Material Safety Data Sheet: Testosterone Propionate

Identification

Product Name: Testosterone Propionate
Chemical Name: 17β-Hydroxyandrost-4-en-3-one 17-propionate
Synonyms: Androst-4-en-17β-ol-3-one propionate, Testoviron
CAS Number: 57-85-2
Molecular Formula: C22H32O3
Molecular Weight: 344.49 g/mol
Recommended Use: Pharmaceutical synthesis, hormone replacement therapies
Supplier Details: Manufacturer/distributor names and emergency contact numbers should appear on official documents
Emergency Contact: Poison Control Center or local emergency services

Hazard Identification

Classification: Reproductive toxicant, possible carcinogenicity, specific target organ toxicity (repeated exposure), skin and eye irritant
Hazard Symbols: GHS08 (health hazard), GHS07 (exclamation mark)
Signal Word: Danger
Hazard Statements: May damage fertility or the unborn child, causes skin irritation, may cause allergic skin reaction, may cause respiratory irritation
Precautionary Statements: Avoid release to the environment, wear protective gloves and clothing, wash hands after handling, avoid breathing dust or vapor

Composition / Information on Ingredients

Chemical: Testosterone Propionate
Concentration: 98% or higher
Impurities: Trace organic byproducts
Other Components: Product may contain stabilizers or solvents in formulated preparations

First Aid Measures

Inhalation: Move to fresh air, seek oversight from medical personnel if symptoms develop such as coughing, wheezing, difficulty breathing
Skin Contact: Remove contaminated clothing, wash exposed skin with soap and water, see medical attention if irritation persists
Eye Contact: Rinse carefully with running water for at least 15 minutes, consult a healthcare provider
Ingestion: Rinse mouth with water if conscious, never induce vomiting, seek immediate medical help
Advice for Physicians: Symptomatic and supportive treatment, monitor hormone-related effects

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry powder, foam, carbon dioxide
Unsuitable Extinguishing Media: High pressure water jets
Specific Hazards: Combustion may yield hazardous gases like carbon monoxide, carbon dioxide, irritating fumes
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective suit
Additional Notes: Control runoff to prevent environmental contamination, move containers from the area if safe to do so

Accidental Release Measures

Personal Precautions: Wear appropriate PPE including gloves, protective clothing, eye/face protection, avoid dust generation or inhalation
Environmental Precautions: Prevent entry into drains, surface and groundwater, avoid soil contamination
Methods of Cleanup: Gather spillage in non-sparking tools, soak up with inert absorbent material like sand or vermiculite, place in suitable, closed containers for disposal
Other Advice: Wash affected area after cleanup, ventilate area well

Handling and Storage

Handling: Use only in well-ventilated spaces, minimize exposure through engineering controls and PPE, prevent release to the environment by working over secondary containment
Storage: Store in tightly closed containers, in a dry, cool, well-ventilated location, segregate from incompatible materials like acids, oxidizers
Special Requirements: Keep away from food, drink, and animal feed, limit access to trained personnel

Exposure Controls and Personal Protection

Engineering Controls: Use chemical fume hoods, local exhaust ventilation, proper laboratory hygiene facilities
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile or similar), lab coat, safety goggles, approved respirator if powder or mist develops
Occupational Exposure Limits: No specific US OSHA or ACGIH value, minimize exposure as a reproductive toxin
Hygiene Measures: Wash thoroughly after handling, do not eat, drink or smoke in handling areas

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless or faint characteristic odor
pH: Not applicable (insoluble in water)
Melting Point: 118–123°C
Boiling Point: Not available (decomposes before boiling)
Solubility: Insoluble in water, soluble in alcohols, chloroform, ethyl acetate
Density: Approx. 1.12 g/cm³
Vapor Pressure: Not relevant at room temperature
Partition Coefficient (log Pow): Estimated >4 (highly lipophilic)
Flash Point: Not established
Other Properties: Stable under normal handling and storage conditions

Stability and Reactivity

Chemical Stability: Stable in dry, cool, dark conditions, away from light and heat
Incompatible Materials: Oxidizing agents, strong acids, strong bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, other noxious fumes in case of fire
Polymerization: Will not occur

Toxicological Information

Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Acute Effects: Irritation of skin, eyes, respiratory system
Chronic Effects: May affect reproductive system, may cause hormonal disruption, potential carcinogen based on hormonal activity
Sensitization: Skin
LD50 (Rat oral): Data not well-documented, generally low acute toxicity
Target Organs: Reproductive organs, endocrine system, liver
Carcinogenicity: Classified as possibly carcinogenic by IARC based on structure–activity, not officially listed by NTP or OSHA

Ecological Information

Aquatic Toxicity: Harmful to aquatic organisms, may cause long-term adverse effects in aquatic environment
Persistence and Degradability: Does not biodegrade rapidly, can persist in water and soil
Bioaccumulation Potential: High due to lipophilicity
Mobility in Soil: Limited, binds to organic material
Other Adverse Effects: Potential endocrine disruptor for aquatic and terrestrial species

Disposal Considerations

Waste Disposal: Dispose of in accordance with local, regional, national, and international regulations, incineration preferred
Contaminated Packaging: Triple rinse, treat as hazardous chemical waste
Special Disposal Precautions: Do not discharge into waterways, avoid landfill disposal, use licensed chemical waste contractors

Transport Information

UN Number: Not assigned for pure substance, but may be regulated under pharmaceutical intermediates
Transport Hazard Class: Not classified as dangerous for transport, refer to local and national guidelines
Packing Group: Not determined
Marine Pollutant: Yes (potential endocrine effects)
Special Transport Precautions: Secure packaging to prevent release, comply with ADR, IMDG or IATA regulations

Regulatory Information

Workplace Regulations: Controlled substance in many countries, prescription-only status, workplace exposure controls under OSHA (US), COSHH (UK), REACH (EU)
Label Requirements: Health hazard warnings, reproductive toxin labeling, user-safe storage and handling instructions
Chemical Inventory Status: Listed on most national inventories (TSCA, EINECS, DSL, etc.)
Other Regulations: Subject to drug enforcement agency restrictions, environmental release may trigger reporting duties under US EPA and EU environmental protection laws