Pregna-1,4,9(11)-Triene-17A,21-Diol-3,20-Dione 21-Acetate: Perspectives on an Enduring Steroid Compound

Historical Development

Stories about synthetic steroids often start with curious scientists in the early twentieth century. By the 1950s, research exploded, targeting better anti-inflammatory and hormonal agents. Pregna-1,4,9(11)-triene-17a,21-diol-3,20-dione 21-acetate, usually called triamcinolone acetate in clinical circles, came out of that era. Lab teams took earlier steroid structures, made careful tweaks at carbon positions, and tested each modification for sharper effects in the body. Their work, built on close collaboration between chemists and pharmacologists, led to both academic publications and an early patent rush. The medical world adopted triamcinolone acetate not just because it worked but because regulators had proof of purity, reproducibility, and measurable benefits over older cortisone alternatives.

Product Overview

Walk into a hospital pharmacy, and the odds are high you’ll see triamcinolone acetate among stock drugs, formulated for injection or topical application. This compound falls under the corticosteroid class, built to quiet aggressive immune responses and reduce inflammation. Unlike bulk chemicals, triamcinolone acetate products turn up in carefully labeled vials or creams, supporting dermatology and some respiratory treatments. Each batch comes with certificates from the producer, documenting synthesis, purity levels, and compliance with about a dozen modern pharmacopoeia standards.

Physical & Chemical Properties

The acetate form solidifies into a nearly white, odorless, and crystalline powder at room temperature. Handling it feels oddly similar to other steroids: smooth and lightweight, resistant to clumping. Triamcinolone acetate barely dissolves in water but spreads evenly in ethanol, acetone, and some fatty solvents. Chemically it shows a molecular formula C24H31FO6. Molecular weight hovers around 434, an important detail for recalculating dosages. That side fluorine atom changes pharmacological activity and stands out in every analytic profile. Stability data, pulled from forced-degradation studies, shows resistance against light but vulnerability when stored near strong oxidants.

Technical Specifications & Labeling

Any label on a triamcinolone acetate vial tells you strength by mass, manufacturer’s lot, and date of expiration. Specifications spell out expected purity (usually above 99%), allowed impurities (less than 0.1% for each related substance), melting point (routinely measured between 270–272°C), and visual appearance. Regulatory bodies require those details and verify them with their own tests, including NMR, FTIR, and HPLC fingerprinting. In my days on the regulatory side, quality audits checked for details right down to stopper extractables and leachables, confirming nothing interferes with active compound stability.

Preparation Method

At lab scale, synthesis starts with pregnadiene skeletons from natural or semi-synthetic sources. Chemists run controlled acetylation reactions, protecting the 21-hydroxyl site with an acetic anhydride under anhydrous conditions, followed by fluorination at C9. Yields often depend on fine-tuning temperatures and solvent ratios. Purification hinges on recrystallization—sometimes with specialized solvents, sometimes by column chromatography when impurities prove stubborn. Manufacturers use larger reactors but keep the stepwise protocol: react, isolate, and test for each modification. That disciplined process ensures batch-to-batch consistency, which doctors and patients rely on.

Chemical Reactions & Modifications

Pregna-1,4,9(11)-triene compounds sit at a crossroads of classic organic routes. The 1,4-diene system makes selective halogenation or reduction straightforward, feeding back into production pipelines for alternative corticosteroids. Acetate hydrolysis, using mild base or certain esterase enzymes, produces the free 21-hydroxy variant. Other modifications concentrate on introducing new esters at carbon 21 or halogen atoms at different positions, all in the hunt for compounds with faster action, better bioavailability, or fewer unwanted metabolic side effects. These tweaks keep research pipelines busy.

Synonyms & Product Names

In day-to-day work, triamcinolone acetate carries a lineup of synonyms and brand names, depending on where you practice. Medical professionals see it under the generic "Triamcinolone Acetonide" or as Kenalog, Ledercort, and others. European suppliers often stick to EINECS or CAS numbers, while compounding pharmacists may just call it “Triam Acetate.” Precision in naming spells the difference between the correct prescription and a near-miss in patient treatment, especially across borders.

