Product Name: Mometasone Furoate
Chemical Formula: C27H30Cl2O6
Synonyms: Mometasone, 9α,21-dichloro-16α-methyl-1,4-pregnadiene-11β,17α-diol 17-(2-furoate)
Molecular Weight: 521.43 g/mol
Supplier Details: Manufacturer’s address, emergency contact number, email address for technical questions
Recommended Use: Pharmaceutical corticosteroid, topical anti-inflammatory agent
GHS Classification: Not classified as hazardous under normal pharmaceutical use, but may be harmful if inhaled or ingested in larger quantities
Signal Word: Warning
Hazard Statements: Irritant to eyes, skin, and respiratory tract; May cause allergic reactions in sensitive individuals; Prolonged exposure can affect adrenal function
Precautionary Statements: Avoid contact with skin and eyes; Use personal protective equipment; Do not breathe dust
Pictograms: Exclamation mark symbol
Chemical Name: Mometasone Furoate
CAS Number: 83919-23-7
Purity: ≥98%
Impurities: May contain trace solvents used in synthesis
Other Components: None typically present in raw material; formulated products may include excipients like propylene glycol, microcrystalline cellulose, or mineral oil (refer to product-specific MSDS)
Eye Contact: Rinse cautiously with water for at least 15 minutes; seek medical advice if irritation persists
Skin Contact: Wash exposed skin with plenty of water and soap; remove contaminated clothing; medical attention for discomfort or rash
Inhalation: Remove person to fresh air; administer oxygen if breathing is difficult; obtain medical attention for any respiratory symptoms
Ingestion: Rinse mouth thoroughly; do not induce vomiting unless advised by medical personnel; seek immediate medical attention
Most Important Symptoms/Effects: Eye, skin, and airway irritation; hypersensitivity reactions; systemic absorption can impact hormone regulation
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide
Specific Hazards Arising from Chemical: May release chlorine-containing and other toxic gases upon decomposition
Special Protective Equipment: Wear self-contained breathing apparatus and full protective gear to avoid dust, toxic fumes
Firefighting Procedures: Move containers from fire area if not hazardous; cool exposed containers with water spray to prevent rupture
Combustion Products: Carbon monoxide, carbon dioxide, hydrochloric acid, furan derivatives
Personal Precautions: Use appropriate personal protection including gloves, goggles, and mask; avoid generation and breathing of dust
Environmental Precautions: Prevent entry into sewers, drains, water courses; minimize area contamination
Methods for Cleaning Up: Moisten spilled material to suppress dust; carefully scoop or vacuum up and place in suitable container for proper disposal; thoroughly clean area with water and detergent
Decontamination Steps: Wash site after removal, ventilate space, check for residual contamination
Precautions During Handling: Minimize dust generation; avoid skin and eye contact; do not ingest or inhale
Advice on Safe Handling: Only handle in well-ventilated areas; use personal protection as indicated; avoid release into environment
Storage Conditions: Store tightly closed in original container, away from heat, light, and moisture; designated controlled-access facility for pharmaceutical compounds
Incompatible Materials: Strong oxidizing agents, acids, bases; avoid contact with incompatible substances to prevent reaction
Occupational Exposure Limits: No official occupational exposure limit established; use pharmaceutical industry guidance for airborne corticosteroid dusts
Engineering Controls: Ventilation systems, dust extraction, process enclosure to minimize airborne exposure
Personal Protective Equipment: Chemical-resistant gloves, lab coat, safety goggles, dust mask or respirator if dust is generated
Hygiene Measures: Wash hands thoroughly after handling; do not eat, drink, or smoke in work area; remove contaminated clothing and clean before reuse
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH (solution): Not available
Melting Point: 220-225 °C (decomposition above 230 °C)
Boiling Point: Decomposes before boiling
Flash Point: Not determined
Solubility: Practically insoluble in water; soluble in methanol, acetone, chloroform
Partition Coefficient (log Pow): Approximately 4.1 (octanol/water)
Vapor Pressure: Negligible at room temperature
Density: Not available
Stability: Stable under normal storage and handling conditions
Chemical Stability: Stable under recommended storage conditions; avoid high humidity, excessive heat, strong light
Possibility of Hazardous Reactions: No dangerous reactions known under standard use; reacts with strong oxidizers
Conditions to Avoid: Direct sunlight, heat sources, high humidity
Incompatible Materials: Oxidizers, strong acids, alkalis
Hazardous Decomposition Products: Chlorine-containing compounds, carbon oxides, furanic derivatives
Likely Routes of Exposure: Skin, eyes, inhalation, ingestion
Potential Health Effects: Eye and skin irritation; allergic reactions; suppresses hypothalamic-pituitary-adrenal axis in excessive exposure or misuse; chronic exposure may impair immune function
LD50 (oral, rat): Not precisely established; estimated >500 mg/kg
Mutagenicity: Data shows no clear evidence of genotoxicity in standard studies
Carcinogenicity: Not classified as carcinogenic to humans, no strong evidence in animal studies
Reproductive Toxicity: At high doses, may affect fetal growth based on animal data
Ecotoxicity: Not expected to be acutely toxic to aquatic life at environmental concentrations used in pharmaceutical contexts; chronic exposure effects unknown
Persistence and Degradability: Degrades slowly in the environment; photodegradation possible; not readily biodegradable in standard tests
Bioaccumulative Potential: Moderate potential due to lipophilicity
Mobility in Soil: Low water solubility, may adsorb to soil particles
Other Adverse Effects: May contribute trace endocrine disruption in aquatic systems
Disposal Methods: Incinerate at authorized facility in accordance with local, state, federal, and international regulations; avoid discharge into environment
Container Disposal: Triple rinse containers prior to reuse or disposal; follow hazardous waste handling procedures
Special Considerations: Pharmaceutical waste requires controlled disposal; consult appropriate environmental authorities for guidance
UN Number: Not assigned, not classified as hazardous for transport under international regulations
Proper Shipping Name: Not regulated; if formulated with solvents or flammable materials, refer to individual MSDS
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions for User: Ship in sealed containers; avoid conditions leading to container rupture; keep detailed documentation for customs and regulatory inspections
Labeling Requirements: Product label must display hazard and precautionary statements, supplier identification, emergency contact; pharmaceutical use governed by prescription laws
International Regulation: Subject to controlled substance and medicine approvals in most regions; not listed under major chemical inventory control lists such as TSCA or REACH for active ingredients
Other Regulatory Information: Workplace exposure governed by OSHA, EU-specific workplace guidelines, U.S. EPA reporting for manufacturing/disposal; follow all local, regional, and national requirements
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