Product Name: Triamcinolone Acetonide
Chemical Family: Glucocorticoid
Synonyms: 9α-Fluoro-16α,17α-isopropylidenedioxypregna-1,4-diene-3,20-dione
CAS Number: 76-25-5
Use: Corticosteroid used for managing allergic disorders, dermatological diseases, rheumatic disorders
Manufacturer: Contact details available from supplier
Emergency Phone: Listed on commercial documentation or as per local poison center information
GHS Classification: Not generally considered hazardous in pharmaceutical context; may pose a risk as a powder or in industrial quantities
Routes of Entry: Inhalation, skin absorption, ingestion, eye contact
Acute Effects: Eye, skin, or respiratory tract irritation, possible allergic reactions on prolonged exposure
Chronic Effects: Long-term handling without proper protection may impact adrenal function, promote skin sensitization, or cause Cushingoid symptoms in extreme misuse
Signal Words: Caution recommended during bulk handling or manufacturing
Active Ingredient: Triamcinolone Acetonide, 99%
Impurities: Less than 1%, trace by-products from synthesis
Other Non-hazardous Components: None unless part of proprietary finished pharmaceutical blends
Eye Contact: Rinse cautiously with water for at least 15 minutes, lifting upper and lower lids; get medical attention if irritation persists
Skin Contact: Wash affected area thoroughly with soap and water; remove contaminated clothing; consult doctor if redness or irritation develops
Inhalation: Move to fresh air, monitor for respiratory distress, seek medical attention for symptoms
Ingestion: Rinse mouth with plenty of water, do not induce vomiting unless directed by medical professionals; obtain medical attention
Notes for Physician: Symptomatic treatment; consider hypersensitivity and overexposure backgrounds
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam; avoid high-pressure streams
Specific Hazards: Combustion produces toxic fumes including carbon monoxide, carbon dioxide, possible halogenated compounds
Protective Equipment: Firefighters should use full protective gear and self-contained breathing apparatus
Precautions: Remove containers from fire area, use water spray to cool unaffected containers
Personal Protection: Wear gloves, goggles, lab coat, NIOSH-approved respirator if dust is airborne
Spill Response: Avoid dust formation; sweep up material without raising dust; place collected material in closed, labeled containers
Environmental Cautions: do not flush into drains, avoid release to environment, prevent spillage from entering water systems
Clean-up Methods: ventilate area, clean with damp cloth or mop, dispose waste according to local regulations
Handling: Use only in well-ventilated areas; avoid dust formation; handle with appropriate personal protective equipment; do not ingest, breathe dust, or get on skin or clothing
Storage Requirements: Store in tightly closed containers, keep in a cool, dry and well-ventilated place; protect from light; avoid excessive heat or freezing
Incompatible Materials: Avoid contact with strong oxidizers or acids; incompatible with strong bases
Engineering Controls: Use local exhaust ventilation or process enclosure to minimize airborne concentration; provide eyewash stations and safety showers
Personal Protection: Use chemical-resistant gloves (nitrile, neoprene), safety goggles, lab coat; respiratory protection with NIOSH-approved dust masks under high dust scenarios
Occupational Exposure Limits: No OSHA or ACGIH exposure limits established but treat as potentially hazardous pharmaceutical
Hygiene Measures: Wash hands thoroughly after handling, avoid transfer of material to mouth, eyes, or skin
Physical State: White to off-white crystalline powder
Odor: Odorless
pH: No data available (insoluble in water)
Melting Point: 274-278°C
Boiling Point: Not applicable (decomposes)
Solubility: Soluble in acetone, methanol, ethanol; practically insoluble in water
Vapor Pressure: Negligible at ambient conditions
Partition Coefficient: log Kow approximately 1.61
Other Properties: Stable under normal temperatures and pressures, flashes when exposed to open flame at high temperatures
Chemical Stability: Remains stable under recommended storage and handling conditions
Reactivity: No dangerous reactions under normal processing or handling
Conditions to Avoid: Excessive heat, light exposure, moisture, contact with incompatible materials
Incompatible Materials: Strong oxidizing agents, strong acids, alkalis
Hazardous Decomposition Products: Carbon oxides, fluorinated compounds, other toxic gases when burning
Acute Toxicity: Low acute toxicity in small quantities; high doses or repeated exposure to dust may cause symptoms such as headache, nausea, fatigue
Chronic Exposure: Long-term contact can affect endocrine system, vision, skin, and immune response; possible suppression of natural corticosteroid production
Carcinogenicity: Animal studies show no clear evidence; not classified as human carcinogen by IARC, NTP, or OSHA
Mutagenicity: Negative in standard bacterial mutation assays; no evidence from animal tests
Reproductive Effects: High doses in animal models may cause teratogenic effects
Sensitization: Possible skin or respiratory sensitizer with repeated exposure
Ecotoxicity: Not readily biodegradable; potential for bioaccumulation in aquatic systems
Aquatic Toxicity: Very limited specific data but use caution due to glucocorticoid activity, which can disrupt aquatic microfauna and flora
Mobility in Soil: Limited movement due to low water solubility
Persistence: Likely to persist due to resistance to microbial degradation
Other Information: Avoid contamination of soil, waterways, and sewers; large-scale release may impact local ecosystems due to hormonal effects
Waste Treatment Methods: Incinerate at a licensed facility equipped for pharmaceutical waste; avoid release to environment
Container Disposal: Empty containers should be triple-rinsed and offered for recycling or disposal per local regulations
Hazardous Waste Designation: Not regulated as hazardous waste under US RCRA but recommended for treatment as chemical waste in medical or laboratory settings
Local Requirements: Consult local, regional, and national regulations for proper disposal practices
UN Number: Not regulated for transport under UN criteria
Proper Shipping Name: Non-regulated pharmaceutical or laboratory chemical
Hazard Class: Not applicable
Packing Group: Not classified
Special Precautions: Use secure packaging to avoid spillage of powder during transit. Ensure shipment complies with regional pharmaceuticals transport laws
US Federal Regulations: Triamcinolone Acetonide is not subject to significant TSCA or CERCLA restrictions; treated as a prescription-only drug by FDA; listed as a Schedule III substance under the Controlled Substances Act when compounded in certain steroid blends
International Regulations: Subject to individual country drug regulations as a controlled or prescription-restricted corticosteroid
Workplace Safety: Not classified under OSHA hazard communication standard but recommended for safe industrial hygiene practices
Other Listings: Included in ICH, EMA, and WHO Model List of Essential Medicines as a topical or injectable corticosteroid
Labeling: Must include substance identification, risk phrases, recommendations for physician or pharmacist control, and personal protection requirements
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