Safety & Operational Standards

Strict protocols sit behind every vial that moves from production site to hospital. Lab workers wear gloves, dedicate fume hoods, and keep waste segregated. Material Safety Data Sheets outline inhalation and dermal hazards, which don’t match everyday hospital use rates but matter when handling raw powder or during spills. Air monitoring and closed-system device technology address any airborne risks, alongside eye-wash stations and organophosphate antidotes for accidental exposures. For patients, medical guidelines limit doses to minimize suppressed adrenal gland function, diabetes risk, and bone density changes. Safety isn’t just about low acute toxicity; it’s also long-term vigilance.

Application Area

Hospitals pivot to triamcinolone acetate during stubborn inflammation—think allergies that defy antihistamines, skin disorders that refuse to clear, and stubborn joints swollen with rheumatoid arthritis. Direct doctors’ experiences show that precise doses can break a flare-up, save tissue, or restore function in severe asthma. Some specialists teach residents to look for subtle steroid side effects, such as subtle mood shifts or increased appetite, and to taper dosages according to recovery pace. Veterinarians value its steadiness too, treating equine joint problems and certain immune-mediated diseases in pets.

Research & Development

Steroid chemistry labs never stand still. Many push for new analogs, searching for compounds that cut inflammation but spare the skin, bone, and muscle from long-term harm. Research groups test slower-release versions and new delivery forms, such as microencapsulated beads or depot injections aimed at tough-to-reach sites. Work continues on exploring nanotechnology applications, where tiny particles could deliver glucocorticoids to precise tissue without flooding the bloodstream. Collaboration between pharmaceutical industries and biotech start-ups has sped up trials and brought fresh delivery ideas to the table.

Toxicity Research

It's not easy to balance a potent anti-inflammatory with minimal side effects. Animal studies trace risks across organs, watching cortisol pathway abuse, glucose spikes, and liver stress. Labs study developmental toxicity, especially for pregnant patients or young children. Chronic exposure charts out bone thinning, muscle wasting, and immune suppression—hard truths for anyone depending long-term on corticosteroids. Still, advances in targeted delivery and ongoing monitoring promise a drop in systemic risk. Practitioners push for greater safety through routine blood tests and patient counseling, addressing concerns before side effects take hold.

Future Prospects

Triamcinolone acetate remains relevant, but the future hinges on smarter formulations and more accountable use. Biotech research explores steroid conjugates responsive to tissue pH, aiming for lower dosages with equal efficacy. Meanwhile, the medical world debates steroid stewardship, pressing for clearer protocols that keep patients off corticosteroids except when absolutely necessary. Synthetic chemists hold out hope for analogs free of weight gain and bone risks, shaping the next wave of anti-inflammatory therapies. Doctors and scientists share a single goal: treatments that help heal, not harm, forged through careful study, open data, and constant vigilance.



What is Pregna-1,4,9(11)-Triene-17A,21-Diol-3,20-Dione 21-Acetate used for?

Punching up Hormone Therapy

Health care has a rich toolbox, especially in managing hormone levels. Pregna-1,4,9(11)-triene-17a,21-diol-3,20-dione 21-acetate stands as a synthetic corticosteroid, a relative of drugs doctors prescribe for managing inflammation, immune responses, and hormone deficiencies. The medical world leans on these lab-created compounds, because our bodies rely on precise hormone balance to thrive.

Real Relief for Real Conditions

Doctors use substances like this to help patients when their bodies don’t produce enough natural cortisol. Addison’s disease, for example, causes fatigue, muscle weakness, and low blood pressure. Synthetic corticosteroids offer much-needed relief. Patients struggling with severe skin conditions—such as eczema or psoriasis—have also benefited. These medications work by calming overactive immune systems, which can flare up and attack healthy skin. I’ve seen people regain confidence and comfort after decades of red, itchy patches, just from the right medicine landing in their hands.

