Product Name: Progesterone
Chemical Name: Pregn-4-ene-3,20-dione
Synonyms: P4; Corpus luteum hormone; 4-Pregnen-3,20-dione
CAS Number: 57-83-0
Recommended Use: Hormone therapy, pharmaceutical applications, laboratory reagent
Manufacturer Information: Please refer to the supplier’s data for address and contact information
Emergency Contact: Local emergency health and chemical incident number
Hazard Classification: Not classified as hazardous according to GHS criteria for physical, health, or environmental hazards
Signal Word: Warning
Hazard Statements: May cause reproductive system effects, can trigger skin and eye irritation in sensitive individuals
Precautionary Statements: Avoid inhalation of dust. Prevent skin and eye contact. Wash hands thoroughly after handling. Use only with adequate ventilation.
Other Hazards: Low risk of fire, but fine dust can form explosive mixtures with air under specific conditions
Chemical Formula: C21H30O2
Main Ingredient: Progesterone (purity typically ≥99%)
Impurities: Trace levels of related steroids, solvents (varies by batch), may include residual process agents below regulatory limits
Concentration: 100% (unless present in a formulated product or mixture)
Inhalation: Move affected person to fresh air. Seek medical attention if symptoms persist, such as respiratory discomfort or coughing.
Skin Contact: Wash skin with soap and water for at least 15 minutes. Remove contaminated clothing. Seek medical advice if irritation or other complaints appear.
Eye Contact: Rinse eyes gently but thoroughly with clean water for at least 15 minutes. Get medical help if irritation, tearing, or pain continues.
Ingestion: Rinse mouth with water. Do not induce vomiting unless directed by a physician. Get medical advice in case of large ingestion or persistent symptoms.
Acute Symptoms/Effects: Dizziness, headaches, hormone-related effects with chronic exposure
Advice for Doctors: Treat symptomatically. Monitor hormone exposure side effects, such as menstrual changes.
Suitable Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide
Unsuitable Media: Avoid high-pressure water jets that may spread burning powder
Specific Hazards: Dust may form explosive mixture with air. Combustion products may include carbon monoxide, carbon dioxide, and traces of hazardous decomposed organics.
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear.
Special Fire Fighting Procedures: Keep containers cool by spraying with water if exposed to fire. Avoid walking through spilled powder. Prevent runoff from contacting waterways.
Personal Precautions: Avoid breathing dust. Wear gloves, safety goggles, dust mask or respirator. Remove all ignition sources if large amounts release.
Environmental Precautions: Prevent entry into sewers, drains, or waterways. Alert appropriate authorities if contamination occurs.
Containment: Collect material using spill control methods. Avoid raising dust.
Clean-up Methods: Sweep up and shovel into suitable containers for disposal. Wash area with water and soap. Ventilate area and dispose of contaminated protective equipment appropriately.
Reporting: Notify supervisor and relevant environmental health and safety staff as per internal protocol.
Precautions: Handle in closed systems or under ventilation. Minimize dust generation and accumulation. Only use non-sparking tools and grounded equipment.
Safe Handling Advice: Wear personal protective equipment. Practice good hygiene; avoid eating, drinking, or smoking while handling. Keep away from incompatible substances, such as strong acids, oxidizers.
Storage Conditions: Keep containers tightly closed. Store in a well-ventilated, dry area, away from heat sources and direct sunlight.
Incompatible Materials: Strong oxidizing agents, strong acids, and bases.
Storage Temperature: Room temperature, recommended between 15-25°C unless otherwise specified.
Occupational Exposure Limits: No established regulatory threshold limit values, but minimize exposure where possible
Engineering Controls: Use local exhaust ventilation to control airborne dust. Provide eye-wash stations and safety showers in working area.
Personal Protective Equipment (PPE): Wear chemical-resistant gloves, safety glasses or goggles, and laboratory coat. Use a dust mask or respirator in cases of insufficient ventilation.
Hygiene Practices: Wash hands after handling, before breaks, and after work. Avoid skin and eye contact.
Appearance: White to off-white crystalline powder
Odor: No distinct odor
Melting Point: 126 – 131°C
Boiling Point: Decomposes before boiling
Solubility: Insoluble in water; soluble in acetone, chloroform, alcohol, and dioxane
Density: 1.13 g/cm³
pH: Not applicable (insoluble in water)
Partition Coefficient (log Kow): ~3.87
Vapor Pressure: Negligible at room temperature
Flash Point: Approx. 186°C (closed cup estimate)
Auto-ignition Temperature: Not established
Explosive Properties: Dust can form explosive mixtures in air
Oxidizing Properties: Not considered oxidizing
Stability: Stable under normal temperatures and handling conditions
Reactivity: Does not rapidly decompose under recommended storage and use
Conditions to Avoid: Excessive heat, open flames, sparks, direct sunlight
Incompatible Materials: Strong oxidizers, strong acids and bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, smaller organics during combustion or decomposition
Polymerization: Not likely to occur
Acute Toxicity: Low acute toxicity; oral rat LD50 >5000 mg/kg. Not acutely toxic by standard exposure routes.
Chronic Effects: Chronic exposure can produce reproductive, endocrine, or developmental effects in humans based on hormonal activity.
Carcinogenicity: Not classed as a carcinogen by IARC, NTP, or OSHA. Long-term effects not fully known but considered low.
Skin/Eye Irritation: Mild skin and eye irritant for sensitive persons.
Sensitization: Not identified as a skin sensitizer, but consultation with occupational health may be advised for frequent exposure.
Mutagenicity: No evidence from available animal testing.
Reproductive Toxicity: Evidence of hormone-related effects exists; handle with care, especially those pregnant or nursing.
Aquatic Toxicity: Potential risk to aquatic organisms. Actual data limited but effects may occur at low levels due to hormonal activity of the compound.
Persistence and Degradability: Not rapidly biodegradable; persistence in the environment possible.
Bioaccumulative Potential: Potential exists due to lipophilicity (log Kow >3).
Mobility in Soil: Poor water solubility, may bind tightly to soils and sediments.
Other Adverse Effects: Even small amounts can affect aquatic wildlife. Environmental release should be minimized.
Waste Treatment Methods: Incinerate in licensed facility or dispose of as hazardous pharmaceutical waste in accordance with local regulations
Contaminated Packaging: Dispose of empty containers as hazardous waste. Do not reuse.
Special Precautions: Do not allow product to reach waterways, sewers, or soil.
Advice for Disposal: Consult local environmental authorities for guidance on disposal methods, especially for large quantities or spills.
UN Number: Not regulated for transport under UN criteria
Proper Shipping Name: Not applicable
Transport Hazard Class: Not classified as dangerous
Packing Group: Not required
Environmental Hazards: Not a marine pollutant per transport rules
Special Precautions: Avoid release into the environment.
Transport Labels: None required
Methods: Standard pharmaceutical freight practices apply. Avoid extreme conditions and protect from moisture.
TSCA: Listed
REACH Registration: May apply in the European Union; refer to manufacturer or supplier for status
OSHA: Not specifically regulated as hazardous
WHMIS (Canada): Not classified as a controlled product
Other International Regulations: Complies with pharmaceutical and laboratory regulations in most jurisdictions; review local standards
Restrictions: Prescription status applies for medical use. Extra caution required for hormone use and disposal.
SARA Title III: Not subject to reporting requirements
California Prop 65: Not listed
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