Material Safety Data Sheet for N-T-Butyl-4-Aza-5-Alpha-Androsta-3-One-17Beta-Carboxamide

Identification

Product Name: N-T-Butyl-4-Aza-5-Alpha-Androsta-3-One-17Beta-Carboxamide
Chemical Formula: C23H36N2O2
Synonyms: Abiraterone Intermediate, Steroidal Carboxamide
Recommended Use: Pharmaceutical intermediate, research chemical
Supplier: Manufacturer or distributor contact info including name, address, and telephone number
Emergency Telephone: 24-hour emergency response number from a recognized authority or local poison control

Hazard Identification

Classification: Eye irritant, skin irritant, may cause respiratory irritation
Signal Word: Warning
Hazard Statements: Causes mild to moderate irritation to eyes and skin, possible risk of respiratory tract irritation, harmful if swallowed in large quantities
Pictograms: Exclamation mark, health hazard
Precautionary Statements: Wash hands thoroughly after handling, avoid inhalation of dust, keep away from food and drink

Composition / Information on Ingredients

Chemical Name: N-T-Butyl-4-Aza-5-Alpha-Androsta-3-One-17Beta-Carboxamide
CAS Number: 154229-18-2
Concentration: 98% or higher (as specified by supplier)
Impurities/Additives: None of toxicological significance
Molecular Weight: 372.54 g/mol

First Aid Measures

Inhalation: Remove exposed individuals to fresh air, keep at rest, seek medical attention if symptoms appear
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, seek medical attention for persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek medical advice
Ingestion: Rinse mouth, seek prompt medical attention, do not induce vomiting unless directed by medical personnel
Most Important Symptoms: Redness, irritation, possible burning sensation, coughing, difficulty breathing (in severe cases)
Notes for Physician: Treat symptomatically, monitor for respiratory distress

Fire-Fighting Measures

Suitable Extinguishing Media: Carbon dioxide, dry chemical, foam, water spray
Unsuitable Media: Direct water stream can spread powdered material
Hazardous Combustion Products: Oxides of carbon, nitrogen compounds, possible toxic fumes
Protective Equipment: Firefighters wear full protective gear, self-contained breathing apparatus
Firefighting Instructions: Move containers from fire area if safe, cool with water spray to prevent overheating, avoid inhalation of fumes

Accidental Release Measures

Personal Precautions: Avoid breathing dust, ventilate area, wear protective equipment including gloves, goggles, and mask
Environmental Precautions: Prevent entry into waterways, drains, sewers
Cleanup Methods: Carefully collect spilled material, sweep up and place in container for disposal, wash area with water after material pickup
Disposal of Contaminated Material: Dispose of in accordance with local regulations, avoid raising dust during cleanup

Handling and Storage

Handling: Use only in well-ventilated areas, minimize dust generation and accumulation, use personal protective equipment, wash hands after handling
Storage: Keep container tightly closed, store in a cool dry place, protect from moisture and direct sunlight, segregate from strong oxidizers and incompatible substances
Incompatibles: Strong acids, strong bases, oxidizing agents
Hygiene Measures: Do not eat, drink, or smoke in area where product is handled, wash thoroughly before breaks and after use

Exposure Controls and Personal Protection

Engineering Controls: Adequate ventilation, use fume hood or local exhaust, avoid formation of airborne dust
Personal Protection: Protective gloves, lab coat, chemical safety goggles, mask or respirator if dust may be inhaled
Exposure Limits: No occupational exposure limits established, handle as potentially hazardous material
Environmental Controls: Use appropriate equipment to avoid environmental contamination, prevent release to water bodies

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless or faint organic smell
pH: Not applicable (solid)
Melting Point: 178-184°C
Boiling Point: Not determined; decomposes before boiling
Solubility: Insoluble in water, soluble in ethanol and organic solvents
Vapor Pressure: Negligible at room temperature
Density: Approx. 1.2 g/cm³
Flash Point: Not relevant (solid)
Partition Coefficient (log Kow): Not determined
Viscosity: Not applicable

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions, no known dangerous reactions under normal use
Reactivity: No dangerous reactions known
Conditions to Avoid: Excessive heat, sources of ignition, exposure to high humidity, direct sunlight
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, hydrogen cyanide under combustion

Toxicological Information

Acute Toxicity: Data not fully available, based on similar compounds, may cause minor irritation or gastrointestinal distress
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Symptoms: Eye or skin irritation, coughing, nausea, mild respiratory discomfort
Chronic Exposure: No detailed studies, handle as potentially hazardous, repeated exposure may lead to sensitization
Carcinogenicity, Mutagenicity, Reproductive Effects: Not classified as carcinogenic, mutagenic, or toxic for reproduction due to lack of data

Ecological Information

Ecotoxicity: Not expected to be acutely toxic to aquatic organisms, avoid release to environment
Persistence and Degradability: Data lacking, likely to persist in environment due to low water solubility
Bioaccumulation Potential: Not expected to bioaccumulate significantly, based on physical properties
Mobility in Soil: Low mobility due to insolubility in water
Other Adverse Effects: No other known ecological impacts

Disposal Considerations

Waste Treatment Methods: Dispose of contents and container in accordance with local, regional, national, and international regulations
Product Disposal: Incinerate in a chemical incinerator equipped with afterburner and scrubber or send to authorized chemical waste facility
Contaminated Packaging: Containers should be emptied completely, and disposed of safely
Sewage Disposal: Do not discharge into drains, surface water, or ground water

Transport Information

UN Number: Not classified as hazardous for transport
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant, but avoid bulk release to waterways
Special Precautions for User: Transport in closed, upright, and secure containers to prevent leaks

Regulatory Information

Safety, Health, and Environmental Regulations: Not listed by major chemical registries or toxic substance lists
Workplace Control Standards: No occupational exposure limits established, suggested monitoring and use of PPE where exposure is possible
Other Regulations: Users should comply with all applicable national, regional, and local laws regarding this substance; refer to industry-specific handling and safety practices
Labeling Requirements: Label all containers clearly with product name, hazards, and handling instructions
Chemical Inventory Status: Check with regional inventories such as TSCA (US), REACH (EU), or other regulatory bodies for current status