Battling Allergies and Asthma

Seasonal allergies knock out productivity and sleep, and for people with asthma, every breath counts. Corticosteroids like this one dampen the inflammation in airways, letting lungs open up. Many steroid sprays and inhalers use similar active ingredients. Having grown up with a family member who juggles asthma, I know how big a difference a medicine can make. One puff clears the path for a good night’s rest—and that impacts every part of life, from school to social outings.

Power Tools Carry Risks

Corticosteroids can sometimes jumpstart healing, but the risks mount with long-term use. Bone thinning, blood sugar spikes, mood swings, and swelling will sneak up on those taking daily doses for months or years. That’s why regular doctor visits matter. Simple check-ins—blood tests, bone scans—can spot trouble before it gets out of hand. Keeping these strong medicines behind the prescription counter helps, too. No one should start or stop such a powerful drug without expert guidance.

Costs and Barriers

Insurance policies and red tape affect who gets these therapies and when. Safe, affordable access remains a struggle for patients with chronic diseases who need reliable, long-term care. I’ve met folks who ration pills or skip doses to save money, risking flare-ups and hospital visits. Solutions will come from health systems working to put people first—streamlining approval processes, capping out-of-pocket costs, and backing up primary care doctors with endocrinologists who understand rare hormone disorders inside-out.

Better Education, Better Outcomes

Plenty of myths cloud understanding of corticosteroids. Families sometimes worry about steroids stunting growth or causing addiction. Education from trusted health providers clears that fog. Pharmacists answering questions in plain language, doctors offering printed guides, and honest discussion of side effects all build trust. Knowledge gives patients ownership over their health, and better outcomes start there.

What are the possible side effects of Pregna-1,4,9(11)-Triene-17A,21-Diol-3,20-Dione 21-Acetate?

Understanding the Real Risks Behind Medical Jargon

Most people haven’t heard the full chemical name “Pregna-1,4,9(11)-Triene-17A,21-Diol-3,20-Dione 21-Acetate” unless they’re thumbing through medical journals, but quite a few have sat nervously in a doctor’s office, pondering a new prescription containing a powerful corticosteroid or hormone. Patients trust that the white coat across from them has read the fine print, yet risks and side effects can feel buried beneath all that scientific language.

What Can Happen with Steroid-Based Medications

Anyone who’s spent time around clinics and pharmacies knows stories about steroids. Some folks recount jittery feelings, while others mention swelling in their hands or ankles. This class of medicine works hard on inflammation and immune reactions, but that power means side effects show up, too. Patients using corticosteroid derivatives such as this one sometimes run into things like insomnia, mood swings, or aches and pains that weren’t bothering them before.

Weight gain rarely gets discussed up front, yet steroids shift metabolism and trigger hunger. People find their faces getting puffy or, as doctors like to call it, “moon face.” The skin doesn’t like high hormone levels, either. Thinning, bruising, and slower wound healing show up for some, especially after longer courses at higher doses.

Beyond the Common: More Serious Side Effects

Blood pressure can creep up quietly. Glucose readings can spike, even in folks who’d never paid much attention to such numbers before. Lab results surprise more than a few who never thought diabetes or hypertension would apply to them, only to have a doctor mention “steroid-induced” before the new diagnosis.

Many parents worry about their kids taking these drugs because high-dose steroids have been linked to stunted growth. In older adults, bones don’t always stay dense and strong. Osteoporosis emerges as a real risk, as calcium levels drop and bones become brittle. Infections sneak in more easily, too, since the immune system doesn’t bounce back quite as fast.

Facing Mental and Emotional Changes

Doctors don’t always pause long enough to discuss the emotional toll. Some patients notice anxiety racing through their minds, losing sleep or snapping at family for no clear reason. Others fall into a low mood or even depression, especially after abrupt changes to their dose. My patients sometimes say, “I just didn’t feel like myself,” and anyone who’s spent time in a busy health clinic can confirm this isn’t rare.

Managing the Downsides

Medical guidelines push for the lowest possible dose for the shortest time, but clear conversations between patients and healthcare providers matter far more. Reporting any odd symptoms—trouble sleeping, increased hunger, swelling, sugar spikes—helps catch problems early.

