Product Name: Pregna-1,4,9(11)-Triene-17A,21-Diol-3,20-Dione 21-Acetate
Chemical Formula: C23H28O5
Chemical Family: Synthetic corticosteroid
Synonyms: Triamcinolone Acetate
CAS Number: 76-25-5
Uses: Pharmaceutical, corticosteroid therapy
Supplier: Contact details as on specific packaging
Emergency Contact: Refer to local supplier emergency number
Recommended Use: Restricted to professional or research environments
Hazard Class: Reproductive toxicity, potential endocrine disruption, skin and eye irritant
Pictogram: Exclamation mark, health hazard symbol
Signal Word: Warning
Hazard Statements: May cause allergic skin reaction, possible hormone disruption, respiratory irritation risk
Precautionary Statements: Wear adequate protection, avoid contact with eyes skin and clothing, use in fume hood if available
Potential Health Effects: Respiratory irritation, nausea, headache, dizziness with prolonged exposure, possible skin absorption, pharmaceutical effects after repeated or high exposure
Environmental Effects: Persistent in aquatic environments, potential long-term hazard to aquatic life
Chemical Identity: Pregna-1,4,9(11)-Triene-17A,21-Diol-3,20-Dione 21-Acetate
Concentration: >98% pure
Impurities: None at dangerous levels
Additives: None
Inhalation: Get to fresh air, keep airways unobstructed, call poison center or physician if symptoms develop
Skin Contact: Remove contaminated clothing, flush skin for 15 minutes with water, seek medical attention if irritation continues
Eye Contact: Flush eyes with water for at least 15 minutes, lift eyelids occasionally, seek medical attention if pain or redness persists
Ingestion: Rinse mouth, do not induce vomiting unless directed by a poison control center, consult a physician immediately
Important Symptoms: Hormonal disturbance, gastrointestinal distress, sensitization
Immediate Medical Attention: Required if inhalation/ingestion or large-area exposure occurs
Suitable Extinguishing Agents: Carbon dioxide, dry chemical powder, foam, water spray for larger fires
Unsuitable Agents: High-pressure water streams may scatter powdered substance
Hazardous Combustion Products: Produces carbon monoxide, carbon dioxide, possible toxic fumes
Special Protective Equipment: Use self-contained breathing apparatus, full protective gear
Fire Hazards: Dust may form explosive mixture with air, substance not highly flammable but combustible at elevated temperature
Personal Precautions: Avoid inhalation, skin, and eye contact; wear protective gloves, eye protection, particle mask
Environmental Precautions: Prevent powder from entering drains, watercourses, soil or sewer systems; alert authorities if released in large quantities
Methods for Clean-up: Use HEPA-filtered vacuum or dampen to gently sweep spilled material, avoid dry sweeping or creating dust clouds, dispose of in compliant chemical waste containers
Decontamination: Wash area thoroughly with water and detergent after spill collection
Handling: Handle under local exhaust ventilation or fume hood; avoid dust generation; avoid ingestion and inhalation; use only with appropriate PPE
Storage: Keep container tightly closed in cool, dry place at controlled room temperature, away from sources of ignition or heat; store away from incompatible materials such as oxidizing agents
Special Precautions: Limit access to authorized personnel, document inventory and log usage
Exposure Limits: No specific occupational exposure limit set, general dust limit applies;
Engineering Controls: Use laminar flow hood or adequate local exhaust ventilation
Respiratory Protection: NIOSH-approved particulate respirator if dust is generated
Skin Protection: Wear chemical-resistant gloves, lab coat, avoid open skin exposure
Eye Protection: Tight-fitting safety goggles, use face shield if splashing may occur
Hygiene Measures: Wash hands thoroughly after handling; do not eat, drink, or smoke in working area
Appearance: White or off-white crystalline powder
Odor: Odorless
Melting Point: 270-275 °C
Boiling Point: Not applicable (decomposes)
Density: Approx. 1.3 g/cm3
Solubility: Poorly soluble in water, soluble in organic solvents such as ethanol, chloroform
pH: Not applicable
Vapor Pressure: Not significant at room temperature
Partition Coefficient: Log Kow estimated >2
Chemical Stability: Stable under recommended storage conditions
Conditions to Avoid: Exposure to strong light, elevated temperatures, strong acids, and oxidants
Reactive Hazards: Reacts with oxidizing agents, acids
Decomposition Products: Carbon monoxide, carbon dioxide, potentially harmful organic by-products
Polymerization: Will not occur
Acute Toxicity: LD50 (oral, rat) estimated >2,000 mg/kg
Chronic Effects: Repeated or prolonged exposure could impact endocrine system and suppression of immune response
Irritation: May cause skin and eye irritation
Sensitization: May cause allergic reactions on skin contact
Mutagenicity: No current data showing mutagenic effects
Carcinogenicity: Not listed by IARC, NTP, OSHA
Reproductive Toxicity: May disrupt hormone function, impair fertility with repeated misuse
Ecotoxicity: Not acutely toxic to fish, algae, or invertebrates under standard test criteria but persistent in aquatic environment
Degradability: Substance expected to degrade slowly in soil and water; half-life could exceed months
Bioaccumulation Potential: Moderate due to lipophilicity; may accumulate in aquatic organisms
Mobility in Soil: Low mobility due to insolubility in water; high potential for sediment binding
Precautionary Actions: Prevent from reaching soil, waterways, drains
Waste Disposal Methods: Dispose as hazardous chemical waste; follow local, regional, national, and international regulations
Container Disposal: Rinse and offer for recycling or dispose of as regulated hazardous waste
Special Instructions: Contact approved disposal company for safe collection and processing
UN Number: Not regulated for transport
Proper Shipping Name: Non-dangerous goods for transport purposes
Transport Hazard Class: Not subject to ADR/RID, IMDG, or IATA regulation as hazardous material
Packaging Group: Not applicable
Safety Precautions: Package securely to prevent release during transit; ship with safety documentation
EU Classification: Substance of health concern; see hazard codes R43 (skin sensitizer), R60 (may impair fertility)
US Federal Regulations: Not on TSCA inventory, not listed as hazardous by OSHA
SARA Title III: No Section 302, 304, or 313 components
Canada Domestic Substances List: Not listed
Other Regulatory Notes: Subject to prescription controls due to pharmaceutical activity; user must ensure compliance with relevant workplace and environmental safety rules
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