ |
| REL (Recommended) | 16 mg |
| IDLH (Immediate danger) | Not Established |
| GHS labelling | GHS02, GHS07 |
| Pictograms | GHS05,GHS07 |
| Signal word | Warning |
| Hazard statements | H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation. |
| Precautionary statements | Precautionary statements: P260, P264, P270, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P308+P313, P314, P321, P330, P332+P313, P362+P364, P405, P501. |
| NFPA 704 (fire diamond) | 1-1-0 |
| Flash point | 134.2°C |
| LD50 (median dose) | LD50 (median dose): Mouse (oral) 1100 mg/kg |
| NIOSH | NA |
| PEL (Permissible) | 6 mg/m³ |
| REL (Recommended) | 24 mg |
| Related compounds | |
| Related compounds |
Prednisolone
Methylprednisolone Hydrocortisone Prednisone Dexamethasone |
| Related compounds |
Prednisolone
Hydrocortisone Methylprednisolone Prednisone Cortisone |
Providing high-quality chemical products and logistics solutions for global trade partners.