Strong routine helps. If you’re prescribed a steroid like Pregna-1,4,9(11)-Triene-17A,21-Diol-3,20-Dione 21-Acetate, regular exercise, bone density checks, and keeping an eye out for infections can all make a difference. A support system—family, friends, or online forums—lets people talk through mood changes or worries that might otherwise get ignored.

Backing Claims with Real-World Research

Studies from reputable sources like the Mayo Clinic and the Cleveland Clinic repeatedly highlight these side effects. The FDA urges extra caution in people with diabetes, heart disease, or weakened bones. No one gets a pass on careful monitoring.

The days of taking pills on blind faith are over. Most want to know what’s happening inside their bodies. Knowing the possible side effects of strong medications empowers patients to act early and work in step with their care team. The safest results come from this partnership, not from statistics on a chart.

How should Pregna-1,4,9(11)-Triene-17A,21-Diol-3,20-Dione 21-Acetate be taken or administered?

Everyday Perspective on Administration

Pharmaceutical names like Pregna-1,4,9(11)-Triene-17A,21-Diol-3,20-Dione 21-Acetate never roll off the tongue. Most folks recognize it better as triamcinolone acetate, a type of corticosteroid. Seeing a lengthy chemical name can feel intimidating, especially if you’re staring at a prescription bottle and wondering what’s coming next. From what I’ve gathered through years living with chronic health issues, the key with any steroid is clear communication with your prescribing doctor.

Doctors usually guide patients to either take or receive triamcinolone acetate as an injection. Oral tablets aren’t the deal here. Instead, the common route runs through the muscle—most often in your glute or thigh. Medical staff keep the dose precise. They use sterile tools, target the muscle, and push the medicine slow and steady. If you’ve ever dreaded a shot at your check-up, this isn’t a wild experience, but timing and preparation matter. Heading to the clinic or your general practitioner remains essential, since drawing and injecting isn’t recommended at home.

Why It Matters to Stick With Proper Administration

Many folks imagine that all steroids work the same way as a daily pill, but the risks with this compound shoot up if you skip a careful method. Triamcinolone acetate’s power comes paired with the chance of raising blood pressure, suppressing immune defense, or threatening bone strength in large or unchecked doses. I’ve seen friends attempt self-administration to dodge the inconvenience of a doctor’s visit, only to run into more trouble—painful injection spots, missed muscles, or even infections from using non-sterile supplies. This stuff isn’t ibuprofen; the right injection site and clean technique make all the difference.

Doctors watch for underlying conditions before deciding on the right approach. Someone fighting a tough allergy or arthritis flare might get a single shot, while those with longer-term disease could need periodic doses. Most professionals check response between appointments, sometimes using blood tests or asking pointed questions. Safety checks like these keep folks from stacking up side effects. My own experience getting cortisone injections taught me the value of medical oversight; what felt like routine soon turned into a learning curve about dosage, site rotation, and recovery.

Practical Steps Make the Difference

Taking Pregna-1,4,9(11)-Triene-17A,21-Diol-3,20-Dione 21-Acetate always begins with a conversation about medical history. Folks with diabetes, fungal infections, or heart trouble need extra safety measures. Always let your clinician know about regular meds, allergies, or symptoms that won’t quit. The only way to get the full benefit without complications involves sticking to those recommendations: schedule follow-ups, check for changes in mood or swelling, watch for infection, and report any odd changes quickly.

Problems can crop up if you double up doses or halt treatment without guidance. Missing a scheduled injection because of a busy week happens, but calling the doctor’s office for advice ends up safer than guessing. Some insurance providers require extra steps or paperwork for these injections, so reading coverage ahead of time helps prevent surprises. If nerve-wracking paperwork blocks your path, medical staff or pharmacists can often explain the important bits.

Key Takeaways and Forward Steps

Sorting out a plan for triamcinolone acetate boils down to teamwork. Trust between patient and provider stands front and center. Experience—and seasoned medical data—points toward sterile, scheduled injection by pros instead of DIY experiments. Anyone facing repeated pain or stubborn inflammation should speak up and get details straight from a healthcare team, since the right use of this medication relies on more than a label or an online search.

