This compound stands out in chemical manufacturing as a synthetic corticosteroid derivative, shaped for pharmaceutical and biochemical research. 11Beta,21-Dihydroxypregna-1,4,16-Triene-3,20-Dione 21-Acetate brings together advanced organic chemistry with real-world applications, finding a place in hormone synthesis and as a reference compound in steroid analysis. Labs relying on its reliability seek purity and consistency, tracking each batch’s structure and confirming its role in building complex molecules.
Each molecule carries the weight of its formula: C23H28O6. Its well-defined steroid backbone opens up possibilities in both research and practical applications. The substance appears white to off-white, commonly as crystalline powder, though some suppliers provide it in solid flakes or small pearls. At ambient temperature, the solid state best supports storage and measurement, protecting the material’s integrity. Density measures often register between 1.1 and 1.3 g/cm3, which lines up well with recognized standards for steroid esters. Whether dissolved or used as a solid, each gram aligns with expected molecular weight—416.46 g/mol—making conversions and lab calculations straightforward.
HS Code tracking falls under 293729, linking it to hormonal steroids for customs and regulatory paperwork. The acetate group on the 21 position introduces just enough polarity to affect solubility, giving researchers flexibility in solvents: ethanol, DMSO, and even acetone dissolve the compound with care. The chemical remains stable under most lab conditions, with a melting point that typically stretches from 210°C to 230°C, depending on water content and handling. Exposure to high temperatures or acids brings risk of decomposition, releasing acetate and destabilizing the molecule. Manufacturers and users track moisture due to potential hydrolysis, especially in humid climates—a reminder that not all raw materials rest safely on the shelf.
Most shipments arrive as a fine, odorless solid, rolled out in tightly sealed amber bottles or double-layered bags to cut down on light exposure and oxygen. Finer particles carry a risk for airborne dust, so weighing and transferring the powder calls for a fume hood or dust mask. Some suppliers offer the material as pre-dissolved stock solutions, but researchers tap dry powder for greatest shelf life. Pearl or flake forms might ease pouring and measurement, but purity always stays a main concern. High-performance liquid chromatography (HPLC) or nuclear magnetic resonance (NMR) establish sample authenticity, a process anyone who’s spent time in the lab can appreciate—nobody wants to lose a run to poor-quality reagent.
11Beta,21-Dihydroxypregna-1,4,16-Triene-3,20-Dione 21-Acetate fits solidly in the “handle with care” category. It can be harmful if inhaled, swallowed, or in contact with the skin. Direct handling calls for gloves, eye protection, and—where needed—a dust mask. Accidents with steroid acetates rarely make headlines, but their effects on hormone balance have led to warnings across regulatory guidelines. In the event of a spill, absorbent materials trap the powder before careful disposal according to chemical waste protocols. Ventilated spaces and tightly managed inventories protect staff and environment alike. Finished or contaminated material never goes down the drain—combustion in controlled settings remains the best route, limiting exposure due to persistent steroid activity.
Sourcing starts with pregnadiene derivatives, then progresses through selective hydroxylation and esterification steps. Specialists rely on robust supply chains for raw materials, keeping close ties with farm, fermentation, or chemical synthesis sources. Each batch undergoes scrutiny for contaminants and residual solvents. After synthesis, 11Beta,21-Dihydroxypregna-1,4,16-Triene-3,20-Dione 21-Acetate often heads toward pharmaceutical intermediates, where purity turns non-negotiable. Its use in research and drug synthesis connects global producers with teams working on new therapies, especially for inflammatory and autoimmune diseases. International shipping routes pose challenges for temperature, moisture, and regulatory declarations, making proper documentation and robust packaging more important than ever.
The molecule’s three double bonds and hydroxyl groups give it both challenge and promise in synthetic chemistry. Its rigid, multi-cyclic structure supports predictable binding in enzyme assays or as a template for analog design. Scientists designing new corticosteroids often lean on this backbone, modifying side chains or ring structures to refine biological activity. The acetate on carbon 21 changes both metabolic handling and duration in biological systems, setting this compound apart from unesterified steroids. As many researchers know, the ability to tweak functional groups on a steroid ring can drive entirely new therapeutic strategies—a process that brings lab work close to real-life patient outcomes.
Labs and manufacturers facing quality control stress can look toward automation in material testing, pushing for early detection of impurities. Secure packaging and real-time tracking during transit cut down on exposure and moisture risk. Outsourcing waste disposal to certified handlers takes worry out of hazardous material management, leaving more time for research and less for compliance paperwork. On the policy side, greater transparency about raw material origins can support sustainable, ethical sourcing—a growing concern as supply chains stretch across continents. For those working daily with chemical intermediates, improving safety data sheet clarity and keeping emergency procedures up to date strengthens health and environmental safeguards for everyone in the pipeline.
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