Product Name: Penfluridol
Chemical Formula: C28H27ClF5NO
CAS Number: 26864-56-2
Synonyms: Semap, Longoperidol
Intended Use: Antipsychotic agent, research chemical reference
Manufacturer Information: Supplied by pharmaceutical and laboratory chemical manufacturers. Contact supplier for further assistance.
Emergency Contact: Check the manufacturer’s data. Most safety concerns should be directed to local poison control and emergency response teams in case of exposure.
GHS Classification: Toxic if swallowed (Acute Toxicity, Oral, Category 3), Skin and Eye Irritant, Possible Reproductive Toxicant
Signal Word: Danger
Hazard Statements: Causes serious eye irritation, harmful if inhaled, can damage fertility or unborn child, may cause drowsiness or dizziness
Pictogram: Health hazard symbol, exclamation mark
Precautionary Statements: Avoid contact with skin and eyes, do not breathe dust or vapors, wash hands thoroughly after handling, use only outdoors or in well-ventilated area, wear suitable gloves and eye protection.
Chemical Name: Penfluridol
Concentration: Pure substance / 100%
CAS Number: 26864-56-2
Impurities/Additives: No significant impurities expected in pharmaceutical-grade material. Research grade may contain trace synthesis by-products; refer to supplier’s documentation.
Inhalation: Move person to fresh air, seek medical attention if symptoms like dizziness or nausea persist.
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, consult physician if irritation develops.
Eye Contact: Rinse eyes under running water for several minutes, remove contact lenses, seek prompt medical care.
Ingestion: Rinse mouth, never give anything by mouth to an unconscious individual, seek immediate medical help.
Important Symptoms: CNS depressant effects, drowsiness, muscular rigidity, gastrointestinal upset, convulsions in severe cases. Immediate care lowers risks.
Suitable Extinguishing Media: Use dry chemical powder, carbon dioxide, alcohol-resistant foam. Water spray can help if safe.
Specific Hazards: Toxic and irritating fumes (hydrogen chloride, nitrogen oxides, fluorine compounds) can release in fire.
Protective Equipment: Firefighters should use full protective clothing and self-contained breathing apparatus.
Advice for Firefighters: Control runoff to prevent environmental contamination. Move containers from fire area if possible without risk.
Personal Precautions: Wear chemical-resistant gloves, goggles, protective clothing, and suitable mask or respirator.
Environmental Precautions: Prevent release into drains, ground waters, or environment. Notify authorities if spill causes significant exposure.
Methods for Cleanup: Scoop spilled material carefully using non-sparking tools, collect in a dry, tightly sealed, labelled container. Ventilate area well. Clean area with water and detergent, avoid raising dust.
Handling: Use with local exhaust ventilation. Avoid dust generation, do not eat, drink, or smoke during handling. Wash up after working, remove contaminated clothing after use.
Storage: Store in original container, tightly closed, in a dry, cool, well-ventilated area, away from direct sunlight and incompatible materials (strong oxidizers, acids). Secure from unauthorized access.
Workplace Controls: Handle under chemical fume hood. Use process enclosures and mechanical ventilation to keep airborne exposure below recommended limits.
Eye Protection: Safety goggles or full face shield.
Skin Protection: Lab coat, chemical-resistant gloves.
Respiratory Protection: Approved respirator if ventilation is inadequate.
Hygiene Measures: Do not touch face with gloves on. Wash hands and forearms thoroughly after handling.
Occupational Exposure Limits: Not established for Penfluridol; use standard industrial hygiene practices.
Appearance: White or off-white crystalline powder
Odor: Odorless
Melting Point: 148-153°C
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water, soluble in methanol, ethanol, chloroform
Relative Density: 1.3-1.4 g/cm³
pH: Not applicable (insoluble in water)
Vapor Pressure: Negligible at room temperature
Flashpoint: Not easily flammable
Chemical Stability: Stable at normal temperature and pressure. Light and moisture can degrade product over time.
Incompatible Materials: Strong oxidizing agents, strong acids, bases.
Decomposition Products: Carbon monoxide, carbon dioxide, hydrogen chloride, nitrogen oxides, fluorine compounds if combusted.
Hazardous Polymerization: Will not polymerize.
Conditions to Avoid: Excess heat, flame, sparks, sources of ignition.
Acute Effects: Toxic if swallowed, may cause serious neurological symptoms. Inhalation or exposure to dust can bring on respiratory effects. Can cause severe drowsiness, disturbed movement, restlessness.
Chronic Effects: Repeated exposure may produce symptoms of extrapyramidal syndrome, tardive dyskinesia, and other neurological disturbances.
Reproductive/Developmental Toxicity: Animal studies have suggested possible effects.
Carcinogenicity: Not classified by IARC, NTP, or OSHA.
Routes of Exposure: Ingestion, inhalation, skin, and eye contact.
Signs and Symptoms: Confusion, muscle rigidity, drowsiness, restlessness, tremor, gastrointestinal discomfort.
Ecotoxicity: Limited testing exists, but pharmaceuticals can affect aquatic organisms and disrupt normal behavior and reproduction.
Persistence and Degradability: Not expected to degrade rapidly in the environment. May persist in water, soil after improper disposal.
Bioaccumulation Potential: Potential to bioaccumulate in aquatic species due to chemical structure.
Mobility in Soil: Likely to have low mobility, binds to soil particles.
Other Adverse Effects: Pharmaceuticals can contribute to antimicrobial resistance and toxicity in aquatic life if not handled as hazardous waste.
Waste Disposal Methods: Dispose through a licensed hazardous waste disposal contractor. Material or contaminated packaging must not be disposed of in general waste or through wastewater.
RCRA Status: Not listed under U.S. RCRA, but always handle as toxic waste to prevent environmental release.
Contaminated Packaging: Decontaminate before recycling if possible, or dispose as hazardous waste.
Physical/Chemical Properties Affecting Disposal: Stable material, minimize dust and environmental release. Avoid incineration except in facilities with proper emission controls.
UN Number: Not classified as dangerous goods for transport under ADR/RID, IMDG, IATA rules.
Transport Hazard Class: No assigned class; treat as toxic chemical.
Packing Group: No assigned group; use robust, sealed packaging.
Special Precautions: Double containment recommended for spills or accidental breakage. Keep away from food and animal feed during transport.
US Federal Regulations: Not specifically listed in SARA Title III or CERCLA; handle using OSHA chemical safety standards. Not considered a controlled substance under DEA regulations.
International Regulations: Subject to regulation as a pharmaceutical ingredient in many countries. Comply with local, regional, and national guidelines.
Labeling Requirements: Labels should indicate toxic hazard, avoid unintentional misuse or accidental exposure.
Workplace Regulatory Information: Ensure all handlers are trained in chemical safety, with material safety sheet available at all locations.
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