Are there any precautions or contraindications for using Pregna-1,4,9(11)-Triene-17A,21-Diol-3,20-Dione 21-Acetate?

Risk factors go far beyond the technical name

Staring at the name Pregna-1,4,9(11)-Triene-17A,21-Diol-3,20-Dione 21-Acetate, most people might guess it belongs to a family of corticosteroid or synthetic hormone medications. These compounds can pack a punch, but that power doesn’t come free. In the pharmacy, patients ask about new medicines all the time, not just about what the drug does, but who needs to stay careful. I’ve watched too many folks run into trouble by thinking a prescription means it’s “safe for anyone.”

Let’s talk about practical issues that come with these medicines. The whole class can cause immune suppression, raising the risk of infection. You’ll find patients with recent vaccinations, existing tuberculosis, fungal infections, or uncontrolled diabetes getting stern warnings from any doctor who understands what’s at stake. My own uncle started coughing constantly after starting a corticosteroid acetate; he ignored his doctor’s orders to avoid crowds during flu season. He paid the price with a pneumonia hospitalization. That story stays with me — these side effects aren’t rare.

Not just about infections: More layers to the story

Steroid derivatives interfere with natural hormone balance. Using them while pregnant always demands a real conversation with a provider. Studies connect steroids with low birth weight, cleft palate, and even possible adrenal suppression in newborns. If anyone’s trying to conceive or already expecting, doctors pause before signing that prescription. Watchful monitoring becomes a must, not just a suggestion.

Anyone with liver or kidney trouble should step back and review their risks. These organs handle the heavy lifting, processing medicine and sweeping out toxic byproducts. If the liver or kidneys lag behind, the compound sticks around too long in the bloodstream. That means side effects like mood swings, leg swelling, muscle wasting, and high blood sugar hit harder. Among my patients living with chronic hepatitis, some suffered mental fogginess and muscle cramps from unmetabolized steroids. No dose feels small if the body can’t clear it properly.

Real-world cautions large and small

Mixing steroid-based drugs with other medications creates a series of traps. Blood thinners, diabetes medications, mifepristone, and even some antibiotics like erythromycin interact at a molecular level, changing how these drugs behave. Reading stories about easy bruising in patients on warfarin plus corticosteroids isn’t just for journals — it shows up in day-to-day life. I recall explaining tough purple bruises to an elderly neighbor only to realize her new pill was creating a perfect storm.

Anyone living with glaucoma or cataracts should know steroids raise eye pressure and make vision problems harder to manage. The same holds true for people with osteoporosis. Bones thin out quicker under the influence of corticosteroids, making falls or breaks more likely. I once saw a runner in his 40s with three rib fractures after a month of high-dose therapy for his autoimmune disease, and the lesson stuck: don’t shrug off the bone risks just because you feel strong now.

More than a label: Smart precautions make a difference

Getting regular checkups, blood sugar reviews, and eye exams—these habits go far in heading off complications. Solutions don’t stop at lab work; they include open, honest dialogue with healthcare providers, pharmacists, and even family. I’ve seen lives saved and quality improved just by pausing, asking questions, and tracking changes in how people feel. With medications like Pregna-1,4,9(11)-Triene-17A,21-Diol-3,20-Dione 21-Acetate, a cautious approach protects everyone.

Is a prescription required to purchase Pregna-1,4,9(11)-Triene-17A,21-Diol-3,20-Dione 21-Acetate?

Questions keep coming up about access to certain hormone-based medications, especially ones with technical names like Pregna-1,4,9(11)-Triene-17A,21-Diol-3,20-Dione 21-Acetate. Most people just know this compound as triamcinolone acetate, a corticosteroid used in a range of treatments from allergies to arthritis. These products carry real health risks in the wrong hands, so getting clear on the rules goes beyond following a bureaucratic checklist—it's about keeping communities safe and giving good care.

