Product Name: Methylprednisolone Intermediate
Chemical Formula: C22H30O5 (subject to specific intermediate structure)
Synonyms: Prednisolone derivative, Methylprednisolone precursor
Recommended Use: Pharmaceutical synthesis
Supplier: Chemical manufacturer or pharmaceutical raw material distributor
Contact Information: Phone number, email, and address for safety support
Emergency Phone: 24/7 emergency hotline
CAS Number: Refer to actual intermediate as it can differ; for base methylprednisolone: 83-43-2
Classification: May cause skin and eye irritation, potential for respiratory sensitivity, not classified as carcinogenic by IARC
GHS Label Elements: Exclamation mark symbol, warning
Hazard Statements: Causes mild to moderate irritation, may cause allergic reaction in sensitive individuals, dust may cause respiratory discomfort
Precautionary Statements: Avoid inhalation, avoid direct contact with skin and eyes, handle with gloves and eye protection
Health Hazards: Irritation on repeated exposure, accidental ingestion may affect endocrine system
Main Constituents: Specify methylprednisolone intermediate structure as per synthesis
Chemical Identity: Synthetic corticosteroid intermediate (detailed structure defined by batch)
Impurities: Residual solvents from synthesis process such as acetone, methanol, or ethyl acetate typically under 0.5%
Active Ingredient Concentration: 98% or greater by weight as verified in certificate of analysis
Additives: None for intermediates intended for further processing
Inhalation: Remove person to fresh air, provide oxygen if breathing becomes difficult, seek medical attention
Skin Contact: Wash area thoroughly with soap and water, remove contaminated clothing, seek medical attention if irritation persists
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, seek medical help if discomfort continues
Ingestion: Rinse mouth, do not induce vomiting, observe for symptoms such as nausea or dizziness, consult physician as soon as possible
Suitable Extinguishing Media: Foam, dry chemical powder, carbon dioxide, water spray for larger fires
Unsuitable Extinguishing Media: High-pressure water jet, which may spread powdered material
Specific Hazards: Combustion may produce toxic fumes including carbon monoxide, carbon dioxide, and other organics
Personal Protective Equipment: Wear self-contained breathing apparatus, protective clothing, gloves, and goggles
Fire Response: Remove containers from fire zone if safe, suppress dust formation, keep area ventilated
Personal Precautions: Put on appropriate respirator, chemical-resistant gloves, goggles, coveralls
Environmental Precautions: Prevent spillage into drains, watercourses, and soil
Clean-up Methods: Contain and collect spillage with non-sparking tools, use absorbent material for liquid, sweep or shovel solid material into labeled containers
Disposal: Dispose in accordance with local, state, and national regulations
Safe Handling: Operate in a well-ventilated area, keep away from food, drink, and animal feed, avoid dust formation, limit direct handling
Storage Conditions: Store in a cool, dry, well-ventilated place, protect containers from sunlight, moisture, and temperature extremes
Incompatible Materials: Strong oxidizers such as nitric acid and peroxides, acids and alkalis
Packaging Materials: High-density polyethylene or glass containers preferred, tightly sealed
Engineering Controls: Use local exhaust ventilation, containment systems for dusty operations
Personal Protective Equipment: Nitrile or neoprene gloves, splash-proof safety goggles, laboratory coat or coveralls, NIOSH-approved dust mask or respirator for powder handling
Hygiene Measures: Wash hands before eating or drinking, remove contaminated clothing and clean it before reuse
Exposure Limits: No established occupational exposure limit, handle as low as reasonably practicable
Appearance: White to off-white crystalline powder
Odor: Nearly odorless
Melting Point: Range depends on intermediate, typically 190°C to 220°C
Boiling Point: Decomposes before boiling
Solubility: Very slightly soluble in water, soluble in organic solvents like ethanol or acetone
pH: Not applicable (solid form)
Flash Point: Not determined, but expected to be above 150°C
Vapor Pressure: Negligible at ambient temperature
Density: About 1.2–1.3 g/cm³
Partition Coefficient (log Pow): Not determined for intermediate, reference methylprednisolone log Pow ~1.5
Chemical Stability: Stable under normal conditions of use and storage
Conditions to Avoid: Exposure to heat, sunlight, humidity, open flames
Incompatible Materials: Strong oxidizing agents, strong acids or bases
Hazardous Reactions: No significant reactivity hazards reported
Decomposition Products: Under fire conditions may release CO, CO₂, and potentially toxic organics
Likely Routes of Exposure: Inhalation, skin and eye contact
Acute Toxicity: Data limited; corticosteroid intermediates generally have low oral and dermal toxicity in laboratory animals
Skin Irritation: Possible mild to moderate irritation with prolonged or repeated exposure
Eye Irritation: May cause discomfort, redness, or watering
Sensitization: Potential to cause allergic reaction in sensitive individuals
Chronic Effects: Overexposure may impact hormone regulation, liver or kidney in high doses
Carcinogen Status: Not listed as carcinogenic by OSHA, IARC, NTP
Aquatic Toxicity: Limited data; expected to be low toxicity to aquatic life at relevant concentrations
Persistence and Degradability: Moderately persistent in the environment, breaks down slowly under environmental conditions
Bioaccumulative Potential: Likely low due to modest fat solubility
Mobility in Soil: Low, binds to organic matter
Other Harmful Effects: Avoid uncontrolled release, which may contribute to local ecotoxicity
Waste Treatment Methods: Dispose through licensed chemical waste contractor
Waste Code: Not specifically listed; follow local pharmaceutical intermediate guidelines
Packaging Disposal: Rinse and treat containers as hazardous unless thoroughly cleaned
Precautions: Do not release to environment, avoid burning except in chemical incinerators equipped with afterburners and scrubbers
UN Number: Not classified as a dangerous good for transport according to UN criteria
Proper Shipping Name: Methylprednisolone intermediate or as specified by regulatory agency
Transport Hazard Class: Not assigned
Packing Group: Not applicable
Marine Pollutant: Not designated
Special Transport Precautions: Prevent container damage, minimize exposure during transport
International Regulations: Not listed as controlled substance under the major conventions
Inventory Listings: Not applicable to all chemical intermediates, confirm with local or regional authorities
OSHA Hazard Communication: Hazardous chemical as per OSHA Hazard Communication Standard
SARA Title III: Not categorized under extremely hazardous substances
California Proposition 65: Not listed
Other Local Regulations: Always refer to regional chemical safety and environmental laws
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