Product Name: Triamcinolone Acetonide Intermediate
Chemical Family: Synthetic Corticosteroid Intermediate
Molecular Formula: C24H31FO6
Molecular Weight: 434.5 g/mol
Synonyms: 9alpha-Fluoro-16alpha,17alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione Intermediate
Recommended Uses: Pharmaceutical manufacturing, research, chemical synthesis
Manufacturer Contact: Refer to supplier documentation for emergency numbers and detailed contact information
Product Code: Provided by manufacturer or distributor
GHS Classification: Not fully classified, but may irritate skin, eyes, and respiratory tract
Hazard Statements: Possible risk of skin sensitization, respiratory irritation, and allergic reactions
Pictograms: Exclamation mark symbol for general hazard and irritation
Precautionary Statements: Avoid dust formation. Avoid breathing dust and vapors. Wash hands after handling. Use only in a well-ventilated area.
Potential Health Effects: May cause mild to moderate eye, skin, and respiratory tract irritation; extended exposure can exacerbate existing health conditions
Environment Hazards: Avoid uncontrolled release into the environment
Chemical Name: Triamcinolone Acetonide Intermediate
CAS Number: Provided by raw material datasheet or supplier
Concentration: Typically 98% or higher pure
Impurities: Trace amounts of process-related byproducts or solvents may remain
Inhalation: Move person to fresh air immediately. Seek medical attention if symptoms like shortness of breath or coughing occur.
Skin Contact: Remove contaminated clothing. Wash skin thoroughly with soap and water. Seek medical advice for irritation or allergic reaction.
Eye Contact: Rinse gently with plenty of water for several minutes. Remove contact lenses. Continue rinsing and get medical assistance if redness or pain persists.
Ingestion: Rinse mouth. Do not induce vomiting. Seek immediate medical advice, noting product details.
Most Important Symptoms: Irritation, redness, allergic reaction, respiratory discomfort.
Note for Responders: Wash contaminated clothes before reuse
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam. Water spray for large fires to cool surroundings.
Unsuitable Extinguishing Media: Straight water streams can spread powdered chemicals.
Special Fire Hazards: Combustion releases hazardous fumes such as carbon oxides, fluorinated compounds.
Protective Equipment: Firefighters should use self-contained breathing apparatus, chemical-resistant suit.
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, hydrogen fluoride, possibly chlorine-containing gases
Personal Precautions: Evacuate unprotected persons from the area. Wear suitable personal protective equipment including gloves, goggles, and dust mask.
Spill Cleanup: Pick up with inert, absorbent material and place in tightly sealed containers for proper disposal.
Environmental Precautions: Prevent entry into waterways, sewers, basements, or confined areas. Advise authorities if significant spill occurs.
Decontamination: Wash spill area thoroughly with water and detergent after removal of bulk material
Safe Handling: Handle in a chemical fume hood or with adequate ventilation. Minimize dust generation and accumulation.
Hygiene Measures: Always wash hands thoroughly after handling. Do not eat, drink, or smoke when using chemicals.
Safe Storage: Store in a tightly closed container in a dry, cool, and well-ventilated place protected from light and incompatible materials.
Special Storage Conditions: Keep away from oxidizing agents, strong acids, and strong bases. Label containers clearly with contents and hazards.
Exposure Limits: No established occupational exposure limits; handle as a sensitizer.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits.
Personal Protection: Wear appropriate gloves (nitrile or latex), lab coat, and chemical splash goggles.
Respiratory Protection: Use NIOSH-approved particulate respirator if dust or aerosol formation is probable.
Environmental Exposure Controls: Prevent further leakage or spillage if safe to do so; avoid contamination of ground and surface water
Physical State: Solid, crystalline powder
Color: White to off-white
Odor: Odorless or faint chemical odor
Melting Point: 250–260°C (varies by purity)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Slightly soluble in water; soluble in organic solvents such as ethanol, methanol, DMSO
pH: Not applicable for solid
Vapor Pressure: Negligible at ambient conditions
Specific Gravity / Density: Approximately 1.3–1.4 g/cm³
Partition Coefficient (log Kow): Estimated 2.3–3.3
Flash Point: Data not available, likely above 100°C due to low volatility
Chemical Stability: Stable under normal temperatures and recommended storage conditions.
Reactivity: Not considered reactive under normal use.
Incompatible Materials: Strong oxidizing agents, acids, bases.
Hazardous Decomposition Products: Burning may release carbon monoxide, carbon dioxide, fluorinated compounds.
Polymerization: No hazardous polymerization expected
Acute Toxicity: Not fully established; based on related corticosteroids, mild to moderate toxicity.
Routes of Exposure: Inhalation, ingestion, skin and eye contact.
Symptoms: Potential skin and eye irritation, allergic dermatitis, respiratory discomfort, headache.
Chronic Effects: Repeated exposure may sensitize the skin or affect hormonal balance.
Carcinogenicity: No data indicating carcinogenic risk for this intermediate.
Other Data: Prolonged or repeated exposure may affect immune function
Ecotoxicity: Data not fully available; avoid uncontrolled release.
Persistence and Degradability: Likely persistent in sediment or soil due to steroid structure.
Bioaccumulation Potential: Moderate, based on predicted log Kow values.
Mobility in Soil: Low; binds to organic material.
Other Effects: Pharmaceutical intermediates can disrupt aquatic organisms even in trace amounts, so containment and proper disposal are critical.
Waste Treatment Methods: Dispose of chemical waste in accordance with local, regional, and national laws. Incinerate or bury at managed chemical waste facility.
Contaminated Packaging: Triple rinse, then dispose with controlled waste practice.
Special Precautions: Do not discharge to natural environment, drains, or public sewage.
UN Number: Not regulated for transport under global dangerous goods codes.
Transport Hazard Class: Not classified as hazardous for transportation.
Packing Group: No specific packing group required.
Proper Shipping Name: Triamcinolone Acetonide Intermediate
Transport Precautions: Keep container tightly closed and dry during transport; avoid exposure to moisture and sunlight; secure load to avoid spillage.
Label Requirements: Container labeling must align with OSHA Hazard Communication Standard or equivalent global laws.
Regulatory Status: Not listed specifically under TSCA, REACH, or other international inventories as a single substance.
SARA Title III: Not regulated.
California Proposition 65: Not listed.
Workplace Classification: Handle as hazardous for safety and training purposes until further toxicological data are available.
Other Regulations: Follow national and regional regulations for workplace safety, environmental protection, and chemical storage.
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