Why It Typically Sits Behind the Pharmacy Counter

With steroids like triamcinolone acetate, the dangers aren't just a list in a medical textbook. Too much, or the wrong dose, can lead to major trouble: immune suppression, hormonal imbalances, blood sugar spikes, and bone thinning. Unmonitored, this medication causes problems that don't always show up right away. I remember hearing stories from pharmacists about folks who tried to self-treat painful joints, only for side effects to stack up, leading to a long cycle of doctor visits and even hospital stays.

The FDA classifies these as prescription-only in the United States, and many other countries do the same. The idea is to have a medical professional weigh risks against benefits. Pharmacies follow these rules for a reason—one look at the lengthy warning leaflet included with those vials will show why.

Holes in Regulation and Online Sales

Where things get murky is with online retailers and gray-market operations, which sometimes list prescription drugs without checking for prescriptions. The temptation is obvious: skip the doctor, save some money, and get relief fast. But this opens the door to counterfeit drugs, adulterated products, and zero guidance for use.

Occasionally, desperate folks order a medication online thinking it’s regulated, only to find out the pills or injectable solution they got were fake or contained the wrong ingredient. Harm from off-label or unsupervised steroid use isn’t a theoretical issue—people have landed in critical care. The World Health Organization keeps updating its warnings about online pharmacies that ignore local rules.

What Responsible Access Looks Like

Doctors write prescriptions after considering lab results, other medicines, and a patient’s specific health story. Pharmacists provide an extra layer of protection, making sure doses fit the situation and running checks for interactions. People sometimes underestimate just how dangerous unsupervised steroid use can be—long-term misuse can lead to Cushing’s syndrome, infections, or severe skin reactions.

Better access doesn’t mean skipping medical oversight. Telemedicine can help solve access problems, especially for people in rural areas or those with mobility challenges. Insurance plans and public health systems could make these visits easier to get, so people don’t feel cornered into buying prescription meds through risky websites.

How to Get Help and Stay Safe

For anyone unsure about a drug’s status, the fastest route to clarity is talking directly to a licensed pharmacist or care provider. Look up medicines in FDA or Health Canada databases, which mark drugs as prescription or over-the-counter. If ever in doubt, steer clear of online sellers that promise prescription drugs without a doctor’s involvement.

Public awareness campaigns, transparent labeling, and honest conversations between patients and caregivers go a long way. Safe access depends on knowing the facts, trusting medical advice, and resisting shortcuts that put health at risk.

Pregna-1,4,9(11)-Triene-17A,21-Diol-3,20-Dione 21-Acetate
Names
Preferred IUPAC name (1S,2R,8S,10S,11S,13R,14S,15S)-17-Acetyl-11-hydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1,4,6-trien-14-yl acetate
Other names Fluocinolone Acetonide
Synalar
Flucinolone acetonide
Fluorocinolone acetonide
Pronunciation /ˈprɛɡ.nə wʌn fɔː naɪn ɪˈlɛv.ən traɪˈiːn ˈsɛv.əntiːn ˈdaɪ.ɒl θriː ˈtwɛnti daɪˈoʊn ˈtwɛnti wʌn əˈsiː.teɪt/
Preferred IUPAC name (1S,2R,8S,10S,11S,13R,14S,15S)-14-acetyl-2,15-dihydroxy-10,13-dimethyl-16-oxo-1,2,6,7,8,11,12,15-octahydrocyclopenta[a]phenanthren-3-yl acetate
Other names Fluocinolone acetonide
Fluocinolon acetonid
Fluor-O-Chlor
Synalar
Retinode
Pronunciation /ˈprɛɡnə ˌwʌn fɔːr naɪn ˈɪl ˈtraɪiːn ˌsɛvənˌtiːn ˈdaɪɒl θriː ˈtwɛnti daɪˈəʊn ˌtwɛntiˈwʌn ˈæsɪteɪt/
Identifiers
CAS Number '24356-94-3'
3D model (JSmol) `3DModel:JSmol|C23H28O5|CC(=O)OCC1C(C2CCC3=CC(=O)C=CC3(C2CC1O)C)O`
Beilstein Reference 1740202
ChEBI CHEBI:76263
ChEMBL CHEMBL1514
ChemSpider 8611601
DrugBank DB00741
ECHA InfoCard 01e0e791-9208-427c-80be-55b1c387042d
EC Number 206-645-2
Gmelin Reference 315784
KEGG C14547
MeSH D04.210.500.340.670.099.500.180
PubChem CID 11225267
RTECS number UI6540000
UNII S934FI9A2T
UN number UN3462
CompTox Dashboard (EPA) DTXSID2021770
CAS Number '24356-94-3'
3D model (JSmol) `6ZVZWS7JBUHDKQ-UHFFFAOYSA-N`
Beilstein Reference 70808
ChEBI CHEBI:76270
ChEMBL CHEMBL1511
ChemSpider 3317
DrugBank DB00603
ECHA InfoCard ECHA InfoCard: 100.036.829
EC Number 206-642-7
Gmelin Reference 10173
KEGG C07361
MeSH D004317
PubChem CID 71310451
RTECS number RY6775000
UNII 1S78037YI7
UN number UN2811
CompTox Dashboard (EPA) DTXSID5010175
Properties
Chemical formula C23H28O5
Molar mass 384.45 g/mol
Appearance White to Off-White Powder
Odor Odorless
Density 1.2 g/cm3
Solubility in water Insoluble in water
log P 2.6
Vapor pressure 7.7E-9 mmHg at 25°C
Acidity (pKa) 12.53
Basicity (pKb) 3.23
Magnetic susceptibility (χ) -85.0e-6 cm³/mol
Refractive index (nD) 1.584
Dipole moment 5.15 D
Chemical formula C23H28O5
Molar mass 384.444 g/mol
Appearance White to Off-White Solid
Odor Odorless
Density 1.2 g/cm3
Solubility in water Insoluble in water
log P 2.47
Vapor pressure 3.8 x 10⁻⁸ mmHg (25°C)
Acidity (pKa) 12.59
Basicity (pKb) 6.38
Magnetic susceptibility (χ) -77.0e-6 cm³/mol
Refractive index (nD) 1.568
Dipole moment 8.57 Debye
Thermochemistry
Std molar entropy (S⦵298) 354.5 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -648.7 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -9151.8 kJ/mol
Std molar entropy (S⦵298) 362.8 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -726.9 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -10060.8 kJ/mol
Pharmacology
ATC code G03DA04
ATC code G03AC06
Hazards
Main hazards H315, H319, H335
GHS labelling GHS07, GHS08
Pictograms GHS07
Signal word Warning
Hazard statements H315, H319, H335
Precautionary statements P210, P261, P264, P271, P280, P301+P312, P304+P340, P305+P351+P338, P308+P313, P405, P501
NFPA 704 (fire diamond) NFPA 704: "Health: 2, Flammability: 1, Instability: 0
Autoignition temperature 455°C
LD50 (median dose) LD50 (median dose) = 1320 mg/kg (rat, oral)
NIOSH RG8220000
REL (Recommended) 0.1 mg/m3
IDLH (Immediate danger) IDLH: Not established
Main hazards May damage fertility or the unborn child. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
GHS labelling GHS02, GHS07
Pictograms GHS07,GHS08
Signal word Warning
Hazard statements H315, H319, H335
Precautionary statements P201, P202, P280, P308+P313, P405, P501
Lethal dose or concentration LD50 oral (rat) 673 mg/kg
LD50 (median dose) LD50 (Rat oral): 6500 mg/kg
NIOSH DN4850000
PEL (Permissible) Not Listed
REL (Recommended) 0.01 mg/m³
IDLH (Immediate danger) Not established
Related compounds
Related compounds Cortisone acetate
Hydrocortisone acetate
Prednisolone acetate
Prednisone acetate
Dexamethasone acetate
Related compounds Cortisone acetate
Hydrocortisone acetate
Prednisolone acetate
Prednisone acetate
Dexamethasone acetate
Betamethasone acetate